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An epidemiology study of fecal incontinence in adult Chinese women living in urban areas

Chinese Medical Journal 2020年第3期133卷 262-268页

作者： Yuan Yuan Lin Qiu Zhi-Yi Li Lei Zhang Tao Xu jing-He Lang Zhao-ai Li Jian Gong Qing Liu Xiao-Chun Liu Jun-Tao Wang Zhi-Jun Xia Zhu Lan Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Children’s Hospital of Shanxi Province TaiyuanShanxi 030013China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Wuxi Jiangsu 214002China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Gansu Province LanzhouGansu 730050China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Foshan Guangdong 528000China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Guiyang Guizhou 550001China Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China.

Background:Fecal incontinence(FI)has been shown to be a common symptom in Western countries;however,there is few researches focusing on its epidemic condition in Chinese *** conducted this national population-based epidemiology study to estimate the prevalence and risk factors of FI among adult Chinese women living in urban ***:This is a subgroup analysis of a national population-based epidemiology study of *** 28,196 adult women from urban regions of six provinces and municipalities participated in this research from 2014 to *** finished the questionnaire under the direction of trained *** was defined as accidental leakage of flatus and/or liquid or solid stool at least once in the *** FI prevalence trend and risk factors were identified by the Cochran-Armitage test,Chi-square test,and multivariable logistic ***:The prevalence of FI in adult females in urban China was 0.43%(95%confidence interval:0.35%-0.51%).Among women with FI,42.96%,82.96%,and 42.22%reported having leakage of solid,liquid stool,and gas,*** overall FI prevalence and the incidence rate of solid stool/liquid stool/gas leakage increased with *** mean Wexner score was 4.0%and 12.0%FI patients reported Wexner score≥*** mass index≥24 kg/m2,pelvic organ prolapses,chronic constipation,chronic cough,alcohol consumption,physical diseases including chronic bronchitis and cancer,gynecological diseases like gynecological inflammation are risk factors for *** delivery was the risk factor for FI in females with labor ***:FI was not a common symptom in adult Chinese women living in urban areas and there were some potential modifiable risk factors.

关键词： Epidemiology Fecal incontinence Prevalence Risk factor Urban area

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脉冲电磁场可抑制老年大鼠膝关节软骨退变

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中国组织工程研究 2024年第28期28卷 4522-4527页

作者：尹林伟黄夏荣孙光华刘静钟培瑞王金玲陈佳倩文幸甘邵婷胡文韬李萌萌周君南华大学衡阳医学院附属第一医院康复医学科湖南省衡阳市421001 南华大学衡阳医学院附属第一医院康复医学中心湖南省衡阳市421001 南华大学衡阳医学院附属第一医院康复医学实验室湖南省衡阳市421001 四川大学华西医院康复医学四川省重点实验室四川省成都市610041

背景:脉冲电磁场作为一种重要的物理治疗方法对骨关节炎的疗效确切,但其作用机制尚未完全明确。目的:观察脉冲电磁场对老年大鼠膝关节软骨退变的影响。方法:选取8只6月龄SD大鼠作为青年组,正常饲养8周,不做任何处理;将16只22月龄SD大鼠... 详细信息

背景:脉冲电磁场作为一种重要的物理治疗方法对骨关节炎的疗效确切,但其作用机制尚未完全明确。目的:观察脉冲电磁场对老年大鼠膝关节软骨退变的影响。方法:选取8只6月龄SD大鼠作为青年组,正常饲养8周,不做任何处理;将16只22月龄SD大鼠随机分为老年组(n=8)和脉冲电磁场组(n=8),对脉冲电磁场组大鼠进行脉冲电磁场干预,1次/d,每周5 d,连续干预8周,老年组正常饲养8周,不做任何处理。8周后麻醉处死所有大鼠,进行相关指标的检测。结果与结论:①与青年组相比,老年组大鼠血清Ⅱ型胶原C端肽水平升高(P<0.05);与老年组相比,脉冲电磁场组大鼠血清Ⅱ型胶原C端肽水平降低(P<0.05);②显微CT显示,与青年组相比,老年组大鼠胫骨的骨体积分数、骨密度、骨小梁数量均降低(P<0.05),骨小梁间隙增大(P<0.05);与老年组相比,脉冲电磁场组大鼠胫骨的骨体积分数、骨密度、骨小梁数量均升高(P<0.05),骨小梁间隙减少(P<0.05);③胫骨平台番红O-固绿染色显示,老年组大鼠关节软骨结构紊乱,软骨细胞明显减少,无法区分潮线;脉冲电磁场组上述情况有所改善;④RT-qPCR与Western blot检测显示,与青年组相比,老年组大鼠关节软骨及软骨下骨中基质金属蛋白酶1、基质金属蛋白酶13、P53、P21的mRNA与蛋白表达均升高(P<0.05);与老年组相比,脉冲电磁场组大鼠关节软骨及软骨下骨中基质金属蛋白酶1、基质金属蛋白酶13、P53、P21的mRNA与蛋白表达均降低(P<0.05);⑤结果表明,脉冲电磁场可能通过抑制P53/P21的表达抑制软骨细胞衰老,缓解关节软骨降解及抑制软骨下骨骨质疏松,改善老年大鼠骨关节炎。

