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Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression

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World Journal of Psychiatry 2024年第10期14卷 1437-1447页

作者： Yi Cheng Li-Jing Lv Yu Cui xiao-mei Han Yan Zhang Cai-xia Hu Department of Dermatology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Androgenetic alopecia(AGA)is a common form of hair loss that can be influenced by psychological *** To investigate the impact of mental stress on neurotrophic factors in patients with AGA and correlate the findings with the progression of *** A total of 120 patients with AGA were analyzed in this study,which were divided into a non-stress group(n=30)and a stress group(n=90)on the basis of the presence or absence of psychological stress confirmed by Depression Anxiety Stress Scale-21 *** baseline demographic characteristics,serum cortisol levels,hair growth parameters,neurotrophic factors,and AGA progression scores between the non-stress and stress groups were *** analyses were conducted to assess the relationships among stress,neurotrophic factors,hair loss progression,and AGA *** This study revealed significantly higher cortisol levels throughout the day in the stress group than in the non-stress *** stress group exhibited lower levels of nerve growth factor,brain-derived neurotrophic factor,and glial cell linederived neurotrophic factor and higher expression levels of neurotrophin(NT)-3 and NT-4 than the non-stress *** parameters indicated lower hair diameter,decreased hair density,and more severe AGA grading in the stress group,whereas follicle count and terminal/vellus hair ratio showed no significant differences between the two *** 1 year of treatment with 5%minoxidil,efficacy was observed to be lower but AGA progression was notably more pronounced in the stress group than in the non-stress *** progression was positively correlated with high stress and NT-4 *** This study provides compelling evidence of the influence of mental stress on neurotrophic factors and its correlation with the progression of *** findings underscore the need for a comprehensive approach to the management of AGA that considers the physiological and psychosocial ***

关键词： Mental stress Neurotrophic factors Androgenetic alopecia Progression

“互联网+”公共卫生应用案例分析及模式研究

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中国公共卫生 2024年第5期40卷 645-648页

作者：钱晨嗣夏天夏寒张诚杨妹上海市疾病预防控制中心上海200336 上海申康医院发展中心上海200070

目前“互联网+”公共卫生服务应用发展迅速,但缺乏相应的数据标准,导致建设过程困难,此外“互联网+”公共卫生服务应用兼具公益性和商业性,涉及多方利益主体和利益相关者,导致其发展模式不完善、供需匹配性差、可持续性不足。为此,本文... 详细信息

目前“互联网+”公共卫生服务应用发展迅速,但缺乏相应的数据标准,导致建设过程困难,此外“互联网+”公共卫生服务应用兼具公益性和商业性,涉及多方利益主体和利益相关者,导致其发展模式不完善、供需匹配性差、可持续性不足。为此,本文选取了上海市健康云平台和疫苗综合管理平台2个案例,分析“互联网+”公共卫生服务的难点、解决方案和应用取得的成效。在此基础上,总结“互联网+”公共卫生应用的特征,并提出相应的对策建议,为我国其他城市及全球城市“互联网+”公共卫生提供可借鉴的理论和方案。

关键词：互联网+ 公共卫生发展模式健康云疫苗管理

Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock

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Journal of Intensive Medicine 2024年第3期4卷 376-383页

