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Different contribution of SBP and DBP variability to vascular events in patients with stroke

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Stroke & Vascular Neurology 2020年第2期5卷 110-115页

作者： Liye Dai aichun cheng Xiwa Hao Jie Xu Yingting Zuo Anxin Wang Xia Meng Hao Li Yilong Wang Xingquan Zhao Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Neurology Inner Mongolia Baotou City Central HospitalBaotouChina

Background High blood pressure variability(BPV)is a novel risk factor for cardiovascular ***,the heterogeneity of systolic blood pressure variability(SBPV)and diastolic blood pressure variability(DBPV)for different vascular events remains *** study aims to investigate whether SBPV or DBPV has different contribution to vascular events in patients with acute ischaemic stroke(IS)or transient ischaemic attack(TIA).Methods Data from the BOSS(blood pressure and clinical outcome in TIA or IS)study were examined for vascular events at 3-month and 1-year *** was defined as the SD and coefficient of variation(CV)of day-to day measurements within 3 months after IS/*** events include cardiovascular events(myocardial infarction,unstable angina,cardiac death and congestive heart failure)and cerebrovascular events(ischaemic or haemorrhagic stroke).Logistic regression model was used to test the associations between BPV and vascular *** Of 2325 patients with IS or TIA,103(4.43%)experienced a recurrent stroke and 64(2.75%)had cardiovascular events within 3 ***-to day SBPV was only associated with stroke recurrence(BPVSD:OR,1.72,95%CI 1.09 to 2.71;BPVCV:1.86,95%CI 1.19 to 2.92),but not cardiovascular events(BPVSD:1.67,95%CI 0.94 to 2.94;BPVCV:1.51,95%CI 0.86 to 2.64).However,DBPV seems to be related to both stroke(BPVSD:1.60,95%CI 1.02 to 2.49;BPVCV:1.53,95%CI 0.99 to 2.37)and cardiovascular events(BPVSD:2.48,95%CI 1.37 to 4.48;BPVCV:1.92,95%CI 1.09 to 3.36).Similar results were found at 1 *** For patients with IS/TIA,stroke recurrence was associated with both SBPV and DBPV;however,cardiovascular events seem to be only related to DBPV.

关键词： patients cardiovascular unstable

血清1,5-脱水葡萄糖醇水平与2型糖尿病患者胰岛素抵抗和微血管并发症的关系

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中华预防医学杂志 2024年第6期58卷 875-882页

作者：谭爱春张骞程杰严湘红南华大学附属长沙中心医院检验科长沙410004

目的探讨血清1,5-脱水葡萄糖醇(1,5-AG)水平与2型糖尿病(T2DM)患者胰岛素抵抗、微血管并发症的关系。方法采用回顾性横断面方法,分析2023年5—12月南华大学附属长沙中心医院收治的836例T2DM患者的临床资料。所有患者入院后采用吡喃糖氧... 详细信息