关键词：脉冲电磁场老年大鼠膝骨关节炎关节软骨退变 P53 P21

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Synthesis and Spectroscopic Characterization of Organophosphoryl Polyoxotungstates α-A-[RP(O)]_2PW_9O_(34)^(5-)

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Chemical Research in Chinese Universities 2000年第1期16卷 90-92页

作者： sun Zhen-gang LIU Ju-tao and LIU jing-fu (Department of Chemistry, Northeast Normal University, Changchun 1 30024, P. R. China) LI jing (Daqing Staff and Workers University, Daqing 163255, P. R. China) 西北师范大学甘肃长春 130024 大庆职工大学黑龙江大庆 163255

Derivatized polyoxometalates(POMs), especially those including organic and organometallic components, have received current attention due to their potential application in catalysis, medicine and material sciences[1].

关键词： Polyoxometalate Organophosphoryl polyoxotungstate Synthesis

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孙升云教授巧用药对治疗慢性肾脏病经验

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光明中医 2024年第6期39卷 1093-1096页

作者：张静葛茂功朱诗平冯伟峰赵鑫海孙升云广州市天河区棠下街道社区卫生服务中心中医科广东广州510600 河南省第二人民医院中医科河南郑州451191 暨南大学附属第一医院中医科广东广州510600 暨南大学广东广州510600

慢性肾脏病为临床常见疾病,中医药治疗慢性肾脏病有明显的优势。孙升云教授从事肾脏疾病临床和科研工作近30年,认为慢性肾脏病乃本虚标实,以脾肾亏虚为本,随着病情进展,水湿、浊毒、瘀血等多种病理产物互为因果,逐渐形成慢性肾脏病“虚... 详细信息

慢性肾脏病为临床常见疾病,中医药治疗慢性肾脏病有明显的优势。孙升云教授从事肾脏疾病临床和科研工作近30年,认为慢性肾脏病乃本虚标实,以脾肾亏虚为本,随着病情进展,水湿、浊毒、瘀血等多种病理产物互为因果,逐渐形成慢性肾脏病“虚、毒、瘀”的基本病机,孙教授在治疗上以补肾固肾、益气健脾、祛湿降浊、活血行血、凉血化瘀为原则,辨证施治,现通过病因病机、治则治法、常用配伍药对、验案举隅方面探析其临床治疗经验.

关键词：水肿慢性肾脏病名医经验药对

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包头市典型牧区环境中隐孢子虫污染状况调查

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环境与健康杂志 2024年第5期41卷 396-398,471页

作者：杨忠委王华然孙栋良周树青武月红尹静军事医学研究院环境医学与作业医学研究所天津300050 内蒙古科技大学包头师范学院

目的掌握内蒙古包头市典型牧区环境中隐孢子虫污染情况。方法于2016年12月,采集包头市牧区土壤、牧草、饲料和饮用水、地表水、地下水、污水处理厂出厂水水样进行镜检,阳性样本利用巢式PCR扩增后进行基因测序,分析隐孢子虫种属特性。结... 详细信息

目的掌握内蒙古包头市典型牧区环境中隐孢子虫污染情况。方法于2016年12月,采集包头市牧区土壤、牧草、饲料和饮用水、地表水、地下水、污水处理厂出厂水水样进行镜检,阳性样本利用巢式PCR扩增后进行基因测序,分析隐孢子虫种属特性。结果牛粪中隐孢子虫感染率为34.6%(72/208),水样隐孢子虫污染率为28.6%(2/7),土壤和植物样本均未检出隐孢子虫。4.2%(9/208)牛粪样本和28.6%(2/7)水样样本扩增出目标片段。测序比对结果显示11个PCR扩增阳性样本中隐孢子虫均为安氏隐孢子虫。结论包头地区牛粪及水样等环境中检出的隐孢子虫在种属上为安氏隐孢子虫,当地卫生部门应关注畜牧业对环境的影响。

