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Appraisal of treatment outcomes in integrative medicine using metabonomics:Taking non-alcoholic fatty liver disease with spleen deficiency syndrome as an example

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Journal of Integrative Medicine 2022年第6期20卷 524-533页

作者： liang Dai Jing-juan Xu Wen-jun Zhou ai-ping lü Guang Ji Clinical Research Academy Peking University Shenzhen HospitalPeking UniversityShenzhen 518032Guangdong ProvinceChina Institute of Digestive Disease Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Integrated Traditional and Western Medicine Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002Jiangsu ProvinceChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China

Objective:Appraisal of treatment outcomes in integrative medicine is a challenge due to a gap between the concepts of Western medicine(WM)disease and traditional Chinese medicine(TCM)*** study presents an approach for the appraisal of integrative medicine that is based on targeted *** use non-alcoholic fatty liver disease with spleen deficiency syndrome as a test ***:A patient-reported outcome(PRO)scale was developed based on literature review,Delphi consensus survey,and reliability and validity test,to quantitatively evaluate spleen deficiency ***,a metabonomic foundation for the treatment of non-alcoholic fatty liver disease with spleen deficiency syndrome was identified via a longitudinal interventional trial and targeted ***,an integrated appraisal model was established by identifying metabolites that responded in the treatment of WM disease and TCM syndrome as positive outcomes and using other aspects of the metabonomic foundation as independent ***:Ten symptoms and signs were included in the spleen deficiency PRO *** internal reliability,content validity,discriminative validity and structural validity of the scale were all *** on treatment responses to treatments for WM disease(homeostasis model assessment of insulin resistance)or TCM syndrome(spleen deficiency PRO scale score)from a previous randomized controlled trial,two cohorts comprised of 30 participants each were established for targeted metabolomics ***-five metabolites were found to be involved in successful treatment outcomes to both WM and TCM,following quantitative comparison and multivariate ***,the model of the integrated appraisal system was exploratively established using binary logistic regression;it included 9 core metabolites and had the prediction probability of 83.3%.Conclusion:This study presented a new and comprehensive research route for integrative appraisal of treatment

关键词： Complementary and alternative medicine Integrative medicine Patient-reported outcome measures Metabolomics Non-alcoholic fatty liver disease Spleen deficiency syndrome

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All electrical switching of 2D multiferroic heterostructure

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Science China Materials 2025年

作者： Kian ping loh Department of Chemistry National University of Singapore

The emergence of generative artificial intelligence (ai) has catalyzed a new wave of intelligence development,resulting in significant growth in computing capabilities and intensifying competition for advanced computational ***-Memory computing based on magnetic random-access memory (MRAM)offers advantages such as high speed and low power consumption is primed for enabling high-performance ai computing[1–6].

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi lai Hua-ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(ai)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation ai method

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Extending the CONSORT Statement to moxibustion

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Journal of Integrative Medicine 2013年第1期11卷 54-63页

作者： Chung-wah Cheng Shu-fei Fu Qing-hui Zhou Tai-xiang Wu Hong-cai Shang Xu-dong Tang Zhi-shun liu Jia liu Zhi-xiu lin lixing lao ai-ping lü Bo-li Zhang Bao-yan liu Zhao-xiang Bian School of Chinese Medicine Hong Kong Baptist University Changhai Hospital of Traditional Chinese Medicine Secondary Military Medical University Chinese Evidence-based Medicine Center Evidence-based Medicine Certer Tianjin University of Traditional Chinese Medicine Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Acupuncture Guang'anmen Hospital China Academy of Chinese Medical Sciences School of Chinese Medicine the Chinese University of Hong Kong Center for Integrative Medicine University of Maryland School of Medicine Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Academy of TCM Tianjin University of Traditional Chinese Medicine Clinial Evaluation Center China Academy of Chinese Medical Sciences

The STandards for Reporting Interventions in Clinical Trials Of Moxibustion （STRICTOM）, in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM.

关键词： moxibustion randomized controlled trials guidelines

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中医药规范化治疗方案研究的思路与方法

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中西医结合学报 2006年第2期4卷 117-119页

作者：吕爱平查青林张志斌中国中医科学院基础理论研究所北京100700 江西中医学院国家制药工程研究中心江西南昌330006 中国中医科学院中国医史文献研究所北京100700

中医药的突出特点和生命力就在于其疗效,即根据中医基本理论应用方药的治疗效果。中医药规范化治疗方案的研究必须体现中医基本理论,遵循现代医学临床试验设计方法以及利用现代医学关于疾病诊断和疗效判断的标准,应将中医证候相关信息(... 详细信息

中医药的突出特点和生命力就在于其疗效,即根据中医基本理论应用方药的治疗效果。中医药规范化治疗方案的研究必须体现中医基本理论,遵循现代医学临床试验设计方法以及利用现代医学关于疾病诊断和疗效判断的标准,应将中医证候相关信息(包括症状、舌象和脉象)纳入临床试验的检查项目之中,开展两次或多次的临床试验,利用多元统计分析方法,对比分析有效和无效人群的特点,寻求与中医药治疗方案有效结局相关的主观症状、舌象和脉象,从而找到该治疗方案的最佳适应症,形成规范的治疗方案。

