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同位素微量试验法检测新化合物抗恶性疟原虫活性试验

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同位素微量试验法检测新化合物抗恶性疟原虫活性试验

Renin-angiotensin system in the central nervous system:focus on Huntington’s disease

2008年上海市动物学会学术会议

作者：陈兆国 Alicia Moreno Agustin Benito Marta Moreno Pedro J.Berzosa aida de lucio Eva Moyano 胡坛仿中国农业科学院上海兽医研究所农业部动物寄生虫学重点开放实验室

同位素微量试验法是 WHO 推荐的评估抗疟活性和检测抗疟药敏感性的方法,国内报道甚少。采用同位素微量试验法检测20个新化合物对恶性疟原虫 Dd2、3D7克隆系的抗疟活性,结果显示,20个新化合物均没有明显的抗疟原虫活性;对照药物氯喹和奎... 详细信息

同位素微量试验法是 WHO 推荐的评估抗疟活性和检测抗疟药敏感性的方法,国内报道甚少。采用同位素微量试验法检测20个新化合物对恶性疟原虫 Dd2、3D7克隆系的抗疟活性,结果显示,20个新化合物均没有明显的抗疟原虫活性;对照药物氯喹和奎宁显示了良好的抗疟活性,结果稳定、重复性好,表明同位素微量试验法是体外筛选新抗疟药的一个稳定、可靠的方法。

关键词：恶性疟原虫抗疟药同位素微量试验法

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Neural Regeneration Research 2023年第10期18卷 2206-2207页

作者： Aline Silva de Miranda Antonio lucio Teixeira Laboratório de Neurobiologia Departamento de MorfologiaInstituto de Ciências BiológicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Laboratório Interdisciplinar de Investigação Médica(LIIM) Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at HoustonTXUSA Faculdade Santa Casa BH Belo HorizonteMGBrasil

The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal *** the discovery of local RAS components in diverse organs,including t... 详细信息

关键词： Huntington organs angiotensin

Onsite strength determination for early-opening decision making of high early strength concrete pavement

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第2期10卷 291-303页

作者： Katelyn Kosar lucio Salles de Salles Naser Pourakbar Sharifi Julie Vandenbossche Lev Khazanovich department of Civil and Environmental Engineering University of PittsburghPittsburghPA 15261USA department of Civil Engineering Technology Environmental Management and SafetyRochester Institute of TechnologyRochesterNY 14623USA

High early strength(HES)concrete pavements are commonly opened to traffic within the first 24 h after construction,making early-opening decisions critical for pavement quality and traffic ***,most state departments of transportation rely on compressive strength testing for early-opening decision ***,there laboratory tests are labor intensive,costly and not always representative of field strength *** this study,non-destructive testing(maturity and ultrasonic tomography)was explored for faster and reliable in-situ strength *** experimental section constructed using HES concrete was routinely monitored using compressive testing,maturity,and ultrasonic tomography in the first 24 h after *** shear wave velocity,measured using ultrasonic tomography,was able to capture the strength-gain variability within a single slab and between different slabs due to the ability to monitor several locations in a short period of *** results were consistently conservative in the first 24 h of *** show that both maturity testing and ultrasonic tomography are able to replace or add to conventional strength testing for HES concrete pavements to facilitate making the opening decision within the first 24 *** tomography proved more beneficial as a result of the device's portability,increased speed of testing,and accurate estimations of HES concrete strength for the entire pavement length.

关键词： Road engineering High early strength concrete pavement Traffic early-opening Strength Maturity Ultrasonic tomography

Fiscal Residuum and Localization of Foreign Direct Investments among Chinese Provinces

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2013年第4期8卷 552-570页

作者： Giuseppe lucio Gaeta Elina de Simone Salvatore Ercolano department of Humanities and Social Sciences University of Naples L'Orientale 80134 Naples Italy department of Economic Studies University of Naples Parthenope 80132 Naples Italy

This paper examines the impact of fiscal residuum--the excess of expenditure benefits over tax burdens--on the location choice of foreign direct investments among China＇s provinces. Using data provided by the National Bureau of Statistics of China we propose two fiscal residuum indexes for China＇s provinces over the period 1998-2004. According to Buchanan＇s original definition of fiscal residuum a first index is given by the difference between government expenditure and revenue. A second index measures enterprises＇ net fiscal benefit and is calculated as the difference between public expenditure that affect business activities and taxes paid by enterprises. We found that the first index does not significantly affect the FDI localization choice while the second one positively affects it. When looking at different subsets of provinces we found that for eastern provinces the first index has a positive and significant effect. These results confirm the role of the net fiscal benefit as a determinant of FDI inflows at the provincial level.

关键词： China foreign direct investments fiscal residuum

Efficient fully blade-coated perovskite solar cells in air with nanometer-thick bathocuproine buffer layer

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维普期刊数据库

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Nano Research 2021年第4期14卷 1034-1042页

作者： Sergio Castro-Hermosa Luana Wouk Izabela Silva Bicalho Luiza de Queiroz Correa Bas de Jong lucio Cina Thomas M.Brown Diego Bagnis CSEM Brasil Avenida Jose Candido da Silveira200031035-536 Belo HorizonteBrazil CHOSE(Centre for Hybrid and Organic Solar Energy) Department of Electronic EngineeringUniversity of Rome Tor VergataVia del Politecnico 100133 RomeItaly Hydro Engineering and Agricultural development Research Group(GHIDA) Faculty of EngineeringUniversidad SurcolombianaAvenida Pastrana Borrero-Carrera 1410001 NeivaColombia Cicci Research srl via Giordania 227 58100 GrossetoItaly department of Biotechnology Chemistry and PharmacyUniversity of SienaVia A.Moro 253100 SienaItaly

Fully printed perovskite solar cells(PSCs)were fabricated in air with all constituent layers,except for electrodes,deposited by the blade coating *** PSCs incorporated,for the first time,a nanometer-thick printed bathocuproine(BCP)hole blocking buffer using blade coating and deposited at relative humidity up to 50%.The PSCs with a p-i-n structure(glass/indium tin oxide(ITO)/poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS)/CH_(3)NH_(3)Pbl_(3)/[6,6]-phenyl-C_(61)-butyric acid methyl ester(PCBM)/BCP/Ag)delivered a maximum power conversion efficiency(PCE)of 14.9%on an active area of 0.5 cm^(2)when measured under standard test *** PSCs with a blade coated BCP delivered performance of 10%and 63%higher(in relative terms)than those incorporating a spin coated BCP or without any BCP film,*** atomic force microscopy(AFM)showed that blade coated films were more homogeneous and acted also as a surface planarizer leading to a reduction of roughness which improved BCP/Ag interface lowering charge *** demonstration of 15%efficient devices with all constituent layers,including nanometer-thick BCP(〜10 nm),deposited by blade coating in air,demonstrates a route for industrialization of this technology.

关键词： perovskite buffer bathocuproine(BCP) blade coating printed electronics

The A-B-A of Floral Transition: The to Do List for Perfect Escape

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Molecular Plant 2019年第3期12卷 289-291页

作者： lucio Conti department of Biosciences Universita degli Studidi MilanoVia Celoria2620133 MilanoItaly

The transition to flowering marks the initiation of reproductive compete nee in plants. After the floral transit! on, the shoot apical meristem (SAM) ceases to produce leaf primordia and starts to gen erate floral primordia, the reproductive organs of plants. To maximize reproductive success, the timing of this transition needs to be precisely aligned with the most favorable environmental conditions (Blackman, 2017). Day length and cold temperature variations usually act as predictable seasonal signals to initiate flowering. However, due to the complexity of natural conditions, plants must gage a much wider array of information before committing to reproductive development. A striking example of this developmental plasticity is the drought escape (de) response, where drought conditions experieneed during vegetative growth cause an accelerated flowering time compared with optimal watering conditio ns (Figure 1A). Among the strategies to cope with drought stress, de may provide ephemeral plants like Arabidopsis with a simple "exit strategy" to anticipate seed set before drought conditions become incompatible with their survival.

关键词： A-B-A of Floral Transition Perfect Escape

Power Curve Modelling for Wind Turbine Using Artificial Intelligence Tools and Pre-established Inference Criteria

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 526-533页

作者： Jonata C.de Albuquerque Ronaldo R.B.de Aquino Otoni Nobrega Neto Milde M.S.Lira aida A.Ferreira Manoel Afonso de Carvalho Jr. the department of Electrical Engineering Federal University of PernambucoRecifeBrazil DASE Federal Institute of PernambucoRecifeBrazil

We propose a new way to develop non-parametric models of power curves using artificial intelligence *** parametric model and eight non-parametric models are developed to emulate the behavior described by the power curve of the wind farms.A comparison between the power curve models based on artificial neural networks(ANNs)and those based on fuzzy logic are also *** of the power curve models based on ANNs and fuzzy inference systems(FISs)are used as well as two new FISs with the proposed new *** initial pre-training is proposed,resulting from the characteristics derived from the expert inference followed by a transformation of a fuzzy Mamdani system into a fuzzy Sugeno *** the presented values by the error indicators are comparable,the results show that the new pre-trained FIS models have better precision compared with the ANN and FIS *** comparative study is conducted in two wind farms located in northeastern *** proposed method is a relevant alternative to improve power curve approximation based on an FIS.

关键词： Wind turbine pre-training artificial intelligence artificial neural network(ANN) fuzzy inference system(FIS)

Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse

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Neuroscience Bulletin 2020年第11期36卷 1242-1258页

作者： James Morgan Mariana Alves Giorgia Conte aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon Smith Annette Nicke Tobias Engel department of Physiology and Medical Physics Royal College of Surgeons in IrelandDublin D02 YN77Ireland FutureNeuro Science Foundation Ireland Research Centre for Chronic and Rare Neurological DiseasesRoyal College of Surgeons in IrelandDublin D02 YN77Ireland Walther Straub Institute of Pharmacology and Toxicology Faculty of MedicineLudwig-Maximilians-Universitat Miinchen80336 MunichGermany

Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the *** increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely *** this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein *** results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and *** of P2X7-EGFP with cell type-specific markers was not detected in neurons or *** data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy.

关键词： Purinergic signaling P2X7 Green fluorescence protein Status epilepticus Epilepsy Cell typespecific expression

Buzz-pollination in Neotropical bees:genus-dependent frequencies and lack of optimal frequency for pollen release

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Insect Science 2020年第1期27卷 133-142页

作者： Conrado Augusto Rosi-denadai Priscila Cassia Souza Araujo lucio Antonio de Oliveira Campos Lirio Cosme Jr. Raul Narciso Carvalho Guedes departamento de Entomologia Universidade Federal de VigosaVigosaMinas GeraisBrazil departamento de Biologia Geral Universidade Federal de VigosaVigosaMinas GeraisBrazil

Over 50 genera of bees release pollen from flower anthers using thoracic vibrations,a phenomenon known as *** efficiency of this process is directly affected by the mechanical properties of the buzzes,namely the duration,amplitude,and ***,although the effects of the former two properties are well described,the role of buzz frequency on pollen release remains ***,nearly all of the existing studies describing vibrational properties of natural buzz-pollination are limited to bumblebees(Bombus)and carpenter bees(Xvlocopa)constraining our current understanding of this behavior and its ***,we attempted to minimize this shortcoming by testing whether flower anthers exhibit optimal frequency for pollen release and whether bees tune their buzzes to match these(optimal)*** true,certain frequencies will trigger more pollen release and lighter bees will reach buzz frequencies closer to this optimum to compensate their smaller buzz *** strategies were used to test these hypotheses:(i)the use of(artificial)vibrational playbacks in a broad range of buzz frequencies and amplitudes to assess pollen release by tomato plants(Solarium Ivcopersicum L.)and(ii)the recording of natural buzzes of Neotropical bees visiting tomato plants during *** playback experiment indicates that although buzz frequency does affect pollen release,no optimal frequency exists for *** addition,the recorded results of natural buzz-pollination reveal that buzz frequencies vary with bee genera and are not correlated with body ***,neither bees nor plants are tuned to optimal pollen release *** frequency of buzz-pollination is a likely consequence of the insect flight machinery adapted to reach higher accelerations,while flower plant response to buzz-pollination is the likely result of its pollen granular properties.

关键词： buzz amplitude buzz frequency floral sonication pollination stingless bees vibration