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Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently

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Science China(Life Sciences) 2023年第4期66卷 754-770页

作者： Zhaoqi Chen Yan Liu Nianci Chen Haiyan Xing Zheng Tian Kejing Tang Qing Rao Yingxi xu Ying Wang min Wang Jianxiang Wang State Key Laboratory of Experimental Hematology Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Haihe Laboratory of Cell Ecosystem Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Key Laboratory of Cell Therapy for Blood Diseases Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

CD19 chimeric antigen receptor(CAR)T cells have shown robust efficacy in relapsed and refractory acute lymphoblastic leukemia(R/R ALL),but compromising result in chronic lymphoblastic leukemia(CLL)and non-Hodgkin’s lymphoma(NHL).CD19-relapse and the lack of CAR-T cell persistence which result in treatment failure are considerable obstacles to ***-T targeting CD20 is an option for salvaging CD19 CAR-T *** studies have established variant structures of bispecific CAR-T which could avoid antigen-loss and immune ***,we constructed tandem and loop CAR structures targeting both CD19 and CD20 *** CAR-T cells could eliminate either CD19 or CD20 negative lymphoma cells,suggesting they exhibited dual antigen targeting of CD19 and *** comparing the efficiency of four bispecific CAR modified T cells,it was found that loop2019 CAR was the best structure among them to eradicate lymphoma cell lines and patients’primary lymphoma or CLL cells in a very low dose in vitro and prolong the survival time dramatically in lymphoma xenograft mice *** data highlighted the potential of loop2019 CAR-T in clinical treatment.

关键词： chimeric antigen receptor CD19 CD20 bispecific targeting CLL lymphoma

Hysteresis of saturation-capillary pressure relations under consecutive drainage-imbibition cycles in fine sandy medium

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Journal of Central South University 2012年第1期19卷 222-230页

作者： XIE Xiao-xi LI Yan XIA Bei-cheng xu Li-min SU Yu GU Qing-bao School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China School of Marine Sciences Sun Yat-sen UniversityGuangzhou 510275China Guangdong Huizhou Environmental Protection Agency Huizhou 516001China Guangdong Environmental Protection Engineering Research and Institute Guangzhou 510635China Chinese Research Academy of Environmental Sciences Beijing 100012China

The hysteresis of saturation-capillary pressure （S-p） relations was investigated in a fine sandy medium under consecutive drainage-imbibition cycles, which resulted from scheduled water level fluctuations. A drainage-imbibition cycle starts with a drainage process and ends with an imbibition process in sequence. The saturation and capillary pressure were measured online with time domain reflectometry （TDR） probes and T5 tensiometers, respectively. Results show that the relation between the degree of hysteresis and the number of the drainage-imbibition cycles is not obvious. However, the degree decreases with the increase of the initial water saturation of the imbibition processes in these drainage-imbibition cycles. The air-entry pressure of a sandy medium is also found to be constant, which is independent of the drainage-imbibition cycles and the initial water saturation of the drainage process. In all the imbibition processes, parameter a of the van Genuchten （VG） model decreases with the increase of the initial water saturation, which corresponds positively to the magnitude of the hysteresis.

关键词： S-p relation hysteresis drainage imbibition van Genuchten model

LINC00475在多发性骨髓瘤中的表达与临床意义

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中国实验血液学杂志 2024年第3期32卷 789-793页

作者：卢玲郭丹洪乐旻蒋钰雯范洪明黄春群卢金凤陈洁徐宏慧黄红铭南通大学附属医院血液内科江苏南通226001

目的:探讨LINC00475在多发性骨髓瘤(MM)患者血清中的相对表达水平及临床意义。方法:用实时荧光定量PCR技术检测108例MM患者血清及RPMI 8226、NCI-H929、U266、OPM2、CAG这5个MM细胞系中LINC00475的表达情况,受试者工作特征曲线评估其对M... 详细信息

