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Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera

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Genes & Diseases 2022年第5期9卷 1290-1300页

作者： Jie Hu Xiao-yu Wei jin Xiang Pai Peng Feng-li Xu Kang Wu Fei-yang Luo ai-shun jin Liang Fang Bei-zhong Liu Kai Wang Ni Tang ai-Long Huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400010PR China Yong-Chuan Hospital Chongqing Medical UniversityChongqing 402177PR China Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqing 400016PR China

Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The Spike protein that mediates coronavirus entry into host cells is a major target for COVID-19 vaccines and antibody ***,multiple variants of SARS-CoV-2 have emerged,which may potentially compromise vaccine *** a pseudovirus-based assay,we evaluated SARS-CoV-2 cell entry mediated by the viral Spike B.1.617 and B.1.1.7 *** also compared the neutralization ability of monoclonal antibodies from convalescent sera and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine)and ZF2001(RBD-subunit vaccine)against B.1.617 and B.1.1.7 *** results showed that,compared to D614G and B.1.1.7 variants,B.1.617 shows enhanced viral entry and membrane fusion,as well as more resistant to antibody *** findings have important implications for understanding viral infectivity and for immunization policy against SARS-CoV-2 variants.

关键词： Coronavirus Immune escape Mutation Neutralizing antibodies SARS-CoV-2 Vaccine Viral entry

Augmenter of Liver Regeneration Monoclonal Antibody Promotes Apoptosis of Hepatocellular Carcinoma Cells

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 605-613页

作者： Li-Li Huang Fei-Yang Luo Wen-Qi Huang Hui Guo Qi Liu Ling Zhang ai-shun jin Hang Sun Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqingChina Key Laboratory of Molecular Biology for Infectious Diseases Ministry of EducationInstitute for Viral HepatitisThe Second Affiliated Hospital of Chong-qing Medical UniversityChongqingChina

Background and aims: Hepatocellular carcinoma (HCC) is one of the most common types of cancer, often resulting in death. Augmenter of liver regeneration (ALR), a widely expressed multifunctional protein, has roles in liver dis-ease. In our previous study, we reported that ALR knock-down inhibited cell proliferation and promoted cell death. However, there is no study on the roles of ALR in HCC. Methods: We used in vitro and in vivo models to inves-tigate the effects of ALR in HCC as well as its mechanism of action. We produced and characterized a human ALR-specific monoclonal antibody (mAb) and investigated the effects of the mAb in HCC cells. Results: The purified ALR-specific mAb matched the predicted molecular weight of IgG heavy and light chains. Thereafter, we used the ALR-specific mAb as a therapeutic strategy to suppress tumor growth in nude mice. Additionally, we assessed the prolif-eration and viability of three HCC cell lines, Hep G2, Huh-7, and MHC97-H, treated with the ALR-specific mAb. Com-pared with controls, tumor growth was inhibited in mice treated with the ALR-specific mAb at 5 mg/kg, as shown by hematoxylin and eosin staining and terminal deoxynu-cleotidyl transferase dUTP nick end labeling. Simultaneous treatment with the ALR-specific mAb and adriamycin pro-moted apoptosis, whereas treatment with the ALR-specific mAb alone inhibited cell proliferation. Conclusions: The ALR-specific mAb might be a novel therapy for HCC by blocking extracellular ALR.

关键词： Hepatocellular carcinoma Augmenter of liver regeneration Mono-clonal antibody Apoptosis

Index Computations in FJRW Theory

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Acta Mathematica Sinica,English Series 2014年第1期30卷 97-118页

作者： ai jin LIN School of Mathematical Sciences Peking University

We compute the index of the real Cauchy–Riemann operator defined in FJRW theory in case of the smooth *** the cylindrical metric,we study the relation between the index of the linearized operator of Witten map and we... 详细信息

关键词： Desingularization smooth metric index gluing index jumping

One-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions:Atom-economic synthesis of selenocarbamates and allyl sulfones

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Chinese Chemical Letters 2021年第2期32卷 721-724页

作者： jing-jing ai Jian Li shun-Jun Ji shun-Yi Wang Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials Science&Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China

In many reactions involving selenosulfonate or thiosulfonate,the sutfone group often leaves in form of benzenesutfinic acid or sodium benzenesulfinate.A one-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions to afford selenocarbamates and allyl sulfone compounds is *** sulfinic acid as the first-step side product is converted to the allyl sulfone compound by water promoted reaction with allyl *** acts as both an oxygen source of selenocarbamates and as a promoter to drive the second step reactio *** reactions have the advantages of mild conditions,green,environment-friendly,and high atomic economy.

关键词： Aqueous conditions One-pot two-step process Benzenesulfinic acid Selenocarbamate Allyl sulfone compound

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Chinese Medical Sciences Journal 2011年第3期26卷 137-140页

作者： shun-hua Zhang Fang-tian Dong jin Mao ai-ling Bian Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing 100730China

