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“梳理与探究”融入口语交际教学的意义审视与实践要旨

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教学与管理 2025年第5期 33-36页

作者：李春清浙江省丽水市实验学校浙江丽水323000

《义务教育语文课程标准(2022年版)》首次提出了“梳理与探究”,将其融入口语交际教学是实践层面的一次新举措、新尝试,有助于学生实现语言经验的统整和思维方式的进阶。因此,可基于递进、并列和归纳三种活动逻辑,将“梳理”分别融入口... 详细信息

《义务教育语文课程标准(2022年版)》首次提出了“梳理与探究”,将其融入口语交际教学是实践层面的一次新举措、新尝试,有助于学生实现语言经验的统整和思维方式的进阶。因此,可基于递进、并列和归纳三种活动逻辑,将“梳理”分别融入口语交际活动的三个阶段,以使学生在交际前梳理语言材料、在交际中梳理言语结构、在交际后梳理语言经验,同时还应在“探究”过程中培养学生的问题意识、工具意识、经验意识和协同意识。

关键词：梳理与探究口语交际活动逻辑

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多维视域下的中吉乌铁路与中亚地缘格局重塑

陕西师范大学学报(哲学社会科学版) 2025年第1期54卷 47-60页

作者：张华清李琪陕西师范大学中亚研究所陕西西安710119

当今世界,以基础设施建设推动经济发展已成为各国共识。中吉乌铁路建设意向提出28年来,国际关系中的各类角色和行为体始终围绕这条跨国铁路的建设和未来运营展开利益竞争,甚至有大国将中吉乌铁路作为在中亚博弈的焦点,试图按照自己的意... 详细信息

当今世界,以基础设施建设推动经济发展已成为各国共识。中吉乌铁路建设意向提出28年来,国际关系中的各类角色和行为体始终围绕这条跨国铁路的建设和未来运营展开利益竞争,甚至有大国将中吉乌铁路作为在中亚博弈的焦点,试图按照自己的意志,塑造参与和控制条件,反制中国的“一带一路”倡议。然而,当代国际关系的特点是多极化发展,而不是由单一国家控制。中亚国家均坚持多元化务实外交政策,根据新时期地缘政治新特点,以思维重组新模式,制定新发展战略,推动本国和地区的社会进步和经济发展。中吉乌铁路的联通将成为中亚地缘格局重塑的关键节点。然因中吉乌铁路所经地区地缘关系和人文环境错综复杂,目前建设和未来运营面临诸多挑战和风险,我们需要未雨绸缪,提出应策。

关键词：中吉乌铁路 “一带一路” 中亚地缘政治乌兹别克斯坦吉尔吉斯斯坦

用于无损离子操纵结构的双极性射频电源的研制

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质谱学报 2025年第1期46卷 97-105页

作者：刘青许润泽张允晶李灵锋李鹏苏州大学电子信息学院江苏苏州215006

无损离子操纵结构(structures for lossless ion manipulations,SliM)是一种在特殊背景气体下,利用静电场、射频电场、离子驱动电场共同作用实现对气相离子无损传输的新结构,在物质传输和分离方面有着广阔的应用前景。为了充分发挥SliM... 详细信息

无损离子操纵结构(structures for lossless ion manipulations,SliM)是一种在特殊背景气体下,利用静电场、射频电场、离子驱动电场共同作用实现对气相离子无损传输的新结构,在物质传输和分离方面有着广阔的应用前景。为了充分发挥SliM在体积和成本上的优势,本研究研制了一款体积小、结构紧凑、成本经济的高频高压双极性射频(radio frequency,RF)电源。该电源使用隔离模块实现控制电路与功率电路的电气隔离,并采用以GaN金属-氧化物-半导体场效应管(MOSFET)为核心的半桥电路作为输出级。针对SliM的容性负载特性,利用电阻-电感-电容(RLC)电路的滤波特性,实现双极性正弦脉冲电压的输出。经测试,该电源可输出频率1 MHz、峰-峰值420 V(±210 V)的双极性正弦射频高压信号。在实验室自建的基于行波(traveling wave,TW)的无损离子操纵结构(TW-SliM)迁移谱实验平台上,以甲基膦酸二甲酯(DMMP)为样本,深入探究了射频电源幅值及频率对小分子离子传输效率的影响。结果表明,射频电源幅值及频率均会对TW-SliM结构的离子传输效率产生影响,并存在1个最优值范围,这与COMSOL的仿真结果相吻合。该射频电源能够有效支持TW-SliM平台的稳定运行,对推动基于SliM的小分子迁移谱技术的小型化和便携化研发具有重要价值。

关键词：无损离子操纵结构(SliM) 射频电源半桥电路隔离电路

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding li-Ming Wang li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Macrophage scavenger receptor A1 promotes skeletal muscle regeneration after hindlimb ischemia

