检索结果-南通市图书馆

Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

引用

CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua huang Fangxu Pu Entao Li Guiyou Wang Wei Wang Yun Ding Gary Wong Sandra Chiu Jiaming Lan aiguo hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key Laboratory of Molecular Virology&Immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical Laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses worldwide.Unfortunately,state-of-the-art treatments still lag behind the continual emergence of new variants.Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural evolution.Here,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)molecules.The core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the molecules.The EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of cycloparaphenylene under spatial nanoconfinement

引用

Chinese Chemical Letters 2023年第6期34卷 298-300页

作者： Jinjie Li huixian Jin Zhikun Shang Jie Wang Donglai Tian Yun Ding aiguo hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Suzuki coupling reactions between symmetrical monomers were conducted in various mesoporous silica nanoreactors grafted with palladium catalysts,enabling the selective formation of[12]cycloparaphenylene precursor with separate yield up to 25%in one-pot reactions,much higher than that in homogeneous reaction.The spatial nanoconfinement of the nanoreactors promotes the macrocyclization while limits the concomitant linear oligomer formation,offering more possibilities for the synthesis of macrocycles from symmetrical monomers in one-pot reaction.

关键词： Nanoreactor Spatial confinement Cyclization reaction One-pot reaction Suzuki coupling reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances of the Bergman cyclization in polymer science

引用

Science China Chemistry 2015年第11期58卷 1710-1723页

作者： Shudan Chen aiguo hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology

The Bergman cyclization has strongly impacted on a number of fields including pharmaceutics, synthetic chemistry, and material science. The diradical intermediates stemmed from enediynes can not only cause DNA cleavage under physiological conditions but also function as monomer or initiator participants in polymer science. The homo-polymerization of enediynes through the Bergman cyclization to fabricate conjugated polymers is a fascinating strategy due to the advantages of facial operation, high efficiency, tailored structure, and catalyst-free operation. Moreover, conjugated polymers generated through the Bergman cyclization show many remarkable properties, such as excellent thermal stability, good solubility, and processability, which enables these polymers to be further manufactured into carbon-rich materials. Recent times have seen extensive efforts devoted to the application of the Bergman cyclization in polymer science and materials chemistry. A variety of synthetic strategies have been developed to fabricate structurally unique materials via the Bergman cyclization, including the fabrication of rod-like polymers with polyester, dendrimers and chiral imide side chains, functionalization of carbon nanomaterials by surface-grafting conjugated polymers, formation of nanoparticles by intramolecular collapse of single polymer chains, and the construction of carbon nanomembranes with different morphologies. Future developments involving the Bergman cyclization in polymer science, probably by altering the reaction mechanism to precisely control the microstructure of polymeric products, are also proposed in this review article.

关键词：共轭聚合物环化反应材料科学高分子科学树枝状大分子微观结构合成化学可加工性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Palladium-catalyzed Cycloaromatization Polymerization of Enediynes

引用

Chinese Journal of Polymer Science 2018年第2期36卷 237-243页

作者： Chonggang Wang Shudan Chen Hao Zhou Jinlou Gu aiguo hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology

Bergman cyclization has shown great promise in constructing conjugated polymers. However, the application of this reaction in polymer science is still limited due to the harsh reaction condition and ill-defined structure of the achieved polymers. To this end, the cycloaromatization polymerization of enediynes catalyzed by a series of transition metal catalysts is investigated in this work, by taking advantage of the coordination chemistry of the enediyne with the transition metal complexes. According to the nuclear magnetic resonance（NMR）, Fourier transform infrared（FTIR）, ultraviolet-visble（UV-Vis） spectroscopies and matrix-assisted laser desorption/ionization time-offlight mass spectrometry（MALDI-TOF MS） analysis, the cycloaromatization polymerization of enediynes proceeds under milder conditions and in a more controlled manner in the presence of palladium（II） complexes, giving structurally regulated conjugated polymers in high yields.

关键词： Transition metal catalysis Enediyne Polymerization Cycloaromatization Bergman cyclization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Catalytic alkane dehydrogenations

引用

Science Bulletin 2015年第15期60卷 1316-1331页

作者： Yuxuan Zhang Wubing Yao huaquan Fang aiguo hu Zheng huang Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

Olefins find widespread applications in the synthesis of polyolefins and fine chemicals. With an increasing demand for olefins, the technologies for alkane dehydrogenation have drawn much attention. Several types of heterogeneous catalysts have found applications in industry for the dehydrogenation of light alkanes, mainly ethane, propane, and butane. In the past three decades, a number of transition-metal complexes,particularly pincer-ligated iridium complexes, have been developed as the homogeneous catalysts for alkane dehydrogenations. The homogeneous catalyst systems operate under much milder conditions compared with the heterogeneous systems, and some systems exhibit good activity and high regioselectivity in dehydrogenation of alkanes longer than butane.