Objective To evaluate the predictive factors of refractory glaucoma treated with diode laser transscleral cyclophotocoagulation(TSCP) in a midterm *** Fifty-four consecutive patients(54 eyes) with refractory glaucoma were enrolled and underwent TSCP(power of 1.5-2.0 W,exposure time of 2 seconds and 20-50 applications).Patients were regularly followed up for 12 *** pressure(IOP) was measured before TSCP treatment and at each follow-up *** were divided into the sensitive and insensitive groups according to the effect of a single treatment of TSCP on *** success rate was defined as the percentage of eyes achieving an IOP between 5 and 21 mm Hg following TSCP therapy at their final follow up *** of age between the sensitive and insensitive groups was evaluated with Independent-samples T test and that of gender distribution of two groups was evaluated with Fisher's exact *** success rate of different types of glaucoma to TSCP was *** A total of 32 patients were sensitive to TSCP(sensitive group) and 22 patients were insensitive to TSCP(insensitive group).The success rates of female(77.8%,14/18) and cases being over 50 years(71.4%,20/28) were higher than those of male(50.0%,18/36) and ones being under 50 years(46.2%,12/26)(all P>0.05).The age of the sensitive and insensitive groups was 56.0±15.5 and 46.4±15.4 years,respectively(P=0.029).The age(P=0.029) and gender distribution(P=0.046) of the two groups had significant *** success rate of neovascular glaucoma,primary angle-closure glaucoma,primary open angle glaucoma,traumatic glaucoma,uveitic glaucoma,and secondary glaucoma after silicone oil injection to TSCP was 57.1%,100.0%,50.0%,20.0%,81.8%,and 0%,*** Age,gender,and type of glaucoma appear to be associated with effect of TSCP on IOP control.

关键词： predictive factor diode laser transscleral cyclophotocoagulation intraocular pressure

Synthesis of Silica Hollow Spheres with Diameter Around 50 nm by Anionic Surfactant

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Chemical Research in Chinese Universities 2012年第3期28卷 361-363页

作者： RAN Hua HAN Lu CHE shun-ai State Key Laboratory of Composite Materials Thin Film and Microfabrication Technology of Ministry of EducationSchool of Chemistry and Chemical TechnologyShanghai Jiaotong UniversityShanghai 200240P.R.China

Silica hollow spheres（SHSs） have attracted great attention because of their low toxicity, low density, large surface area, high chemical and thermal stability, and surface permeability. They can be widely applied in storage^[l], catalysis^[2], drug deli- very^[3,4], low-dielectric-constant materials^[5], low-refractive materials^[6-8], and so on. Up to now, there have been various methods to produce SHSs. Inorganic^[9] or organic particles^[10], such as polystyrene or calcium carbonate, were used as hard templates to create hollow cavities, However, the multistep synthetic process and the lack of structural robustness of the shells upon template removal process weaken their applica- tion. Soft templates, including oil-in-water emulsions^[11,12], vesicles^[13], micelle^[14,15] and gas bubbles^[16], are applied widely.

关键词： Anionic surfactant Co-Structure directing agent(CSDA) Vesicle

Effect of Spontaneously Generated Coherence and Detuning on 2D Atom Localization in Two Orthogonal Standing-Wave Fields

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Chinese Physics Letters 2014年第3期31卷 77-81页

作者： ZHAO shun-Cai WU Qi-Xuan GONG ai-Ling Department of Physics Kunming University of Science and Technology Kunming 650500 College English Department Kunming University of Science and Technology Kunming 650500

Two-dimensional （2D） atom localization via the spontaneously generated coherence （SGC） and detunings associated with the probe and standing-wave driving fields in a three-level V-type atomic system are investigated. In the gain process, two equal and tunable peak maxima of position distribution in the – plane via the detunings are observed. However, one decreasing and the other increasing peak maxima in the absorption process via the SGC are achieved in the quadrants I and III of the x–y plane. A better resolution and more novelty for the 2D atom localization in our scheme are obtained.

关键词： Atoms

Supersymmetric Quantum Mechanics and SUSY Dependent SU(2) Symmetry for a Spin-1/2 Charged Particle in a Magnetic Field

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Communications in Theoretical Physics 2008年第8期50卷 335-340页

作者： JIA Wen-Zhi WANG shun-jin Center of Theoretical Physics Department of Physics Sichuan University Chengdu 610064 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China

We find that in a supersymmetric quantum mechanics （SUSY QM） system, in addition to supersymmetric algebra, an associated SU（2） algebra can be obtained by using semiunitary （SUT） operator and projection operator, and the relevant constants of motion can be constructed. Two typical quantum systems are investigated as examples to demonstrate the above finding. The first example is the quantum system of a nonrelativistic charged particle moving in x-y plane and coupled to a magnetic field along z-axis. The second example is provided with the Dirac particle in a magnetic field. Similarly there exists an SUτ（2） SUσ（2） symmetry in the context of the relativistic Pauli Hamilt onian squared. We show that there exists also an SU（2） symmetry associated with the supersvmmetrv of the Dirac particle.

关键词： supersymmetric quantum mechanics Dirac equation semi-unitary transformation

Local Control of Two-Photon Absorption in a Six-Level Atomic System by Using a Coherent Perturbation Field

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Communications in Theoretical Physics 2009年第11期52卷 929-935页

作者： JIA Wen-Zhi WANG shun-jin Laboratory of Quantum Opt-Electronic Information Southwest Jiaotong University Chengdu 610031 China Center of Theoretical Physics School of Physics Sichuan University Chengdu 610064 China

If a coherent perturbation field is used to couple the excited level of the coupling transition in the five-level K-type atom with another higher excited level, the two-photon electromagnetically induced transparency can be locally modulated by altering the parameters of the additional perturbation field. With different detunings of the coherent perturbation field, the absorption peak or transparency window with sharp and high-contrast speetrM feature can be generated in the two-photon absorption spectrum. The physical interpretation of these phenomena is given in terms of the dressed states.

关键词： dressed states electromagnetically induced transparency coherent perturbation field