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Recent advances on catalysts for preferential oxidation of CO

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Nano Research 2023年第4期16卷 4399-4410页

作者： Huimin liu Dezheng Li Jiawen Guo Yuqiao Li aidi liu Yitong Bai Dehua He School of Chemical and Environmental Engineering Liaoning University of TechnologyJinzhou 121001China Innovative Catalysis Program Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China

The trace amount of CO in H2-rich gas poisons Pt electrode when it is adopted as feedstock for proton-exchange-membrane fuel *** oxidation of CO(PROX)is a promising approach to selectively oxidize the trace amount of CO while keeping H2 *** plays important roles in *** date,enormous catalysts have been developed for *** the catalysts developed for PROX and unveiling the reaction mechanism could definitely advance this research ***,in this review,according to the nature of the active sites on the catalysts,we classify the catalysts into group VIII metal-based catalyst,group IB metal-based catalysts,group VIII-group IB bimetallic catalysts,transitional metal oxide catalysts as well as others,describe the progress of the catalysts in PROX in the latest five years,and extract the underlying reaction mechanism,with the aim to provide guidance for the rational design of efficient catalysts in the future.

关键词： preferential oxidation of CO group VIII metal-based catalysts group IB metal-based catalysts bimetallic catalysts mechanism exploration

原位生成砒霜的生物杂化体的制备及其体内外抗肝细胞癌评价

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中国现代应用药学 2024年第16期41卷 2167-2175页

作者：刘爱迪方威祥孙蒋李斌陈欣欣余凯玲叶婷娴朴寄纲李范珠浙江中医药大学药学院杭州310053

目的制备一种原位生成砒霜的生物杂化体(CeAs-Bac),并评价其体内外抗肝细胞癌效果。方法用静电吸附法和原位矿化法制备CeAs-Bac,并通过透射电镜、扫描电镜、马尔文粒径仪和X射线光电子能谱评价其外观形貌、电位及元素组成;采用透析袋法... 详细信息

目的制备一种原位生成砒霜的生物杂化体(CeAs-Bac),并评价其体内外抗肝细胞癌效果。方法用静电吸附法和原位矿化法制备CeAs-Bac,并通过透射电镜、扫描电镜、马尔文粒径仪和X射线光电子能谱评价其外观形貌、电位及元素组成;采用透析袋法和X射线光电子能谱考察CeAs-Bac的体外释放和释放前后砷(As)价态变化;以吲哚菁绿为荧光标记物考察HepG2摄取情况;采用MTT、活/死细胞染色法和Annexin V-FITC凋亡试剂盒分别考察CeAs-Bac的细胞毒性和凋亡情况;建立H22肝癌小鼠模型考察CeAs-Bac的体内抗肿瘤效果。结果成功制备了生物杂化体CeAs-Bac,透射电镜和扫描电镜结果表明砷铈(Ce)化合物紧密附着在希瓦氏菌表面,且修饰Ce和As后细菌表面电位由(−32.2±2.05)mV变为(−15.3±0.81)mV,As装载效率为60.6%;体外释放显示CeAs-Bac具有乳酸响应性释放的特点,且能在乳酸存在条件下生成砒霜;细胞实验结果证明CeAs-Bac对HepG2具有较高细胞毒性,并可诱导HepG2细胞凋亡;体内抗肿瘤结果显示CeAs-Bac可有效靶向肿瘤部位,抑制肿瘤生长,并促进肿瘤组织坏死。结论本研究成功制备了具有乳酸响应性释放及原位生成砒霜特点的生物杂化体CeAs-Bac,其能够有效降低砒霜在应用过程中的不良反应,实现肝细胞癌的安全有效治疗。

关键词：生物杂化体砒霜希瓦氏菌肝细胞癌乳酸

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Lignin-assisted construction of sub-10 nm supramolecular self-assembly for photothermal immunotherapy and potentiating anti-PD-1 therapy against primary and distant breast tumors

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Asian Journal of Pharmaceutical Sciences 2022年第5期17卷 713-727页

作者： Xudong Fan Tianxiang Yue aidi liu Xiaowei Xie Weixiang Fang Yinghui Wei Hangsheng Zheng Hongyue Zheng Meiqi Zhou Jigang Piao Fanzhu Li School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Libraries of Zhejiang Chinese Medical University Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Breast Surgery Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationSecond Hospital of ZhejiangUniversity College of MedicineHangzhou 310009China Academy of Chinese Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

Photothermal therapy(PTT)has brought hope for cancer treatments,with hyperthermia-induced immunogenic cell death(ICD),which is a critical part of therapeutically induced antitumor immune *** immune stimulation response in PTT is the primary reason for incomplete tumor ablation,therefore demonstrating urgent requirements for ICD ***,a sub-10 nm supramolecular nanoassembly was formed by coassembly of clinically approved aluminum adjuvant and commonly used indocyanine green(ICG)under the assistance of lignosulfonate(LS,a green and sustainable multifunctional lignin derivative)for localized photothermal-immunotherapy of breast *** overall results revealed that LS-Al-ICG is capable of inducing amplified ICD,efficiently eliciting solid immune responses through dendritic cells(DCs)activation and cytotoxic T-cell responses initiation for tumor ***,anti-PD-1 therapy blocked the PD-1 pathway and led to remarkable anti-tumor efficacy against laser-irradiated primary tumors and distant tumors by potentiating systemic tumor specific T cell *** results of this study demonstrate a handy and extensible approach for engineering green natural lignin nanoparticles for cancer immunotherapy,which shows promise for delivering other therapeutics in biomedical applications.

关键词： Lignin Supramolecular self-assembly Photothermal-immunotherapy Anti-PD-1

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An aidi Jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

A Potential Role for GLUT4 in Predicting Sepsis in Critically Ill Children

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Open Journal of Internal Medicine 2024年第1期14卷 1-15页

作者： Yanna Zhou Guangming liu Xiaohui Wu aidi Kuang Cuiping Zhu Qiuyan Peng Department of Pediatric Emergency Medicine Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Background: This study investigated serum Glucose transporter (GLUT) 4 levels and examined the relationship between serum GLUT4 levels and sepsis in critically ill children. Methods: This was a retrospective study of 77 critically ill children and 33 non-diabetic healthy children (controls) who were admitted between 07/2015 and 05/2016. Patient data, clinical information, and blood samples were collected on admission, alongside a large number of laboratory parameters that were routinely assessed. Critically ill patients were divided into sepsis and non-sepsis/systemic inflammatory response syndrome (SIRS). Serum GLUT4 was measured using western blotting and enzyme-linked immunosorbent assays. Insulin resistance indexes, clinical data, laboratory parameters, and inflammatory cytokines were assessed. Results: GLUT4 serum levels were higher in critically ill children than in healthy children (90.5 vs. 30.3 μg/L, P 0.05). Compared to healthy children, hyperglycemic patients (n = 48) had elevated GLUT4 serum levels (30.3 vs. 103.7 g/L, P Conclusions: GLUT4 serum levels might be significantly increased in critically ill children compared with healthy children, particularly those in septic shock. Serum GLUT4 could predict disease severity.

关键词： Children Critical Illness Glucose Transporter Type 4 Hyperglycemia Insulin Resistance

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

Real-Time Monitoring Method for Cow Rumination Behavior Based on Edge Computing and Improved MobileNet v3

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智慧农业（中英文） 2024年第4期6卷 29-41页

作者： ZHANG Yu LI Xiangting SUN Yalin XUE aidi ZHANG Yi JIANG Hailong SHEN Weizheng College of Electrical and Information Northeast Agricultural UniversityHarbin 150030China Harbin Aerospace Stellar Data System Technology Co. LtdHarbin 150030China Harbin Electric Machinery Company Co. Ltd.Harbin 150030China

[Objective]Real-time monitoring of cow ruminant behavior is of paramount importance for promptly obtaining relevant information about cow health and predicting cow ***,various strategies have been proposed for monitoring cow ruminant behavior,including video surveillance,sound recognition,and sensor monitoring ***‐ever,the application of edge device gives rise to the issue of inadequate real-time *** reduce the volume of data transmission and cloud computing workload while achieving real-time monitoring of dairy cow rumination behavior,a real-time monitoring method was proposed for cow ruminant behavior based on edge computing.[Methods]Autono‐mously designed edge devices were utilized to collect and process six-axis acceleration signals from cows in *** on these six-axis data,two distinct strategies,federated edge intelligence and split edge intelligence,were investigat‐ed for the real-time recognition of cow ruminant *** on the real-time recognition method for cow ruminant behavior leveraging federated edge intelligence,the CA-MobileNet v3 network was proposed by enhancing the MobileNet v3 network with a collaborative attention ***,a federated edge intelligence model was designed uti‐lizing the CA-MobileNet v3 network and the FedAvg federated aggregation *** the study on split edge intelli‐gence,a split edge intelligence model named MobileNet-LSTM was designed by integrating the MobileNet v3 network with a fusion collaborative attention mechanism and the Bi-LSTM network.[Results and Discussions]Through compara‐tive experiments with MobileNet v3 and MobileNet-LSTM,the federated edge intelligence model based on CA-Mo‐bileNet v3 achieved an average Precision rate,Recall rate,F1-Score,Specificity,and Accuracy of 97.1%,97.9%,97.5%,98.3%,and 98.2%,respectively,yielding the best recognition performance.[Conclusions]It is provided a real-time and effective method for monitoring cow rumin

关键词： cow rumination behavior real-time monitoring edge computing improved MobileNet v3 edge intelligence model Bi-LSTM

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

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光热协同催化甲烷二氧化碳重整反应研究进展

化工新型材料 2023年第S2期51卷 203-207页

作者：刘爱迪李玉巧刘会敏李德正辽宁工业大学化学与环境工程学院锦州121001

在光热协同催化条件下的甲烷二氧化碳重整(CRM)反应耦合了光效应和热效应,可在低温下反应生成合成气(CO和H_(2)),减少碳排放的同时将太阳能转化为化学能储存起来,是实现双碳目标的有效策略之一。催化剂是光热协同催化CRM反应的核心,同... 详细信息

在光热协同催化条件下的甲烷二氧化碳重整(CRM)反应耦合了光效应和热效应,可在低温下反应生成合成气(CO和H_(2)),减少碳排放的同时将太阳能转化为化学能储存起来,是实现双碳目标的有效策略之一。催化剂是光热协同催化CRM反应的核心,同时调控热催化活性中心(活性金属)的结构性质和吸光材料(载体)的光学特性以及活性组分与吸光材料的协同作用,使光热协同催化剂的热催化性能及光催化性能同时得到提高,是研发高效光热协同催化剂的有效途径之一。介绍了光热协同催化CRM反应的机理及相关金属催化剂和半导体材料的研究进展,并展望了其未来发展趋势。

关键词：光热协同催化甲烷二氧化碳重整催化剂