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Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2613-2630页

作者： Xuemin He Siying wen Xixiang Tang Zheyao wen Rui Zhang Shasha Li Rong Gao Jin Wang Yanhua Zhu Dong Fang Ting Li Ruiping Peng Zhaotian Zhang Shiyi wen Li Zhou Heying ai Yan Lu Shaochong Zhang Guojun Shi Yanming Chen Department of Endocrinology and Metabolic Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Diabetology&Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Fundus Shenzhen Eye Hospital of Jinan UniversityShenzhen 518048China

Glucagon-like peptide-1 receptor agonists(GLP-1 RAs)protect against diabetic cardiovascular diseases and ***,their activity in diabetic retinopathy(DR)remains *** retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other glucose-lowering medications,suggesting their advantage in DR *** single-cell RNA-sequencing analysis and immunostaining,we observed a high expression of GLP-1R in retinal endothelial cells,which was down-regulated under diabetic *** of GLP-1 RAs significantly restored the receptor expression,resulting in an improvement in retinal degeneration,vascular tortuosity,avascular vessels,and vascular integrity in diabetic *** and GSEA analyses further implicated enhanced mitochondrial gene translation and mitochondrial functions by GLP-1 ***,the treatment attenuated STING signaling activation in retinal endothelial cells,which is typically activated by leaked mitochondrial *** of STING mRNA was positively correlated to the levels of angiogenic and inflammatory factors in the endothelial cells of human fibrovascular *** investigation revealed that the cAMP-responsive element binding protein played a role in the GLP-1R signaling pathway on suppression of STING *** study demonstrates a novel role of GLP-1 RAs in the protection of diabetic retinal vasculature by inhibiting STING-elicited inflammatory signals.

关键词： GLP-1 RAs STING signaling Retinal endothelial cells Mitochondrial leakage Retinal vascular dysfunction Diabetic retinopathy CREB Inflammation

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Study on the mechanism of near-field underwater explosion on supported thin plates with prefabricated holes

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Acta Mechanica Sinica 2024年第8期40卷 32-44页

作者： Si Chen Jian Qin Xiangyao Meng Zhichao Lai Yanbo wen Ruiyuan huang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Naval Academy Beijing100161China College of Civil Engineering Fuzhou UniversityFuzhou350116China

In this study,underwater explosion tests with 2.5 g trinitrotoluene explosive under different fixed plates with prefabricated holes were *** experimental results showed that the air inflow from the prefabricated hole caused the bubble to collapse earlier with an increase in the hole *** addition,the deformation mode of the thin plate transitioned from“convex”to“concave”(up to down).Next,the coupled Eulerian-Lagrangian method was used to perform the corresponding numerical *** accuracy of the numerical simulation method was verified through a comparison with the experimental *** addition,a series of numerical simulations were conducted with different prefabricated-hole diameters,blast distances,and prefabricated-hole *** results showed that the bubble-pulsating water jet substantially influenced the deformation of the thin plate when the diameter of the prefabricated hole was within the theoretical maximum bubble *** the blast distance was within the theoretical maximum bubble radius,the thin plate was subjected to only a single bubble pulsation owing to the air inflow from the prefabricated hole.

关键词： Underwater explosion Hole High-speed camera Bubble pulsation Fixed plate

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Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2636-2641页

作者： Zhi-Yun weng wen-Ye huang Bin-Kan Shi Jian-Jia Pan Department of Hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor ***,its pathogenesis remains *** testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)***,treatment with savolitinib,a small molecule inhibitor of c-Met,was *** SUMMARY A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back *** and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine *** patient experienced frequent generalized seizures and persistent drowsiness in the emergency *** testing of cerebrospinal fluid and peripheral blood revealed increased MET *** discussing treatment options with the patient,savolitinib tablets were *** a month of treatment,the intracranial lesions shrank *** BM is very rare in advanced GaC,especially in meningeal cancer,that is characterized by rapid disease *** are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized ***,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： Cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma Case report

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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts

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Nano Research 2024年第5期17卷 3516-3532页

作者： Asad Ali Aatto Laaksonen Guo huang Shahid Hussain Shuiping Luo wen Chen Pei Kang Shen Jinliang Zhu Xiaoyan Ji Energy Engineering Division of Energy ScienceLuleåUniversity of Technology97187 LuleåSweden Department of Materials and Environmental Chemistry Arrhenius LaboratoryStockholm UniversitySE-10691 StockholmSweden Center of Advanced Research in Bionanoconjugates and Biopolymers “Petru Poni”Institute of Macromolecular ChemistryIasi 700469Romania State Key Laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing 211816China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China School of Resources Environment and MaterialsState Key Laboratory of Processing for Non-ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004China