关键词：隐孢子虫环境水牛粪便

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One-dimensional Vanadyl Phosphate Containing the Tancoite-like{Ⅴ^(Ⅳ)O(HPO_4)_2}^(2–)Chain

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Chinese Journal of Structural Chemistry 2013年第12期32卷 1821-1828页

作者： WEN Lei HUANG Ya-Xi sun Wei LIU Biao HUANG Chun-Zuo MI Jin-Xiao ZHUANG Rong-Chuan TANG Mei-Bo ZHAO jing-Tai Fujian Provincial Key Laboratory of Advanced Materials Department of Materials Science and EngineeringCollege of MaterialsXiamen University Xiamen Zijin Mining and Metallurgy Technology Co.Ltd. State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences

A vanadyl phosphate containing a new member of tancoite-like single chain, （DAPH2）[VIVO（HPO4）2]·xH20 （x ≈ 0.2, DAP = 1,3-diaminopropane, C3H10N2）, has been synthesized under hydro（solvo）thermal conditions. It crystallizes in orthorhombic space group P21212 （No. 18） with a = 7.1730（14）, b = 19.252（4）, c = 8.6557（17） A, Z= 4, V= 1195.3（4）A3, C3H14.38N2P2VO9.19, Mr = 338.47, Dc = 1.881 g/cm3,μ（MoKa） = 1.138 mm-1 and F（000） = 692. The final full-matrix least-squares refinement converged to R = 0.0408, wR = 0.1046 for 2498 observed reflections with I 〉 2σ（I） and R = 0.0456 and wR = 0.1080 for all data （2750） and S = 1.001. Its one-dimensional 1 structure consists of tancoite-like ∞1 {vIVO（HPO4）2}2- single chains surrounded by DAPH22＋ ions and water molecules. The single chain is built from trans-corner-sharing octahedral {VIV= O…VIV} backbone loop-branched by HPO4 groups like staple forming a new member of tancoite single chain. Due to the special coordination of VIVO6, the ∞1 {VO（HPO4）2-} chain adopts a larger M-O-M angle （V-O-V = 135°） than those of tancoite chains reported before. The corner-sharing linear {VIV = O…VIV} chain structure also leads to a one-dimensional weak antiferromagnetic interaction at low temperature. The magnetic measurements confirm the 4＋ valence state of vanadium. IR and TG results of the title compound are also discussed.

关键词： magnetic properties one-dimensional structure,phosphate tancoite-like single chain vanadium

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Multi-view feature fusion for rolling bearing fault diagnosis using random forest and autoencoder

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Journal of Southeast University(English Edition) 2019年第3期35卷 302-309页

作者： sun Wenqing Deng aidong Deng Minqiang Zhu jing Zhai Yimeng Cheng Qiang Liu Yang National Engineering Research Center of Turbo-Generator Vibration Southeast UniversityNanjing 210096China School of Energy and Environment Southeast UniversityNanjing 210096China

To improve the accuracy and robustness of rolling bearing fault diagnosis under complex conditions, a novel method based on multi-view feature fusion is proposed. Firstly, multi-view features from perspectives of the time domain, frequency domain and time-frequency domain are extracted through the Fourier transform, Hilbert transform and empirical mode decomposition (EMD).Then, the random forest model (RF) is applied to select features which are highly correlated with the bearing operating state. Subsequently, the selected features are fused via the autoencoder (AE) to further reduce the redundancy. Finally, the effectiveness of the fused features is evaluated by the support vector machine (SVM). The experimental results indicate that the proposed method based on the multi-view feature fusion can effectively reflect the difference in the state of the rolling bearing, and improve the accuracy of fault diagnosis.

关键词： multi-view features feature fusion fault diagnosis rolling bearing machine learning

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The role of capecitabine as maintenance therapy in de novo metastatic nasopharyngeal carcinoma:A propensity score matching study

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Cancer Communications 2020年第1期40卷 32-42页