目的探讨血清1,5-脱水葡萄糖醇(1,5-AG)水平与2型糖尿病(T2DM)患者胰岛素抵抗、微血管并发症的关系。方法采用回顾性横断面方法,分析2023年5—12月南华大学附属长沙中心医院收治的836例T2DM患者的临床资料。所有患者入院后采用吡喃糖氧化酶法检测血清1,5-AG水平。同时根据微血管并发症情况(糖尿病周围神经病变、糖尿病肾病、糖尿病视网膜病变)将患者分为单纯组(无微血管并发症,n=490)、并发症1组(1种微血管并发症,n=217)、并发症2组(2种及以上微血管并发症,n=129)。采用Spearman相关分析探讨T2DM患者血清1,5-AG水平与胰岛素抵抗相关指标的关系,采用多元有序logistic回归分析探讨T2DM患者微血管并发症的影响因素。结果单纯组空腹血糖(fasting blood glucose,FBG)[(7.37±0.56)mmol/L]、空腹胰岛素(fasting insulin,FINS)[(11.34±1.86)mU/L]、胰岛素抵抗指数(homeostatic model assessment of insulin resistance,HOMA-IR)(0.96±0.31)水平低于并发症1组[(8.37±1.02)mmol/L、(16.26±2.32)mU/L、(1.32±0.41)]、并发症2组[(10.25±2.13)mmol/L、(18.53±2.67)mU/L、(1.54±0.44)],且并发症1组FBG、FINS、HOMA-IR低于并发症2组,差异均有统计学意义(F=537.470、791.690、136.340,均P<0.001)。单纯组血清1,5-AG水平[77.16(16.30,128.07)μg/ml]高于并发症1组[51.05(14.67,63.18)μg/ml]、并发症2组[30.42(12.53,47.26)μg/ml],且并发症1组血清1,5-AG水平高于并发症2组,差异有统计学意义(H=210.020,P<0.001)。Spearman相关分析显示,T2DM患者血清1,5-AG水平与FBG、FINS、HOMA-IR均呈负相关(r=-0.431、-0.372、-0.546,均P<0.001)。多元有序logistic回归分析显示,糖尿病病程长(OR=2.261,95%CI:1.564~3.269)、HbA1c升高(OR=2.040,95%CI:1.456~2.858)、HOMA-IR升高(OR=2.158,95%CI:1.484~3.137)、1,5-AG降低(OR=2.512,95%CI:1.691~3.732)是T2DM患者微血管并发症的独立危险因素(P<0.05)。ROC曲线分析显示,血清1,5-AG鉴别T2DM患者1种微血管并发症的曲线下面积为0.763(95%CI:0.731~0.795),血清1,5-AG鉴别T2DM患者2种及以上微血管并发症的曲线下面积为0.730(95%CI:0.692~0.767)。结论血清1,5-AG水平与T2DM患者胰岛素抵抗呈负相关,低水平血清1,5-AG可能是T2DM患者微血管并发症的独立危险因素。

关键词： 2型糖尿病 1,5-脱水葡萄糖醇微血管并发症胰岛素抵抗

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HPLC法测定注射用乳糖酸阿奇霉素的含量

中国药师 2007年第11期10卷 1067-1069页

作者：张集盘程爱春卢晶晶黄新兰钱生稳刘德南龚任湖北浩信药业有限公司质量控制部湖北鄂州436070 扬子江药业集团质量管理部

目的:建立测定注射用乳糖酸阿奇霉素含量的HPLC法。方法:Dikma Diamonsil^(TM)C_(18)柱(250 mm×4.6 mm,5μm),流动相为0.05 mol·L^(-1)磷酸二氢铵溶液(三乙胺调节pH至7.0)-乙腈-水(10:35:55),流速为1.0 ml·min^(-1),检测波长为215 nm,柱温为40℃。结果:阿奇霉素的线性范围为99.76～4988.0μg·ml^(-1),平均回收率为102.0%,RSD=1.0%(n=6)。结论:HPLC法简便,准确,其他组分不干扰测定,可用于本品的质量控制。

关键词：注射用乳糖酸阿奇霉素含量高效液相色谱法

Environmental archaeology on Longshan Culture （4500-4000 aBP） at Yuhuicun Site in Bengbu, Anhui Province

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Journal of Geographical Sciences 2010年第3期20卷 455-468页

作者： ZHANG Guangsheng ZHU cheng WANG Jihuai ZHU Guangyao MA Chunmei ZHENG Chaogui ZHAO Lanhui LI Zhongxuan LI Lan JIN aichun School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China Department of Urban Construction and Environment Science West Anhui University Lu＇an 237012 Anhui China Institute of Archaeological Studies Chinese Academy of Social Sciences Beijing 100710 China Department of Humanities and Social Sciences Bengbu College Bengbu 233000 Anhui China Department of Land Information Engineering Chuzhou University Chuzhou 239012 Anhui China The Museum of Bengbu Bengbu 233000 Anhui China School of Geographical Science Nanjing Normal University Nanjing 210097 China

