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Analyzing the Relationship between Urban Patterns and Land Surface Temperature Using WorldView-2 and Landsat-ETM＋

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Journal of Earth Science and Engineering 2014年第4期4卷 195-202页

作者： aikaterini Stamou Petros Patias Laboratory of Photogrammetry and Remote Sensing Department of Rural and Surveying Engineering Faculty of EngineeringA UTH (Aristotle University of ThessalonikO Thessaloniki 54124 Greece

Global climate destabilization as a result of the increased urbanization is one of today＇s most urgent issues. The detected urban heat island phenomenon in urbanized areas, combined with the decreased vegetation and the anthropogenic heat discharge, is an example of this climate change and in order to take proper actions to reduce this effect, the urban environmental analysis is more than necessary. This paper aims at analyzing and exploring the relationship between land uses of a densely populated urban area with the LST （land surface temperature） combining with WorldView-2 and Landsat ETM＋ satellite imagery. The available thermal band of the Landsat image is used to extract surface temperatures of the study area on a hot summer day. Continuously, the high resolution satellite image of WorldView-2 is used for extracting the land uses. Zonal statistics were applied highlighting the zones with high and low average temperatures. Additional statistical tests （correlation analysis, analysis of variance-ANOVA, etc.） were applied, for evaluating the interaction between the temperature results with the land use types.

关键词： Land use land surface temperature WorldView-2 urban heat island statistical analysis.

Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients

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World Journal of Gastroenterology 2010年第47期16卷 5965-5974页

作者： aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris Department of Experimental Physiology Medical School National and Kapodistrian University of Athens Third Department of Surgery Athens General Hospital "G. Gennimatas" Department of Surgical Oncology Hellenic Anticancer Institute "Saint Savvas" Hospital Endo/OncoResearch Medical Center Department of Surgical Oncology Hellenic Anticancer Institute "Saint Savvas" Hospital 11522 Athens Greece Second Department of Internal Medicine Propaedeutic Oncology Section University of Athens Attikon University Hospital Department of Hygiene Epidemiology and Medical Statistics Medical School National and Kapodistrian University of Athens

AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients.

关键词： Peripheral blood Carcinoembryonic antigen Cytokeratin 20 Epidermal growth factor receptor Multiplex reverse transcription polymerase chain reaction

Management of primary retroperitoneal synovial sarcoma: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2019年第1期11卷 27-33页

作者： aikaterini Mastoraki Dimitrios Schizas Ioannis S Papanikolaou George Bagias Nikolaos Machairas George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Surgery National and Kapodistrian University of Athens Laikon Hospital Hannover Medical School Clinic for General Visceral and Transplant Surgery 3rd Department of Surgery National and Kapodistrian University of Athens Attikon University Hospital 1st Department of Pathology National and Kapodistrian University of Athens

BACKGROUND Synovial sarcoma(SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the ***, several cases of retroperitoneal SS(RSS) have been described. We herein report a case of RSS presented in our *** SUMMARY A 69-year-old female patient was admitted with a large, palpable, firm mass in the right abdominal space SS. Computerized tomography scan depicted a concentric, sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver. Subsequently, the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm. The final histological diagnosis of the tumour was grade II monophasic *** RSS is encountered in the biphasic type, the monophasic fibrous, and the monophasic epithelial category as well. Relevant clinical manifestations are not always documented at early stages. Therefore, the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis. Therapeutic approach happens often late when metastases at the lungs and the liver are apparent. Thus, 5-year survival rates remain low.

关键词： Retroperitoneal tumours Synovial sarcoma Case report Clinical presentation Diagnostic modalities Therapeutic management

Receptor activator of nuclear factorκB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease

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World Journal of Nephrology 2016年第1期5卷 1-5页

作者： Michalis Spartalis aikaterini Papagianni Department of Nephrology Aristotle University of Thessaloniki"Hippokration"General Hospital54642 ThessalonikiGreece

Vascular calcifications are commonly observed in patients with chronic kidney disease （CKD） and contri-bute to the excessive cardiovascular morbidity and mortality rates observed in these patients populations. Although the pathogenetic mechanisms are not yet fully elucidated, recent evidence suggests a link between bone metabolism and the development and progression of vascular calcifications. Moreover, accumulating data indicate that receptor activator of nuclear factor κB ligand/osteoprotegerin axis which plays essential roles in the regulation of bone metabolism is also involved in extra-osseous bone formation. Further studies are required to establish the prognostic significance of the above biomarkers as predictors of the presence and severity of vascular calcifications in CKD patients and of cardiovascular morbidity and mortality. Moreover, randomized clinical trials are needed to clarify whether inhibition of osteoclast activity will protect from vascular calcifcations.