作者： Xue-Song sun Sai-Lan Liu Yu-jing Liang Qiu-Yan Chen Xiao-Yun Li Lin-Quan Tang Hai-Qiang Mai Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background:Capecitabine was previously used as a second-line or salvage therapy for metastatic nasopharyngeal carcinoma(NPC)and has shown satisfactory curative effect as maintenance therapy in other metastatic *** study aimed to explore the role of capecitabine as maintenance therapy in de novo metastatic NPC patients with different plasma Epstein-Barr virus(EBV)DNA levels before ***:We selected de novo metastatic NPC patients treated with locoregional radiotherapy(LRRT)for this retrospective *** propensity score matching(PSM)was applied to balance potential confounders between patients who underwent capecitabine maintenance therapy and those who did not with a ratio of 1:*** survival(OS)was the primary *** association between capecitabine maintenance therapy and survival was assessed using the log-rank test and a Cox proportional hazard ***:Among all patients eligible for this study,64 received capecitabine maintenance therapy after *** PSM,192 patients were identified in the nonmaintenance *** the matched cohort,patients treated with capecitabine achieved a higher 3-year OS rate compared with patients in the non-maintenance group(68.5%vs.61.8%,P=0.037).Multivariate analysis demonstrated that capecitabine maintenance therapy was an independent prognostic *** subgroup analysis,3-year OS rate was comparable between the maintenance and non-maintenance groups in patients with high pretreatment EBV DNA levels(˃30,000 copies/mL)(54.8%vs.45.8%,P=0.835),whereas patients with low pretreatment EBV DNA levels(≤30,000 copies/mL)could benefit from capecitabine maintenance therapy in OS(90.0%vs.68.1%,P=0.003).Conclusion:Capecitabine maintenance therapy may be superior to non-maintenance therapy in prolonging OS for de novo metastatic NPC patients with pretreatment EBV DNA≤30,000 copies/*** in patients with high pretreatment EBV DNA levels(˃30,000 copies/mL)(54.8%vs.45.8%,P=0.835),whereas patients with

关键词： capecitabine de novo Epstein-Barr virus locoregional maintenance therapy nasopharyngeal carcinoma propensity score matching radiotherapy survival

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MiR-200家族与子宫内膜异位症相关性的研究进展

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生殖医学杂志 2024年第6期33卷 837-842页

作者：吴兴柳杨三会李泽武吴春玲王靖雯杨爱军济宁医学院临床医学院济宁272000 济宁医学院附属医院济宁272000

子宫内膜异位症(EMs)是一种具有恶性肿瘤特征的良性疾病,严重影响患者的生活质量,增加患者的医疗、经济负担。目前子宫内膜异位症的发病机制不明,临床治疗效果欠佳。近年来发现,miR-200家族在多种疾病的发病中发挥着重要的作用。有研究... 详细信息

子宫内膜异位症(EMs)是一种具有恶性肿瘤特征的良性疾病,严重影响患者的生活质量,增加患者的医疗、经济负担。目前子宫内膜异位症的发病机制不明,临床治疗效果欠佳。近年来发现,miR-200家族在多种疾病的发病中发挥着重要的作用。有研究表明,miR-200家族在EMs中存在差异表达并稳定存在,认为其在EMs发病过程中起重要作用,但作用机制尚不明确。本文就有关miR-200家族与EMs相关性的研究进行综述,为进一步研究及临床治疗EMs提供新思路。

关键词：子宫内膜异位症 miR-200家族上皮-间质转化血管生成恶性转化

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A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 485-491页

作者： Qi WANG jing QIN Lu-yue Gai Yun-dai CHEN Wei DONG Zhi-wei GUAN Zhi-guo WANG Zhi-jun sun Jia-he TIAN Department of Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Ultrasound Chinese Armed Police General Hospital Beijing 100039 China Department of Nuclear Medicine Chinese PLA General Hospital Beijing 100853 China

Background:Although computed tomography coronary angiography (CTCA) can identify coronary stenosis,little data exists on the ability of multislice computed tomography (MSCT) to detect myocardial perfusion defects at ***:In 33 patients with diagnosed or suspected coronary artery disease (CAD),CTCA using retrospective electrocardiography (ECG) gating at rest and invasive coronary angiography (ICA) was *** 2D myocardial images were reconstructed in diastolic and systolic phases using the same raw data for *** values of the myocardium were used as an estimate of myocardial enhancement,which were shown by color *** ischemia was defined as a pattern of transient endocardial hypo-enhancement at systole and normal enhancement at *** results of ICA were taken as the reference ***:When a diameter reduction of more than 50% in ICA was used as diagnostic criteria of CAD,the sensitivity,specificity,positive predictive value (PPV),and negative predictive value (NPV) of CT first-pass myocardial perfusion imaging (MPI) at rest were 0.85,0.67,0.92,and 0.50 per patient,respectively,and 0.58,0.93,0.85,and 0.76 per vessel,***:CT first-pass MPI at rest could detect CAD patients,which could become a practical and convenient way to detect ischemia,consequently offering the ability for MSCT to act as a "one stop shop" for the diagnosis of CAD.

关键词： Coronary artery disease Myocardial ischemia Perfusion Multislice computed tomography

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