The global practical implementation of proton exchange membrane fuel cells(PEMFCs)heavily relies on the advancement of highly effective platinum(Pt)-based electrocatalysts for the oxygen reduction reaction(ORR).To achieve high ORR performance,electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass *** this critical review,we introduce different approaches for the emerging development of effective ORR electrocatalysts,which offer high activity and *** strategies,including morphological engineering,geometric configuration modification via supporting materials,alloys regulation,core-shell,and confinement engineering of single atom electrocatalysts(SAEs),are discussed in line with the goals and requirements of ORR performance *** review the ongoing development of Pt electrocatalysts based on the syntheses,nanoarchitecture,electrochemical performances,and *** eventually explore the obstacles and research directions on further developing more effective electrocatalysts.

关键词： oxygen reduction reaction(ORR) Pt-based electrocatalysts proton exchange membrane fuel cells(PEMFCs) morphology and alloys strategies single atom electrocatalysts(SAEs)

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Atmospheric VOCs in an industrial coking facility and the surrounding area:Characteristics,spatial distribution and source apportionment

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Journal of Environmental Sciences 2024年第4期138卷 660-670页

作者： Meicheng wen Weiqiang Deng Jin huang Shu Zhang Qinhao Lin ChaoWang Shengtao Ma Wanjun Wang Xin Zhang Guiying Li Taicheng An Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlInstitute of Environmental Health and Pollution controlGuangdong University of TechnologyGuangzhou 510006China Guangdong Engineering Technology Research Center for Photocatalytic Technology Integration and Equipment Guangzhou Key Laboratory of Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China Institute of Environmental Science Shanxi UniversityTaiyuan 030006China

Industrial coking facilities are an important emission source for volatile organic compounds(VOCs).This study analyzed the atmospheric VOC characteristics within an industrial coking facility and its surrounding *** concentrations of total VOCs(TVOCs)in the surrounding residential activity areas(R1 and R2),the coking facility(CF)and the control area(CA)were determined to be 138.5,47.8,550.0,and 15.0μg/m^(3),*** cold drum process and coking and quenching areas within the coking facility were identified as the main polluting *** spatial variation in VOCs composition was analyzed,showing that VOCs in the coking facility and surrounding areas were mainly dominated by aromatic compounds such as BTX(benzene,toluene,and xylenes)and naphthalene,with concentrations being negatively correlated with the distance from the coking facility(p<0.01).The sources of VOCs in different functional areas across the monitoring area were analyzed,finding that coking emissions accounted for 73.5%,33.3% and 27.7% of TVOCs in CF,R1 and R2,*** results demonstrated that coking emissions had a significant impact on VOC concentrations in the areas surrounding coking *** study evaluates the spatial variation in exposure to VOCs,providing important information for the influence of VOCs concentration posed by coking facility to surrounding residents and the development of strategies for VOC abatement.

关键词： Coking facility Volatile organic compounds Emission inventory Spatial distribution Source apportionment

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Energy beam-based direct and assisted polishing techniques for diamond:A review

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International Journal of Extreme Manufacturing 2024年第1期6卷 93-124页

作者： Zhuo Li Feng Jiang Zhengyi Jiang Zige Tian Tian Qiu Tao Zhang Qiuling wen Xizhao Lu Jing Lu Hui huang Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021People’s Republic of China School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021People’s Republic of China State Key Laboratory of High Performance Tools Huaqiao UniversityXiamen 361021People’s Republic of China

Diamond is a highly valuable material with diverse industrial applications,particularly in the fields of semiconductor,optics,and high-power ***,its high hardness and chemical stability make it difficult to realize high-efficiency and ultra-low damage machining of *** address these challenges,several polishing methods have been developed for both single crystal diamond(SCD)and polycrystalline diamond(PCD),including mechanical,chemical,laser,and ion beam processing *** this review,the characteristics and application scope of various polishing technologies for SCD and PCD are ***,various energy beam-based direct and assisted polishing technologies,such as laser polishing,ion beam polishing,plasma-assisted polishing,and laser-assisted polishing,are *** current research progress,material removal mechanism,and infuencing factors of each polishing technology are *** some of these methods can achieve high material removal rates or reduce surface roughness,no single method can meet all the ***,the future development prospects and application directions of different polishing technologies are presented.

