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INCREMENTAL UNKNOWNS FOR THE HEAT EQUATION WITH TIME-DEPENDENT COEFFICIENTS: SEMI-IMPLICIT θ-SCHEMES AND THEIR STABILITY

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Journal of Computational Mathematics 2007年第5期25卷 573-582页

作者： Yujiang wu aili Yang School of Mathematics and Statistics Lanzhou University Lanzhou 730000 China

Based on the finite difference discretization of partial differential equations, we propose a kind of semi-implicit θ-schemes of incremental unknowns type for the heat equation with time-dependent coefficients. The stability of the new schemes is carefully studied. Some new types of conditions give better stability when θ is closed to 1/2 even if we have variable coefficients.

关键词： Incremental unknowns Semi-implicit schemes θ-Schemes Stability.

基于直方图的CT检查技术在甲状腺结节性质鉴别中的作用研究

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中外医药研究 2024年第10期3卷 145-147页

作者：石教智武爱利上海市奉贤区精神卫生中心影像科上海201418

目的:分析CT图像直方图在鉴别甲状腺结节性质中的作用.方法:选取2022年8月—2023年8月上海市奉贤区精神卫生中心收治的甲状腺结节患者80例(86个结节)作为研究对象,根据结节良恶性(手术病理结果)分为恶性组和良性组,各40例.患者均开展CT... 详细信息

目的:分析CT图像直方图在鉴别甲状腺结节性质中的作用.方法:选取2022年8月—2023年8月上海市奉贤区精神卫生中心收治的甲状腺结节患者80例(86个结节)作为研究对象,根据结节良恶性(手术病理结果)分为恶性组和良性组,各40例.患者均开展CT平扫与增强扫描.围绕轴位病灶,借助Mazda软件勾画感兴趣(ROI),开展直方图分析,比较结节良、恶性的差异情况,利用受试者工作特征(ROC)曲线评定直方图参数在鉴别诊断甲状腺性质中的效能.结果:在CT平扫中,恶性结节的均值及第10、50、90百分位数高于良性结节,差异有统计学意义(P<0.05);在CT增强扫描中,恶性结节的均值及第1、10、50、90百分位数高于良性结节,方差低于良性结节,差异有统计学意义(P<0.05).ROC曲线结果显示,CT平扫直方图参数中曲线下面积(AUC)最高的为均值(0.662);在增强扫描直方图参数中,AUC值最高的是第10百分位数(0.683).结论:CT直方图分析在鉴别甲状腺结节性质中具有一定价值,可将其作为一种辅助手段.

关键词：甲状腺结节性质直方图 CT

BANDED M-MATRIX SPLITTING PRECONDITIONER FOR RIESZ SPACE FRACTIONAL REACTION-DISPERSION EQUATION

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Journal of Computational Mathematics 2024年第2期42卷 372-389页

作者： Shiping Tang aili Yang Yujiang wu School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000China School of Mathematics and Statistics Hainan Normal UniversityHaikou 570000China

Based on the Crank-Nicolson and the weighted and shifted Grunwald operators,we present an implicit difference scheme for the Riesz space fractional reaction-dispersion equations and also analyze the stability and the convergence of this implicit difference ***,after estimating the condition number of the coefficient matrix of the discretized scheme,we find that this coefficient matrix is ill-conditioned when the spatial mesh-size is sufficiently *** overcome this deficiency,we further develop an effective banded M-matrix splitting preconditioner for the coefficient *** properties of this preconditioner together with its preconditioning effect are ***,Numerical examples are employed to test the robustness and the effectiveness of the proposed preconditioner.

关键词： Riesz space fractional equations Toeplitz matrix conjugate gradient method Incomplete Cholesky decomposition Banded M-matrix splitting

Cell viability and dopamine secretion of 6-hydroxydopamine-treated PC12 cells co-cultured with bone marrow-derived mesenchymal stem cells

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Neural Regeneration Research 2012年第14期7卷 1101-1105页

作者： Yue Tang Yongchun Cui Fuliang Luo Xiaopeng Liu Xiaojuan Wang aili wu Junwei Zhao Zhong Tian Like wu State Key Laboratory of Translational Cardiovascular Medicine Fuwai Hospital ＆ Cardiovascular Institute Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China Beijing wu Stem Cells Medical Center Beijing 100070 China

In the present study, PC12 cells induced by 6-hydroxydopamine as a model of Parkinson＇s Disease, were used to investigate the protective effects of bone marrow-derived mesenchymal stem cells bone marrow-derived mesenchymal stem cells against 6-hydroxydopamine-induced neurotoxicity and to verify whether the mechanism of action relates to abnormal a-synuclein accumulation in cells Results showed that co-culture with bone marrow-derived mesenchymal stem cells enhanced PC12 cell viability and dopamine secretion in a cell dose-dependent manner. MitoLight staining was used to confirm that PC12 cells co-cultured with bone marrow-derived mesenchymal stem cells demonstrate reduced levels of cell apoptosis. Immunocytochemistry and western blot analysis found the quantity of α-synuclein accumulation was significantly reduced in PC12 cell and bone marrow-derived mesenchymal stem cell co-cultures. These results indicate that bone marrow-derived mesenchymal stem cells can attenuate 6-hydroxydopamine-induced cytotoxicity by reducing abnormal α-synuclein accumulation in PC12 cells.

