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Phase jump in resonance harmonic emission driven by strong laser fields

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Chinese Physics B 2020年第2期29卷 243-248页

作者： Yuan-Yuan Zhao Di Zhao Chen-Wei Jiang ai-ping fang Shao-Yan Gao Fu-Li Li School of Science Xi'an Jiaotong UniversityXi'an 710049China

We present a theoretical investigation of the multiphoton resonance dynamics in the high-order-harmonic generation(HHG)process driven by a strong driving continuous wave(CW)field along with a weak control harmonic *** Floquet theorem is employed to provide a nonperturbative and exact treatment of the interaction between a quantum system and the combined laser *** multiphoton-transition paths for the harmonic emission are coherently *** phase information about paths can be extracted via the Fourier transform analysis of the harmonic signals which oscillate as a function of the relative phase between driving and control *** jumps are observed when sweeping across the resonance by varying the frequency or intensity of the driving *** phase variation as a function of driving frequency at a fixed intensity and as a function of the intensity at a fixed driving frequency allows us to determine the intensity dependence of the transition energy of quantum systems.

关键词： phase jump high-order harmonic generation Stark-shifted transition energy

Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 393-411,I0001,I0002页

作者： Chen Wang Zhao-Yan Liu Wen-Ge Huang Zhi-Jun Yang Qiu-Ye Lan ai-ping fang Meng-Jun Hou Xiao-Lin Luo Yao-Jun Zhang Si Chen Hui-Lian Zhu Department of Nutrition School of Public HealthSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouChina Center of Experimental Animals Sun Yat-sen UniversityGuangzhouChina Experimental and Teaching Center for Public Health School of Public HealthSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterGuangzhouChina

Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated *** evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and *** is an essential nutrient related to prolonged survival and reduced risk of ***,it remains unclear whether this phenomenon is mediated by ***:Two HCC cell lines(HUH-7 and Hep3B)were used in the present *** growth was evaluated by cell counting kit 8(CCK-8),colony formation,and in vivo mouse xenografts *** motility was calculated by wound healing and transwell *** were measured by transmission electron microscope(TEM),and autophagy flux was detected by mRFP-GFP-labeled LC3 *** mRNA level of genes was measured by quantitative real-time polymerase chain reaction(qRT-PCR).The protein levels were detected by Western blotting(WB).Results:We found that choline inhibited the proliferation,migration,and invasion of HCC cells by downregulating autophagy in vitro and in *** expression of the solute carrier family 5 member 7(SLC5A7),a specific choline transporter,correlated with better HCC *** further discovered that choline could promote SLC5A7 expression,upregulate cytoplasm p53 expression to impair the AMPK/mTOR pathway,and attenuate ***,we found that choline acted synergistically with sorafenib to attenuate HCC development in vitro and in ***:Our findings provide novel insights into choline-mediated autophagy in HCC,providing the foothold for its future application in HCC treatment.

关键词： Hepatocellular carcinoma(HCC) autophagy choline solute carrier family 5 member 7(SLC5A7)

A nomogram predicting the recurrence of hepatocellular carcinoma in patients after laparoscopic hepatectomy

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Cancer Communications 2019年第1期39卷 499-509页

作者： Yang-Xun Pan Jian-Cong Chen ai-ping fang Xiao-Hui Wang Jin-Bin Chen Jun-Cheng Wang Wei He Yi-Zhen Fu Li Xu Min-Shan Chen Yao-Jun Zhang Qi-Jiong Li Zhong-Guo Zhou State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Liver Surgery Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Public Health Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Molecular Medicine California Campus The Scripps Research Institute10550North Torrey Pines RoadLa JollaCA 92037USA

Background:Patients with hepatocellular carcinoma(HCC)undergoing surgical resection still have a high 5-year recurrence rate(~60%).With the development of laparoscopic hepatectomy(LH),few studies have compared the efficacy between LH and traditional surgical approach on *** objective of this study was to establish a nomo-gram to evaluate the risk of recurrence in HCC patients who underwent ***:The clinical data of 432 patients,pathologically diagnosed with HCC,underwent LH as initial treatment and had surgical margin>1 cm were *** significance of their clinicopathological features to recurrence-free survival(RFS)was assessed,based on which a nomogram was constructed using a training cohort(n=324)and was internally validated using a temporal validation cohort(n=108).Results:Hepatitis B surface antigen(hazard ratio[HR],1.838;P=0.044),tumor number(HR,1.774;P=0.003),tumor thrombus(HR,2.356;P=0.003),cancer cell differentiation(HR,0.745;P=0.080),and microvascular tumor invasion(HR,1.673;P=0.007)were found to be independent risk factors for RFS in the training cohort,and were used for con-structing the *** C-index for RFS prediction in the training cohort using the nomogram was 0.786,which was higher than that of the 8th edition of the American Joint Committee on Cancer TNM classification(C-index,0.698)and the Barcelona Clinic Liver Cancer staging system(C-index,0.632).A high consistency between the nomogram prediction and actual observation was also demonstrated by a calibration *** improved predictive benefit in RFS and higher threshold probability of the nomogram were determined by receiver operating characteristic curve analysis,which was also confirmed in the validation cohort compared to other ***:We constructed and validated a nomogram able to quantify the risk of recurrence after initial LH for HCC patients,which can be clinically implemented in assisting the planification of individual postoperative surveil-lance

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Recurrence Nomogram American Joint Committee on Cancer TNM classification Barcelona Clinic Liver Cancer staging system Hepatitis B surface antigen Tumor thrombus Tumor invasion

Dissipation-assisted generation of steady-state single-mode squeezing of collective excitations in a solid-state spin ensemble

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Dissipation-assisted generation of steady-state single-mode ...