关键词： Arterial stiffness Bone turnover Chronic kidney disease Osteoprotegerin RANK ligand Receptor activator nuclear factor κB Vascular calcifcations

Apolipoprotein E in diet-induced obesity:a paradigm shift from conventional perception

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The Journal of Biomedical Research 2018年第3期32卷 183-190页

作者： Kyriakos E.Kypreos Eleni A.Karavia Caterina Constantinou aikaterini Hatziri Christina Kalogeropoulou Eva Xepapadaki Evangelia Zvintzou Department of Pharmacology University of Patras Medical School

Apolipoprotein E（APOE） is a major protein component of peripheral and brain lipoprotein transport *** in peripheral circulation does not cross the blood brain barrier or blood cerebrospinal fluid barrier. As a result,peripheral APOE expression does not affect brain APOE levels and vice versa. Numerous epidemiological studies suggest a key role of peripherally expressed APOE in the development and progression of coronary heart disease while brain APOE has been associated with dementia and Alzheimer＇s disease. More recent studies, mainly in experimental mice, suggested a link between Apoe and morbid obesity. According to the latest findings, expression of human apolipoprotein E3（APOE3） isoform in the brain of mice is associated with a potent inhibition of visceral white adipose tissue（WAT） mitochondrial oxidative phosphorylation leading to significantly reduced substrate oxidation,increased fat accumulation and obesity. In contrast, hepatically expressed APOE3 is associated with a notable shift of substrate oxidation towards non-shivering thermogenesis in visceral WAT mitochondria, leading to resistance to obesity. These novel findings constitute a major paradigm shift from the widely accepted perception that APOE promotes obesity via receptor-mediated postprandial lipid delivery to WAT. Here, we provide a critical review of the latest facts on the role of APOE in morbid obesity.

关键词： apolipoprotein E morbid obesity white adipose tissue energy metabolism

Synchronous resection of esophageal cancer and other organ malignancies: A systematic review

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World Journal of Gastroenterology 2019年第26期25卷 3438-3449页

作者： Dimitrios Papaconstantinou Diamantis I Tsilimigras Dimitrios Moris Adamantios Michalinos aikaterini Mastoraki Efstratia Mpaili Natasha Hasemaki Anargyros Bakopoulos Dimitrios Filippou Dimitrios Schizas Third Department of Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research InstituteColumbusOH 43210United States Department of Surgery Duke University Medical CenterDurhamNC 27710United States Department of Anatomy European University of CyprusNicosia 2404Cyprus First Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Anatomy and Surgical Anatomy National and Kapodistrian University of AthensMedical SchoolAthens 11527Greece

BACKGROUND Neoplasms arising in the esophagus may coexist with other solid organ or gastrointestinal tract neoplasms in 6%to 15%of *** of both tumors synchronously or in a staged procedure provides the best chances for long-term *** resection of both esophageal and second primary malignancy may be feasible in a subset of patients;however,literature on this topic remains rather *** To analyze the operative techniques employed in esophageal resections combined with gastric,pancreatic,lung,colorectal,kidney and liver resections and define postoperative outcomes in each *** We conducted a systematic review according to PRISMA *** searched the Medline database for cases of patients with esophageal tumors coexisting with a second primary tumor located in another organ that underwent synchronous resection of both *** English language articles deemed eligible for inclusion were accessed in full *** criteria included:(1)Hematological malignancies;(2)Head/neck/pharyngeal neoplasms;(3)Second primary neoplasms in the esophagus or the gastroesophageal junction;(4)Second primary neoplasms not surgically excised;and(5)Preclinical *** regarding the operative strategy employed,perioperative outcomes and longterm outcomes were extracted and analyzed using descriptive *** The systematic literature search yielded 23 eligible studies incorporating a total of 117 *** these patients,71%had a second primary neoplasm in the *** who underwent total gastrectomy had a reconstruction using either a colonic(n=23)or a jejunal(n=3)conduit while for those who underwent gastric preserving resections(i.e.,non-anatomic/wedge/distal gastrectomies)a conventional gastric pull-up was ***,in cases of patients who underwent esophagectomy combined with pancreaticoduodenectomy(15%of the cohort),the decision to preserve part of the stomach or not dictated the reconstruction met

关键词： Esophagectomy Esophageal neoplasm Second primary Multiple primary Concurrent neoplasms Management

Endoscopic management and outcome of non-variceal bleeding in patients with liver cirrhosis:A systematic review

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 163-175页

作者： Georgios Demetiou aikaterini Augoustaki Evangelos Kalaitzakis Department of Gastroenterology University Hospital of HeraklionHeraklion 71500Greece

