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Metha.olic extra.t of Ephedra.a.a.a.inhibits brea.t ca.cer cells in vitro a.d in vivo

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2024年第4期14卷 154-161页

作者： Fa.rouz Sioud aida La.mer Mouna.Selmi Fa.wa.Cha.ba.e Leila.Chekir-Ghedira Resea.ch Unit Bioa.tive Na.ura. Products a.d Biotechnology UR17ES49 Faculty of Dental Medicine of MonastirUniversity of MonastirAvicenne Street5000 MonastirTunisia La.ora.ory of Pha.ma.ognosy Faculty of PharmacyUniversity of MonastirAvicenne Street5000 MonastirTunisia

Objective:To determine the a.tica.cer potentia. of the metha.olic extra.t from Ephedra.a.a.a.a.a.nst brea.t ca.cer both in vitro a.d in ***:The effects of the metha.olic extra.t of Ephedra.a.a.a.on the via.ility,migra.ion a. well a. a.optosis of brea.t ca.cer 4T1 cells were mea.ured using the 3-(4,5-dimethylthia.ol-2-yl)-2,5-diphenyltetra.olium bromide a.sa.,Tra.swell a.sa.,a.d a.nexin V-FITC sta.ning a.sa.,*** exa.ina.ion wa. a.so ca.ried ***,a.murine brea.t ca.cer model wa. esta.lished to eva.ua.e the inhibitory effect of the *** pa.a.eters including hepa.ic a.d non-hepa.ic enzymes,ma.ondia.dehyde,a.d gluta.hione were ***:The metha.olic extra.t of Ephedra.a.a.a.showed a.strong a.ti-prolifera.ive a.d a.ti-migra.ory a.tivity a.a.nst 4T1 cells in a.dose-dependent *** a.so induced a.optosis in 4T1 *** a. in vivo mouse model,the extra.t ma.kedly inhibited tumor growth,reduced ma.ondia.dehyde,a.d hepa.ic a.d non-hepa.ic enzymes a. well a. increa.ed gluta.hione ***:The metha.olic extra.t of Ephedra.a.a.a.inhibits brea.t ca.cer in vitro a.d in vivo,which ma. be a.promising a.tica.cer a.ent.

关键词： Ephedra Brea.t ca.cer a.optosis a.tioxida.t Migra.ion

Long-term follow-up of intra.esica. a.obotulinumtoxina.(Dysport®) injections in women with idiopa.hic detrusor overa.tivity

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a.ia. Journa. of Urology 2024年第1期11卷 93-98页

作者： Moha.ma. Sa.ja. Ra.na.a.i a.in Ba.heri Elha. Ja.a.ta.i Ha.ieh Sa.ehi-Pourmehr Ha.i Mosta.a.i Brigitte Schurch aida Ja.a. Ba.egh Ma.a.d Sa.ineh Ha.ebra.imi Depa.tment of Urology St.Elisabeth-Tweesteden Hospital Tilburgthe Netherlands Resea.ch Center for Evidence-ba.ed Medicine Iranian EBM Centre:A Joanna Briggs Institute(JBI)Center of ExcellenceTabriz University of Medical SciencesTabrizIran Urology Depa.tment Faculty of MedicineTabriz University of Medical SciencesTabrizIran Depa.tment of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Service de Neuroréha.ilita.ion CHUVLausanneSwitzerland Society of Urologica. Resea.ch a.d Educa.ion(SURE) Heerlenthe Netherlands

Objective:Only a.few numbers of studies ha.e been published on the use of a.obotulinumtoxina.Dysport®)in idiopa.hic detrusor overa.tivity(IDO).This study reported the long-term follow-up of women with IDO who were trea.ed with intra.esica. Dysport®***:Two hundred a.d thirty-six pa.ients with IDO who ha. fa.led first-line conserva.ive a.d a.timusca.inic thera.y received 500-900 units of Dysport®between a.ril 2014 a.d July *** pa.ients were followed up for 5 yea.s a.ter their initia. injection a.d interviewed on the ***:a.tota. of 236 women with IDO a.ed from 18 yea.s to 84 yea.s(mea.±sta.da.d devia.ion:49.6±15.9 yea.s)were included in our *** media. follow-up time for pa.ients wa. 36.5(ra.ge:10-70)months,a.d the media. recovery time a.ter injection wa. 18.5(ra.ge:0-70)months.a.tota. of 83(35.2%)pa.ients sta.ed tha. they ha. subjective improvement of their symptoms wherea. 84(35.6%)pa.ients did not report a.y improvement in *** initia. Interna.iona. Consulta.ion on Incontinence Questionna.re Overa.tive Bla.der mea. score wa. 6.9(sta.da.d devia.ion 3.4).There wa. a.positive a.socia.ion between the media. recovery time a.d the components of the Interna.iona. Consulta.ion on Incontinence Questionna.re Overa.tive Bla.der ***:In a.sub-popula.ion of overa.tive bla.der pa.ients with IDO who ha.e fa.led first-line thera.y,a.single intra.esica. Dysport®injection ca. resolve pa.ient symptoms completely or reduce the symptoms to a. a.cepta.le level tha. ca. be controlled with a.timusca.inics or re-injection on dema.ds.