Simultaneous Strain and Temperature Measurement Using Single High-duty-cycle Sampled Fiber Bragg Grating

第十六届全国量子光学学术报告会

作者： Sheng-li Ma Peng-bo Li ai-ping fang Shao-yan Gao Fu-li Li MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Department of Applied PhysicsXi’an Jiaotong University

＜正＞Hybrid quantum systems involving superconducting quantum circuits and nitrogen-vacancy（NV）centers,have emerged as one of the most promising candidates for the present-day realization of quantum information *** hybrid system benefits not only from the exceptional electron spin properties of NV centers,but also fast

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Semiconductor Photonics and Technology 2002年第2期8卷 102-105页

作者： HUANG Rui, ZHOU Ying-wu, GAO Kan, LUO ai-ping, fang Zu-jie (Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Science, Shanghai 201800, CHN) Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Science 上海 201800

A novel and simple fiber grating sensor based on high-duty-cyclesample fiber bragg grating is proposed and demonstratedexperimentally. This type of sensor can measure strain andtemperature simultaneously with merits of low cost, high sensitivityand immunity to electro- magnetic interference. The sensor has anaccuracy of 20 με and 0.8 deg.C over a strain range of 500～1 500 με and a temperature range of 5～36 deg.C under experimentalconditions.

关键词： fiber grating sampled fiber bragggrating srating strin

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酒精处理对草莓连作土壤微生物群落的影响

现代农业科技 2017年第18期 54-55,59页

作者：陈爱平周逢芳宁德师范学院生物系福建宁德352100

在定植期、盛花期、盛果期和生长末期4个时期,研究3种处理(日晒、酒精、水稻轮作)对连作草莓根际土壤微生物群落的影响。结果表明,处理后的土壤较对照组细菌、真菌和放线菌数量总数减少,细菌/真菌的比值显著升高,并与病果率有显著相关... 详细信息

在定植期、盛花期、盛果期和生长末期4个时期,研究3种处理(日晒、酒精、水稻轮作)对连作草莓根际土壤微生物群落的影响。结果表明,处理后的土壤较对照组细菌、真菌和放线菌数量总数减少,细菌/真菌的比值显著升高,并与病果率有显著相关线性。微生物总量和虫数量在定植期最少,随后上升,到盛果期达最大值。

关键词：草莓连作酒精土壤微生物群落影响

阿德福韦酯体外对慢性乙型肝炎患者树突状细胞功能的影响

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世界华人消化杂志 2008年第33期16卷 3759-3764页

作者：陈月陈洪涛吴诗品岳化葵马云方爱萍深圳市人民医院(暨南大学医学院附属二院)检验医学部广东省深圳市518020

目的:探讨体外阿德福韦酯(adefovir dipivoxil,ADV)对慢性乙型肝炎(chronic hepatitis B,CHB)患者外周血树突状细胞(dendritic cell,DC)功能的影响.方法:分离CHB患者及健康自愿者外周血单核细胞(Mo),在含rhGM-CSF+rhIL-4及不同浓度ADV(20、100、500μg/L)培养条件下制备单核细胞源DC(MoDC).在倒置显微镜下观察DC的形态;FACS分析DC的表型;MTT法测定DC刺激同种异体T细胞增殖的能力;ELISA检测DC培养上清中IL-12 p40+p70的含量.结果:与CHB未处理组比较,CHB ADV处理组DC形态分化明显,激发初始T细胞增殖的能力加强,上清液中分泌的IL-12 p40+p70增多;在CHB ADV处理组(100μg/L),CD1a+、CD83+、CD86+和MHC-DR+DC的数量均最多,显著高于CHB未处理组(43.5±5.7 vs 20.6±2.8,34.6±1.9 vs 16.7±3.4,40.9±2.8 vs25.8±6.6,66.9±5.4 vs 40.7±4.2,均P<0.05),但低于健康对照组,三组间差异具有统计学意义(P<0.05).结论:ADV可以增强CHB患者外周血MoDC的免疫功能,提示其可能通过调节DC的功能而参与免疫应答,发挥间接抗病毒作用.

