检索结果-南通市图书馆

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 176-185页

作者： Zariyantey abdul hamid Siti Balkis BUDIN Ng WEN JIE Asmah hamid Khairana HUSAIN Jamaludin MOHAMED Department of Biomedical Science Faculty of Health Sciences Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur Malaysia Drug and Herbal Research Center Faculty of Pharmacy Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur Malaysia

Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.

关键词： Zingiber zerumbet Antioxidant Oxidative stress Nephrotoxicity Paracetamol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of fluoride treatment on corrosion behavior of Mg-Ca binary alloy for implant application

引用

Transactions of Nonferrous Metals Society of China 2013年第3期23卷 699-710页

作者： hamid Reza Bakhsheshi-Rad Mohd Hasbullah Idris Moha mmed Rafiq abdul Kadir Mohammadreza Daroonparvar Materials Engineering Department Faculty of Mechanical EngineeringUniversiti Teknologi MalaysiaSkudai 81310JohorMalaysia Department of Biomechanics & Biomedical Materials Faculty of Biomedical Engineering & Health SciencesUniversiti Teknologi MalaysiaSk udai 81310JohorMalaysia

The influence of hydrofluoric acid（HF） treatment on the corrosion behavior of the Mg-0.5Ca alloys was investigated by immersion specimen in sodium hydroxide and HF solutions with various concentrations and durations at room *** evolutions of the specimens were characterized by atomic force microscopy,X-ray diffraction,field-emission scanning electron *** corrosion resistance was examined through potentiodynamic polarization and immersion test in Kokubo *** results revealed that the fluoride treated Mg-0.5Ca alloys produced by immersion in 40% HF provided more uniform,dense and thicker coating layer（12.6 μm） compared with the 35% HF treated *** electrochemical test showed that the corrosion resistance of fluoride treated specimen was 35 times higher compared with the untreated Mg-0.5Ca alloy specimen in Kokubo *** vitro degradation rate of the fluoride treated specimens was much lower than untreated Mg-0.5Ca alloy in Kokubo *** immersion test the surface of 40% HF treated sample showed a few corrosion dots,while untreated specimens were fully covered by corrosion products and *** treated Mg-0.5Ca alloy with 40% HF is a promising candidate as biodegradable implants due to its low degradation kinetics and good biocompatibility.

关键词： Mg-Ca alloy surface treatment corrosion behavior biocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Weighted-adaptive Inertia Strategy for Multi-objective Scheduling in Multi-clouds

引用

Computers, Materials & Continua 2022年第7期72卷 1529-1560页

作者： Mazen Farid Rohaya Latip Masnida Hussin Nor Asilah Wati abdul hamid Department of Communication Technology and Networks Universiti Putra Malaysia(UPM)Serdang43400Malaysia Institute for Mathematical Research(INSPEM) Universiti Putra Malaysia(UPM)Serdang43400Malaysia Faculty of Education-Saber University of AdenAden2408Yemen

One of the fundamental problems associated with scheduling workflows on virtual machines in a multi-cloud environment is how to find a near-optimum *** workflow scheduling involves assigning independent computational jobs with conflicting objectives to a set of virtual *** optimization methods for solving non-deterministic polynomial-time hardness(NP-hard)problems deploy multi-objective *** such,Pareto dominance is one of the most efficient criteria for determining the best solutions within the Pareto ***,the main drawback of this method is that it requires a reasonably long time to provide an optimum *** this paper,a new multi-objective minimum weight algorithm is used to derive the Pareto *** conflicting objectives considered are reliability,cost,resource utilization,risk probability and *** multi-objective algorithms select a number of permutations with an optimal trade-off between conflicting objectives,we propose a new decisionmaking approach named the minimum weight optimization(MWO).MWO produces alternative weight to determine the inertia weight by using an adaptive strategy to provide an appropriate alternative for all optimal *** way,consumers’needs and service providers’interests are taken into *** standard scientific workflows with conflicting objectives,we compare our proposed multi-objective scheduling algorithm using minimum weigh optimization(MOS-MWO)with multi-objective scheduling algorithm(MOS).Results show that MOS-MWO outperforms MOS in term of QoS satisfaction rate.

关键词： Multi-cloud environment multi-objective optimization Pareto optimization workflow scheduling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第1期23卷 42-57页

作者： Haslinda abdul hamid Vahid Hosseinpour SARMADI Vivek PRASAD Rajesh RAMASAMY Azizi MISKON Bio-artificial Organ and Regenerative Medicine Unit National Defense University of MalaysiaKuala Lumpur57000Malaysia Cellular and Molecular Research Centre Iran University of Medical SciencesTehran***Iran Institutes of Regenerative Medicine Iran University of Medical SciencesTehran***Iran Stem Cell and Immunity Research Group Immunology LaboratoryDepartment of PathologyFaculty of Medicine and Health SciencesUniversiti Putra Malaysia(UPM)Seri KembanganSelangor43400Malaysia

Mesenchymal stem/stromal cell(MSC)-based therapy has been regarded as one of the most revolutionary breakthroughs in the history of modern medicine owing to its myriad of immunoregulatory and regenerative *** the rapid progress in the fields of osteo-and musculoskeletal therapies,the demand for MSC-based treatment modalities is becoming increasingly *** this endeavor,researchers around the world have devised new and innovative techniques to support the proliferation of MSCs while minimizing the loss of hallmark features of stem *** such example is electromagnetic field(EMF)exposure,which is an alternative approach with promising *** this review,we present a critical discourse on the efficiency,practicability,and limitations of some of the relevant methods,with insurmountable evidence backing the implementation of EMF as a feasible strategy for the clinically relevant expansion of MSCs.

关键词： Electromagnetic field Proliferation Mesenchymal stem cell Therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geotechnical forensic investigation of a slope failure on silty clay soil--A case study

引用

Frontiers of Structural and Civil Engineering 2020年第2期14卷 501-517页

作者： Mohammad Abubakar NAVEED Zulfiqar ALI abdul QADIR Umar Naveed LATIF Saad hamid Umar SARWAR Military College of Engineering National University of Sciences and TechnologyRisalpur 24080Pakistan School of Civil Environmental and Mining EngineeringThe University of AdelaideAdelaibe 5096Australia

Qila Bala Hisar is one of the noteworthy places of Peshawar,Khyber *** fort was constructed on a flled ground during the 18th century and it was renovated several times by the occupants ever ***,due to an earthquake of magnitude 7.3,the upper part of the south-western wall of the fort *** collapse of the wall was attributed to the failure of the retained *** research was undertaken to characterize the slope material,study causal factors of failure and evaluate remedial *** investigation involved conventional field and laboratory testing and geophysical investigation using electrical resistivity technique to evaluate the nature of ***,X-ray Diffraction and Scanning Electron Microscopy was used to study the slope material at a molecular level to evaluate the existence of swelling *** analysis has shown that excessive seepage of water caused by the poor maintenance of runoff and sewage drains is the causal factor triggered by the seismic event.A remedial strategy involving soil nails,micro piles and improvement of the surface drainage is recommended.

关键词： forensic geotechnical investigation slope failure slope analysis finite element method numerical analysis seismic loading Qila Bala Hisar

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis,Characterization,Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acids

引用

Chinese Journal of Structural Chemistry 2021年第3期40卷 291-300,271页

作者： hamid Aziz AAMER Saeed FARUKH Jabeen abdul Basit IRFAN Zia Qureshi abdul Aziz ATIF Haroon ASHFAQ Ur Rehman Department of Chemistry Quaid-I-Azam University Islamabad 45320 Pakistan Computation ScienceResearch and Development Organization14012485 Hurontraio StreetMississaugaONCaL5A2G6 Department of Biology Laurentian University935 Ramsey Lake RoadSudburyONCanada P3E2C6 Department of Animal Sciences Quaid-I-Azam University Islamabad 45320 Pakistan Department of Microbiology Quaid-I-Azam University Islamabad 45320 Pakistan Department of Biochemistry Shankar CampusAbdul Wali Khan UniversityMardan 23200Khyber PukhtoonkhwaPakistan Department of Bioinformatics and Biostatistics Shanghai Jiaotong UniversityShanghai 200240China

The present research paper presents the synthesis, characterization, biological and computational studies of 4-(benzylideneamino) benzoic acid derivatives(3a~3g). Derivatives 3a~3c displayed best antidiabetic potential with a glucose-lowering effect compared to the reference drug Glibenclamide. Biochemical parameters including plasma glucose, serum triglycerides, cholesterol, alanine amino transferase and aspartate amino transferase levels showed significant alterations in concentrations relative to the control. Similarly, the derivatives 3a, 3d and 3e displayed potent in vitro antibacterial potential. Molecular docking simulations delineated that the ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces, consistent with the corresponding experimental results. In silico study of the binding pattern predicted that the synthesized ligands, 3d and 3a could serve as a potential surrogate for hit-to-lead generation and the design of novel antibacterial drugs.

