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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU ai-ling CHEN Ken huang Yun-ke ZHAO Qiu-long huang wen-ya huang Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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Distributed Stochastic Scheduling of Massive Backup Batteries in Cellular Networks for Operational Reserve and Frequency Support Ancillary Services

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 393-404页

作者： Kun Li Jiakun Fang Xiaomeng ai Shichang Cui Rongkang Zhao Jinyu wen State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China IEEE

Base station(BS)backup batteries(BSBBs),with their dispatchable capacity,are potential demand-side resources for future power *** enhance the power supply reliability and post-contingency frequency security of power systems,we propose a two-stage stochastic unit commitment(UC)model incorporating operational reserve and post-contingency frequency support provisions from massive BSBBs in cellular networks,in which the minimum backup energy demand is considered to ensure BS power supply *** energy,operational reserve,and frequency support ancillary services are co-optimized to handle the power balance and post-contingency frequency security in both forecasted and stochastic variable renewable energy(VRE)***,we propose a dedicated and scalable distributed optimization framework to enable autonomous optimizations for both dispatching center(DC)and *** BS model parameters are stored and processed locally,while only the values of BS decision variables are required to upload to DC under the proposed distributed optimization framework,which safeguards BS privacy *** studies on a modified IEEE 14-bus system demonstrate the effectiveness of the proposed method in promoting VRE accommodation,ensuring post-contingency frequency security,enhancing operational economics,and fully utilizing BSBBs'energy and power ***,the proposed distributed optimization framework has been validated to converge to a feasible solution with near-optimal performance within limited ***,numerical results on the Guangdong 500 kV provincial power system in China verify the scalability and practicality of the proposed distributed optimization framework.

关键词： Base station backup battery operational reserve frequency security distributed optimization privacy

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Noninvasive beam diagnosis based on the TM_(010)mode

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Nuclear Science and Techniques 2024年第7期35卷 115-125页

作者： Chuang-Ye Song wen-Hui huang Department of Engineering Physics Tsinghua University BeijingBeijing100084China of Education Beijing100084China

A resonant cavity based on the TM_(010)mode is an effective tool for noninvasive beam characterization. This technique has the advantages of a high signal-to-noise ratio, compact structure, and is related to multiple parameters compared with other beam monitors. In this study, high-precision measurements of the bunch charge, arrival time, bunch length, and energy parameters based on the TM_(010)mode are discussed. A cavity beam arrival time monitor(BAM) utilizing a phase cavity has been widely used in many facilities. Regarding bunch-length measurements, the influence of the beam energy, beam offset,and longitudinal spectrum on the TM_(010)mode are carefully considered to reduce errors, and the theoretical resolution of two cavities with different frequencies is analyzed. Owing to the dependence of the beam velocity of the beam loss factor, this method can also be used for the detection low beam energy using two cavities with the same frequency but different cavity lengths. A set of three cavities with different lengths and frequencies of 1.902 and 11.424 GHz is presented for measuring the four aforementioned parameters.

关键词： TM_(010)mode Noninvasive diagnosis Beam length Low energy

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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong huang ai-Xing Guan wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang huang Zan-Song huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding Ya-wen Wang Qiu-wen Li Li-Li Zhang ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

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Hole cleaning evaluation and installation spacing optimization of cuttings bed remover in extended-reach drilling

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Petroleum Science 2024年第3期21卷 2005-2022页

作者： Shuo Peng wen-Jun huang De-Li Gao MOE Key Laboratory of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China

In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the *** cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,and pipe stuck probably occur,which results in a lot of non-productive time and remedial *** bed remover can efficiently destroy deposited cuttings in time through hydraulic and mechanical stirring *** paper aims to build a method for hole cleaning evaluation and installation spacing optimization of cuttings bed remover to improve the wellbore cleaning ***,a Computational Fluid Dynamics approach with Eulerian—Eulerian multiphase model was utilized to investigate the mechanism of cuttings transportation,and a new type of cuttings bed remover was ***,an evaluation method of hole cleaning effect of remover was *** that,the effects of several drilling parameters on hole cleaning including flow rate of drilling fluid,rotational speed of drillpipe,rate of penetration,wellbore size,rheological property of drilling fluid,and remover eccentricity on the performance of cuttings bed remover were *** results demonstrate that the new type of remover with streamline blade performs better than conventional *** efficiency of hole cleaning is greatly improved by increasing the rotational speed of drillpipe,flow rate of drilling fluid,remover eccentricity,and 6 rpm Fann dial reading for drilling *** higher rate of penetration and large wellbore size result in worse hole *** findings can serve as an important guide for the structure optimization design of cuttings bed remover and installation spacing of removers.

