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Development of Ti–V–Cr–Mn–Mo–Ce high-entropy alloys for high-density hydrogen storage in water bath environments

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Rare Metals 2024年第10期43卷 5229-5241页

作者： hua-Zhou hu Hou-qun Xiao Xin-Cong He Wen-Hao Zhou Xiao-Xuan Zhang Rui-Zhu Tang Jie Li Chuan-Ming Ma Qing-Jun Chen Key Laboratory of Rare Earths Chinese Academy of SciencesJiangxi Institute of Rare EarthsGanjiang Innovation AcademyChinese Academy of Sciences

The V-based body-centered cubic （BCC）-type hydrogen storage alloys have attracted significant attention due to their high theoretical hydrogen storage capacity of3.80 wt%.However,their practical application faces challenges related to low dehydriding capacity and poor activation *** overcome these challenges,a BCC-type Ti–V–Cr–Mn–Mo–Ce high-entropy alloy（HEA） with an effectively dehydriding capacity of 2.5 wt% above 0.1 MPa was *** introduction of Mo and conducting heat treatment,the precipitation of Ti-rich phase in HEA was successfully suppressed,resulting in improved compositional uniformity and dehydriding ***,the effective dehydriding capacity increased significantly from 0.60 wt% to 2.50 wt% a65℃,surpassing that of other types of hydrogen storage alloys under the same ***,the addition of 1 wt%Ce enabled initial hydrogen absorption at 25℃ without the need for activation at 400℃.Furthermore,Ce doping reduced the dehydriding activation energy of the Ti–V–Cr–Mn–Mo–Ce HEA from 52.71 to 42.82 kJ·mol-1Additionally,the enthalpy value of dehydrogenation decreased from 46.89 to 17.96 k J·mol-1,attributed to a decrease in the hysteresis factor from 0.68 to *** findings provide valuable insights for optimizing the hydrogen storage property of HEA.

关键词： BCC structure Ce doping Heat treatment High-entropy alloys Hydrogen storage alloys

3D printed multicore fiber-tip discriminative sensor for magnetic field and temperature measurements

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Light(Advanced Manufacturing) 2024年第1期5卷 82-92页

作者： Cong Xiong Caoyuan Wang Ruowei Yu Wei Ji Yu Qin Yichun Shen Wei Chen ai-qun Liu Limin Xiao Advanced Fiber Devices and Systems Group Key Laboratory of Micro and Nano Photonic Structures(MoE)Key Laboratory for Information Science of Electromagnetic Waves(MoE)Shanghai Engineering Research Center of Ultra-Precision Optical ManufacturingSchool of Information Science and TechnologyFudan UniversityShanghaiChina Zhongtian Technology Advanced Materials Co. Ltd.NantongJiangsuChina Key laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai University.ShanghaiChina Department of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityHong KongChina

Miniaturized fiber-optic magnetic field sensors have attracted considerable interest owing to their superiorities in anti-electromagnetic interference and ***,the intrinsic thermodynamic properties of the material make temperature cross-sensitivity a challenging problem in terms of sensing accuracy and *** this study,an ultracompact multicore fiber(MCF)tip sensor was designed to discriminatively measure the magnetic field and temperature,which was subsequently evaluated *** novel 3D printed sensing component consists of a bowl-shaped microcantilever and a polymer microfluid-infiltrated microcavity on the end-facet of an MCF,acting as two miniaturized Fabry-Perot *** magnetic sensitivity of the microcantilever was implemented by incorporating an iron micro ball into the microcantilever,and the microfluid-infiltrated microcavity enhanced the capability of highly sensitive temperature *** this tiny fiber-facet device in the two channels of an MCF allows discriminative measurements of the magnetic field and temperature by determining the sensitivity coefficient matrix of two *** device exhibited a high magnetic field intensity sensitivity,approximately 1805.6 pm/mT with a fast response time of~213 ms and a high temperature sensitivity of 160.3 pm/℃.Moreover,the sensor had a low condition number of 11.28,indicating high reliability in two-parameter *** proposed 3D printed MCF-tip probes,which detect multiple signals through multiple channels within a single fiber,can provide an ultracompact,sensitive,and reliable scheme for discriminative *** bowl-shaped microcantilever also provides a useful platform for incorporating microstructures with functional materials,extending multi-parameter sensing scenarios and promoting the application of MCFs.