关键词： antidiabetic biochemical cholesterol glibenclamide simulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Applied bias photon-to-current conversion efficiency of ZnO enhanced by hybridization with reduced graphene oxide

引用

Journal of Energy Chemistry 2017年第2期26卷 302-308页

作者： Sharifah Bee abdul hamid Swe Jyan Teh Chin Wei Lai Siglinda Perathoner Gabriele Centi Nanotechnology and Catalysis Research Centre (NANOCAT) University of Malaya Department of Industrial Chemistry University of Messina

The role of reduced graphene oxide（rGO） in the enhancement of photo-conversion efficiency of ZnO films for photoelectrochemical（PEC） water-splitting applications was analyzed. ZnO and rGO-hybridized ZnO（rGO/ZnO） films were prepared via a two-step electrochemical deposition method followed by annealing at 300 °C under argon gas flow. The physical, optical and electrochemical properties of the films were characterized to identify the effect of rGO-hybridization on the applied bias photon-to-current efficiency（ABPE） of ZnO. Scanning electron microscopy and X-ray diffraction indicated the formation of verticallyaligned, wurtzite-phase ZnO nanorods. Diffuse-reflectance UV–visible spectroscopy indicated that rGO-hybridization was able to increase the light absorption range of the rGO/ZnO film. UPS analysis showed that hybridization with rGO increased the band gap of ZnO（3.56 eV） to 3.63 eV for rGO/ZnO sample,which may be attributed to the Burstein–Moss effect. Photoluminescence（PL） spectra disclosed that rGOhybridization suppressed electron-hole recombination due to crystal defects. Linear sweep voltammetry of the prepared thin films showed photocurrent density of 1.0 and 1.8 m A/cm;for ZnO and rGO/ZnO at+0.7 V, which corresponded to an ABPE of 0.55% and 0.95%, respectively. Thus, this report highlighted the multi-faceted role of rGO-hybridization in the enhancement of ZnO photo-conversion efficiency.

关键词： Zinc oxide Photoelectrochemical water-splitting Reduced graphene oxide Photo-conversion efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tin stearate organometallic precursor prepared SnO_2 quantum dots nanopowder for aqueous- and non-aqueous medium photocatalytic hydrogen gas evolution

引用

Journal of Energy Chemistry 2016年第4期25卷 691-701页

作者： Choonyian Haw Weesiong Chiu Noor Hamizah Khanis Saadah abdul Rahman Poisim Khiew Shahidan Radiman Roslan Abd-Shukor Muhammad Azmi abdul hamid Low Dimensional Materials Research Centre Department of PhysicsUniversity of Malaya Department of Chemical Engineering Faculty of EngineeringUniversity of Nottingham Malaysia CampusJalan Broga School of Applied Physics Faculty of Science and TechnologyNational University of Malaysia

Current study reports a rapid one-pot non-hydrolytic condition in the synthesis of Sn O2QDs nanopowder using tin(II) stearate(Sn(St)2) as environmentally-benign organometallic precursor,which is an unprecedentedly employed-compound in preceding Sn O2nanopowder *** as-synthesized Sn O2QDs that are hydrophobic can be easily transferred from organic solvent to aqueous solution through a robust ligand exchange *** stearate-capping ligands on the surface of QDs can be replaced by beta-cyclodextrin(β-CD) and eventually render the QDs highly water soluble,which ultimately make it exhibit bi-functionality for different liquid medium *** characterizations reveal that the bi-functional QDs are indeed well-matched with the standard rutile Sn O2cassiterite phase without the presence of any *** QDs can be interchangeably used as photocatalyst for both aqueous and non-aqueous phase,where it shows significant enhancement of hydrogen gas production as compared to that of commercial Sn O2nanopowder.