关键词： single crystal diamond polycrystalline diamond energy beam polishing technology material removal mechanism influencing factors

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Stability analysis of longwall top-coal caving face in extra-thick coal seams based on an innovative numerical hydraulic support model

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International Journal of Mining Science and Technology 2024年第4期34卷 491-505页

作者： Jun Guo wenbo huang Guorui Feng Jinwen Bai Lirong Li Zi Wang Luyang Yu Xiaoze wen Jie Zhang wenming Feng College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of TechnologyTaiyuan 030024China Shanxi Coking Coal Group Co. Ltd.Taiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

The relationship between support and surrounding rock is of great significance to the control of surrounding rock in mining *** view of the fact that most of the existing numerical simulation methods construct virtual elements and stress servo control to approximately replace the hydraulic support problem,this paper establishes a new numerical model of hydraulic support with the same working characteristics as the actual hydraulic support by integrating numerical simulation software Rhino,Griddle and FLAC3D,which can realize the simulation of different working *** on this model,the influence mechanism of the supporting strength of hydraulic support on surrounding rock stress regulation and coal stability in front of the top coal caving face in extra thick coal seam were ***,under different support intensity,the abutment pressure of the bearing coal and the coal in front of it presents the “three-stage”evolution *** influence range of support intensity is 15%–30%.Secondly,1.5 MPa is the upper limit of impact that the support strength can have on the front coal failure ***,within a displacement range of 2.76 m from the coal wall,a support strength of1.5 MPa provides optimal control of the horizontal displacement of the coal.

关键词： Extremely thick coal seam Fully mechanized top coal caving Support strength Support-surrounding rock interaction

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Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

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Virologica Sinica 2024年第1期39卷 9-23页

作者： Jie-Li Hu ai-Long huang Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing400016China

The achievement of a functional cure for chronic hepatitis B(CHB)remains limited to a minority of patients treated with currently approved *** primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB.A critical prerequisite for the functional cure of CHB is a substantial reduction,or even eradication of covalently closed circular DNA(cccDNA).Within this context,the changes in cccDNA levels during treatment become as a pivotal *** have previously analyzed the factors influencing cccDNA dynamics and introduced a preliminary classification of hepatitis B treatment strategies based on these *** this review,we employ a systems thinking perspective to elucidate the fundamental aspects of the HBV replication cycle and to rationalize the classification of treatment strategies according to their impact on the dynamic equilibrium of *** upon this foundation,we categorize current anti-HBV strategies into two distinct groups and advocate for their combined use to significantly reduce cccDNA levels within a well-defined timeframe.

关键词： Hepatitis B cccDNA Functional cure Dynamics Treatment Strategy

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Cation-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode with high rate performance

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Chinese Journal of Chemical Engineering 2024年第6期70卷 139-148页

作者： Long Zhang Dongsheng Yang Lilei Miao Chunmeng Zhang Jiexiang Li Jiawei wen Chunxia Wang Tiantian Cao Guoyong huang Shengming Xu College of New Energy and Materials China University of PetroleumBeijing 102249China State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumBeijing 102249China Beijing Spacecrafts Beijing 100094China SINOPEC Sales Co. Ltd.Beijing 100728China SINOPEC Research Institute of Petroleum Processing Co. LtdBeijing 100083China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Beijing Key Laboratary of Fine Ceramics Tsinghua UniversityBeijing 100084China

The nickel-rich layered cathode material LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)has high energy density,lower cost and is a promising cathode material currently under ***,its electrochemical and structural stability is poor during *** the many modification methods,cation doping has been consistently proven to be an effective strategy for enhancing electrochemical ***,the NCM811 cathode material was modified by solid-phase reactions with Mg and Al *** addition,the corresponding mechanism of NCM811 cathode material-doped modification is explored by density functional theory(DFT)calculations,and we have extended this approach to other ternary cathode materials with different ratios and obtained universal *** with DFT calculations,the results show that Mg2+occupies the Li+site and reduces the degree of Li^(+)/Ni^(2+) mixture;Al^(3+) acts as a structural support during charging and discharging to prevent structural *** electrochemical properties were tested by an electrochemical workstation and the LAND system,and the results showed that the capacity retention rate increased to varying degrees from 63.66%to 69.87%and 89.05%for NCM811-Mg and NCM811-Al at room temperature after 300 cycles,*** study provides a theoretical basis and design strategy for commercializing cationic-doped modification of nickel-rich cathode materials.

关键词： Li-ion batteries Cathode materials Doped Electrochemical properties DFT calculation

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