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Journal of Biomedical Research 2025年第1期39卷 23-35页

作者： Siying Wang Saiya Wang Wenhan Cai Jie Wang Jianan Huang qing Yang Hui Bai Bin Jiang Jingjing Ben Hanwen Zhang Xudong Zhu Xiaoyu li Qi Chen Department of Pathophysiology Key Laboratory of Targeted Intervention of Cardiovascular Disease and Molecular InterventionCollaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingJiangsu 211166China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

The macrophage-mediated inflammatory response is crucial for the recovery of skeletal muscle following ***,macrophage-based therapeutic targets need to be explored for ischemic *** the current study,we found that the mRNA levels of scavenger receptor A1(Sr-a1)were elevated in patients with critical limb ischemia,based on an analysis of the Gene Expression Omnibus *** then investigated the role and underlying mechanisms of macrophage SR-A1 in a mouse hindlimb ischemia(Hli)*** with the Sr-a1^(fl/fl)mice,the Lyz^(Cre+)/Sr-a1^(flox/flox)(Sr-a1~(ΔMΦ))mice showed significantly reduced laser Doppler blood flow in the ischemic limb on day seven after ***,histological analysis revealed that the ischemic limb of the Sr-a1~(ΔMΦ)mice exhibited more severe and prolonged necrotic morphology,inflammation,fibrosis,decreased vessel density,and delayed regeneration than that of the control Sr-a1~(fl/fl)***,restoring wild-type myeloid cells to the Sr-a1 knockout mice effectively improved the Doppler perfusion in the ischemic limb and mitigated skeletal muscle damage seven days after *** with these in vivo findings,co-cultivating macrophages with the mouse myoblast cell line C2C12 revealed that the Sr-a1^(-/-)bone marrow macrophages significantly inhibited myoblast differentiation in ***,SR-A1 enhanced the skeletal muscle regeneration in response to Hli by inhibiting oncostatin M production via suppression of the NF-κB signaling *** findings indicate that SR-A1 may be a promising candidate protein to improve tissue repair and regeneration in peripheral ischemic arterial disease.

关键词： scavenger receptor A1 macrophage hindlimb ischemia oncostatin M

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糖尿病早期视网膜神经变性研究新进展

国际眼科杂志 2025年第1期25卷 76-81页

作者：魏凡彭立谢青中南大学湘雅医学院附属海口医院眼科海南省海口市570208

糖尿病视网膜病变(DR)是由慢性高血糖引起的晚期微神经血管并发症,可导致血-视网膜屏障受损和视网膜功能障碍。近年来研究发现,糖尿病视网膜神经变性(DN)可能是糖尿病的视网膜改变最早事件之一,主要表现包括:新诊断糖尿病患者的视网膜... 详细信息

糖尿病视网膜病变(DR)是由慢性高血糖引起的晚期微神经血管并发症,可导致血-视网膜屏障受损和视网膜功能障碍。近年来研究发现,糖尿病视网膜神经变性(DN)可能是糖尿病的视网膜改变最早事件之一,主要表现包括:新诊断糖尿病患者的视网膜电图反应缺陷;发病初期,小胶质细胞和Müller细胞在几周内自我激活并激活相关蛋白;神经递质(如DOPA/GABA)活性降低,损害神经节信号传递;早期线粒体功能障碍,如Drp1-Fis1持续裂变及mtDNA甲基化和碱基错配之间的潜在串扰等。探讨糖尿病早期视网膜神经变性的分子基础对于理解DN的发病机制及早期治疗至关重要。文章总结糖尿病早期视网膜感光功能及神经胶质细胞、神经递质、线粒体和其他因子的病理变化及机制,旨在为研究DN早期机制及靶向治疗提供理论依据。

关键词：糖尿病视网膜病变糖尿病视网膜神经变性视网膜电图线粒体自噬神经胶质细胞多巴胺

Poorly controlled type Ⅱ diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage Ⅲ colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan liu Zi-Zhu liu Zhi-Cong Xiao Jing-Hui li Cheng-Zhi Huang Jun-Jiang Wang Xue-qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis TypeⅡdiabetes mellitus

YOLOX-SwinT algorithm improves the accuracy of AO/OTA classification of intertrochanteric fractures by orthopedic trauma surgeons

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Chinese Journal of Traumatology 2025年第1期28卷 69-75页

作者： Xue-Si liu Rui Nie Ao-Wen Duan li Yang Xiang li Le-Tian Zhang Guang-Kuo Guo qing-Shan Guo Dong-Chu Zhao Yang li He-Hua Zhang Department of Medical Engineering Daping HospitalArmy Medical UniversityChongqing400042China Department of Information Southwest HospitalArmy Medical UniversityChongqing400038China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Division of Trauma and War Injury Daping HospitalArmy Medical University of PLAState Key Laboratory of Trauma and Chemical PoisoningChongqing400042China