目的:探讨LINC00475在多发性骨髓瘤(MM)患者血清中的相对表达水平及临床意义。方法:用实时荧光定量PCR技术检测108例MM患者血清及RPMI 8226、NCI-H929、U266、OPM2、CAG这5个MM细胞系中LINC00475的表达情况,受试者工作特征曲线评估其对MM的诊断价值,并结合患者的临床资料分析LINC00475与患者临床特征的关系。结果:与健康对照组相比,MM患者血清及MM细胞系中LINC00475的表达明显上调(均P<0.05)。受试者工作特征曲线分析显示,LINC00475的最佳截断值为262.4,曲线下面积为0.924(95%CI:0.884-0.964),灵敏度83.3%,特异度91.7%,表明LINC00475在MM患者中具有良好的评估价值。与LINC00475低表达组的MM患者相比,高表达组的患者具有较高水平的β2-微球蛋白和胱抑素C(均P<0.05),但白蛋白水平较低(P<0.05)。与ISS分期Ⅰ期的MM患者相比,Ⅱ期和Ⅲ期患者LINC00475的表达水平均明显增高(均P<0.05)。结论:检测LINC00475的相对表达水平有助于区分MM患者和正常人群,其相对表达水平与MM患者的β2-微球蛋白、白蛋白、ISS分期等预后指标相关。

关键词：多发性骨髓瘤 LINC00475 长链非编码RNA

Value of a new post-procedural intravascular ultrasound score in predicting target vessel revascularization after coronary drug-eluting stents implantation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 624-630页

作者： Kai xu Ya-ling HAN Quan-min JING Shou-li WANG Ying-yan MA Xiao-zeng WANG Geng WANG Zu-lu WANG Department of Cardiology Shenyang Northern HospitalShenyang 110016China

Objective:There is no simple or feasible post-procedural intravascular ultrasound (IVUS) score to predict major adverse cardiac events (MACE) in patients undergoing drug-eluting stents (DES) implantation. The aim of this study is to validate a new IVUS score for predicting MACE. Methods:A total of 295 patients (with 322 lesions) were enrolled. IVUS score was calculated in each lesion based on five IVUS morphological characteristics:inflow/outflow disease, malapposition, underexpansion, tissue protrusion, and edge dissection (iMUTE score). We assigned two points to an underexpansion and one point for each presence of other factors. Patients were divided into low score (iMUTE score<2, n=137) and high score (iMUTE score≥2, n=158) groups. Results:At one year follow-up, a trend was seen in favor of the low iMUTE score group in MACE (3.65% vs. 10.10%; P=0.052), and there was more target vessel revascularization (TVR) in the high iMUTE score group compared with low score group (6.96% vs. 1.46%; P=0.044). Low iMUTE score was an independent predictor of freedom from TVR at one year (adjusted hazard ratio (HR) 0.5, 95% confidence interval (CI) 0.1-0.8; P=0.02). Conclusions:Post-procedural IVUS iMUTE scoring was simple and feasible in clinical practice, and can provide independent prognostic value for TVR in patients undergoing DES implantation.

关键词： Intravascular ultrasound Drug eluting stents Scoring schemes percutaneous coronary intervention

Two Brominated-sesquiterpene from Alga Laurencia Majuscula

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Chemical Research in Chinese Universities 2002年第2期18卷 226-227页

作者： xu Xiao-hua YAO Guang-min LU Jian-hua LI Yan-ming CHANG Jiang-lin KONG Chui-hua Institute of Elemento-Organic Chemistry Nankai UniversityTianjin 300071P.R.China Institute of Tropic and Subtropical Ecology South China Agriculture UniversityGuangzhou 510642P.R.China

Two brominated sesquiterpenes were isolated from the Alga Laurencia majuscula collected from the Xisha Islands in the South China Sea. Compound 1 was first reported, and determined, on spectral evidence, to be 8 bromo... 详细信息

关键词： Laurencia majuscula Brominated sesquiterpene Spectral analysis

Safety management of nasopharyngeal specimen collection from suspected cases of coronavirus disease 2019

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International Journal of Nursing Sciences 2020年第2期7卷 153-156页

作者： Yan Qian Tieying Zeng Hui Wang min xu Junhua Chen Na Hu Daiqi Chen Yu Liu Tongji Hospital Tongji Medical College of Huazhong University of Science&TechnologyWuhanHubeiChina

This article introduces safety management strategies of nasopharyngeal specimen collection from suspected cases of coronavirus disease 2019 in a tertiary designated *** key points include establishing a special sampling room,strict sterilization of the entire environment,training of professional nurses,enhancement of personal protection,standardization of methods and processes for swab collection,and a timely and safety sample *** than 11,000 nasopharyngeal specimens were collected by eight nurses,with an average of 1,375 specimen swab collections each nurse,and no one was infected.

