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Levels of vaccination coverage among HIV-exposed children in China: a retrospective study

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Infectious Diseases of Poverty 2021年第2期10卷 98-99页

作者： Rui Shen ai-ling wang Xiao-Ping Pan Ya-Ping Qiao Qian wang Xiao-Yan wang Shui-ling Qu Tong Zhang National Center for Women and Children's Health Chinese Center for Disease Control and PreventionNo.12 Dahuisi RoadHaidian DistrictBeijing 100081China 不详 Capital Institute of Pediatrics No.2 Yabao RoadChaoyang DistrictBeijing 100020China

Background:Vaccination is crucial for human immunodeficiency virus(HlV)-exposed children because of their increased risk of morbidity and mortality from various vaccine-preventable ***,studies have shown that they are at high risk of incomplete *** China has developed prevention of mother-to-child transmission(PMTCT)of HIV programs substantially over the past decades,few studies have investigated the immunization levels of Chinese HIV-exposed ***,we aimed to evaluate vaccination coverage and its associated factors among HIV-exposed children in China during 2016-2018.

关键词： HIV Children Coverage Vaccination China

Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27^kipl via the ERK signal pathway

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Chinese Medical Journal 2011年第19期124卷 3098-3104页

作者： LIU ai-jun ling Feng wang Dong wang Qiang LU Xiao-dong LIU Ying-long Department of Pediatric Cardiac Surgery Center Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 China

Background RhoA/ Rho kinase （ROCK） pathway is involved in pulmonary arterial hypertension （PAH） and pulmonary artery smooth muscle cell （PASMC） proliferation. Inhibition of ROCK has been proposed as a treatment for PAH. But the mechanism of RhoA/ROCK pathway and its downstream signaling in proliferation of human PASMCs is unclear. We investigated the effect of fasudil, a selective ROCK inhibitor, on platelet-derived growth factor （PDGF） induced human PASMC proliferation, and the possible association between RhoA/ROCK and extracellular signal-regulated kinase （ERK）,*** Human PASMCs were cultured with the stimulation of 10 ng/ml PDGF, and different concentrations of fasudil were added before the addition of mitogen. Cell viability and cell cycle were determined with MTT and flow cytometry respectively. ROCK activity, ERK activity and protein expression of proliferating cell nuclear angigen （PCNA） and p27Kip1 were measured by *** By MTT assay, PDGF significantly increased the OD value that represented human PASMC proliferation, and pretreatment with fasudil significantly reversed this effect in a dose-dependent manner. After PDGF stimulation, the percentage of cells in S phase increased dramatically from 15.6% to 24.3%, while the percentage in G0/G1 phase was reduced from 80.6% to 59%. And pretreatment with fasudil reversed the cell cycle effect of PDGF significantly in a dose-dependent manner. PDGF markedly induced ROCK activity and ERK activity with a peak at 15 minutes, which were significantly inhibited by fasudil. In addition, fasudil significantly inhibited PDGF-induced PCNA expression and fasudil also upregulated p27Kip1 expression in human PASMCs, which decreased after PDGF *** RhoA/ROCK is vital for PDFG-induced human PASMC proliferation, and fasudil effectively inhibited PDGF-induced human PASMC proliferation by up-regulation of p27Kip1, which may be associated with inhibition of ERK activity.

关键词： human pulmonary smooth muscle cell proliferation Rho-kinase fasudil extracellular signal-regulated kinase p27^kip1

Elimination of Mother-to-child Transmission of Syphilis:Challenge and Solution

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Maternal-Fetal Medicine 2019年第2期1卷 95-104页

作者： Shang-Rong Fan ai-ling wang Lin-Hong wang Department of Obstetrics and Gynecology Peking University Shenzhen HospitalShenzhen 518036China Maternal and Child Health-Care Center China Disease Prevention andControl CenterBeijing 100050China National Center for Chronic and Non-Communicable DiseaseControl and Prevention China Disease Prevention and Control CenterBeijing 100050China

Congenital syphilis(CS)is a significant public health problem *** majority of cases of CS are caused by in utero *** World Health Organization launched the global elimination of CS initiative with the goal of reducing mother-to-child transmission of *** risk for CS is mainly related to three factors:(1)high matemal prevalence,(2)low coverage of antenatal care services,and(3)treatment *** long-acting penicillin preparations such as benzathine penicillin G are the preferred therapies for maternal *** are several challenges in preventing CS from both pregnant women and their health care *** problems include that prenatal care lack or delay,syphilis management flaws from health care providers,lacks of basic information,and awareness about maternal syphilis and CS by *** efforts have been made to solve the *** include that dual elimination of mother-to-child transmission(EMTCT)of both human immunodeficiency virus(HIV)and syphilis or triple EMTCT of HIV,syphilis and hepatitis B,World Health Organization country validation of EMTCT of syphilis and HIV,set up a CS case review board and a National Day to combat syphilis and CS.