关键词： Two-photon polymerization Multicore fiber-tip sensor Magnetic field sensing Discriminative sensing

Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 852-864页

作者： REN qun-li LI Xiao-lan TIAN Tian LI Shuang SHI Rong-yi WANG Qian Zhu Yuan WANG Miao hu huan LIU Jian-guo School of Stomatology Zunyi Medical UniversityZunyiGuizhou Province563000China Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution Zunyi Medical UniversityZunyiGuizhou Province563000China School of Basic Medicine Zunyi Medical UniversityZunyiGuizhou Province563000China

Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the *** treatment of OSCC is mainly radiotherapy,chemotherapy and surgery,however,the prognosis of patients is still poor and the recurrence rate is *** paper reviews the range of effects of natural medicinal plant active ingredients(NMPais)on OSCC cancer,including the types of NMPais,anti-cancer mechanisms,involved signaling pathways,and clinical *** NMPais include terpenoids,phenols,flavonoids,glycosides,alkaloids,coumarins,and volatile *** active ingredients inhibit proliferation,induce apoptosis and autophagy,inhibit migration and invasion of OSCC cells,and regulate cancer immunity to exert anti-cancer *** mechanism involves signaling pathways such as mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,nuclear factor kappa B,miR-22/WNT1/β-catenin and Nrf2/***,NMPais can inhibit the growth of OSCC,and the combined drug is more *** medicinal plants are promising candidates for the treatment of OSCC.

关键词： natural medicinal plant active ingredients oral squamous cell carcinoma mechanism signaling pathway review

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Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression

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World Journal of Psychiatry 2024年第6期14卷 848-856页

作者： Yi Wang qun Lu Ittipalanukul Penpat Juan Wu Dilinuer Abulikemu Fei-Cui Zeng Jia-Ying huang Zhi-Hai hu Department of Acupuncture and Moxibustion Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Laboratory Medicine Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Postgraduate Student Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Radiology Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of General Practice Shanghai University of Traditional Chinese Medicine Affiliated Shuguang HospitalShanghai 200120China General Practice of Traditional Chinese Medicine North Bund Street Community Health Service CenterShanghai 200080China General Practice of Traditional Chinese Medicine Shanghai Hongkou District Jiaxing Road Community Health Service CenterShanghai 200082China

BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health *** hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is *** present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently *** To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate *** This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June *** were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were *** before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were *** The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent group

关键词： Depression Prick Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index

Personalized surgical recommendations and quantitative therapeutic insights for patients with metastatic breast cancer: Insights from deep learning

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Cancer Innovation 2024年第3期3卷 65-80页

作者： Enzhao Zhu Linmei Zhang Jiayi Wang Chunyu hu Qi Jing Weizhong Shi Ziqin Xu Pu ai Zhihao Dai Dan Shan Zisheng ai School of Medicine Tongji UniversityShanghaiChina Shanghai Engineering Research Center of Tooth Restoration and Regeneration Research Institute of StomatologyStomatological Hospital and Dental School of Tongji UniversityShanghaiChina Tenth People's Hospital of Tongji University School of MedicineTongji UniversityShanghaiChina Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's HospitalSchool of MedicineTongji UniversityShanghaiChina Shanghai Hospital Development Center ShanghaiChina Columbia University New YorkNYUSA School of Medicine Royal College of Surgeons in IrelandUniversity of Medicine and Health SciencesDublinIreland Department of Biobehavioral Sciences Columbia UniversityNew YorkNYUSA Department of Medical Statistics School of MedicineTongji UniversityShanghaiChina Clinical Research Center for Mental Disorders Chinese-German Institute of Mental HealthShanghai Pudong New Area Mental Health CenterSchool of MedicineTongji UniversityShanghaiChina

Background:The role of surgery in metastatic breast cancer(MBC)is currently *** novel statistical and deep learning(DL)methods promise to infer the suitability of surgery at the individual ***:The objective of this study was to identify the most applicable DL model for determining patients with MBC who could benefit from surgery and the type of surgery ***:We introduced the deep survival regression with mixture effects(DSME),a semi-parametric DL model integrating three causal inference *** models were trained to make individualized treatment *** who received treatments in line with the DL models'recommendations were compared with those who underwent treatments divergent from the *** probability weighting(IPW)was used to minimize *** effects of various features on surgery selection were visualized and quantified using multivariate linear regression and causal ***:In total,5269 female patients with MBC were *** was an independent protective factor,outperforming other models in recommending surgery(IPW-adjusted hazard ratio[HR]=0.39,95%confidence interval[CI]:0.19–0.78)and type of surgery(IPW-adjusted HR=0.66,95%CI:0.48–0.93).DSME was superior to other models and traditional guidelines,suggesting a higher proportion of patients benefiting from surgery,especially breast-conserving *** debiased effect of patient characteristics,including age,tumor size,metastatic sites,lymph node status,and breast cancer subtypes,on surgery decision was also ***:Our findings suggested that DSME could effectively identify patients with MBC likely to benefit from surgery and the specific type of surgery *** method can facilitate the development of efficient,reliable treatment recommendation systems and provide quantifiable evidence for decision-making.