作者： Qianyi Peng xia Liu meilin ai Li Huang Li Li Wei Liu Chunguang Zhao Chenghuan Hu Lina Zhang Department of Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunanChina Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Background When resuscitating patients with septic shock,cerebrovascular reactivity parameters are calculated by monitoring regional cerebral oxygen saturation(rSO_(2))using near-infrared spectroscopy to determine the optimal blood ***,we aimed to analyze the impact of cerebral autoregulation-directed optimal blood pressure management on the incidence of delirium and the prognosis of patients with septic *** This prospective randomized controlled clinical study was conducted in the xiangya Hospital of Central South University,***-one patients with septic shock(December 2020–May 2022)were enrolled and randomly allocated to the experimental(n=26)or control group(n=25).Using the ICM+software,we monitored the dynamic changes in rSO_(2) and mean arterial pressure(MAP)and calculated the cerebrovascular reactivity parameter tissue oxygen reactivity index to determine the optimal blood pressure to maintain normal cerebral autoregulation function during resuscitation in the experimental *** control group was treated according to the Surviving Sepsis Campaign *** in the incidence of delirium and 28-day mortality between the two groups were compared,and the risk factors were *** The 51 patients,including 39 male and 12 female,had a mean age of(57.0±14.9)*** incidence of delirium was 40.1%(23/51),and the 28-day mortality rate was 29.4%(15/51).The mean MAP during the first 24 h of intensive care unit(ICU)admission was higher([84.5±12.2]mmHg vs.[77.4±11.8]mmHg,P=0.040),and the incidence of delirium was lower(30.8%vs.60.0%,P=0.036)in the experimental group than in the control *** use of cerebral autoregulation-directed optimal blood pressure(odds ratio[OR]=0.090,95%confidence interval[CI]:0.009 to 0.923,P=0.043)and length of ICU stay(OR=1.473,95%CI:1.093 to 1.985,P=0.011)were risk factors for delirium during septic *** drug dose(OR=8.445,95%CI:1.26 to 56.576,P=0.028)and partial pressure of o

关键词： Septic shock Cerebral regional oxygen saturation Optimal blood pressure Delirium Mortality

领导与员工的超连接匹配对工作绩效的影响及其机制

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管理科学学报 2024年第1期27卷 61-74页

作者：李爱梅王海侠刘培陈晨马捷秦昕暨南大学管理学院广州510632 暨南大学新闻与传播学院广州510632 中山大学旅游学院珠海519082 中山大学管理学院广州510275

数字技术在企业的创新应用正在重构传统企业管理学理论与方法.工作中片刻不离手机和笔记本等多种设备的“超连接”成为常态.已有研究关注了互联网超连接对个体心理和行为的一系列消极影响,却忽略了数字技术赋能下的领导与员工超连接对... 详细信息

数字技术在企业的创新应用正在重构传统企业管理学理论与方法.工作中片刻不离手机和笔记本等多种设备的“超连接”成为常态.已有研究关注了互联网超连接对个体心理和行为的一系列消极影响,却忽略了数字技术赋能下的领导与员工超连接对工作绩效的潜在积极影响.本文基于平衡理论,连续三个月跟踪调查了343份领导与员工的配对样本,结果发现:领导与员工之间的超连接越匹配,员工自主性越高,工作目标进展越快,工作绩效显著增加.进一步发现,当领导与员工同处于高超连接时,员工的自主性高,工作目标进展和工作绩效最佳;而在“员工低—领导高”的不匹配模式下,员工的自主性和工作进展都低.本文从匹配视角探究领导与员工超连接模式对工作绩效的积极后效,为数字技术赋能组织管理的工作模式提供了更加全面和均衡的分析视角,同时也为实现领导与员工的工作模式匹配、协同推进工作绩效提供实践指导.

关键词：互联网超连接匹配员工自主性工作目标进展工作绩效

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“五星出东方利中国”织锦动物图案身份考辨

丝绸 2024年第1期61卷 120-128页

作者：梅月姣吕钊黄霞西安工程大学服装与艺术设计学院西安710048

“五星出东方利中国”汉代织锦出土于尼雅遗址,被誉为20世纪中国考古学最伟大的发现之一。它色彩鲜艳,图案丰富,意蕴独特。目前对于此织锦上动物图案身份的研究,众多学者仍结论不一。文章以此织锦中争议较大的动物图案为研究对象,采用... 详细信息