Based on the samples collected from the west wall of the ABYT2004 at Yuhuicun Site in Bengbu, Anhui Province, the multi-environmental substitute indexes such as the grain-size, Rb/Sr, zircon crystal morphology and magnetic susceptibility were analyzed. The age of archaeological strata was determined by AMS^14C dating. According to the results, combined with the information of the ancient human activities and the cultural heritage data obtained from the Longshan cultural archaeological strata, it can be concluded that （1） Before 4500 aBP, the climate was humid and water level was high in the Huaihe River and its tributaries, the drainage basin and its surrounding areas were even flooded, so the site area was submerged and there were no human activities around the site. （2） About 4500 aBP, the climate began to become drier and water level of the Huaihe River and its tributaries began to decline, thus floodplain gradually appeared, Yuhuicun Site and Longshan Culture began to appear. （3） Around 4100 aBP, the climate was humid and rainfall was abundant, which resulted in frequent flood disasters in the whole Huaihe River Basin. （4） After 4100 aBP, the climate gradually transited to be cold and dry, agricultural production was constrained to reduce the food source, Yuhuicun Site was almost abandoned. （5） The environmental information in sedimentary strata and historical records based on ancient books agree with each other. In addition, Yuhuicun Site was related to Dayu Zhishui （Yu the Great in taming the floods） in ancient books.

关键词： Yuhuicun Site Longshan Culture 4500-4000 aBP environmental change Huaihe River Basin

QTL mapping of economically important traits in Silkworm (Bombyx mori)

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Science China(Life Sciences) 2004年第5期47卷 477-484页

作者： LU cheng, LI Bin, ZHAO aichun & XIANG Zhonghuai The Key Sericulture Laboratory of the Ministry of Agriculture of China, College of Sericulture & Biotechnology, Southwest Agricultural University, Chongqing 400716, China The Key Sericulture Laboratory of the Ministry of Agriculture of China College of Sericulture & BiotechnologySouthwest Agricultural UniversityChongqing 400716China

A backcrossed population (BC1) was derived from a cross between C100 and Dazao. AFLP technique was employed for mapping the QTLs. The QTLs for the whole cocoon weight, cocoon shell weight, ratio of cocoon shell, weight of pupae etc. were analyzed and 11 QTLs were detected based on the constructed linkage map. Two QTLs for whole cocoon weight were local-ized on linkage group 6 and 19; three QTLs for cocoon shell weight were localized on linkage group 3, 14 and 19; three QTLs for ratio of cocoon shell were localized on the linkage group 2, 11 and 15, and three QTLs for the weight of pupae were localized on linkage 2, 14 and 19. All these have laid an important base for the marker assisted breeding of the silkworm.

关键词： Bombyx mori,genetic linkage map,AFLP,QTL,green cocoon.

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φ5mm碳素钢丝的疲劳性能

铁道学报 1989年第1期11卷 74-80页

作者：程育仁王家石李鸿发朱爱春北方交通大学

根据预应力混凝土碳素钢丝的承载特点,测定了固定最小循环应力下应力范围对疲劳寿命的关系曲线。对疲劳强度的统计特性进行了分析,并验证了Miner法则。作者通过三种不同强度级别碳素钢丝疲劳性能的比较,得出一些重要结论,这对选用以承... 详细信息

根据预应力混凝土碳素钢丝的承载特点,测定了固定最小循环应力下应力范围对疲劳寿命的关系曲线。对疲劳强度的统计特性进行了分析,并验证了Miner法则。作者通过三种不同强度级别碳素钢丝疲劳性能的比较,得出一些重要结论,这对选用以承受疲劳载荷为主的预应力混凝土的钢丝强度级别具有指导意义。此外,还通过扫描电镜对钢丝断口进行了分析,并对钢丝的裂纹萌生、扩展、断裂韧度及疲劳机理进行了探讨。

关键词：钢丝疲劳性能碳素钢裂纹萌生断口疲劳强度断裂韧度预应力混凝土承载循环应力

Characterization and Expression of Genes Involved in the Ethylene Biosynthesis and Signal Transduction during Ripening of Mulberry Fruit

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Characterization and Expression of Genes Involved in the Eth...

基于香气活力值分析白酒风味化合物对乙醇代谢关键酶的影响

第十二届家（柞）蚕遗传育种暨良种繁育学术研讨会

作者： Changying Liu aichun Zhao Panpan Zhu Jun Li Leng Han Xiling Wang Wei Fan Ruihua Lü Chuanhong Wang Zhengang Li cheng Lu Maode Yu College of Biotechnology Southwest University

Although ethylene is well known as an essential regulator of fruit development, little work has examined the role ethylene plays in the development and maturation of mulberry（Morus L.） fruit. To study the mechanism of ethylene action during fruit development in thisspecies, we measured the ethylene production, fruit firmness, and soluble solids content（SSC） during fruit development and harvest. By comparing the results with those from other climacteric fruit, we concluded that Morus fruit are probably climacteric. Genes associated with the ethylene signal transduction pathway of Morus were characterized from M. notabilis Genome Database, including four ethylene receptor genes, a EIN2-like gene, a CTR1-like gene, four EIN3-like genes, and a RTE1-like gene. The expression patterns of these genes were analyzed in the fruit of M. atropurpurea cv. Jialing No.40. During fruit development, transcript levels of MaETR2, MaERS, MaEIN4, MaRTE, and MaCTR1 were lower at the early stages and higher after 26 days after full bloom（DAF）, while MaETR1, MaEIL1, MaEIL2, and MaEIL3 remained constant. In ripening fruit, the transcripts of MaACO1 and MaACS3 increased, while MaACS1 and MaACO2 decreased after harvest. The transcripts of MaACO1, MaACO2, and MaACS3 were inhibited by ethylene, and 1-MCP（1–methylcyclopropene） upregulated MaACS3. The transcripts of the MaETR-like genes, MaRTE, and MaCTR1 were inhibited by ethylene and 1-MCP, suggesting that ethylene may accelerate the decline of MaETRs transcripts. No significant changes in the expression of MaEIN2, MaEIL1, and MaEIL3 were observed during ripening or in response to ethylene, while the expressions of MaEIL2 and MaEIL4 increased rapidly after 24 h after harvest（HAH） and were upregulated by ethylene. The present study provides insights into ethylene biosynthesis and signal transduction in Morus plants and lays a foundation for the further understanding of the mechanisms underlying Morus fruit development and ripening.

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中国酿造 2021年第2期40卷 170-174页

作者：曾礼兰刘嫒春方帅孙群胡承四川大学生命科学学院生物资源与生态环境教育部重点实验室四川戚都610065

以香气活力值(OAV)为基础,通过体外酶学实验研究了浓香型白酒中酯类、醇类物质对乙醇脱氢酶(ADH)和乙醛脱氢酶活性(ALDH)的影响。结果表明,浓香型白酒中己酸乙酯香气活力值最大(OAV≥7284),其次分别为戊酸乙酯(OAV≥1276)和丁酸乙酯(OAV... 详细信息

以香气活力值(OAV)为基础,通过体外酶学实验研究了浓香型白酒中酯类、醇类物质对乙醇脱氢酶(ADH)和乙醛脱氢酶活性(ALDH)的影响。结果表明,浓香型白酒中己酸乙酯香气活力值最大(OAV≥7284),其次分别为戊酸乙酯(OAV≥1276)和丁酸乙酯(OAV≥845);白酒中风味化合物对两种酶活性的影响差异很大,醇类和酯类的加入会抑制ADH活性,其中正戊醇、异丁醇和戊酸乙酯的抑制率最高,分别为27.64%、29.32%和26.72%,且具有剂量依赖性(R^(2)>0.9);然而,除了正丙醇,大部分醇类和酯类的加入会不同程度的促进ALDH活性。

关键词：白酒风味化合物乙醇脱氢酶乙醛脱氢酶乙醇代谢香气活力值

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浅谈话剧《龙须沟》的小说特征

江西广播电视大学学报 2009年第1期27卷 38-41页

作者：丁爱春程恒江西师范大学政法学院江西南昌330408 江西枫林涉外经贸职业学院江西永修330309

老舍留下的宝贵文学遗产中最具代表性的当属小说和话剧。受创作过程中的文体身份无意识心理影响,老舍不可避免地沿用小说的某些经验来创作话剧。话剧《龙须沟》在戏剧结构、人物刻画和情节安排方面都表现出小说的特征。

关键词：龙须沟老舍小说特征