关键词：中医药治疗学规范临床方案

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基于神经网络分析方法探索类风湿关节炎证病信息对疗效的预测作用

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中西医结合学报 2007年第1期5卷 32-38页

作者：查青林何羿婷闫小萍苏励宋跃进曾升平刘维冯兴华钱先朱婉华林色奇吕诚吕爱平江西中医学院国家制药工程研究中心江西南昌330006 广州中医药大学第二附属医院临床流行病学室广东广州510120 北京中日友好医院中医风湿病科北京100029 上海中医药大学龙华医院风湿科上海200032 湖北省中医药研究院湖北武汉430074 成都中医药大学附属医院风湿免疫科四川成都610075 天津中医学院第一附属医院风湿科天津300193 中国中医科学院广安门医院风湿免疫科北京100053 江苏省中医院风湿免疫科江苏南京210029 南通良春中医药临床研究所江苏南通226000 中国中医科学院基础理论研究所北京100700

目的:利用神经网络模型分析方法探索类风湿性关节炎(rheumatoidarthritis,RA)证候疾病信息对疗效的预测作用。方法:397例确诊为活动期RA的病例来自9个临床中心,随机分成中药治疗组203例和西药治疗组194例。西药治疗方案包括非甾体抗炎... 详细信息

目的:利用神经网络模型分析方法探索类风湿性关节炎(rheumatoidarthritis,RA)证候疾病信息对疗效的预测作用。方法:397例确诊为活动期RA的病例来自9个临床中心,随机分成中药治疗组203例和西药治疗组194例。西药治疗方案包括非甾体抗炎药和慢作用药,中药治疗包括基础治疗和辨证用药。治疗前后收集患者中医四诊信息和西医疾病诊查指标,治疗效果用美国风湿病学会20%改善标准(theAmericanCollegeofRheu-matology20,ACR20)判断,抽取患者初诊时的信息进行分析,分析方法在SAS8.2上实施。通过单因素探索性分析,计算疗效与变量的比数比,以P<0.2作为入选模型的标准;采用神经网络模型进行数据分析,以疗效为分层变量,随机将数据集分为训练集(占75%)和验证集(占25%),对分析方法进行验证。结果:数据分析模型中,中药治疗组共纳入18个变量,西药治疗组纳入24个变量。中药治疗组中,晨僵、关节肿胀数、免疫球蛋白M、关节压痛数、关节压痛、类风湿因子、C反应蛋白和关节疼痛等与疗效正相关,病程和夜尿多与疗效呈负相关。西药治疗组中,血沉、腰膝酸软、苔白、关节疼痛、屈伸不利和关节肿胀等与疗效呈正相关,苔黄、舌红、白细胞检测与疗效呈负相关。在随机选取的验证集患者中,神经网络模型的预测作用表现为:RA中药治疗方案使用中,可预测20%患者有效率达到90%;RA西药治疗方案使用中,可预测20%患者有效率达到100%。结论:根据证候疾病信息与中西医疗法疗效的临床数据所建立的神经网络模型,能够显示证病信息对疗效的预测作用。

关键词：神经网络模型类风湿关节炎预测数据分析

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对中医药标准化发展战略制订方法的思考

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中西医结合学报 2011年第5期9卷 483-486页

作者：宇文亚韩学杰王丽颖史楠楠王永炎吕爱平中国中医科学院中医临床基础医学研究所北京100700

中医药标准化是中医药现代化、国际化的重要基础,中医药标准化战略规划是中医药事业发展的核心问题。目前,一些发达国家和有较好经济基础的发展中国家纷纷研究制定传统医药标准化战略。我国中医药标准化战略研究尚处于起步阶段,本文对... 详细信息

中医药标准化是中医药现代化、国际化的重要基础,中医药标准化战略规划是中医药事业发展的核心问题。目前,一些发达国家和有较好经济基础的发展中国家纷纷研究制定传统医药标准化战略。我国中医药标准化战略研究尚处于起步阶段,本文对其研制步骤和方法进行了初步探索。首先,基于SWOT矩阵分析法对中医药事业的机遇、挑战、优势和弱势进行综合分析,确定战略策略;在此基础上,以相关法规为指导,确定战略目标;围绕战略目标,综合运用文献分析法和专家调研法形成战略优先领域;针对战略目标和优先领域,制订相应的保障措施。其次,综合上述内容,形成中医药标准化发展战略草案。然后,征询专家意见,修改、形成中医药标准化发展战略。

关键词：中医药标准化发展战略方法

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类风湿关节炎肾虚证大鼠模型的建立

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中西医结合学报 2011年第9期9卷 973-982页

作者：王燕赵宏艳刘梅洁肖诚吕诚谭勇査青林李艳刘红吕爱平鞠大宏民航总医院病理科北京100123 中国中医科学院中医基础理论研究所北京100700 中日友好医院临床医学研究所北京100029 中国中医科学院中医临床基础医学研究所北京100700 江西中医学院数据分析中心江西南昌330006

