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Body-focused Anxiety in Women: Associations with Internalization of the Thin-ideal, Dieting Frequency, Body mass Index and media Effects

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Open Journal of medical Psychology 2013年第4期2卷 17-24页

作者： aileen Pidgeon Rachel A. Harker Bond University Australia

Exposure to media that portrays thin women as ideal and attractive can lead to women internalizing the thin ideal, which results in incorporating societal standards of thinness into belief systems. Internalization of the thin-ideal is associated with numerous detrimental effects on women, including decreased levels of self-esteem and increased levels of body-focused anxiety, negative emotions and disordered eating. The present study utilized a sample of women (N = 208) aged between 18 and 67 years (m = 29.44, SD = 13.08) to examine the relationship between internalization of the thin- ideal, body-focused anxiety, body mass index (BmI), and dieting frequency. Correlational, regression and mediation analyses conducted on the data showed that internalization of the thin-ideal, BmI and dieting frequency significantly contributed to body-focused anxiety in women. In addition, body-focused anxiety fully mediated the relationship between internalization of the thin-ideal and dieting frequency among women. BmI did not moderate the relationship between internalization of the thin-ideal and body-focused, indicating that women who internalize the thin-ideal are less vulnerable to dieting unless experiencing body-focused anxiety. The results of the current study enhance our understanding of the relationship between internalization of the thin-ideal, body-focused anxiety, BmI, and dieting frequency among women. Clinical implications will be discussed.

关键词： Body-focused Anxiety Internalization of the Thin-ideal BmI Dieting

Current concepts on osteonecrosis of the femoral head

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世界骨科杂志：英文版 2015年第8期6卷 590-601页

作者： Joaquin moya-Angeler Arianna L Gianakos jordan C Villa Amelia Ni Joseph m Lane Hospital for Special Surgery

It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(mRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore mRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated.

关键词： Osteonecrosis Femoral head Conservative treatment Core decompression Stem cells Total hip arthroplasty

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印度板块和亚洲大陆在何时何地碰撞

地质通报 2008年第9期27卷 1351-1370页

作者： Jonathan C Aitchison Jason R Ali aileen m Davis 戴紧根(译) 赵西西(校) 香港大学地球科学系青藏高原研究组中国香港不详

印度板块和亚洲大陆的初始碰撞时间是所有相关的喜马拉雅-西藏造山体系演化模式的主控条件,并严重影响到对众多与青藏高原隆升和东亚大陆挤出相关的地质过程速率的解释,以及对新生代全球气候变化的理解。尽管印度板块和亚洲大陆汇聚的... 详细信息

印度板块和亚洲大陆的初始碰撞时间是所有相关的喜马拉雅-西藏造山体系演化模式的主控条件,并严重影响到对众多与青藏高原隆升和东亚大陆挤出相关的地质过程速率的解释,以及对新生代全球气候变化的理解。尽管印度板块和亚洲大陆汇聚的速率在55ma突然减缓被广泛地认为是初始碰撞的标志,但这次碰撞所造成的主要构造效应直到20多个百万年以后才显现出来。对印度板块和亚洲大陆相对位置的重新估算,表明它们在55ma时并没有达到可以彼此发生碰撞的距离。基于来自西藏新的野外证据和对已有数据的重新评估,认为初始碰撞发生在始新世—渐新世之交(约34ma),并对55ma时发生的地质事件提出了另一种解释。

关键词：印度板块亚洲大陆碰撞喜马拉雅-西藏

Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： Lena Stevens Zachary J Brown Ryan Zeh Christina monsour Sharla Wells-Di Gregorio Heena Santry Aslam m Ejaz Timothy michael Pawlik jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Neoadjuvant therapy(NT)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing NT,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during NT may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of NT and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving NT to identify opportunities to improve neoadjuvant cancer care *** Semi-structured interviews of patients with localized PDAC during NT were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using NVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing NT was the doctor’s recommendation,while most reported not being familiar with the concept of NT(n=11)and that NT was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma Neoadjuvant therapy Patient experience Patient-centered care Quality of life Qualitative research

An overview of resistance to chemotherapy in osteosarcoma and future perspectives

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Cancer Drug Resistance 2022年第3期5卷 762-793页

作者： Dorian Yarih Garcia-Ortega Sara aileen Cabrera-Nieto Haydee Sarai Caro-Sanchez marlid Cruz-Ramos Cirugia Oncologica Instituto Nacional de Cancerologia(INCAN)Ciudad de Mexico 14080Mexico Posgrado en Ciencias medicas Facultad de Ciencias de la SaludUniversidad AnahuacCiudad de Mexico 52786Mexico Departamento de Patologi Instituto Nacional de Cancerologia(INCAN)Ciudad de México 14080Mexico Catedras de Consejo Nacional de Ciencia y Tecnologia(CONACYT) Instituto Nacional de CancerologiaCiudad de Mexico 14080Mexico

Osteosarcoma(OS)is the most common type of bone *** the availability of multimodal treatment with surgery and chemotherapy,the clinical results remain *** main reason for the poor outcomes in patients with OS is the development of resistance to methotrexate,cisplatin,doxorubicin,and *** and cellular mechanisms associated with resistance to chemotherapy include DNA repair and cell-cycle alterations,enhanced drug efflux,increased detoxification,resistance to apoptosis,autophagy,tumor extracellular matrix,and *** versatility of cells to generate chemoresistance has motivated the use of anti-angiogenic therapy based on tyrosine kinase *** approach has shown that other therapies,along with standard chemotherapy,can improve responses to therapy in patients with ***,microRNAs may act as predictors of drug resistance in *** review provides insight into the molecular and cellular mechanisms involved in the development of resistance during the treatment of OS and discusses promising novel therapies(e.g.,afatinib and palbociclib)for overcoming resistance to chemotherapy in OS.

关键词： Osteosarcoma therapy resistance tyrosine kinase inhibitor tumoral extracellular microenvironment cell cycle

Association between tourniquet use and intraoperative blood loss during below-knee amputation

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World Journal of Orthopedics 2022年第7期13卷 644-651页

作者： Alden E Wyland Erik Woelber Liam H Wong jordan Arakawa Zachary m Working James meeker School of medicine Oregon Health and Sciences UniversityPortlandOR 97239United States Department of Orthopaedics and Rehabilitation Oregon Health and Sciences UniversityPortlandOR 97239United States

BACKGROUND Despite over 150000 amputations of lower limbs annually,there remains a wide variation in tourniquet practice patterns and no consensus on their necessity,especially among orthopedic patient *** purpose of this study was to determine whether tourniquet use in orthopedic patients undergoing below knee amputation(BKA) was associated with a difference in calculated blood loss relative to no tourniquet *** To determine if tourniquet use in orthopedic patients undergoing BKA was associated with a difference in calculated blood loss relative to no tourniquet *** We performed a retrospective review of consecutive patients undergoing BKA by orthopedic surgeons at a tertiary care hospital from 2008 through *** loss was calculated using a combination of the Nadler equation for preoperative blood volume and a novel formula utilizing preoperative and postoperative hemoglobin levels and *** and forwards step-wise multivariate linear regressions were performed to determine the association between tourniquet use and blood loss.A Wilcoxon was used to determine the univariate relationship between tourniquet use and blood loss for in the restricted subgroups of patients who underwent BKA for trauma,tumor,and *** Of 97 eligible patients identified,67 underwent surgery with a tourniquet and 30 did *** multivariate regression,tourniquet use was associated with a 488 mL decrease in calculated blood loss(CI 119-857,P = 0.01).In subgroup analysis,no individual group showed a statistically significant decrease in blood loss with tourniquet *** was no significant association between tourniquet use and either postoperative transfusions or reoperation at one *** We found that tourniquet use during BKA is associated with decreased calculated intraoperative blood *** recommend that surgeons performing this procedure use a tourniquet to minimize blood loss.

关键词： Amputation Tourniquet Blood loss Hemostasis

multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence

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Nano Research 2013年第2期6卷 113-120页

作者： Bo Zhang jordan Price Guosong Hong Scott m. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng Paul J. Utz Hongjie Dai Department of Chemistry Stanford University Stanford California USA Department of medicine Division of Immunology and Rheumatology Stanford University School of Medicine Stanford California USA Institute for Immunity Transplantation and Infection Stanford University School of Medicine Stanford California USA

Protein microarrays based on fluorescence detection have been widely utilized for high-throughput functional proteomic analysis. However, a drawback of such assays has been low sensitivity and narrow dynamic range, limiting their capabilities, especially for detecting low abundance biological molecules such as cytokines in human samples. Here, we present fluorescence-enhancing microarrays on plasmonic gold films for multiplexed cytokine detection with up to three orders of magnitude higher sensitivity than on conventional nitrocellulose and glass substrates. Cytokine detection on the gold plasmonic substrate is about one to two orders of magnitude more sensitive than enzyme-linked immunosorbent assay （ELISA） and can be multiplexed. A panel of six cytokines （Vascular endothelial growth factor （VEGF）, Interleukin 1β （IL-1β）, Interleukin 4 （IL-4）, Interleukin 6 （IL-6）, Interferon γ （IFN-γ）, and Tumor necrosis factor （TNF）） were detected in the culture media of cancer cells. This work establishes a new method of high throughput multiplexed cytokine detection with higher sensitivity and dynamic range than ELISA.

