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A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019

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Virologica Sinica 2021年第6期36卷 1475-1483页

作者： Xiangpeng chen Yun Zhu Wei Wang Changchong Li Shuhua An Gen Lu Rong Jin Baoping Xu Yunlian Zhou aihuan chen Lei Li Meng Zhang Zhengde Xie Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027China Children's Hospital of Hebei Province Shijiazhuang 050031China Guangzhou Women and Children's Medical Center Guangzhou 510623China Guiyang Maternal and Child Health Hospital Guiyang 550003China Beijing Children's Hospital Capital Medical UniversityNational Center for Children's HealthBeijing 10045China The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003China The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120China Yinchuan Maternal and Child Health Care Hospital Yinchuan 750001China

Human respiratory syncytial virus(RSV) is a major pathogen of acute lower respiratory tract infection among young children. To investigate the prevalence and genetic characteristics of RSV in China, we performed a molecular epidemiological study during 2015–2019. A total of 964 RSV-positive specimens were identified from 5529 enrolled patients during a multi-center study. RSV subgroup A(RSV-A) was the predominant subgroup during this research period except in2016. Totally, 535 sequences of the second hypervariable region(HVR-2) of the G gene were obtained. Combined with182 Chinese sequences from GenBank, phylogenetic trees showed that 521 RSV-A sequences fell in genotypes ON1(512),NA1(6) and GA5(3), respectively;while 196 RSV-B sequences fell in BA9(193) and SAB4(3). ON1 and BA9 were the only genotypes after December 2015. Genotypes ON1 and BA9 can be separated into 10 and 7 lineages, respectively. The HVR-2 of genotype ON1 had six amino acid changes with a frequency more than 10%, while two substitutions H258 Q and H266 L were co-occurrences. The HVR-2 of genotype BA9 had nine amino acid substitutions with a frequency more than10%, while the sequences with T290 I and T312 I were all from 2018 to 2019. One N-glycosylation site at 237 was identified among ON1 sequences, while two N-glycosylation sites(296 and 310) were identified in the 60-nucleotide duplication region of BA9. To conclusion, ON1 and BA9 were the predominant genotypes in China during 2015–2019. For the genotypes ON1 and BA9, the G gene exhibited relatively high diversity and evolved continuously.

关键词： Human respiratory syncytial virus(RSV) Genetic characteristics Molecular epidemiology Genotype Acute lower respiratory tract infection(ALRTI)

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Nursing Care of the Laryngeal Mask Airway in Pediatric Cataract Surgery

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Eye Science 2014年第2期29卷 121-124页

作者： aihuan chen Ronghua Ye Yanchan Liu Weici Liu Jingyi Lin Zhongshan Ophthalmic Center Sun Yat-sen University

Purpose:.To investigate the important experience of nursing care of the laryngeal mask airway(LMA) in children undergoing cataract surgery.Methods: Fifty-five children undergoing cataract surgery were anesthetized by inhaling sevoflurane through a LMA and received perioperative nursing care. The safety of perioperative nursing for these children was also evaluated.Results: Through perioperative nursing care and psychological counseling for children with LMA,.all patients were anesthetized without complications and underwent successful surgeries..No severe postoperative complications were observed.Conclusion: Nursing care specific for LMA is a vital part of the success of anesthesia and pediatric cataract surgery.

关键词：白内障手术护理小儿围手术期吸入麻醉 LMA 组成部分并发症

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Prevention and Control of Perioperative Incision Infection in Patients Undergoing Day Cataract Surgery

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Eye Science 2014年第3期29卷 182-185页

作者： Chunyan Yang aihuan chen Yinghuan Wang Xiaoqun Fang Ronghua Ye Jingyi Lin Zhongshan Ophthalmic Center Sun Yat-sen University

Purpose:To explore the effects of the prevention and control of perioperative incision infection on the quality of day cataract surgery.Methods:.The nursing care and efficacy of 5087 patients undergoing day cataract surgery between October 2012 and October 2013 were retrospectively reviewed. The disinfection and isolation guidance was established for perioperative prevention and control of infection,.topical administration of ocular agents, reexamination and healthcare instruction, and alternative measures were taken.Results: All 5087 patients successfully underwent day surgery of phacoemulsification combined with intraocular lens implantation. All cases recovered without incision infection.Conclusion: Preoperative preparation, and intraoperative and postoperative prevention and control of infection serve as vital measures for effectively avoiding the incidence of incision infection in patients undergoing day cataract surgery.

关键词：白内障手术围手术期感染控制切口预防患者消毒隔离

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A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland

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Virologica Sinica 2021年第6期36卷 1543-1553页

作者： Yun Zhu Baoping Xu Changchong Li Zhimin chen Ling Cao Zhou Fu Yunxiao Shang aihuan chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen Laboratory of Infection and Virology Beijing Pediatric Research InstituteBeijing Key Laboratory of Pediatric Respiratory Infection DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Beijing Children's HospitalCapital Medical UniversityKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Respiratory Diseases I Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027China The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310005China Children's Hospital Capital Institute of Pediatrics Beijing 100020China Children's Hospital of Chongqing Medical University Chongqing 400015China Shengjing Hospital of China Medical University Shenyang 110004China The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120China Guangzhou Women and Children's Medical Center Guangzhou 510623China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092China Yinchuan Women and Children Healthcare Hospital Yinchuan 750000China Children's Hospital of Changchun Changchun 130000China The 2nd Affiliated Hospital of Harbin Medical University Harbin 150086China Baoding Children's Hospital Baoding 071051China Laboratory of Respiratory Diseases Beijing Key Laboratory of Pediatric Respiratory Infection DiseasesBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Beijing Children's Hospital Capital Medical UniversityNationa

Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland.

关键词： Children Community-acquired pneumonia Multicenter study Viral aetiology Multiplex PCR assay

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条华蜗牛破厣前后体内总糖含量的变化

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北京农学院学报 2024年第1期39卷 23-28页

作者：张民照覃晓春赵晨张爱环北京农学院生物与资源环境学院/农业农村部华北都市农业重点实验室北京102206

【目的】了解条华蜗牛破厣前后体内总糖含量变化规律,为深入研究蜗牛破厣生化机理提供参考。【方法】用蒽酮-硫酸比色法测定了两个体质量组条华蜗牛在破厣、休眠、取食或饥饿等条件下足和内脏的总糖含量。【结果】条华蜗牛破厣后体内含... 详细信息

【目的】了解条华蜗牛破厣前后体内总糖含量变化规律,为深入研究蜗牛破厣生化机理提供参考。【方法】用蒽酮-硫酸比色法测定了两个体质量组条华蜗牛在破厣、休眠、取食或饥饿等条件下足和内脏的总糖含量。【结果】条华蜗牛破厣后体内含糖量升高,体质量组IV蜗牛足、内脏含糖量都高于相应体质量组I。破厣前蜗牛足内含糖量与破厣后的差异显著(P<0.05),而内脏的差异不显著。休眠蜗牛体内含糖量随休眠天数增加有降低的趋势,除体质量组I蜗牛足内含糖量休眠1 d后(27.62μg/mg)显著高于5 d~15 d外,其他休眠时间之间差异都不显著。蜗牛取食后,足和内脏含糖量变化趋势基本类似,都是取食12 h~24 h后增加,然后有所下降。除体质量组IV足外,取食24 h后都显著高于取食12 h和36 h。活动蜗牛体内含糖量随饥饿时间延长有降低趋势,饥饿36 h后含糖量均显著低于饥饿12 h。【结论】条华蜗牛破厣前后体内总糖含量变化与多个因素有关,总糖量变化规律反映了蜗牛破厣的生理生化特征。

关键词：条华蜗牛破厣总糖含量体质量取食饥饿

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心房颤动患者介入手术围术期护理专家共识

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中华介入放射学电子杂志 2024年第1期12卷 1-9页

作者：黄淑萍龚蓓申铁梅杨丹莉陈秀梅李国琪李星麦爱欢钟冰广东省护士协会心血管疾病护理分会南方心血管护理联盟南方医科大学附属广东省人民医院(广东省医学科学院)广东省心血管病研究所广东广州510080 南方医科大学附属广东省人民医院(广东省医学科学院)护理部广东广州510080 南方医科大学附属广东省人民医院(广东省医学科学院)广东省肺癌研究所广东广州510080 中山大学孙逸仙纪念医院心导管室广东广州510120 南方医科大学附属珠江医院心血管内科一区广东广州510260 深圳市人民医院(南方科技大学第一附属医院/暨南大学第二临床医学院)心血管内科广东深圳518020 不详

为促进心房颤动患者介入手术围术期护理规范化和标准化,保证患者安全,改善预后,本共识通过系统总结研究证据和专家意见,结合临床护理实践,从卒中风险与出血风险评估、药物管理、围手术期护理要点、并发症的预防与护理、出院指导与随访... 详细信息

为促进心房颤动患者介入手术围术期护理规范化和标准化,保证患者安全,改善预后,本共识通过系统总结研究证据和专家意见,结合临床护理实践,从卒中风险与出血风险评估、药物管理、围手术期护理要点、并发症的预防与护理、出院指导与随访管理等方面进行全面论述,旨在为心房颤动患者介入手术围术期护理工作提供指引。

关键词：心房颤动风险评估围术期护理并发症专家共识

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外汇市场压力问题的研究综述

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上海金融 2010年第1期 72-75页

作者：陈国进胥爱欢厦门大学金融系

本文从外汇市场压力的测度、外汇市场压力与货币政策、外汇市场压力与货币危机的识别与测度以及外汇市场压力与汇率制度四个方面总结了国外研究者对此的最新研究成果,从中我们发现外汇市场压力对于一国经济有着重要的影响,特别是在当前... 详细信息

本文从外汇市场压力的测度、外汇市场压力与货币政策、外汇市场压力与货币危机的识别与测度以及外汇市场压力与汇率制度四个方面总结了国外研究者对此的最新研究成果,从中我们发现外汇市场压力对于一国经济有着重要的影响,特别是在当前通胀预期下,外汇市场压力与我国资产价格波动和货币政策之间的相互作用过程值得我们去进一步研究。

关键词：外汇市场压力货币危机货币政策汇率制度

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表面麻醉下不同吸氧方式对白内障超声乳化手术成年患者手术期生命体征变化的影响

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眼科学报 2022年第9期37卷 720-724页

作者：陈蔼环杜春梅林静仪中山大学中山眼科中心眼科学国家重点实验室广东省眼科视觉科学重点实验室广东省眼部疾病临床医学研究中心广州510060

目的:观察表面麻醉下不同吸氧方式对白内障超声乳化手术患者生命体征变化的影响,探讨适宜的超声乳化手术中吸氧的方式。方法:选取2020年4月至2020年9月于中山大学中山眼科中心行白内障超声乳化摘除术的患者291例,随机分成3组,分别为简... 详细信息

目的:观察表面麻醉下不同吸氧方式对白内障超声乳化手术患者生命体征变化的影响,探讨适宜的超声乳化手术中吸氧的方式。方法:选取2020年4月至2020年9月于中山大学中山眼科中心行白内障超声乳化摘除术的患者291例,随机分成3组,分别为简易面罩吸氧组(面罩组)97例、鼻导管吸氧(鼻导管组)97例、无吸氧组(对照组)97例,其中面罩组和鼻导管组的吸氧流量均为氧流量2~4 L/min。监测患者进入手术室时(T_(0))、手术开始时(T_(1))以及手术结束时(T_(2))的血压、心率以及血氧饱和度(SpO_(2))。结果:三组患者在进入手术间时生命体征差异无统计学意义,三组患者术中血压变化不显著(P>0.05)。在T_(2)时点,氧气吸入的患者其SpO_(2)高于对照组(P<0.05),但均在正常范围内。结论:表面麻醉下白内障超声乳化手术的患者在无严重基础疾病的情况下,术中适当吸氧及监测血流动力学可以增加患者的舒适度及临床安全,对患者使用的吸氧方式应以不影响术中操作及患者舒适度的方式。