“五星出东方利中国”汉代织锦出土于尼雅遗址,被誉为20世纪中国考古学最伟大的发现之一。它色彩鲜艳,图案丰富,意蕴独特。目前对于此织锦上动物图案身份的研究,众多学者仍结论不一。文章以此织锦中争议较大的动物图案为研究对象,采用二重证据法,通过对汉代不同文物上同种类型的动物图案与文献的比较分析,对此织锦上争议较大的动物图案,如鸾鸟、鸵鸟和青龙的身份进行探究,并探讨了动物图案的寓意和背后的文化内涵。

关键词：汉代织锦鸾鸟鸵鸟青龙白虎

A particle-resolved heat-particle-fluid coupling model by DEM-IMB-LBM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2267-2281页

作者： Ming xia Jinlong Fu Y.T.Feng Fengqiang Gong Jin Yu Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China Zienkiewicz Institute for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civil Engineering Southeast UniversityNanjing211189China Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Multifield coupling is frequently encountered and also an active area of research in geotechnical *** this work,a particle-resolved direct numerical simulation(PR-DNS)technique is extended to simulate particle-fluid interaction problems involving heat transfer at the grain *** this extended technique,an immersed moving boundary(IMB)scheme is used to couple the discrete element method(DEM)and lattice Boltzmann method(LBM),while a recently proposed Dirichlet-type thermal boundary condition is also adapted to account for heat transfer between fluid phase and solid *** resulting DEM-IBM-LBM model is robust to simulate moving curved boundaries with constant temperature in thermal *** facilitate the understanding and implementation of this coupled model for non-isothermal problems,a complete list is given for the conversion of relevant physical variables to lattice ***,benchmark tests,including a single-particle sedimentation and a two-particle drafting-kissing-tumbling(DKT)simulation with heat transfer,are carried out to validate the accuracy of our coupled *** further investigate the role of heat transfer in particle-laden flows,two multiple-particle problems with heat transfer are *** examples demonstrate that the proposed coupling model is a promising high-resolution approach for simulating the heat-particle-fluid coupling at the grain level.

关键词： Particle-fluid interaction Heat transfer Discrete element method(DEM) Lattice Boltzmann method(LBM) Dirichlet-type thermal boundary Direct numerical simulation

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不同衣藻光合作用响应汞胁迫的比较研究

水生生物学报 2024年第6期48卷 1040-1050页

作者：夏亦雪艾晓寒朱飞霞毕永红中国科学院水生生物研究所淡水生态与生物技术国家重点试验室武汉430072 中国科学院大学北京100049 大连海洋大学水产与生命学院大连116023

为筛选耐受汞胁迫的衣藻(Chlamydomonas reinhardtii)藻株,研究不同衣藻光合作用过程响应汞胁迫的差异,比较了不同汞浓度下11株衣藻的生长、叶绿素a含量及叶绿素荧光活性。结果表明,随着汞离子浓度升高,叶绿素a含量显著下降且生长受抑制... 详细信息

为筛选耐受汞胁迫的衣藻(Chlamydomonas reinhardtii)藻株,研究不同衣藻光合作用过程响应汞胁迫的差异,比较了不同汞浓度下11株衣藻的生长、叶绿素a含量及叶绿素荧光活性。结果表明,随着汞离子浓度升高,叶绿素a含量显著下降且生长受抑制,叶绿素荧光活性参数W_(k)、V_(j)和M_(o)快速增加,ψ_(o)和φEo快速下降,表明光合系统Ⅱ(PSⅡ)反应中心的供体侧和受体侧的电子传递受阻,光合活性被抑制。在11株衣藻中,衣藻FACHB-889(EC_(50)为0.762 mg/L)对汞耐受能力最弱,衣藻FACHB-2217对汞耐受能力最强(EC_(50)为2.848 mg/L)。与对照相比,在低浓度汞(1.0 mg/L)胁迫下,衣藻FACHB-889光合活性受抑制,单位面积活性反应中心数量(RC/CS_(o))显著下降(P<0.05),单位活性反应中心吸收的能量(ABS/RC)持续增加,单位反应中心耗散的能量(DIo/RC)和单位反应中心捕获的用于电子传递的能量(ET_(o)/RC)呈下降趋势,表明吸收的能量不能被光合作用有效利用,且无法通过热耗散释放,导致能量的非正常积累,使细胞失活甚至死亡;衣藻FACHB-2217单位活性反应中心吸收的能量(ABS/RC)、用于还原Q_(A)的能量(TR_(o)/RC)及用于电子传递的能量(ET_(o)/RC)均显著升高,细胞通过有活性的单位反应中心光合能力的增强,有效转化吸收的能量,消除部分反应中心失活的负面影响。研究表明,光合活性及其能量分配的差异是衣藻对汞敏感/耐受的重要原因。

