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Reduced-complexity multiple parameters estimation via toeplitz matrix triple iteration reconstruction with bistatic MIMO radar

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Chinese Journal of Aeronautics 2024年第7期37卷 482-495页

作者： Chenghong ZHAN Guoping HU Junpeng SHI Fangzheng zhao Hao ZHOU Graduate College Air Force Engineering UniversityXi’an 710051China Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China College of electronic Countermeasure National University of Defense TechnologyHefei 230037China Beijing Aeronautical Technology research center Beijing 100076China

In this advanced exploration, we focus on multiple parameters estimation in bistatic Multiple-Input Multiple-Output(MIMO) radar systems, a crucial technique for target localization and imaging. Our research innovatively addresses the joint estimation of the Direction of Departure(DOD), Direction of Arrival(DOA), and Doppler frequency for incoherent targets. We propose a novel approach that significantly reduces computational complexity by utilizing the TemporalSpatial Nested Sampling Model(TSNSM). Our methodology begins with a multi-linear mapping mechanism to efficiently eliminate unnecessary virtual Degrees of Freedom(DOFs) and reorganize the remaining ones. We then employ the Toeplitz matrix triple iteration reconstruction method, surpassing the traditional Temporal-Spatial Smoothing Window(TSSW) approach, to mitigate the single snapshot effect and reduce computational demands. We further refine the highdimensional ESPRIT algorithm for joint estimation of DOD, DOA, and Doppler frequency, eliminating the need for additional parameter pairing. Moreover, we meticulously derive the Cramér-Rao Bound(CRB) for the TSNSM. This signal model allows for a second expansion of DOFs in time and space domains, achieving high precision in target angle and Doppler frequency estimation with low computational complexity. Our adaptable algorithm is validated through simulations and is suitable for sparse array MIMO radars with various structures, ensuring higher precision in parameter estimation with less complexity burden.

关键词： MIMO Radar Multipleparameters estimation Temporal-spatial Nested Sampling Multi-linear mapping mechanism Toeplitz matrix triple iteration reconstruction Reduce computational complexity

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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao Jiang Siyuan zhao Dong Xie Qing Chen Qi zhao Hao Wu Jian Luo Lili Yang Spine center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

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Self-assembled VS_(2) microflowers buffering volume change during charging and discharging towards high-performance zinc ion batteries

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Journal of Materials Science & Technology 2024年第6期173卷 107-113页

作者： Tingsheng Wang Wujie Gao Yuanxi zhao Songcan Wang Wei Huang Frontiers Science center for Flexible electronics Xi’an Institute of Flexible Electronics(IFE)Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

VS_(2) has attracted increasing attention as a cathode material for aqueous zinc ion batteries because of its proper large layer spacing,weak interlayer interactions,multiple valence states of V,and excellent electrical conductivity,but its large volume change during charging and discharging leads to poor cycling ***,we report a one-step hydrothermal synthesis of VS_(2) microflowers with proper lamellar spacing,which provides a stable framework for the insertion/deinsertion of zinc ions and enhances the cycling stability,delivering an initial charge capacity of 128.3 mAh g^(-1) at 3 A g^(-1) and maintains a charge capacity of 100.1 mAh g^(-1) after 900 *** addition,the optimized VS_(2) cathode shows specific capacities of 215.7 and 150.5 mAh g^(-1) at the current densities of 0.1 and 2 A g^(-1),respectively,demonstrating that the microflower structure with a high specific surface area and a short diffusion distance also significantly enhances the rate performance.

关键词： Vanadium sulfide Microflower Zinc ion batteries Cathode materials Volume change

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The pathogenic mechanism of syndactyly type V identified in aHoxd13Q50R knock-in mice

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Bone research 2024年第2期12卷 349-360页

作者： Han Wang Xiumin Chen Xiaolu Meng Yixuan Cao Shirui Han Keqiang Liu Ximeng zhao Xiuli zhao Xue Zhang McKusick-Zhang center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13Q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13Q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD13Q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

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Current status of liver transplantation for human immunodeficiency virus-infected patients in China's Mainland

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World Journal of Gastroenterology 2024年第14期30卷 1958-1962页

作者： Jian-Xin Tang Dong zhao Department of Liver Surgery and Organ Transplantation center Shenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

According to the report from the Chinese center for Disease Control and Prevention,the prevalence of human immunodeficiency virus(HIV)infection exceeded 1.2 million individuals by the year 2022,with an annual increase of about 80000 *** overall prevalence of hepatitis B surface antigen among individuals co-infected with HIV reached 13.7%,almost twice the rate of the general population in *** addition to the well-documented susceptibility to opportunistic infections and new malignancies,HIV infected patients frequently experience liver-related organ damage,with the liver and kidneys being the most commonly *** often leads to the development of end-stage liver and kidney ***,organ transplantation has emerged as an important part of active treatment for HIV infected ***,the curative effect is not *** infection has been considered a contraindication for organ *** the emergence of highly active anti-retroviral therapy in 1996,the once intractable replication of retrovirus was effectively *** prolonged survival,the failure of important organs has become the main cause of death among HIV ***,transplant centers worldwide have resu-med exploration of organ transplantation for HIV-infected individuals and reached a positive *** study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation(LT)in main-land *** date,our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV,and all but one,who died two months postoperatively due to sepsis and progressive multi-organ failure,have *** analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions,cytomegalovirus infection,bacteremia,pulmonary infections,acute kidney injury,new-onset cancers,or vascular and biliary co

关键词： Liver transplantation Human immunodeficiency virus Infection Hepatitis B virus End-stage liver disease China'Mainland

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Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for Wound Healing

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research 2024年第1期2023卷 107-118页

作者： Xiaocheng Wang Jinxuan Jia Mengying Niu Wenzhao Li Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Chemistry and Biomedicine Innovation center Nanjing UniversityNanjing 210023China

Biological scaffolds have been widely employed in wound healing applications,while their practical efficiency is compromised by insufficient oxygen delivery to the 3-dimensional constructs and inadequate nutrient supply for the long-term healing ***,we present an innovative living Chinese herbal scaffold to provide a sustainable oxygen and nutrient supply for promoting wound *** a facile microfluidic bioprinting strategy,a traditional Chinese herbal medicine(Panax notoginseng saponins[PNS])and a living autotrophic microorganism(microalgae Chlorella pyrenoidosa[MA])were successfully encapsulated into the *** encapsulated PNS could be gradually released from the scaffolds,which promoted cell adhesion,proliferation,migration,and tube formation in *** addition,benefiting from the photosynthetic oxygenation of the alive MA,the obtained scaffolds would produce sustainable oxygen under light illumination,exerting a protective effect against hypoxia-induced cell *** on these features,we have demonstrated through in vivo experiments that these living Chinese herbal scaffolds could efficiently alleviate local hypoxia,enhance angiogenesis,and thereby accelerate wound closure in diabetic mice,indicating their great potential in wound healing and other tissue repair applications.

关键词： healing wound protective

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Summer gregarine infection in Antarctic krill Euphausia superba in the Dumont D’Urville Sea,East Antarctic

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Journal of Oceanology and Limnology 2024年第5期42卷 1651-1658页

作者： Yi XIONG Sijie zhao Guoping ZHU College of Marine Living Resource Sciences and Management Shanghai Ocean UniversityShanghai 201306China center for Polar research Shanghai Ocean UniversityShanghai 201306China Polar Marine Ecosystem Group the Key Laboratory of Sustainable Exploitation of Oceanic Fisheries ResourcesMinistry of EducationShanghai 201306China National Engineering research center for Oceanic Fisheries Shanghai 201306China

Antarctic krill Euphausia superba plays a key role in the Antarctic food *** trophic linkage between krill and other macro-organisms has been studied in the past decades,but the variability of parasites in krill is less studied and remains poorly ***,it is important to understand the factors that influence abundance and infection of parasites in ***,the relationship between the infection intensity of parasite and krill diet needs to be clarified,which is helpful for understanding the role of parasite in the food *** investigated the abundance of the highly prevalent gregarine parasites in the digestive tract of krill and the factors influencing the gregarine infection to krill in the East *** infection rate of Cephaloidophora pacifica Avdeev,1985 to krill(n=50 individuals)was 94%.The results of generalized linear model show the infection intensity of *** to the host was related significantly to the station,krill size,and maturity stage,but not the food species and abundance in the stomach of *** of *** in krill differed among stations,and the lowest abundance occurred in the station nearest to the *** abundance varied among sexual maturity stages of krill and increased with krill size.

关键词： Cephaloidophora pacifica Euphausiids parasite diet dinoflagellate

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Tuning the selectivity of CO_(2)conversion to CO on partially reduced Cu_(2)O/ZnO heterogeneous interface

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Interdisciplinary Materials 2024年第3期3卷 380-388页

作者： Tianci Xiang Ting Liu Ting Ouyang Shenlong zhao zhao-Qing Liu School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials/Huangpu Hydrogen Innovation center Guangzhou Higher Education Mega CenterGuangzhou UniversityGuangzhouGuangdongPeople's Republic of China School of Chemical and Biomolecular Engineering The University of SydneySydneyNew South WalesAustralia

The development of stable and efficient low-cost electrocatalysts is conducive to the industrialization of CO_(2).The synergy effect between the heterogeneous interface of metal/oxide can promote the conversion of CO_(2).In this work,Cu_(2)O/ZnO heterostructures with partially reduced metal/oxide heterointerfaces in Zn plates(CZZ)have been synthesized for CO_(2)electroreduction in different cationic solutions(K^(+)and Cs^(+)).Physical characterizations were used to demonstrate the heterojunction of Cu_(2)O/ZnO and the heterointerfaces of metal/oxide,electrochemical tests were used to illustrate the enhancement of the selectivity of CO_(2)to CO in different cationic *** efficiency for CO with CZZ as catalyst reaches 70.9%in K+solution(current density for CO−3.77 mA cm^(−2)and stability 24 h),and the Faraday efficiency for CO is 55.2%in Cs^(+)solution(−2.47 mA cm^(−2)and 21 h).In addition,in situ techniques are used to elucidate possible reaction mechanisms for the conversion of CO_(2)to CO in K^(+)and Cs^(+)solutions.

关键词： CO CO_(2)reduction electrochemical catalysis heterogeneous interface

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The relationship between compartment models and their stochastic counterparts:A comparative study with examples of the COVID-19 epidemic modeling

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Journal of Biomedical research 2024年第2期38卷 175-188,I0016-I0018页

作者： Ziyu zhao Yi Zhou Jinxing Guan Yan Yan Jing zhao Zhihang Peng Feng Chen Yang zhao Fang Shao Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Nanjing Hanwei Public Health research Institute Co. LtdNanjingJiangsu 210005China China International Cooperation center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic ***,the relationship between CMs and their corresponding stochastic models is not well *** present study aimed to address this gap by conducting a comparative study using the susceptible,exposed,infectious,and recovered(SEIR)model and its extended CMs from the coronavirus disease 2019 modeling *** demonstrated the equivalence of the numerical solution of CMs using the Euler scheme and their stochastic counterparts through theoretical analysis and *** on this equivalence,we proposed an efficient model calibration method that could replicate the exact solution of CMs in the corresponding stochastic models through parameter *** advancement in calibration techniques enhanced the accuracy of stochastic modeling in capturing the dynamics of ***,it should be noted that discrete-time stochastic models cannot perfectly reproduce the exact solution of continuous-time ***,we proposed a new stochastic compartment and agent mixed model as an alternative to agent-based models for large-scale population simulations with a limited number of *** model offered a balance between computational efficiency and *** results of this research contributed to the comparison and unification of deterministic CMs and stochastic models in epidemic ***,the results had implications for the development of hybrid models that integrated the strengths of both ***,the present study has provided valuable epidemic modeling techniques and their practical applications for understanding and controlling the spread of infectious diseases.

关键词： compartment models agent-based models compartment-agent mixed models comparative study COVID-19

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Operando NMR methods for studying electrocatalysis

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Magnetic Resonance Letters 2024年第2期4卷 54-64页

作者： Zhiyu Zhu Ruipeng Luo Evan Wenbo zhao Magnetic Resonance research center Institute for Molecules and MaterialsRadboud University6525 AJ Nijmegenthe Netherlands

The combination of electrochemical measurements with spectroscopic characterizations provides valuable insights into reaction *** magnetic resonance(NMR)spectroscopy,as a powerful technique due to its atomic specificity and versatility in studying gas,liquid,and solid,allows the study of electrolyte solution,catalyst and catalyst-adsorbate *** applied in operando,NMR can offer molecular-level insights into various electrochemical *** NMR has been applied extensively in battery research,but relatively underexplored for electrocatalysis in the past two *** this mini review,we first introduce the operando electrochemical NMR setups,categorized by different probe *** we review the applications of operando NMR for monitoring the electrolyte solution and the catalyst-adsorbate *** the high environmental impact of electrochemical conversion of CO_(2)into value-added products,we zoom in to the use of operando NMR in studying electrochemical CO_(2)***,we provide our perspective on further developing and applying operando NMR methods for understanding the complex reaction network of Cu-catalyzed electrochemical CO_(2)reduction.

关键词： Operando NMR In situ NMR EC-NMR electrocatalysis electrochemical CO_(2)reduction

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