关键词：白内障超声乳化鼻导管吸氧面罩吸氧血氧饱和度心理状态

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南方五省儿童哮喘治疗现状及哮喘控制简易方案临床应用的可行性

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广东医学 2005年第5期26卷 684-686页

作者：李俊梅陈爱欢广东省广州呼吸疾病研究所广州510120

目的调查南方五省儿童哮喘治疗现状,探讨哮喘控制简易方案(easyasthmamanagement,EAM)在临床应用的疗效及可行性。方法在广东、广西、海南、贵州、云南五省的医院选取1178例4～14岁的哮喘儿童,通过详细询问病史、查阅既往相关病历、了... 详细信息

目的调查南方五省儿童哮喘治疗现状,探讨哮喘控制简易方案(easyasthmamanagement,EAM)在临床应用的疗效及可行性。方法在广东、广西、海南、贵州、云南五省的医院选取1178例4～14岁的哮喘儿童,通过详细询问病史、查阅既往相关病历、了解过去1年哮喘治疗情况,然后依据中华医学会制订的简化哮喘治疗方案EAM分为轻度、中度、重度哮喘3组,分别给予吸入糖皮质激素丙酸氟替卡松气雾剂(FP125μg/喷)、二丙酸倍氯米松气雾剂(BDP250μg/喷)或布地奈德定量气雾剂(BUD200μg/喷)1喷(晚上使用)、2喷(早1晚1)、3喷(早1晚2)或4喷(早2晚2),疗程3个月。结果①吸入激素疗法在南方五省哮喘儿童中普及率仅38%。②吸入激素治疗2,4,12周后,无论是轻度、中度还是重度的哮喘患儿,各项临床症状计分均有所改善,与治疗前比较差异有显著性(P<0.001)。③大部分患儿及家长对吸入激素的疗效比较满意,用药依从性好。结论吸入激素疗法目前在儿童哮喘中仍不普及。EAM临床应用效果好,患儿及家长依从性好,并且该方案简单,医生、患儿及家长易于掌握,值得推广使用。

关键词：哮喘控制简易方案儿童哮喘治疗现状南方氟替卡松气雾剂吸入糖皮质激素二丙酸倍氯米松吸入激素治疗临床应用效果激素疗法中华医学会定量气雾剂用药依从性家长依从性治疗情况治疗方案重度哮喘布地奈德哮喘患儿

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构建眼科高值手术耗材全生命周期的管理实践方法

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眼科学报 2022年第9期37卷 752-759页

作者：林静仪杜春梅陈蔼环甘小亮中山大学中山眼科中心眼科学国家重点实验室广东省眼科视觉科学重点实验室广东省眼部疾病临床医学研究中心广州510060

目的:探讨构建眼科高值手术耗材管理体系的思路和具体实践方法,加强眼科高值手术室耗材管理。方法:通过信息化手段,建立眼科高值手术耗材可视化管理系统,与医院各信息系统对接,整合相关数据,建立眼科高值手术耗材合理使用监测系统,将耗... 详细信息

目的:探讨构建眼科高值手术耗材管理体系的思路和具体实践方法,加强眼科高值手术室耗材管理。方法:通过信息化手段,建立眼科高值手术耗材可视化管理系统,与医院各信息系统对接,整合相关数据,建立眼科高值手术耗材合理使用监测系统,将耗材的供应、使用到监测的全生命周期管理与日常监管相结合。结果:通过对眼科高值手术耗材全生命周期体系的建立,实现了术前可控制、术中可监测、术后可追溯的全流程管理。结论:该体系的建立可提高眼科手术高值耗材的管理效率及质量。

关键词：眼科高值手术耗材信息化质量安全全生命周期手术室管理

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