关键词： Coronavirus disease 2019 Nasopharyngeal swabs Safety management Specimen collection

Preparation of porous Si_(3)N_(4) ceramics via tailoring solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) poly‐hollow microsphere content

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Journal of Advanced Ceramics 2015年第4期4卷 260-266页

作者： Jia-min WU Xiao-Yan ZHANG Jie xu Ke GAN Jia-Lu LI Chen-Hui LI Jin-Long YANG Yu-Sheng SHI State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of New Ceramic and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Porous Si_(3)N_(4) ceramics were prepared by aqueous gelcasting using Si_(3)N_(4) poly-hollow microspheres(PHMs)as pore-forming *** effects of solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content on the properties of porous Si_(3)N_(4) ceramics were ***β-Si_(3)N_(4) phase is observed in porous Si_(3)N_(4) ceramics,and Si_(3)N_(4) PHMs distribute uniformly both in Si_(3)N_(4) green samples and porous Si_(3)N_(4) *** show that solid loading of Si_(3)N_(4) slurry and Si_(3)N_(4) PHM content could considerably influence the properties of porous Si_(3)N_(4) *** the increase of solid loading of Si_(3)N_(4) slurry(decrease of Si_(3)N_(4) PHM content),the distributing state of Si_(3)N_(4) PHMs changes from contacting with each other to just embedding in the matrix,thus their porosity decreases,while their shrinkage,flexural strength,and fracture toughness increase.

关键词： porous Si_(3)N_(4)ceramics Si_(3)N_(4)poly-hollow microspheres(PHMs) solid loading aqueous gelcasting mechanical properties

Upgrade of macromolecular crystallography beamline BL17U1at SSRF

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Nuclear Science and Techniques 2018年第5期29卷 58-64页

作者： Qi-Sheng Wang Kun-Hao Zhang Yin Cui Zhi-Jun Wang Qiang-Yan Pan Ke Liu Bo Sun Huan Zhou min-Jun Li Qin xu Chun-Yan xu Feng Yu Jian-Hua He Shanghai Institute of Applied Physics Chinese Academy of Sciences

Beamline BL17 U1 at Shanghai Synchrotron Radiation Facility is an energy-tunable macromolecular crystallography beamline that has been in user operation since 2009. Growing demand from the user community for a small beam and related experimental methods have motivated upgrades of the devices in the *** modes have already been developed for operation. A self-integrated diffractometer reduces the sphere of confusion of the rotatory axis to 1μm. The new diffractometer is equipped with an upgraded on-axis viewing system that can improve the resolving power. Additionally,the area detector was also upgraded to the newest generation of detectors, the EIGER X 16 M, which can collect data at 133 Hz. After these upgrades, the endstation became virtually new. This paper covers the upgrade of the endstation devices and gives the first data collection results.

关键词： Shanghai Synchrotron Radiation Facility Macromolecular crystallography Endstation Goniometer Fine-phi slicing

Carpel of cucumber (Cucumis sativus. L) male flowers maintains early primordia characteristics during organ development

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Chinese Science Bulletin 2000年第8期45卷 729-733页

作者： YANG Lingling CHEN min LIU Fuquan GENG Yi CHEN Chong LI Yiqin CAO Zongxun xu Zhihong Bai Shunong Department of Biological Sciences and Biotechnology Tsinghua UniversityBeijing 100084China College of Life Sciences Peking UniversityBeijing 10871China Shanghai Institute of Plant Physiology CASShanghai 200032China

Diclinism is not only an interesting natural phenomenon in plant kingdom, but also of significance in the yield of crops, e.g. cucumber and watermelon. Cucumber has been a model plant for studying the diclinism for decades. However, it is stili obscure how the carpel primordia of cucumber male flower undergo the developmental processes after the initiation of their development. By showing morphological alternation, metabolic activity, as well as CFL gene expression, the present study demonstrated that the carpel primordia of cucumber male flowers maintained the characteristics of primordium until anthesis, although it developed significantly slower than that of the female flowers.

关键词： cucumber dilinism primordium carpel development.