关键词：非均相催化剂烷烃脱氢过渡金属配合物工业应用脱氢催化剂催化剂系统聚烯烃精细化工

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-Delivery Nanoparticles of Amphiphilic Acyclic Enediynes for Efficient Tumor Cell Suppression

引用

Chinese Journal of Chemistry 2019年第5期37卷 479-485页

作者： Jing Li Yuequn Wu Lili Sun Shuai huang Baojun Li Yun Ding aiguo hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China The State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 China

Summary of main observation and conclusion Four acyclic maleimide-based enediyne compounds with different hydrophilicity were synthesized through Sonogashira reaction to reveal a self-delivery antitumor drug platform. As proved by ESR analysis, the enediyne compounds undergo Bergman- like cyclizati on and generate diradical in termediates at physiological temperature, which are able to induce DNA-cleavage through the abstraction of H atoms from the sugar-phosphate backbones. When the critical aggregation concentration is reached in water, the amphiphilic enediyne compounds self-assemble into nanoparticles and possess the self-delivery ability to be facilely admitted by tumor cells, resulting in greatly improved cytotoxicity (IC50 down to 10 μmol·L^-1) and much higher tumor cell apoptosis rate (up to 86.6%) in comparison with either the hydrophilic or the lipophilic enediyne compound. The enhanced endocytosis of the amphiphilic en ediyne compo unds was further confirmed through con focal laser scan ning microscopy analysis. The unveiled relationship between the hydrophilicity of enediyne drugs and their therapeutic efficacy will provide a guideline for the design of new self-delivery drugs employed in medicinal applications.

关键词： hydrophilicity platform

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

共轭聚合物“电子舌”检测四环素类抗生素

引用

华东理工大学学报（自然科学版） 2024年第3期50卷 354-359页

作者：陈世勇王杰朱琰超张丽娟王贵友胡爱国华东理工大学材料科学与工程学院上海市先进聚合物材料重点实验室上海200237

通过将6种共轭聚合物(CPs)与水性聚氨酯(WPU)物理共混,制备了WPU包覆的荧光传感阵列,用以检测水中的四环素类抗生素(TCs)。WPU与CPs共混后制备的薄膜阵列形状规则,荧光亮度高且稳定。WPU基体在溶胀后,存在泡孔状的孔道结构,增大了附着... 详细信息

通过将6种共轭聚合物(CPs)与水性聚氨酯(WPU)物理共混,制备了WPU包覆的荧光传感阵列,用以检测水中的四环素类抗生素(TCs)。WPU与CPs共混后制备的薄膜阵列形状规则,荧光亮度高且稳定。WPU基体在溶胀后,存在泡孔状的孔道结构,增大了附着于其中的CPs与水中待测物TCs的接触概率,增强了阵列的荧光响应。通过相机捕捉检测前后的荧光照片,并提取照片的红绿蓝(RGB)值,获得了18维向量数据库。通过主成分分析(PCA)和线性判别分析(LDA)等方法对数据进行降维处理。结果发现该荧光传感阵列具有良好的区分不同结构TCs的能力,LDA模型的分析预测准确度可达100%。这种WPU包覆CPs的荧光检测阵列具有制备便捷、成本低和稳定性好等优点,可望作为环境检测中的“电子舌”,检测并甄别水体中的污染物如四环素类抗生素。

关键词：共轭聚合物水性聚氨酯荧光传感阵列四环素类抗生素环境监测

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnesium isotopes of chlorite-rich hydrothermal sediments in the Okinawa Trough and indications for Mg cycle

引用

Science China Earth Sciences 2023年第3期66卷 648-662页

作者： Hebin SHAO Shouye YANG aiguo DONG Zhongya hu Key Laboratory for Polar Science of the State Oceanic Administration Polar Research Institute of ChinaShanghai 200136China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Institute of Earth Sciences China University of Geosciences(Beijing)Beijing 100083China