关键词：慢性乙型肝炎树突状细胞阿德福韦酯细胞表型抗原提呈

预测肝细胞癌腹腔镜肝切除术后复发风险的列线图模型

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癌症 2019年第12期38卷 551-562页

作者： Yang-Xun Pan Jian-Cong Chen ai-ping fang Xiao-Hui Wang Jin-Bin Chen Jun-Cheng Wang Wei He Yi-Zhen Fu Li Xu Min-Shan Chen Yao-Jun Zhang Qi-Jiong Li Zhong-Guo Zhou 华南肿瘤学国家重点实验室肿瘤医学协同创新中心中山大学肿瘤防治中心广东广州510060 肝外科中山大学肿瘤防治中心东风东路651号广东广州510060 公共卫生系中山大学广东广州510080 Department of Molecular Medicine California Campus The Scripps Research Institute10550North Torrey Pines RoadLa JollaCA 92037USA

背景与目的肝细胞癌(hepatocellular carcinoma,HCC)患者手术切除术后5年复发率很高(60%)。腹腔镜肝切除术(laparoscopic hepatectomy,LH)不断发展,但鲜有研究对LH与传统手术方法治疗HCC的疗效进行比较。本研究旨在建立一种预测HCC患者L... 详细信息

背景与目的肝细胞癌(hepatocellular carcinoma,HCC)患者手术切除术后5年复发率很高(60%)。腹腔镜肝切除术(laparoscopic hepatectomy,LH)不断发展,但鲜有研究对LH与传统手术方法治疗HCC的疗效进行比较。本研究旨在建立一种预测HCC患者LH后复发风险的列线图模型。方法收集432例病理确诊为HCC并首次接受LH治疗且手术切缘>1cm的患者的临床资料。评估了其临床病理特征对无复发生存期(recurrence-free survival,RFS)的影响,在此基础上,使用训练队列(n=324)建立了列线图,并在现有的验证队列(n=108)中进行了内部验证。结果乙型肝炎表面抗原[风险比(hazard ratio,HR),1.838;P=0.044]、肿瘤数目(HR,1.774;P=0.003)、癌栓(HR,2.356;P=0.003)、癌细胞分化程度(HR,0.745;P=0.080)和肿瘤微血管浸润(HR,1.673;P=0.007)是训练队列中RFS的独立预后因素,并用于建立列线图。采用列线图预测RFS的C-index为0.786,高于第8版美国癌症联合会TNM分期系统(C-index,0.698)和巴塞罗那临床肝癌分期系统(C-index,0.632)。校准曲线也证明了列线图预测结果与实际生存一致性较高。受试者工作特征曲线分析表明,与其他系统相比,该列线图对RFS的预测效果更佳,具有更高的阈值概率,这在验证队列中也得到了证实。结论我们建立和验证了可将HCC患者首次接受LH后复发风险量化的列线图,该列线图可应用于临床,辅助医生对患者制订个性化术后监测方案。

关键词：肝细胞癌腹腔镜肝切除术复发列线图美国癌症联合会TNM分期系统巴塞罗那临床肝癌分期系统乙型肝炎表面抗原癌栓肿瘤浸润

17-β雌二醇对小鼠腹腔巨噬细胞吞噬功能、一氧化氮产生和诱导型一氧化氮合酶表达的影响

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新乡医学院学报 2009年第2期26卷 126-129页

作者：孙爱平王芳段长恩宋向凤新乡医学院免疫学教研室河南新乡453003 新乡医学院生物化学教研室河南新乡453003

目的研究17-β雌二醇(E2)在体外对小鼠腹腔巨噬细胞吞噬功能、一氧化氮(NO)生成及诱导型一氧化氮合酶(iNOS)表达的影响。方法取小鼠腹腔巨噬细胞,Griess反应检测不同浓度E2对小鼠腹腔巨噬细胞NO生成时间和剂量依赖性影响,中性红吞噬试... 详细信息

目的研究17-β雌二醇(E2)在体外对小鼠腹腔巨噬细胞吞噬功能、一氧化氮(NO)生成及诱导型一氧化氮合酶(iNOS)表达的影响。方法取小鼠腹腔巨噬细胞,Griess反应检测不同浓度E2对小鼠腹腔巨噬细胞NO生成时间和剂量依赖性影响,中性红吞噬试验检测小鼠腹腔巨噬细胞吞噬功能,逆转录多聚酶链反应(RT-PCR)法检测iNOSmRNA的表达。结果低浓度E2组(10-9mol.L-1、10-8mol.L-1、10-7mol.L-1)巨噬细胞吞噬能力、NO产生及iNOS表达从4 h开始均较对照组增高(P<0.05),其中10-7mol.L-1E2作用最为明显;高浓度E2组(10-6mol.L-1、10-5mol.L-1)巨噬细胞吞噬能力、NO产生及iNOS表达则有明显的降低(P<0.05),且浓度越高降低越明显。结论E2对小鼠腹腔巨噬细胞的吞噬功能、NO产生及iNOS表达有显著的调节作用,且呈现剂量相关性。

关键词：雌激素一氧化氮诱导型一氧化氮合酶巨噬细胞小鼠