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微量油膜水滴切削加工不锈钢的效果试验研究

现代制造工程 2010年第2期 9-12页

作者：刘永姜王爱玲王彪郑智贞中北大学山西省先进制造技术重点实验室太原030051

主要应用微量油膜水滴切削液,在C620-1普通机床上,通过改变切削速度、进给量以及调整喷嘴的喷射角度,对奥氏体1Cr18Ni9Ti不锈钢材料进行切削加工的效果试验研究。试验结果表明,与干切削、乳化液切削相比,微量油膜水滴切削不仅能够有效... 详细信息

主要应用微量油膜水滴切削液,在C620-1普通机床上,通过改变切削速度、进给量以及调整喷嘴的喷射角度,对奥氏体1Cr18Ni9Ti不锈钢材料进行切削加工的效果试验研究。试验结果表明,与干切削、乳化液切削相比,微量油膜水滴切削不仅能够有效地降低切削力和加工表面粗糙度,而且其刀具寿命分别是干切削、乳化液切削的2.28倍和1.6倍。在喷射方向效果研究中,微量油膜水滴在对刀具后刀面和侧面进行喷射的切削加工效果更佳。试验研究表明,微量油膜水滴切削液具有一定的冷却效果和良好的润滑效果。

关键词：油膜水滴切削试验切削力刀具寿命表面粗糙度

基于相关指数分析增强的功能近红外光谱脑机接口

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科技导报 2017年第2期35卷 60-64页

作者：李喆张屾郑燕春汪待发马建爱王玲李德玉北京航空航天大学生物与医学工程学院北京100191 虚拟现实技术与系统国家重点实验室(北京航空航天大学) 北京100191

由于对运动伪迹不敏感、适合特殊人群和可穿戴式检测等优势,功能近红外光谱技术(fNIRS)在脑机接口(BCI)、心理认知等领域发挥着日益重要的作用。肢体运动想象是BCI在残疾人康复训练等领域应用的重要范式,伴随穿戴式fNIRS的发展,有望帮... 详细信息

由于对运动伪迹不敏感、适合特殊人群和可穿戴式检测等优势,功能近红外光谱技术(fNIRS)在脑机接口(BCI)、心理认知等领域发挥着日益重要的作用。肢体运动想象是BCI在残疾人康复训练等领域应用的重要范式,伴随穿戴式fNIRS的发展,有望帮助残疾人在家庭或社区开展长期脑康复训练。本文针对目前基于fNIRS的运动想象任务分类准确率普遍不高这一现状,应用基于Pearson积差相关系数的相关指数R^2,对被试进行个性化参数优化,期望改善运动想象的分类结果。实验采集了17名被试的左、右手运动想象任务期间大脑皮层主运动区的血红蛋白浓度变化数据,并采用支持向量机(SVM)分类。结果表明,经过R^2参数优化之后,分类准确率相对无优化情况显著提升,分类准确率在60%以上的被试比例由原本的58.8%提高到了94%,分类准确率在65%以上的被试比例由原本的41.2%提升到了64.7%。

关键词：功能近红外脑功能成像运动想象支持向量机相关指数分析

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang Lian-Lian wang Wen-Wen Liu Xin Yang Ming-Zhao Xiao Hao-ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Painstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

应用GM(1,1)模型对甘肃省2006—2016年艾滋病发病率的预测

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兰州大学学报（医学版） 2017年第3期43卷 29-31页

作者：李健余爱玲王斌王晓蕊李慧甘肃省疾病预防控制中心甘肃兰州730000

目的探讨GM(1,1)模型在甘肃省艾滋病发病率预测中的应用。方法用2006—2016年甘肃省艾滋病发病率建立GM(1,1)模型,进行拟合分析,预测2017、2018年艾滋病发病率。结果甘肃省2006—2016年艾滋病发病率呈上升趋势,GM(1,1)模型显示预测精度... 详细信息