Purpose:Intertrochanteric fracture(ITF)classification is crucial for surgical ***,orthopedic trauma surgeons have shown lower accuracy in ITF classification than *** objective of this study was to utilize an artificial intelligence(ai)method to improve the accuracy of ITF ***:We trained a network called YOLOX-SwinT,which is based on the You Only Look Once X(YOLOX)object detection network with Swin Transformer(SwinT)as the backbone architecture,using 762 radiographic ITF examinations as the training ***,we recruited 5 senior orthopedic trauma surgeons(SOTS)and 5 junior orthopedic trauma surgeons(JOTS)to classify the 85 original images in the test set,as well as the images with the prediction results of the network model in *** analysis was performed using the SPSS 20.0(IBM Corp.,Armonk,NY,USA)to compare the differences among the SOTS,JOTS,SOTS+ai,JOTS+ai,SOTS+JOTS,and SOTS+JOTS+ai *** images were classified according to the AO/OTA 2018 classification system by 2 experienced trauma surgeons and verified by another expert in this *** on the actual clinical needs,after discussion,we integrated 8 subgroups into 5 new subgroups,and the dataset was divided into training,validation,and test sets by the ratio of 8:1:***:The mean average precision at the intersection over union(IoU)of 0.5(mAP50)for subgroup detection reached 90.29%.The classification accuracy values of SOTS,JOTS,SOTS+ai,and JOTS+ai groups were 56.24%±4.02%,35.29%±18.07%,79.53%±7.14%,and 71.53%±5.22%,*** paired t-test results showed that the difference between the SOTS and SOTS+ai groups was statistically significant,as well as the difference between the JOTS and JOTS+ai groups,and the SOTS+JOTS and SOTS+JOTS+ai ***,the difference between the SOTS+JOTS and SOTS+JOTS+ai groups in each subgroup was statistically significant,with all p<*** independent samples t-test results showed that

关键词： Artificial intelligence Intertrochanteric fracture Fracture classification Assist diagnosis YOLOX Swin transformer

Recent progress on surface chemistryⅡ:Property and characterization

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Chinese Chemical Letters 2025年第1期36卷 8-57页

作者： Xin li Zhen Xu Donglei Bu Jinming Cai Huamei Chen Qi Chen Ting Chen Fang Cheng lifeng Chi Wenjie Dong Zhenchao Dong Shixuan Du Qitang Fan Xing Fan Qiang Fu Song Gao Jing Guo Weijun Guo Yang He Shimin Hou Ying Jiang Huihui Kong Baojun li Dengyuan li Jie li qing li Ruoning li Shuying li Yuxuan lin Mengxi liu Peinian liu Yanyan liu Jingtao Lü Chuanxu Ma Haoyang Pan Jinliang Pan Minghu Pan Xiaohui Qiu Ziyong Shen Qiang Sun Shijing Tan Bing Wang Dong Wang li Wang lili Wang Tao Wang Xiang Wang Xingyue Wang Xueyan Wang Yansong Wang Yu Wang Kai Wu Wei Xu Na Xue linghao Yan Fan Yang Zhiyong Yang Chi Zhang Xue Zhang Yang Zhang Yao Zhang Xiong Zhou Junfa Zhu Yajie Zhang Feixue Gao Yongfeng Wang Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices School of ElectronicsPeking UniversityBeijing 100871China Spin-X Institute School of MicroelectronicsSouth China University of TechnologyGuangzhou 511442China School of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006China Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China i-Lab CAS Key Laboratory of Nanophotonic Materials and DevicesSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210023China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Hefei National Research Center for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Institute of Physics&University of Chinese Academy of Sciences Beijing 100190China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry Beijing Normal UniversityBeijing 100875China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China School

Surface with well-defined components and structures possesses unique electronic,magnetic,optical and chemical *** a result,surface chemistry research plays a crucial role in various fields such as catalysis,energy,materials,quantum,and *** science mainly investigates the correspondence between surface property and *** probe microscopy(SPM)techniques are important tools to characterize surface properties because of the capability of atomic-scale imaging,spectroscopy and manipulation at the single-atom *** this review,we summarize recent advances in surface electronic,magnetic and optical properties characterized mainly by SPM-based *** focus on elucidating theπ-magnetism in graphene-based nanostructures,construction of spin qubits on surfaces,topology properties of surface organic structures,STM-based light emission,tip-enhanced Raman spectroscopy and integration of machine learning in SPM studies.

关键词： Surface chemistry Scanning probe microscopy π-Magnetism Spin qubits Tip-enhanced Raman spectroscopy