关键词：汞光系统Ⅱ 毒性效应衣藻

Voidage correction method for DEM study of 3D pebble flows in a bed of cycloidal base

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PARTICUOLOGY 2024年第10期93卷 30-40页

作者： xia, Zirui Shi, Minglei Zou, Quan Gui, Nan Yang, Xingtuan Tu, Jiyuan Jiang, Shengyao Tsinghua Univ Inst Nucl & New Energy Technol Collaborat Innovat Ctr Adv Nucl Energy Technol Key Lab Adv Reactor Engn & SafetyMinist Educ Beijing 100084 Peoples R China Tsinghua Univ Dept Engn Phys Beijing 100084 Peoples R China Tsinghua Univ Dept Automat Beijing 100084 Peoples R China RMIT Univ Sch Engn Melbourne Vic 3083 Australia

Voidage (porosity or void fraction) in packed particles (or pebbles) is of fundamental importance in calculating the pressure drop, obtaining the drag, predicting the bed permeability, estimating the neutron streaming, etc. For the case when particles are deformed, a method of voidage correction during the packing state is proposed using a Discrete Element Method (DEM) simulation of 3D pebble flow inside a bed of cycloidal base. A function to evaluate the remaining volume of a pebble intercepted by horizontal and vertical planes is proposed for voidage calculation. After that, the process of solving voidage distribution is provided in detail. Using this method, the voidage inside the cycloidal-base pebble bed is obtained to refer to reported similar data for validation. This method can be potentially used for dynamical voidage calculation in CFD-DEM simulation which can get suitable voidage distribution after the correction. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, ai training, and similar technologies.

关键词： Voidage Pebble flow Packed bed Discrete element method Cycloidal base KD-Tree Volume correction RADIAL POROSITY GAS MODEL SIMULATION PACKINGS SPHERES

车前子的炮制历史沿革、化学成分及药理作用研究进展

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中国中药杂志 2024年第16期49卷 4372-4386页

作者：卢美琪徐万爱于欢江西中医药大学药学院江西南昌330004

车前子为我国临床常用的传统中药材,具有清热利尿通淋、渗湿止泻、明目、祛痰的功效。车前子炮制历史悠久,早在汉代就有炒制的记载,其后出现了酒制、盐制、米泔水制等多种炮制方法,车前子炮制加工后可减弱药物寒性,利于临床应用。现代... 详细信息

车前子为我国临床常用的传统中药材,具有清热利尿通淋、渗湿止泻、明目、祛痰的功效。车前子炮制历史悠久,早在汉代就有炒制的记载,其后出现了酒制、盐制、米泔水制等多种炮制方法,车前子炮制加工后可减弱药物寒性,利于临床应用。现代研究表明,车前子的主要化学成分有苯乙醇苷类、环烯醚萜类、多糖类、黄酮类等,具有利尿、抗炎、降血糖、降血脂、抗氧化等药理作用。该文查阅历代本草、医药典籍和相关文献资料,从车前子的炮制历史沿革、化学成分及药理作用等方面进行论述,以期为车前子的相关研究提供参考。

关键词：车前子炮制历史沿革化学成分药理作用