关键词： Pregnancy Syphilis Congenital Therapeutics

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The Clinical Role of Changes of Maximum Expiratory Flow at 25%and 50%of Vital Capacity before and after Bronchodilator Reversibility Test in Diagnosing Asthma

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Current Medical Science 2020年第4期40卷 677-682页

作者： Xu-xuc GUO Xiao-fan LIU ai-ling wang Qian-hui CHEN Shuo CHEN Ni-shan DENG Rui-yun LI Xu-hong DING Su ping HU Han-xiang NIE Department of Respiratory&Critical Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Pulmonary and Critical Care Medicine The Central Hospial of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Nursing Department Wuhan University School of Health SciencesWuhan 430071China

Summary:Changes of maximum expiratory flow at 25%and 50%of vital capacity(MEF2s and MEFso,respectively),and predominant parameters indicating small airways function in asthmatics before and after bronchodilator(BD)reversibility test have been less *** study aimed to investigate the clinical role of changes of MEF2s and MEFso before and after BD reversibility test in diagnosing *** expiratory volume in the first second(FEV),MEF2s,and MEFso were measured before and after BD reversibility test in 207 asthmatic patients using standard *** healthy individuals were enrolled as *** operating characteristic(ROC)curve was used to assess the diagnostic accuracy of reversibility of MEF2s and MEFgo before and after BD reversibility test(OMEF 2s%and AMEF so%,respectively)in diagnosing *** these functional criteria,AMEF2;%and 0MEFs%≥25%performed the best diagnostic *** sensitivity,specificity,and accuracy of AMEF 25%≥25%as an objcctive diagnostic test for asthma were 63.29%,87.50%,and 67.21%,and of AMEFs0%≥25%were 79.23%,85.00%,and 80.16%,*** area under the ROC curve of the indicators was 0.8203 and 0.9104,*** contrast,an increase in FEV≥12%and 200 mL demonstrated a sensitivity of 62.32%,specificity of 82.50%,and accuracy of 65.59%in diagnosing *** changes of MEF2s and MEFso before and after BD reversibility test may be of additional value in the clinical diagnosis of asthma,with cutoff values of 25%being the most.

关键词： asthma bronchodilator reversibility test maximum expiratory flow at 25%of vital capacity maximum expiratory flow at 50%of vital capacity

Cost-effectiveness analysis of the prevention of mother-to-child transmission of HIV

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Infectious Diseases of Poverty 2022年第3期11卷 97-97页

作者： Shui-ling Qu ai-ling wang Hong-mei Yin Jin-qi Deng Xiao-yan wang Ye-huan Yang Xiao-ping Pan Tong Zhang 不详 National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionNo.12 Dahuisi RoadHaidian DistrictBeijing100081China Capital Institute of Pediatrics No.2 Yabao RoadChaoyang DistrictBeijing100020China

Background:The number of HIV-positive pregnant women accounted for about 10% of China’s total over the past few years in Liangshan Prefecture, Sichuan province in China. Although cost-effectiveness of the PMTCT of HIV have been evaluated in other previous studies, no specific study has been conducted in Liangshan prefecture, nor has the expenses paid individually by HIV-positive pregnant women been included. The purpose of this study was to evaluate both the short-term and long-term cost-effectiveness of PMTCT of HIV in Liangshan Prefecture from the social ***:From December 2018 to January 2019, individual expenses and the other costs were collected: individual expenses of 133 recruited HIV-positive pregnant women registered in the National Information System of Prevention of Mother-to-Child Transmission of HIV, Syphilis, and HBV, and the other costs from local maternal and child healthcare hospitals, Centers for Disease Control and Prevention, and general hospitals. The costs, the number of pediatric infections averted from being HIV infected were analyzed. And, Life years gained by pediatric infections averted were calculated by using a life table. Besides, Direct benefit was calculated through a Markov mode. Furthermore, One-way sensitivity analysis was conducted for key variables affecting the benefit–cost ***:The estimated number of pediatric infections averted was *** total cost was USD 114.1 million, including direct medical costs, direct non-medical costs, and indirect costs, which were USD 54.2 million, USD 53.4 million, and USD 6.5 million, respectively. 630.6 person-years discounted to 2017 were gained at a 3% annual rate, and cost per life year gained was USD 1809.50. Direct benefits were USD 198.4 million, indirect benefits USD 82.5 million, and the benefit–cost ratio was 1.5. The sensitivity analysis showed that if PMTCT costs hypothetically ranged from USD 85.6 million to USD 142.6 million, benefit–cost ratio would vary f

关键词： Cost-effectiveness PMTCT HIV Benefit-cost ratio Individual cost

Influence of Initial Chirp on Propagation of Super-Gaussian Pulse inside Fiber

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Semiconductor Photonics and Technology 2002年第4期8卷 202-207,214页

作者： YANG ai ling, wang Jing, MIAO Hong li, REN Zhi jun (Dept. of Phys., Ocean University of Qingdao, Shandong, Qingdao 266003,CHN) Dept. of Phys. Ocean University of Qingdao 山东 Qingdao 266003

Under the condition of combined effects of group--velocitydispersion and self- phase modulation, the step Fourier method isused to simulate the propagation of initial chirped super-Gaussianpulses inside fiber. The initial chirp influences the shapes of superGaussian pulses in propagation process, and positive and negativechirps have different effects. For the existing of initial chirp, thesplits of pulses and the spreading speed move ahead and *** the amplitude of super-Gaussian pulses increases by 1.4 times,in the range of │C│<1.5, pulses can keep good shapes along theirpropagation distance.

关键词： Initial chirp Super-Gaussian pulse Group-velocity dispersion

学科教学的“道言悖反”现象及其弱化路径——基于《老子》的道言矛盾

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基础教育 2017年第3期14卷 37-44页

作者：朱爱玲王康宁山东师范大学数学与统计学院山东济南250014 山东师范大学教育学部山东济南250014

"道言悖反"是为学界广泛认可的《老子》中的理论矛盾。此矛盾的产生一方面为语言本身的局限性所致,另一方面则归因于老子所赋予的"道"不可尽知的特性。作为言与言说对象矛盾的体现,"道言悖反"的现象在学科教学中较为常见,并有多种表现... 详细信息

"道言悖反"是为学界广泛认可的《老子》中的理论矛盾。此矛盾的产生一方面为语言本身的局限性所致,另一方面则归因于老子所赋予的"道"不可尽知的特性。作为言与言说对象矛盾的体现,"道言悖反"的现象在学科教学中较为常见,并有多种表现形式。学科教学中的"道言悖反"现象,虽是不可避免的,但因其对于知识的传递与接受构成阻碍,故而需要找寻弱化"道言悖反"现象的途径。"不言""不言之教"作为弱化及规避"道言悖反"现象的方式及理念,有助于学科教学的顺利开展。

关键词：学科教学老子道言悖反

Recommendations for the Diagnosis and Treatment of Maternal SARS-CoV-2 Infection

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Maternal-Fetal Medicine 2023年第2期5卷 74-79页

作者： Dunjin Chen Yue Dai Xinghui Liu Hongbo Qi Chen wang Lan wang Yuan Wei Xiaochao Xu Chuan Zhang lingli Zhang Yuquan Zhang Ruihua Zhao Yangyu Zhao Borong Zhou ai-ling wang Huixia Yang Li Song Department of Obstetrics and Gynecology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China National Health Commission of the People’s Republic of China Beijing 100044China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Administration Office Chongqing Health Center for Women and ChildrenChongqing 401120China Department of Obstetrics and Gynecology Peking University First HospitalBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes MellitusBeijing 100034China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100083China Department of Obstetrics and Gynecology Affiliated Hospital of Nantong UniversityNantong 226001China Department of Obstetrics and Gynecology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijing 100081China.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide and threatened human’s *** the passing of time,the epidemiology of coronavirus disease 2019 evolves and the knowledge of SARS-CoV-2 infection *** further improve the scientific and standardized diagnosis and treatment of maternal SARS-CoV-2 infection in China,the Chinese Society of Perinatal Medicine of Chinese Medical Association commissioned leading experts to develop the Recommendations for the Diagnosis and Treatment of Maternal SARS-CoV-2 Infection under the guidance of the Maternal and Child Health Department of the National Health *** recommendations includes the epidemiology,diagnosis,management,maternal care,medication treatment,care of birth and newborns,and psychological support associated with maternal SARS-CoV-2 *** is hoped that the recommendations will effectively help the clinical management of maternal SARS-CoV-2 infection.

关键词： COVID-19 Diagnosis SARS-CoV-2 Newborns Pregnancy Recommendation Treatment

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生产系统反求及其应用

同济大学学报（自然科学版） 2001年第12期29卷 1490-1494页

作者：王爱玲王俊元华北工学院机械工程系山西太原030051

采用生产系统反求技术及多目标模糊设计理论解决了频临报废的复杂断面形状辊弯成型件生产线上多组辊弯模具的设计、制造问题。

关键词：系统反求模糊设计辊弯模具生产系统辊弯成型汽车车门