BACKGROUND Acute non-variceal bleeding accounts for approximately 20%of all-cause bleeding episodes in patients with liver *** is associated with high morbidity and mortality therefore prompt diagnosis and endoscopic management are *** To evaluate available data on the efficacy of endoscopic treatment modalities used to control acute non-variceal gastrointestinal bleeding(GIB)in cirrhotic patients as well as to assess treatment *** Employing PRISMA methodology,the MEDLINE was searched through PubMed using appropriate MeSH *** are reported in a summative manner and separately for each major non-variceal cause of *** Overall,23 studies were identified with a total of 1288 cirrhotic patients of whom 958/1288 underwent endoscopic therapy for acute non-variceal *** ulcer bleeding was the most common cause of acute non-variceal bleeding,followed by portal hypertensive gastropathy,gastric antral vascular ectasia,Mallory-Weiss syndrome,Dieaulafoy lesions,portal hypertensive colopathy,and *** to control bleeding from all-causes of non-variceal GIB accounted for less than 3.5%of cirrhotic ***(range 2%-25%)and mortality(range 3%-40%)rates varied,presumably due to study *** was usually managed endoscopically and salvage therapy using arterial embolisation or surgery was undertaken in very few *** was usually associated with liver function deterioration and other organ failure or infections rather than uncontrolled *** treatment-related complications were extremely *** acute non-variceal bleeding was examined in two studies(197/1288 patients)achieving initial hemostasis in all patients using argon plasma coagulation for portal hypertensive colopathy and endoscopic band ligation or sclerotherapy for bleeding hemorrhoids(rebleeding range 10%-13%).Data on the efficacy of endoscopic therapy of cirrhotic patients vs non-cirrhotic controls wi

关键词： Liver cirrhosis Non-variceal gastrointestinal hemorrhage Gastrointestinal endoscopy Endoscopic therapy Patient outcomes Peptic ulcer Mallory Weiss syndrome Gastric antral vascular ectasia

Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 328-335页

作者： aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras Nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos Nikolaos Arkadopoulos 4th Department of Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece Department of Vascular Surgery National and Kapodistrian University of AthensAttikon University HospitalAthens 12462Greece 1st Department of Surgery National and Kapodistrian University of AthensLaikon HospitalAthens 11527Greece

Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of *** includes two identical entities with regards to deep vein thrombosis and pulmonary *** incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without *** use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been ***,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d *** aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted *** addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease.

关键词： Deep vein thrombosis Pulmonary embolism Gastro-intestinal cancer Thromboprophylaxis Venous thromboembolism

Primary adrenal Ewing sarcoma:A systematic review of the literature

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世界临床病例杂志 2023年第28期11卷 6782-6791页

作者： Dimitrios K Manatakis Ioannis Tsouknidas Emmanouil Mylonakis Nikolaos Tasis Maria Ioanna Antonopoulou Vasileios Acheimastos aikaterini Mastoropoulou Dimitrios P Korkolis 2^(nd)Department of Surgery Athens Naval and Veterans HospitalAthens 11521Greece General Surgery Lankenau Medical CenterMain Line HealthWynnewoodPA 19096United States Department of Surgical Oncology St Savvas Cancer HospitalAthens 11522Greece Department of Surgery Naval Hospital of CreteChania 73200Greece Department of Pediatrics Stony Brook University HospitalStony BrookNY 11794United States

BACKGROUND Ewing sarcoma(ES)is a malignant neoplasm of neuroectodermal origin and is commonly observed in children and young *** musculoskeletal system is the main body system impacted and ES is rarely seen in the visceral organs particularly the adrenal *** To present a comprehensive review of primary adrenal ES,with emphasis on diagnosis,therapy and oncological *** A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses ***/MEDLINE,EMBASE and Google Scholar bibliographic databases were searched to identify articles from 1989 to 2022 and included patients with ES/primitive neuroectodermal tumor(PNET)of the adrenal ***,Google Scholar and EMBASE medical databases were searched,combining the terms“adrenal”,“ES”and“PNET”.Demographic,clinical,pathological and oncological data of patients were analyzed by SPSS version *** A total of 52 studies were included for review(47 case reports and 5 case series)with 66 patients reported to have primary adrenal *** age at diagnosis was 26.4±15.4 years(37.9%males,57.6%females,sex not reported in 3 cases).The most frequent complaint was abdominal/flank pain or discomfort(46.4%)followed by a palpable mass(25.0%),and the average duration of symptoms was 2.6±3.1 *** imaging modality of choice was computed tomography scan(81.5%),followed by magnetic resonance imaging(20.4%).Preoperative staging revealed that 17 tumors(27.9%)were metastatic and 14 patients had inferior vena cava or renal vein neoplastic thrombus at initial *** adrenalectomy was performed in the majority of cases(80.0%),of which 27.9%required more extensive *** invasive surgery was attempted in 8.2%of *** surgical resection was achieved in 89.4%of the *** therapy was administered to 32 patients,in the form of chemotherapy(62.5%),radiotherapy(3.1%)or combination(34.4%).Median overall s

关键词： Ewing sarcoma Primary adrenal tumor Adrenalectomy