目的探讨GM(1,1)模型在甘肃省艾滋病发病率预测中的应用。方法用2006—2016年甘肃省艾滋病发病率建立GM(1,1)模型,进行拟合分析,预测2017、2018年艾滋病发病率。结果甘肃省2006—2016年艾滋病发病率呈上升趋势,GM(1,1)模型显示预测精度为Ⅰ级,预测2017、2018年艾滋病的发病率分别为5.04/10万、7.05/10万,即未来2年甘肃省艾滋病发病率将维持在较高水平。结论运用GM(1,1)模型对艾滋病疫情进行预测,拟合结果满意,可为进一步制定预防措施提供依据。

关键词：艾滋病 GM(1,1)模型预测

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie Shengan ling Xiaoyue Du Wenfeng Chen Xinrui wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

抗TCRαβ单抗联合供体骨髓细胞输注诱导小鼠皮肤移植耐受的研究

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现代免疫学 2004年第1期24卷 27-31页

作者：马建波刘家望李爱玲王光明郝洁谢蜀生北京大学医学部免疫学系北京100083

探讨抗TCRαβ单克隆抗体联合大剂量供体骨髓细胞输注方法对同种异基因小鼠皮肤移植耐受诱导的促进作用。第 0天 ,C5 7BL/ 6 (H 2 b,B6 )小鼠尾静脉注入 2× 10 8BALB/c (H 2 d,B/c )来源的骨髓细胞 ,同时腹腔注射抗TCRαβ单克隆抗体5 ... 详细信息

探讨抗TCRαβ单克隆抗体联合大剂量供体骨髓细胞输注方法对同种异基因小鼠皮肤移植耐受诱导的促进作用。第 0天 ,C5 7BL/ 6 (H 2 b,B6 )小鼠尾静脉注入 2× 10 8BALB/c (H 2 d,B/c )来源的骨髓细胞 ,同时腹腔注射抗TCRαβ单克隆抗体5 0 0 μg ;第 6天进行皮肤移植 ;在不同的时间对B6小鼠进行迟发型超敏反应 (DTH )、混合淋巴细胞反应 (MLR )等耐受状态进行检测 ,并进行MLR的IL 2逆转实验、过继转移实验和嵌合状态分析以初步探讨耐受形成机制。结果显示 ,经抗TCRαβ单克隆抗体联合大剂量供体骨髓细胞输注处理的B6小鼠的供体皮肤移植物平均存活 5 0 4d ,显著长于其他各组 (P <0 0 0 1)。相对于正常对照组小鼠 ,耐受B6小鼠在DTH和MLR中均表现出显著的低反应性 (P <0 0 0 1)。IL 2逆转实验结果表明克隆无能参与了移植耐受的形成。体内、外过继转移实验均显示耐受B6小鼠脾细胞中存在抑制细胞活性。嵌合体检查结果表明在耐受B6小鼠的胸腺和脾脏中均形成了混合嵌合体 ,在皮肤移植后第 15、 30和 70天时脾脏内供体来源嵌合体水平依次为 15 86 % ,10 5 7%和 1 77% ,胸腺中依次为 8 19% ,5 72 %和 1 87% ,嵌合体水平随时间而下降。这些表明 ,抗TCRαβ单抗联合大剂量供体骨髓细胞输注可以在异基因成年小?

关键词：抗TCRαβ单抗骨髓细胞输注诱导皮肤移植移植耐受

Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： Yun-Peng Guo ling-Xue Bao Yu-Yang wang Quan Wen Gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

Corrosion resistance of composite coating on magnesium alloy using combined microarc oxidation and inorganic sealing

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中国有色金属学会会刊：英文版 2012年第S3期22卷 760-763页

作者： YANG Wei wang ai-ying JIANG Bai-ling Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences School of Material Science and Engineering Xi'an University of Technology

The combined microarc oxidation (MAO) and inorganic sealing process was used to deposit a composite coating to improve the corrosion resistance of AZ31 magnesium *** surface morphologies of the resulting duplex coatings were studied by ***,the corrosion resistance of the coated Mg alloy substrates was investigated using electrochemical workstation and dropping corrosion *** results show that the composite coating surface consists of Mg,Si,O and *** is difficult to deposit inorganic coating on a thick MAO coating *** the composite coating was solidified by CO2 under 175 °C,it exhibits a better corrosion resistance than the MAO monolayer,owing to the thick and compact inorganic coating.

关键词： AZ31 magnesium alloy microarc oxidation composite coating microstructure corrosion resistance

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai wang Shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes