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Milestones in the discovery of hepatitis C

World Journal of Gastroenterology 2022年第37期28卷 5395-5402页

作者： Octavio Campollo Gerardo Amaya p aiden mccormick Center of Studies on Alcohol and Addictions Antiguo Hospital Civil de GuadalajaraDepartment of Medical ClinicsUniversidad de GuadalajaraGuadalajara 44280JaliscoMexico Medical Clinics CUCSUniversidad de GuadalajaraGuadalajara 44280JaliscoMexico Department of Hepatology Saint Vincent’s University HospitalNational Liver Transplant UnitDublin D04Ireland

The discovery of hepatitis C has been a landmark in public health as it brought the opportunity to save millions of lives through the diagnosis,prevention and cure of the *** combined work of three researchers,Alter H,Houghton M and Rice C,which set the basis for the diagnosis,treatment and prevention of hepatitis C apart from laying the ground work for a new approach to study infections in general and developing new antiviral *** is a story of a transfusion-associated infection.A series of clinical studies demonstrated the existence of an infectious agent associated with *** was followed by the identification of what was later known to be the hepatitis C virus(HCV)and the development of diagnostic *** all preceded the full molecular identification and demonstration of a causal *** it ended up with the development and discovery of a new class of therapeutic drugs,the direct acting antivirals,which are now used not only to cure the disease but most probably,to eliminate the *** work started with Dr Alter H who demonstrated that a new virus was responsible for the majority of post-transfusion hepatitis followed by Houghton M who cloned the virus and developed the blood test to identify those cases that carried the ***,the work of Rice C demonstrated that a cloned HCV produced after applying molecular biology techniques could cause long-standing infection and cause the same disease as the one observed in humans.

关键词： Hepatitis C Nobel prize Discovery Diagnosis Treatment Elimination World Health Organization initiative

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New guidelines for screening,evaluation and management of hepatobiliary disease in cystic fibrosis

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 875-878页

作者： p.aiden mccormick Emer Fitzpatrick Liver Unit St Vincent’s University HospitalDublinIreland Department of Medicine UCD School of MedicineUniversity College DublinDublinIreland Gastroenterology and Liver Department Children’s Health IrelandCrumlinDublinIreland

The recently published guidelines on screening,monitoring and treatment update previous guidelines published 25 years ago(1,2).This update is timely as much has happened in the *** fibrosis(CF)modulator therapy has dramatically improved prognosis for patients with CF,although it is not yet clear whether liver disease is *** understanding of the pathophysiology of CF liver disease has also changed with the recognition of the importance of non-cirrhotic portal hypertension(3,4).Non-invasive tests for fibrosis and elastography have changed the practice of hepatology and reduced the need for liver *** guideline committee was made up of experts from North America and Europe and included adult and paediatric hepatologists and pulmonologists together with allied health practitioners and representatives of the CF community.A systematic literature search was performed and a vote of 80%was required to adopt a *** guidelines contain 7 recommendations for screening,13 for disease monitoring and 14 for treatment.

关键词： Cirrhosis oesophageal varices non-cirrhotic portal hypertension porto-sinusoidal vascular disease hepatobiliary

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Liver transplantation for hepatocellular carcinoma in Ireland:pre-operative alpha-fetoprotein predicts tumour recurrence in a 14-year single-centre national experience

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World Journal of Transplantation 2016年第2期6卷 396-402页

作者： Donal B O'Connor John p Burke John Hegarty aiden p mccormick Niamh Nolan Emir Hoti Donal Maguire Justin Geoghegan Oscar Traynor Department of Surgery Trinity Centre for Health SciencesTallaght Hospital Departments of Hepatobiliary Surgery St Vincent’s University Hospital National Liver Transplant programme St Vincent’s University Hospital Departments of pathology St Vincent’s University Hospital

AIM: To examine the results of orthotopic liver transplantation(OLT) for hepatocellular carcinoma(HCC) in Ireland over a 14-year ***: Cases of HCC receiving OLT between January 1995 and September 2009 in the Irish Liver Transplant Unit were reviewed from a prospectively maintained database. Outcome measures included overall and recurrence free survival, alpha-fetoprotein(AFp) and tumour pathological features. RESULTS: On explant pathology, 57 patients had HCC. The median follow-up time was 42.7 mo. The overall 1, 3 and 5 years survival was 87.7%, 72.1% and 72.4%. There was no difference in survival when comparedto patients undergoing OLT without malignancy. The tumour recurrence rate was 14%. The Milan criteria were exceeded in 32% of cases but this did not predict overall survival or recurrence. On multivariate analysis pre-operative AFp > 100 ng/m L was an independent risk factor for recurrence(RR = 5.2, CI: 1.1-24.3, p = 0.036).CONCLUSION: patients undergoing OLT for HCC had excellent survival even when conventional listing criteria were exceeded. pre-operative AFp predicts recurrence independent of tumour size and its role in selection criteria should be investigated in larger studies.

关键词： Liver transplantation Alpha-fetoprotein Hepatocellular carcinoma Transplantation selection criteria Liver cirrhosis

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