关键词： microarray cytokine plasmonic multiplex near infrared fluorescence

Phenotypic and genomic relationships between vulva score categories and reproductive performance in first-parity sows

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Journal of Animal Science and Biotechnology 2021年第2期12卷 479-491页

作者： Flor-Anita Corredor Leticia P.Sanglard Jason W.Ross aileen F.Keating Richard J.Leach Nick V.L.Serão Department of Animal Science Iowa State UniversityAmesIA 50011USA Iowa Pork Industry Center Iowa State UniversityAmesIA 50011USA

Background:One of the biggest challenges in the swine industry is to increase female reproductive ***,vulva score categories(VSC),assessed prior to puberty,has been proposed as an indicator trait of efficient reproductive performance in *** objective of this study was to validate the use of VSC as an indicator trait for reproductive performance,and to perform genetic and genomic analyses for ***:The phenotypic relationship of VSC,using a three-point scale:small(VSC-S),medium(VSC-m),and large(VSC-L),on reproductive performance was evaluated on three *** was measured at 15 weeks of age,for farms 1 and 2,and at 14 weeks of age for farm 3 on 3981 Yorkshire gilts,in which 1083 had genotypes(~50 K SNPs).Genetic parameters for VSC with reproductive traits were estimated using ssGBLUP.A Genome-wide association study(GWAS)for VSC was performed using ***:For the phenotypic analysis of VSC across datasets,differences in performance were identified there was a significant effect(P≤0.05)for the interaction between Farm and VSC for total number dead(TND),and a trend(Pmber born(TNB).There were significant(P≤0.05)pre-defined contrasts of VSC-S versus VSC-m+L on TNB,number born alive(NBA),TND,number of stillborn(NSB),and number of mummies(mUm).Heritability estimates for VSC as a categorical trait(VSCc)and a quantitative trait(VSCq)were 0.40±0.02 and 0.83±0.02,respectively,for across farm,0.13±0.07 and 0.20±0.10,respectively,for Farm1,0.07±0.07 and 0.09±0.09,respectively,for Farm2,and 0.20±0.03 and 0.34±0.05,respectively,for *** across farms,favorable genetic correlations estimates were found for TNB(0.28±0.19)and NBA(0.26±0.17).Within farms,moderate genetic correlations between VSC with reproductive traits were found for TNB(0.61±0.47)and mUm(0.69±0.47)for farm 1,for number of services until first farrow(NS;0.69±0.38)and unique service with successful first farrow(SFS;−0.71±0.38)for farm *** genomic regions

关键词： Genetic parameters GWAS Reproduction Swine Vulva

Combined immunohistochemical and retrograde tracing reveals little evidence of innervation of the rat dentate gyrus by midbrain dopamine neurons

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Frontiers in Biology 2016年第3期11卷 246-255页

作者： Charlotte m. Ermine jordan L. Wright Clare L. Parish Davor Stanic Lachlan H. Thompson The Florey Institute for Neuroscience and mental Health The University of Melbourne Parkville Victoria 3010 Australia Current address Wolfson Institute for Biomedical Research University College London Gower Street London WC1E 6BT UK

Although the functional neuroanatomy of the midbrain dopamine （mDA） system has been well characterized, the literature regarding its capacity to innervate the hippocampal formation has been inconsistent. The lack of expression of definitive markers for dopaminergic fibers, such as the dopamine transporter, in the hippocampus has complicated studies in this area. Here we have used immunohistochemical techniques to characterize the tyrosine hydroxylase expressing fiber network in the rat hippocampus, combined with retrograde tracing from the dentate gyrus to assess the capacity for afferent innervation by mDA neurons. The results indicate that virtually all tyrosine hydroxylase fibers throughout the hippocampus are of a noradrenergic phenotype, while the overlying cortex contains both dopaminergic and noradrenergic fiber networks. Furthermore, retrograde tracing from the dentate gyrus robustly labels tyrosine hydroxylase-immunoreactive noradrenergic neurons in the locus coeruleus but not mDA neurons.

关键词： noradrenaline hippocampus connectivity DAT neurogenesis