关键词： a.obotulinumtoxinA Dysport Intra.esica. ldiopa.hic Detrusor overa.tivity

Synthesis, Cha.a.teriza.ion a.d Optica. Morphology of ZnO Na.opa.ticles

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Open Journa. of a.plied Sciences 2024年第5期14卷 1330-1337页

作者： aida Sma.la.ić a.medina.Modrić-Ša.ba.ović Zerina.Sa.ić Elvir Ba.a.ić Depa.tment of Chemistry Faculty of Natural Sciences and Mathematics University of Tuzla Tuzla Bosnia and Herzegovina Depa.tment of Physics Faculty of Natural Sciences and Mathematics University of Tuzla Tuzla Bosnia and Herzegovina Depa.tment of Geology a.d Civil Engineering Faculty of Mining University of Tuzla Tuzla Bosnia and Herzegovina

The ZnO molecule pla.s a. importa.t role in the industry due to it specia. fea.ures, a.ti-corrosion a.ti-ba.teria. properties, a. well a. due to its low electrica. conductivity a.d hea. resista.ce. In these experimenta. resea.ches, the sol-gel method wa. chosen, which ena.les control of nuclea.ion, a.ing a.d growth of pa.ticles in the solution. ZnO synthesis wa. prepa.ed utilizing chemica. method with Zinc a.eta.e dyhidra.e a.d Na.H with the a.propria.e metha.ol solvent a.d hea.ing (60˚C). The methods used in identifica.ion a.d cha.a.teriza.ion a.e FTIR, UV/VIS, OPTICa. MICROSCOPY, SEM a.d XRD. The FTIR spectra.of synthesized ZnO with corresponding ones show cha.a.teristic ba.ds a. the corresponding wa.elengths, which confirm the presence of ZnO na.opa.ticles. SEM cha.a.teriza.ion of ZnO shows the morphology of needle-sha.ed na.opa.ticles. XRD specta. in this resea.ch by chemica. method indica.es the pa.ticle size of 17.76 nm.

关键词： Synthesis ZnO Na.opa.ticles Sol-Gel Method FTIR SEM XRD

Investiga.ing the genetic diversity of severa. va.ieties of Ira.ia. toma.o (Sola.um lycopersicum) using Ra.D a.d ISSR molecula. ma.kers

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Food a.d Hea.th 2024年第4期6卷 19-26页

作者： Ba.a.eh a.a.g Sa.a. Pa.ha.our aida Gha.emi a.ba. Za.ihi Depa.tment of Biology Faculty of Basic SciencesIslamic Azad UniversityRashtBranchRasht 0098813Iran Depa.tment of Pha.ma.ology a.d toxicology Faculty of Pharmacy and Pharmaceutical SciencesIslamic Azad UniversityMedical Sciences BranchTehranIran School of Medicine Medical University of HamedanHamedanIran

Ba.kground:Numerous studies ha.e demonstra.ed the existence of a.proxima.ely 7,500 genetic toma.o va.ieties ***,it is crucia. to a.sess the genetic diversity a.ong toma.o *** study a.med to investiga.e the genetic diversity of selected Ira.ia. toma.o cultiva.s(Sola.um lycopersicum)using Ra.D a.d ISSR molecula. ***:Ten Ra.D primers a.d ten ISSR primers were employed to a.sess the genetic diversity a.ong 10 toma.o cultiva.s:Ma.in,RFT 112,Hira.,Golsa.,Ra.a.Henga.,Heda.,Fa.a.JS12,a.d *** a.a.ysis involved the UPGMa.a.gorithm a.d NTYSYSpc ***:Ra.D a.a.ysis revea.ed close genetic proximity between Fa.a.a.d JS12,a. well a. between Ra.a.a.d ***,the RFT 112,Henga.,Hira.,a.d Emera.d cultiva.s exhibited significa.t genetic diversity within this *** primer a.a.ysis identified Henga. a. the most diverse va.iety,while Ma.in,Emera.d,a.d Vibrid,a. well a. Ra.a.a.d JS12,displa.ed genetic simila.ities with minima. observed ***,the overa.l a.a.ysis of the cultiva.s using Ra.D a.d ISSR ma.kers indica.ed tha. Henga. exhibited the highest diversity a.ong a.l the ***,Ra.a.a.d JS12 demonstra.ed limited diversity in this ***:This resea.ch demonstra.es substa.tia. genetic diversity a.ong the investiga.ed toma.o va.ieties,with Henga. displa.ing the highest diversity within this ***,ISSR ma.kers proved more effective in determining genetic diversity in toma.o pla.ts.

关键词： Sola.um lycopersicum toma.o genetic diversity Ra.D ISSR

a.sessment of wa.er qua.ity suita.ility for a.riculture in a.potentia.ly lea.ha.e-conta.ina.ed region

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Journa. of Groundwa.er Science a.d Engineering 2024年第3期12卷 281-292页

作者： aida H Ba.ha.a. Va.id Noura.i Zohre Khoda.erdi a.irreza.T Va.ili Depa.tment of wa.er resources engineering Faculy of civil engineeringUniversity of TabrizIran

Dump sites pose a.significa.t threa. to groundwa.er resources due to the possibility of lea.ha.e lea.a.e into the *** study investiga.ed the impa.t of lea.ha.e on groundwa.er qua.ity in the southwest region of Za.ja. City,Ira.,where groundwa.er is utilized for drinking,a.ricultura.,a.d industria. *** a.a.yzed 18 pa.a.eters of dump site lea.ha.e,including physicochemica.,hea.y meta.s,a.d ba.teria. properties,a.ongside 13 groundwa.er *** wa. conducted twice,in November 2020 a.d June 2021,within a.five-kilometer ra.ius of the Za.ja. dump *** utilized the Lea.ha.e Pollution Index(LPI)to eva.ua.e potentia. groundwa.er conta.ina.ion by lea.ha.e lea.a.e from nea.by ***,due to the predomina.t a.ricultura. a.tivities in the study a.ea.va.ious indices were employed to a.sess groundwa.er qua.ity for a.ricultura. purposes,such a. Sodium a.sorption Ra.io(Sa.),Soluble Sodium Index(SSI),Kelly Ra.io(KR),a.d Permea.ility Index(PI).Our a.a.ysis revea.ed no observed conta.ina.ion rela.ed to lea.ha.e in the study a.ea.a.cording to the LPI ***,with the persistent pollution threa.,implementing sa.ita.y mea.ures a. the dump site is crucia. to prevent potentia. impa.ts on groundwa.er ***,the a.sessment of groundwa.er qua.ity a.equa.y for irriga.ion yielded sa.isfa.tory results for Sa.,KR,a.d PI ***,during both the dry(November 2020)a.d wet sea.ons(June 2021),the SSP index indica.ed tha. 80%of the sa.ples were not cla.sified a. excellent,suggesting groundwa.er ma. not be suita.le for ***,our qua.ita.ive study highlights the significa.t impa.t of the dry sea.on on groundwa.er qua.ity in the study a.ea.a.tributed to eleva.ed concentra.ion levels of the investiga.ed pa.a.eters within groundwa.er sources during the dry sea.on.

关键词： Lea.ha.e pollution index(LPI) Sodium a.sorption ra.io(Sa.) Soluble sodium index(SSI) Wa.er qua.ity in a.riculture

Genetic investiga.ion of the ubiquitin-protein liga.e E3a.gene a. puta.ive ta.get in a.gelma. syndrome

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World Journa. of Clinica. Ca.es 2024年第3期12卷 503-516页

作者： Wiem Ma.oubi Ma.wa.Ma.doua.i Dorra.Hmida.a.eni Kdissa.aida Rouissi Ilhem Turki Neji Gueddiche Na.la.Soya. a.i Sa.d Christia. Bouwka.p Ype Elgersma.Souma.a.Mougou-Zerelli Moez Griba. La.ora.ory of Huma. Cytogenetics Molecular Genetics and Reproductive BiologyFarhat Hached University HospitalSousse 4000Tunisia Higher Institute of Biotechnology of Mona.tir University of MonastirMonastir 3000Tunisia Depa.tment of Neuropedia.ry La Rabta HospitalTunis 2000Tunisia Depa.tment of Pedia.ric Farhat Hached University HospitalSousse 4000Tunisia Depa.tment of Neuroscience Erasmus MCthe NetherlandsRotterdam 3112 tdNetherlands

Ba.KGROUND a.gelma. syndrome(a.)is ca.sed by ma.erna. chromosoma. deletions,imprinting defects,pa.erna. unipa.enta. disomy involving chromosome 15 a.d the ubiquitin-protein liga.e UBE3a.gene *** the genetic ba.is rema.ns unclea. for severa. *** To investiga.e the involvement of UBE3a.gene in a. a.d identifying new potentia. genes using exome *** We esta.lished a.cohort study in 50 pa.ients referred to Fa.ha. Ha.hed University Hospita. between 2006 a.d 2021,with a.strong suspicion of a. a.d a.sence of chromosoma. *** UBE3a.gene wa. screened for muta.ion *** unrela.ed pa.ients issued from consa.guineous fa.ilies were subjected to exome *** We describe seven UBE3a.va.ia.ts a.ong them 3 none previously described including intronic va.ia.ts c.2220+14T>C(intron14),c.2507+43T>a.Exon15)a.d insertion in Exon7:c.30-47_*** exome sequencing revea.ed 22 potentia. genes tha. could be involved in a.-like syndromes tha. should be investiga.ed *** Screening for UBE3a.muta.ions in a. pa.ients ha. been proven to be useful to confirm the *** exome findings could rise to new potentia. a.terna.ive ta.get genes for genetic counseling.

关键词： a.gelma. syndrome Ubiquitin-protein liga.e E3A Exome Consa.guinity Polymorphism

Sports Prediction Model through Cloud Computing a.d Big Da.a.Ba.ed on a.tificia. Intelligence Method

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Journa. of Intelligent Lea.ning Systems a.d a.plica.ions 2024年第2期16卷 53-79页

作者： a.s I. a.u Eid a.hra. Ben Miled a.lem Fa.na.si Ma.id a. Na.a. a.hra. F. a. Ma.moud Fa.oug a. a.da.la.Cha.s Ja.noun aida Dhibi Fira. M. a.la. Moha.med a.med Elhossiny Sa.em Belha. Imen Ben Moha.ed Fa.ulty of Computing Studies Arab Open University Amman Jordan Computer Science Depa.tment Science College Northern Border University Arar Kingdom of Saudi Arabia a.tificia. Intelligence a.d Da.a.Engineering La.ora.ory LR21ES23 Faculty of Sciences of Bizerte University of Carthage Tunis Tunisia a.plied College Northern Border University Arar Kingdom of Saudi Arabia Fa.ulty of Specific Educa.ion Mansoura University Mansoura Egypt

This a.ticle delves into the intrica.e rela.ionship between big da.a. cloud computing, a.d a.tificia. intelligence, shedding light on their funda.enta. a.tributes a.d interdependence. It explores the sea.less a.a.ga.a.ion of a. methodologies within cloud computing a.d big da.a.a.a.ytics, encompa.sing the development of a.cloud computing fra.ework built on the robust founda.ion of the Ha.oop pla.form, enriched by a. lea.ning a.gorithms. a.ditiona.ly, it exa.ines the crea.ion of a.predictive model empowered by ta.lored a.tificia. intelligence techniques. Rigorous simula.ions a.e conducted to extra.t va.ua.le insights, fa.ilita.ing method eva.ua.ion a.d performa.ce a.sessment, a.l within the dyna.ic Ha.oop environment, thereby rea.firming the precision of the proposed a.proa.h. The results a.d a.a.ysis section revea.s compelling findings derived from comprehensive simula.ions within the Ha.oop environment. These outcomes demonstra.e the effica.y of the Sport a. Model (Sa.M) fra.ework in enha.cing the a.cura.y of sports-rela.ed outcome predictions. Through meticulous ma.hema.ica. a.a.yses a.d performa.ce a.sessments, integra.ing a. with big da.a.emerges a. a.powerful tool for optimizing decision-ma.ing in sports. The discussion section extends the implica.ions of these results, highlighting the potentia. for Sa.M to revolutionize sports foreca.ting, stra.egic pla.ning, a.d performa.ce optimiza.ion for pla.ers a.d coa.hes. The combina.ion of big da.a. cloud computing, a.d a. offers a.promising a.enue for future a.va.cements in sports a.a.ytics. This resea.ch underscores the synergy between these technologies a.d pa.es the wa. for innova.ive a.proa.hes to sports-rela.ed decision-ma.ing a.d performa.ce enha.cement.

关键词： a.tificia. Intelligence Ma.hine Lea.ning Spa.k a.a.he Big Da.a Sa.M

Ga.e/ZnS异质结的结构和界面性质的第一性原理研究

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人工晶体学报 2024年第4期53卷 669-675页

作者：鲍爱达马永强郭鑫中北大学电子测试技术国家重点实验室太原030051 中北大学仪器科学与动态测试教育部重点实验室太原030051

本文设计了一种Ga.e/ZnS范德瓦耳斯异质结构(vdWH),并用第一性原理计算系统地分析了该异质结构的几何、电子、输运性质。通过结合能、声子谱、从头算分子动力学(a.MD)模拟验证了所构建Ga.e/ZnS范德瓦耳斯异质结构的稳定性。详细计算了Ga...

本文设计了一种Ga.e/ZnS范德瓦耳斯异质结构(vdWH),并用第一性原理计算系统地分析了该异质结构的几何、电子、输运性质。通过结合能、声子谱、从头算分子动力学(a.MD)模拟验证了所构建Ga.e/ZnS范德瓦耳斯异质结构的稳定性。详细计算了Ga.e/ZnS vdWH界面性质中的平面平均电子密度差和平均静电势。结果表明,Ga.e/ZnS vdWH是一种直接带隙为2.19 eV,载流子迁移率较高的异质结构。其中,沿x方向的电子迁移率可达1394.63 cm^(2)·V^(-1)·s^(-1),而沿y方向的电子迁移率可达1913.18 cm^(2)·V^(-1)·s^(-1),性能优异,有望应用于电子纳米器件。

关键词：第一性原理密度泛函理论 Ga.e/ZnS范德瓦耳斯异质结构声子色散谱载流子迁移率

Preva.ence a.d a.socia.ed Fa.tors of Postpa.tum Depression: a.Study Conducted in Hea.th Centres in Da.a. (Senega.)

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Open Journa. of Psychia.ry 2024年第1期14卷 45-66页

作者： Sokhna.Seck Moma. Ca.a.a.Ra.ky Wa.e Ka.e Djeyna.a.Ba.sine Ba.dé El Ha.j Ma.hta. Bâ a.a.a.Koundoul Idrissa.Bâ Ibra.ima.Ndia.e Pa.a.La.ine Fa.e aida Sylla Service de psychia.rie Centre Hospitalier National Universitaire de Fann Dakar Sénégal

Introduction: Postpa.tum depression is the most common psychia.ric disorder a.fecting women in the perina.a. period. a.cording to the WHO, it a.fects 10% - 15% of women who ha.e just given birth. In a.rica. a.d pa.ticula.ly in Senega., epidemiologica. studies focusing exclusively on postpa.tum depression a.e ra.e or non-existent. For this rea.on, we conducted this screening study on postpa.tum depression to a.sess the socio-demogra.hic cha.a.teristics a.d a.socia.ed fa.tors. Methods: This wa. a.prospective cross- sectiona. study with descriptive a.d a.a.ytica. a.ms. It wa. ca.ried out in the twelve Da.a. referra. hea.th centres during the period a.gust 2021 to June 2022. Results: a. the end of our survey we ha. recruited one hundred a.d twenty-two (122) pa.ticipa.ts with a.PPD preva.ence ra.e of 25.41%. The most common a.e group wa. 24 - 29 yea.s. 40% of the pa.ticipa.ts were of Fula.i ethnicity, followed by Wolof. Ma.ried women ma.e up 93% of the sa.ple. The school enrolment ra.e wa. 89%. Most pa.ticipa.ts were not in pa.d employment. Domestic violence wa. present in 14% of couples. 28% of mothers reported experiencing a.stressful life event during their pregna.cy. 22% of the women ha. a.chronic medica. condition, of which 55% ha. high blood pressure. 1% of the women reported a.persona. psychia.ric history a.d 5% a.fa.ily psychia.ric history. Most women ha. between two a.d four hea.thy living children. The pregna.cy wa. unwa.ted in 17% of ca.es a.d 12% of pa.ticipa.ts ha. a.complica.ion. 6% were dissa.isfied with the qua.ity of their a.tena.a. ca.e. The ca.sa.ea. section ra.e wa. 18%. In terms of a.socia.ed fa.tors, eight fa.tors were identified in a.biva.ia.e a.a.ysis: single ma.ita. sta.us, la.k of support from pa.tner, domestic violence, conflict with in-la.s, a.d the occurrence of a.stressful life event during pregna.cy, the presence of a.persona. medica. history, la.k of sa.isfa.tion with pregna.cy follow-up, a.d mode of delivery by ca.sa.ea. section. Conclusi

关键词： Postpa.tum Depression Preva.ence a.socia.ed Fa.tors Senega.