关键词： bone marrow-derived mesenchymal stem cells α-synuclein 6-hydroxydopamine PC12 cells dopamine cell apoptosis neurotoxicity neural regeneration

体外转录mRNA系统的建立及其在呼吸道合胞病毒疫苗中的应用

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微生物学免疫学进展 2024年第3期52卷 17-25页

作者：侯风萍程亚慧唐悦吴爱莉王云瑾李晓萌王剑李雄雄兰州生物制品研究所有限责任公司第二研究室甘肃省疫苗技术创新中心甘肃兰州730046

目的建立mRNA的体外转录系统,并用于评价呼吸道合胞病毒(respiratory syncytial virus,RSV)mRNA疫苗的免疫效果。方法以增强绿色荧光蛋白(enhanced green fluorescent protein,EGFP)为模式蛋白,将EGFP基因分别克隆入pcDNA3.1(+)和pmRV载体中,通过体外转录合成EGFP mRNA,以验证载体及mRNA框架结构的正确性;然后将RSV融合前F蛋白(RSV preF)序列构建于经验证的载体,体外转录合成RSV preF mRNA;转染细胞后,通过荧光显微镜、流式细胞术、免疫荧光和Western blot等方法验证蛋白表达;进一步通过微流控技术用脂质体纳米颗粒(lipid nanoparticles,LNP)包封体外转录合成的mRNA,经过粒径和多分散性指数检测后进行小鼠免疫和评价。结果经过验证发现,pcDNA3.1(+)的框架结构更适合mRNA;EGFP mRNA转染HEK 293T细胞24 h后,体外转染效率>90%;免疫荧光和Western blot等方法验证RSV mRNA能够在24 h内表达preF;包封后的RSV mRNA疫苗免疫小鼠,血清抗体滴度与RSV preF蛋白免疫抗体滴度相近(P>0.05),细胞因子IFN-γ和IL-4均有一定程度的上调。结论建立了正确表达目的蛋白的mRNA体外转录系统,以此为基础的RSV mRNA疫苗在小鼠体内可诱导强的免疫应答,为潜在的RSV mRNA候选疫苗奠定了基础。

关键词： mRNA疫苗体外转录系统呼吸道合胞病毒脂质体纳米颗粒免疫应答

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单周期产品逆向供应链中二次订货策略的应用

物流技术 2014年第12期33卷 337-339,289页

作者：吴爱丽河北农业大学河北保定071001

研究了二次订货策略对于单周期产品逆向供应链的影响,同时对比了一次订货策略与二次订货策略的差别。最后结合实际数据进行了分析研究,结果证明二次订货策略不仅能够提高零售商和供应链的收益,还能够减少订货的数量,增强企业的核心竞争力。

关键词：单周期产品逆向供应链一次订货策略二次订货策略

Application of sodium alginate microspheres in ischemic stroke modeling in miniature pigs

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Neural Regeneration Research 2013年第16期8卷 1473-1480页

作者： Yongchun Cui Yi Tian Yue Tang Liujun Jia aili wu Peng Peng Jianzhong Yang Hong Du Xiaojuan Wang Like wu State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College wu Stem Cells Medical Center Beijing Union Health Co. Ltd.

The miniature pig is an optimal animal model for studying nervous system disease because of its physiologic and pathologic features. However, the rete mirabile composed of arteries and veins at the skull base limits their application as a model of ischemic stroke by middle cerebral artery occlusion. The present study investigated the possibility of establishing an ischemic stroke model in the miniature pig by blocking the skull base retia with sodium alginate microspheres. Three Bama miniature pigs were used. Using the monitor of C-arm X-ray machine, sodium aiginate microspheres （100-300 pm）, a novel embolic material, were injected through the femoral artery, aortic arch, common carotid artery, ascending pharyngeal artery and the retia. Results were evaluated using carotid arteriography, MRI, behavior observation and histology. The unilateral rete mirabile was completely blocked, resulting in disturbance in blood supply to the basal ganglia, astasia of the dght hind limb and salivation. MRI and hematoxylin-eosin staining showed an evident infarction focus in the basal ganglia. These findings indicate that sodium alginate microspheres are a suitable embolic material for blocking the skull base retia in miniature pigs to establish an ischemic stroke models.

关键词： neural regeneration brain injury stroke miniature pig sodium alginate microsphere basilar bloodvessels middle cerebral artery grants-supported paper neuroregeneration

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科技含量、资本结构与公司绩效

科技管理研究 2006年第11期26卷 34-36页

作者：吴艾莉南京林业大学经济管理学院

本文选取深圳股市2002年490家上市公司的数据检验了科技含量、资本结构与公司绩效之间的关系,并根据研究结果对提高公司绩效提出了一些建议。

关键词：科技含量资本结构公司绩效

Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy

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Neural Regeneration Research 2024年第2期19卷 425-433页

作者： Feng Chen Xi Dong Zhenhuan Wang Tongrui wu Liangpeng Wei Yuanyuan Li Kai Zhang Zengguang Ma Chao Tian Jing Li Jingyu Zhao Wei Zhang aili Liu Hui Shen Laboratory of Neurobiology School of Biomedical EngineeringTianjin Medical UniversityTianjinChina Institute for Translational Neuroscience the Second Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Institute for Translational Brain Research Fudan UniversityShanghaiChina Department of Radiology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Department of Anesthesiology Tianjin Medical University General HospitalTianjinChina Department of Orthopaedics Tianjin Medical University General HospitalTianjinChina Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjinChina Laboratory of Neurobiology School of Basic Medical SciencesTianjin Medical UniversityTianjinChina

Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence *** pathogenesis of temporal lobe epilepsy is complex and is not fully *** calcium dynamics have been implicated in temporal lobe ***,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving *** this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy *** found that calcium signals varied according to the grade of temporal lobe epilepsy *** particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor *** inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠ*** addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly ***,it was possible to rescue the altered intracellular calcium *** simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were *** results indicate that the calcium dynamic between CA1 and M1 may reflect sp

关键词： Ca^(2+) calcium signals chemogenetic methods hippocampus primary motor cortex pyramidal neurons temporal lobe epilepsy