关键词： breast surgery causal inference deep learning metastatic breast cancer

Cost analysis of radical resection of malignant breast tumors under the China Healthcare Security Diagnosis Related Groups payment system

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World Journal of Clinical Cases 2024年第20期12卷 4174-4179页

作者： Yun-He hu ai-Dong Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Breast cancer is one of the most common malignant tumors in women worldwide and poses a severe threat to their ***,this study examined patients who underwent breast cancer surgery,analyzed hospitalization costs and structure,and explored the impact of China Healthcare Security Diagnosis Related Groups(CHS-DRG)management on patient *** aimed to provide medical institutions with ways to reduce costs,optimize cost structures,reduce patient burden,and improve service *** To study the CHS-DRG payment system’s impact on breast cancer surgery *** Using the CHS-DRG(version 1.1)grouping criteria,4073 patients,who underwent the radical resection of breast malignant tumors from January to December 2023,were included in the JA29 group;1028 patients were part of the CHS-DRG payment system,unlike the *** an independent sample t-test,the length of hospital stay as well as total hospitalization,medicine and consumables,medical,nursing,medical technology,and management expenses were ***’s correlation coefficient was used to test the cost *** In terms of hospitalization expenses,patients in the CHS-DRG payment group had lower medical,nursing,and management expenses than those in the diagnosis-related group(DRG)non-payment *** patients in the DRG payment group,the factors affecting the total hospitalization cost,in descending order of relevance,were medicine and consumable costs,consumable costs,medicine costs,medical costs,medical technology costs,management costs,nursing costs,and length of hospital *** patients in the DRG nonpayment group,the factors affecting the total hospitalization expenses in descending order of relevance were medicines and consumable expenses,consumable expenses,medical technology expenses,the cost of medicines,medical expenses,nursing expenses,length of hospital stay,and management *** The CHS-DRG system can help control and reduce unnecessary m

关键词： China Healthcare Security Diagnosis Related Groups Real-world study Radical resection of malignant breast tumors Hospitalization costs Cost structure Average length of stay

Oligomeric procyanidins combined with Parabacteroides distasonis ameliorate high-fat diet-induced atherosclerosis by regulating lipid metabolism,inflammation reaction and bile acid metabolism in ApoE^(-/-)mice

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Food Science and human Wellness 2024年第5期13卷 2847-2856页

作者： Mingjuan Xu Cheng Lü Yiqing hu Mo Zhang Jinxin Shen Chunyi Liu qun Lu Rui Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Wuhan Engineering Research Center of Bee Products on Quality and Safety Control Wuhan 430070China Institute for Environment and Safety Wuhan Academy of Agricultural SciencesWuhan 430070China Key Laboratory of Environment Correlative Dietology(huazhong Agricultural University) Ministry of EducationWuhan 430070China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430070China

Atherosclerosis(AS)is the main pathological basis of cardiovascular ***,the prevention and treatment strategies of AS have attracted great research *** a potential probiotic,Pararabacteroides distasonis has a positive regulatory effect on lipid metabolism and bile acids(BAs)*** procyanidins have been confirmed to be conducive to the prevention and treatment of AS,whose antiatherosclerotic effect may be associated with the promotion of gut ***,it remains unclear whether and how oligomeric procyanidins and *** combined(PPC)treatment can effectively alleviate high-fat diet(HFD)-induced *** this study,PPC treatment was found to significantly decrease atherosclerotic lesion,as well as alleviate the lipid metabolism disorder,inflammation and oxidative stress injury in ApoE^(-/-)***,targeted metabolomics demonstrated that PPC intervention altered the BA profile in mice by regulating the ratio of secondary BAs to primary BAs,and increased fecal BAs ***,quantitative polymerase chain reaction(qPCR)analysis showed that PPC intervention facilitated reverse cholesterol transport by upregulating Srb1 expression;In addition,PPC intervention promoted BA synthesis from cholesterol in liver by upregulating Cyp7a1 expression via suppression of the farnesoid X receptor(FXR)pathway,thus exhibiting a significant serum cholesterol-lowering *** summary,PPC attenuated HFD-induced AS in ApoE^(-/-)mice,which provides new insights into the design of novel and efficient anti-atherosclerotic strategies to prevent AS based on probiotics and prebiotics.