关键词： Extended-reach drlling Drilling hydraulics Cuttings transport Hole cleaning Cuttings bed remover

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Shock-induced energy localization and reaction growth considering chemical-inclusions effects for crystalline explosives

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Defence Technology（防务技术） 2024年第3期33卷 278-294页

作者： Ruqin Liu Yanqing Wu Xinjie Wang Fenglei huang Xiaona huang Yushi wen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072HubeiChina Institute of Chemical Materials China Academy of Engineering Physics(CAEP)Mianyang621999SichuanChina

Chemical inclusions significantly alter shock responses of crystalline explosives in macroscale gap experiments but their microscale dynamics origin remains *** shock-induced energy localization,overall physical responses,and reactions in a-1,3,5-trinitro-1,3,5-triazinane(a-RDX)crystal entrained various chemical inclusions were investigated by the multi-scale shock technique implemented in the reactive molecular dynamics *** indicated that energy localization and shock reaction were affected by the intrinsic factors within chemical inclusions,i.e.,phase states,chemical compositions,and *** atomic origin of chemical-inclusions effects on energy localization is dependent on the dynamics mechanism of interfacial molecules with free space volume,which includes homogeneous intermolecular compression,interfacial impact and shear,and void collapse and *** introducing various chemical inclusions,the initiation of those dynamics mechanisms triggers diverse decay rates of bulk RDX molecules and hereby impacts on growth speeds of final *** chemical inclusions can reduce the effectiveness of the void during the shock *** the shockwave velocity of 9 km/s,the parent RDX decay rate in RDX entrained amorphous carbon decreases the most and is about one fourth of that in RDX with a vacuum void,and solid HMX and TATB inclusions are more reactive than amorphous carbon but less reactive than dry air or acetone *** lessdense shocking system denotes the greater increases in local temperature and stress,the faster energy liberation,and the earlier final reaction into equilibrium,revealing more pronounced responses to the present intense *** quantitative models associated with the relative system density(RD_(sys))were proposed for indicating energy-localization mechanisms and evaluating initiation safety in the shocked crystalline ***_(sys)is defined by the density ratio of defective RDX to perfec

关键词： Shock responses Energy localization Crystalline explosives Chemical inclusions Reactive molecular dynamics

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Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing

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Chinese Journal of Chemical Engineering 2024年第4期68卷 156-164页

作者： Kexin Zhang wenmin Zhang Heng An Zhe huang Yanzhen wen Xiangyu Jiao Yongqiang wen College of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research InstituteSchool of Chemistry&Biological EngineeringUniversity of Science&Technology BeijingBeijing 100083China

Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on *** stem cells(MSCs)promote diabetic wound *** when MSCs aggregate into multicellular spheroids,their therapeutic effect is ***,traditional culture platforms are inadequate for the efficient preparation and delivery of MSC spheroids,resulting in inefficiencies and inconveniences in MSC spheroid *** this study,a three-dimensional porous nanofibrous dressing(NFD)is prepared using a combination of electrospinning and homogeneous *** thermal crosslinking,the NFD not only achieves satisfactory elasticity but also maintains notable *** the design of its structure and chemical composition,the NFD allows MSCs to spontaneously form MSC spheroids with controllable sizes,serving as MSC spheroid delivery systems for diabetic wound *** importantly,MSC spheroids cultured on the NFD exhibit improved secretion of vascular endothelial growth factor,basic fibroblast growth factor,and hepatocyte growth factor,thereby accelerating diabetic wound *** NFD provides a competitive strategy for MSC spheroid formation and delivery to promote diabetic wound healing.

关键词： Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing

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Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： Jie-Li Wang wen-Jun huang De-Li Gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear shape is simplified into three categories according to common mathematical ***,based on the mechano-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show that the existence of wear defects results in a stress concentration and enhanced M-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more than one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

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Constitutive Behavior of the Interface between UHPC and Steel Plate without Shear Connector:From Experimental to Numerical Study

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1863-1888页

作者： Zihan Wang Boshan Zhang Hui Wang Qing ai Xingchun huang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Bridge Engineering Tongji UniversityShanghai200092China

The application of ultra-high performance concrete(UHPC)as a covering layer for steel bridge decks has gained widespread *** employing a connection without a shear connector between the steel plate and UHPC,namely,the sandblasted interface and the epoxy adhesive with sprinkled basalt aggregate interface,the installation cannot only be simplified but also the stress concentration resulting from the welded shear connectors can be *** study develops constitutive models for these two interfaces without shear connectors,based on the interfacial pull-off and push-out *** validation,three-point bending tests on the steel-UHPC composite plates are *** results indicated that the proposed bilinear traction-separation model for the sandblasted interface and the trapezoidal traction-separation model for the epoxy adhesive with sprinkled basalt aggregate interface can generally calibrate the interfacial ***,the utilization of the experimentally determined pure shear strength underestimates the load-carrying capacity of the composite plates in the case of three-point bending *** recalling the Mohr-Coulomb criterion,this underestimation is attributed to the enhancement of the interface shear strength by the presence of normal stress.

关键词： Cohesive zone model interfacial behavior finite element simulation UHPC steel plate

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