目的:建立类风湿关节炎(rheumatoid arthritis,RA)肾虚证病证结合大鼠模型。方法:选用6周龄无特殊病原体级Sprague-Dawley大鼠110只,雌雄各半。分别采用去势法和羟基脲法制作肾虚动物模型,然后采用尾根部皮下注射Ⅱ型胶原与不完全弗氏... 详细信息

目的:建立类风湿关节炎(rheumatoid arthritis,RA)肾虚证病证结合大鼠模型。方法:选用6周龄无特殊病原体级Sprague-Dawley大鼠110只,雌雄各半。分别采用去势法和羟基脲法制作肾虚动物模型,然后采用尾根部皮下注射Ⅱ型胶原与不完全弗氏佐剂混合物的方法诱导出关节炎。通过对大鼠一般状态观察,关节炎指数计算和关节肿胀度测量对比两种RA肾虚证病证结合动物模型的发病情况,并采用酶联免疫吸附测定法检测血浆抗Ⅱ型胶原抗体、白细胞介素6(interleukin-6,Il-6)、Il-10、γ干扰素(interferon-γ,IFN-γ)和皮质酮(corticosterone,CORT)含量,放射免疫法检测肾上腺环腺苷酸(cyclic adenylic acid,cAMP)和环鸟苷酸(cyclic guanylic acid,cGMP)含量。结果:与胶原诱导性关节炎(collagen-induced arthritis,CIA)对照组大鼠相比,结合去势法、羟基脲法制作的肾虚CIA大鼠关节红肿程度和关节损伤程度明显加重,并且这两组大鼠出现倦怠、精神萎靡,弓背蜷缩,体毛枯疏,自主活动少,反应逐渐迟钝,喜扎堆,饮食减少,大便质稀,肛周污秽等与临床肾虚证相似的症状;肾虚CIA大鼠cAMP与cGMP比值明显降低,雄性大鼠CORT含量升高,雌性大鼠的CORT水平下降,抗Ⅱ型胶原抗体含量明显升高。采用去势法制作的肾虚CIA大鼠与CIA对照组大鼠相比,Il-6、Il-10及IFN-γ水平明显升高。结论:用去势法和羟基脲法制作的肾虚证RA动物模型,既有明显的肾虚症状,又有明显的RA特征,说明这两种肾虚型RA病证结合模型能够部分地反映肾虚证RA病人的发病特点,具有可行性。而去势法制作的肾虚CIA大鼠更适合RA肾虚证的实验研究。

关键词：类风湿关节炎病证结合动物模型肾虚证大鼠

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Accelerating leaching of copper ore with surfactant and the analysis of reaction kinetics

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International Journal of Minerals,Metallurgy and Materials 2019年第3期26卷 274-281页

作者： Chun-ming ai ping-ping Sun ai-xiang Wu Xun Chen Chao liu College of Safety Science and Engineering Liaoning Technical University Key laboratory of Ministry of Education of China for Efficient Mining and Safety of Metal Mines University of Science and Technology Beijing Wanbao Mining limited

To solve the problem of low permeability and lower extraction rates of high-mud ores, a surfactant was added as a penetrant to the pregnant leaching solution during column leaching tests. On the basis of the theories of physical chemistry and seepage flow mechanics, the mechanism by which seepage is enhanced under the effects of the surfactant was analyzed. The results show that the action modes of the surfactant were divided into four aspects: changing the wettability of the ore, reducing the viscosity of the leaching solution, adsorbing onto the surface of ore, and enhancing the permeability effect. The findings of column leaching tests demonstrated that permeability was substantially improved by the surfactant. In the later period of leaching, the permeability coefficient was two times higher than that of the control group. Meanwhile, the ore extraction rate increased by approximately 10%. During the leaching process, the surface tension of the solution did not substantially change, and that of the solution with surfactant increased slightly. The kinetics analysis of ore column leaching illustrated that the leaching processes were controlled by both internal diffusion(principal factor) and chemical reaction.

关键词： surfactant permeability reaction kinetics leaching

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Genomic Characterization of the First Sequenced Clinical legionella micdadei Isolate from China

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Biomedical and Environmental Sciences 2023年第2期36卷 185-190页

作者： CHEN ai ping ZHANG Yong Jun Chongqing Medical and Pharmaceutical College Chongqing 401331China Chongqing Municipal Key laboratory for High Pathogenic Microbes Chongqing 400042China

Since legionella pneumophila(***)was identified in 1976 as the causative microorganism for severe pneumonia termed legionnaires Disease(lD),more than 65 species belonging to the genus legionella have been isolated worldwide[1].Approximately 20 legionella *** been documented to be pathogenic in humans,primarily leading to transient flu-like illness(Pontiac fever)or rapid and potentially fatal pneumonia(lD).

关键词： Clinical primarily transient

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