关键词： SnO2 Tinstearate Precursors Ligand exchange Photocatalyst Hydrogen gas production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Determination of Water Quality of Rivers under Various Land Use Activities Using Physico-chemical Parameters and Bacterial Populations in Northern Peninsular Malaysia

引用

湿地科学 2016年第6期14卷 788-798页

作者： Ezatul Huda Muhd Redzuan Cheah Suhaila abdul hamid School of Biological Sciences Universiti Sains Malaysia

A study on water quality of rivers with different land use activities by using physico-chemical parameters and bacterial population was conducted around Kedah, Penang and Perak, Malaysia. The water quality parameters such as dissolved oxygen(DO), five-day biochemical oxygen demand(BOD5), chemical oxygen demand(COD), total dissolved solids(TDS), total suspended solids(TSS), nitrate, p H, ammonia-nitrogen, water temperature, water depth and velocity were measured and the densities of bacteria which were total coliform(TC) and fecal coliform(FC) were monitored simultaneously using IDEXX-Colilert?technique from selected rivers. The greatest population of TC and FC(>2 419.6 n MPN/100ml) were recorded from industrial rivers while the lowest reading recorded in less disturbed rivers with less than 1 MPN/100 ml. Total coliform count categorized all rivers into Class I and FC count showed five rivers fell into Class I(Sungai Sedim, Bukit Hijau, Teluk Bahang, Kurau and Tukun), two rivers fell into Class IIA(Sungai Batu Hampar and Salleh) and eight rivers fell into IIB categories(Sungai Jerejak,Pinang, Air Hitam, Kluang, Chelong, Titi Hayun and Cherok Tokun). There was a significant difference between the TC population with TSS content(r=0.43), TDS content(r=0.813), river depth(r=0.513) and DO level(r=-0.401) from all selected *** coliform population was greatly influenced by contents of BOD5(r=0.456), COD(r=0.531), TSS(r=0.813), TDS(r=0.724), and water temperature(r=0.711). The rivers with industrial land-use setting recorded the highest range of water quality index scores and fell into Class III(Sungai Jerejak, Air Hitam and Kluang) and Class V(Sungai Pinang). Both plantation rivers(Sungai Chelong and Sungai Salleh) fell into Class II and all recreational and less disturbed rivers fell into Class I.

关键词：湿地生态系统服务价值评价生态保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of the coronavirus disease 2019 pandemic on breastfeeding during and at discharge from neonatal care:An observational cohort study

引用

Pediatric Investigation 2022年第3期6卷 189-196页

作者： Haslina Binti abdul hamid Lisa SzatkowskiHelen Budge Shalini Ojha Lifespan and Population Health School of MedicineUniversity of NottinghamNottinghamUK Dietetic Programme Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia Neonatal Unit University Hospitals of Derby and Burton NHS TrustDerbyUK

Importance:During the coronavirus disease 2019(COVID-19)lockdown,changes in the visiting rules in neonatal units might have affected the initiation and continuation of ***:To investigate the effects of the implementation of the COVID-19 lockdown in the UK on mother’s own milk(MOM)feeding in hospital and at the time of discharge in two UK neonatal ***:Retrospective cohort study using routinely recorded data from electronic patient *** were retrieved from two neonatal services in the UK East Midlands *** logistic regression was used to compare the odds of MOM feeding before,and after the implementation of the UK ***:Among 2073 infants,after adjusting for maternal and infant characteristics and underlying trends over time,there were no differences in the odds of infants receiving any MOM during admission;any MOM at discharge or exclusive MOM at discharge before and after the imposition of the *** with birthweight2500 g(adjusted odds ratio[OR]0.33,95%confidence interval[CI]:0.22–0.50).Younger mothers were less likely,and Black British mothers more likely,to be feeding MOM to their infants at discharge,while women in the least deprived Index of Multiple Deprivation(IMD)quintiles were 2–4 times more likely to do so,compared to those in the most deprived IMD quintile(adjusted OR 2.78,95%CI:1.97–3.90).Interpretation:Despite the difficulties faced during COVID-19 pandemic-induced restrictions,infants in the participating neonatal units continued to receive MOM in similar proportions as before the pandemic.

关键词： Breastfeeding COVID-19 Infant Newborn

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：