关键词： Atherosclerosis Pararabacteroides distasonis Oligomeric procyanidins Reverse cholesterol transport Bile acid metabolism

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双阶受力干式装配梁-柱节点抗震性能试验研究

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工程力学 2024年第1期41卷 56-63页

作者：杨参天李爱群东南大学土木工程学院江苏南京210096 北京建筑大学土木与交通工程学院北京100044

研究提出了一种双阶受力干式装配梁-柱节点(DADBJ)。该节点的关键组件是摩擦铰(RFH)和预设缝防屈曲钢板(SBRSP),具备2个受力工作阶段和损伤集中易修复的特性。为了验证DADBJ构造的合理性,揭示其双阶段受力工作机理,设计加工了DADBJ试件,... 详细信息

研究提出了一种双阶受力干式装配梁-柱节点(DADBJ)。该节点的关键组件是摩擦铰(RFH)和预设缝防屈曲钢板(SBRSP),具备2个受力工作阶段和损伤集中易修复的特性。为了验证DADBJ构造的合理性,揭示其双阶段受力工作机理,设计加工了DADBJ试件,以SBRSP的预设缝隙宽度作为试验变量,进行了2个工况的低周往复拟静力试验。结果表明:提出的DADBJ构造实现了预期的双阶段受力特性,第一阶段由RFH提供节点的力学性能,第二阶段由RFH和SBRSP共同提供节点的力学性能;DADBJ的损伤集中于芯板,通过更换SBRSP芯板对节点快速修复,节点的性能可恢复到初始状态;SBRSP的预设缝隙宽度可直接决定DADBJ第二阶段的启动位移;提出的DADBJ双阶屈服荷载理论公式和二阶启动位移理论公式精确度好。该研究可为装配式框架结构和多阶受力型结构的设计和研究提供参考。

关键词：装配式框架结构干式装配梁-柱节点双阶受力转动摩擦阻尼器金属屈服阻尼器

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Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1477-1482页

作者： hui-Ling hu Serena Zhe-Chuang Li ai-Ying Feng Hao-Xi Zhong Jing-Feng Mu Mei-Zhou Liu Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina NIMO Ophthalmology Research Institute Beijing 100176China

aiM:To compare relative peripheral refraction(RPR)in Chinese school children with different refractive errors using multispectral refraction topography(MRT).METHODS:A total of 713 eyes of primary school children[172 emmetropia(E),429 low myopia(LM),80 moderate myopia(MM),and 32 low hypermetropia(LH)]aged 10 to 13y were *** were measured using MRT without *** results showed RPR at 0-15°(RPR 0-15),15°-30°(RPR 15-30),and 30°-45°(RPR 30-45)annular in the inferior(RPR-I),superior(RPR-S),nasal(RPR-N),and temporal(RPR-T)*** equivalent(SE)was detected and calculated using an ***:There were significant differences of RPR 15-30 between groups MM[0.02(-0.12;0.18)]and LH[-0.13(-0.36;0.12)](P<0.05),MM and E[-0.06(-0.20;0.10)](P<0.05),and LM[-0.02(-0.15;0.15)]and E(P<0.05).There were also significant differences of RPR 30-45 between groups MM[0.45(0.18;0.74)]and E[0.29(-0.09;0.67)](P<0.05),and LM[0.44(0.14;0.76)]and E(P<0.001).RPR values increased from the hyperopic to medium myopic group in each *** were significant differences of RPR-S between groups MM[-0.02(-0.60;0.30)]and E[-0.44(-0.89;-0.04)](P<0.001),and LM[-0.28(-0.71;0.12)]and E(P<0.05).There were also significant differences of RPR-T between groups MM[0.37(0.21;0.78)]and LH[0.14(-0.52;0.50)](P<0.05),LM[0.41(0.06;0.84)]and LH(P<0.05),and LM and E[0.29(-0.10;0.68),P<0.05].A Spearman’s correlation analysis showed a negative correlation between RPR and SE in the 15°-30°(P=0.005),30°-45°(P<0.05)annular(P=0.002),superior(P<0.001),and temporal(P=0.001)***:Without pupil dilation,values for RPR 15-30,30-45,RPR-S,and T shows significant differences between myopic eyes and emmetropia,and the differences are negatively correlated with SE.

关键词： relative peripheral refraction myopia school children multispectral refraction topography