Seafloor hydrothermal systems play a significant role in the oceanic Mg cycle due to ubiquitous deposits of secondary Mg-rich clays during the strong fluid-rock reactions.However,the magnitude of net Mg enrichment and Mg isotopic fractionation,particularly within the medium-high temperature hydrothermal systems in felsic-hosted settings,are not well studied yet.Here we report elemental and isotopic compositions of Mg in hydrothermal chlorite-rich sediments,volcanic materials,and terrigenous sediments collected during the IODP Expedition 331 drilled to the thick sediment-covered and felsic-hosted middle Okinawa Trough(Iheya North Knoll) in the West Pacific.We investigate the sources of Mg in chlorite and Mg isotopic behavior at medium-high temperature hydrothermal alteration.After 1 mol/L HCl leaching,Mg isotopic compositions of chlorite-rich sediments present overall similar values in the residual fractions and bulk samples albeit with slightly higher values in the leachates.Mineralogical differentiation primarily determines the Mg isotopic compositions,showing that siliciclastic residues have slightly higher δ^(26) Mg values than the leachates dominated by carbonates and oxides/hydroxides.Significant Mg isotopic fractionation happened in the medium-high temperature(~150°C to 260°C) felsic-hosted hydrothermal system,with Δ^(26)MgChl-SW ranging from 0.15‰ to 0.71‰ and yielding a negative correlation with temperature.This observation suggests the preferential incorporation of heavy Mg isotopes by the secondary chlorite precipitation.We infer that the medium-high temperature hydrothermal systems can take up about 8–14% of riverine input of Mg in the arc and back-arc regions.Incomplete removal of aqueous Mg in porewater and vent fluids by the medium-high temperature hydrothermal alterations in the arc and back-arc basins provides constraints on the Mg budget and isotopic composition of seawater.

关键词： Hydrothermal alteration Chlorite Okinawa Trough Magnesium(Mg)isotopes Integrated Ocean Drilling Program

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于率相关改进桥联模型的CFRP材料动态力学性能研究

引用

兵器装备工程学报 2024年第3期45卷 190-199页

作者：周佳伦刘柳吴闻酉侯许佳胡衍东皮爱国北京理工大学爆炸科学与技术国家重点实验室北京100081 郑州航空工业管理学院郑州450046

桥联模型在预测CFRP材料静态力学性能上具有较高的精度,但目前鲜有基于桥联模型描述CFRP材料动态力学性能的报道。基于此,采用考虑应变率效应的本构方程与强度准则改进桥联模型。利用文献实验数据对改进后的模型进行了确认,针对侵彻弹... 详细信息

桥联模型在预测CFRP材料静态力学性能上具有较高的精度,但目前鲜有基于桥联模型描述CFRP材料动态力学性能的报道。基于此,采用考虑应变率效应的本构方程与强度准则改进桥联模型。利用文献实验数据对改进后的模型进行了确认,针对侵彻弹使用环境,设计制备了CFRP层合结构并进行SHPB动态实验。理论预估模量与实验结果基本一致,理论强度值高于实验值约7%,由此校验了相关改进桥联模型在动载环境下的适用性。结合课题组已有的CFRP壳体侵彻试验结果,进一步验证了该理论模型可用于CFRP材料在冲击载荷下的性能预测。进一步的试验结果细观分析和数值模拟研究表明,X方向试样的动态破坏模式以层间分层为主,而Y方向则以纤维的压缩破坏与基体的剪切破坏为主。为CFRP材料用于抗冲击等动态载荷下的力学行为预测提供了一种可行的分析手段。

关键词： CFRP 桥联模型动态压缩冲击破坏机理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Construction and performance of CdS/MoO_(2)@Mo_(2)C-MXene photocatalyst for H_(2) production

引用

Journal of Advanced Ceramics 2022年第9期11卷 1431-1444页

作者： Sen JIN huijuan JING Libo WANG Qianku hu aiguo ZHOU School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454003China

Nowadays,photocatalytic technologies are regarded as promising strategies to solve energy problems,and various photocatalysts have been synthesized and explored.In this paper,a novel CdS/MoO_(2)@Mo_(2)C-MXene photocatalyst for H_(2)production was constructed by a two-step hydrothermal method,where MoO_(2)@Mo_(2)C-MXene acted as a binary co-catalyst.In the first hydrothermal step,MoO_(2)crystals with an egged shape grew on the surface of two-dimensional(2D)Mo_(2)C MXene via an oxidation process in HCl aqueous solution.In the second hydrothermal step,CdS nanorods were uniformly assembled on the surface of MoO_(2)@Mo_(2)C-MXene in ethylenediamine with an inorganic cadmium source and organic sulfur source.The CdS/MoO_(2)@Mo_(2)C-MXene composite with MoO_(2)@Mo_(2)C-MXene of 5 wt%exhibits an ultrahigh visible-light photocatalytic H_(2)production activity of 22,672μmol/(g·h),which is~21%higher than that of CdS/Mo_(2)C-MXene.In the CdS/MoO_(2)@Mo_(2)C-MXene composite,the MoO_(2)with metallic nature separates CdS and Mo_(2)C MXene,which acts as an electron-transport bridge between CdS and Mo_(2)C MXene to accelerate the photoinduced electron transferring.Moreover,the energy band structure of CdS was changed by MoO_(2)@Mo_(2)C-MXene to suppress the recombination of photogenerated carriers.This novel compound delivers upgraded photocatalytic H_(2)evolution performance and a new pathway of preparing the low-cost photocatalyst to solve energy problems in the future.

关键词： Mo_(2)C MXene MoO_(2) CdS photocatalysis H_(2)production

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：