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Systematic understanding of the underlying target and mechanism of sanguinarine against nasopharyngeal carcinoma through a networkpharmacology approach

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Precision Medicine Research 2020年第3期2卷 104-115页

作者： Meng-Zhe Yang Bei-Bei Zhang Zhen-Qiang Liang Ning Xu Nan-Nan Cheng An-Qiao Lv Jian-Yu Yang Xing-Zhe Guo Xian-Yu Bai ai-jun jiao Yuan-jiao Huang Graduate School of Guangxi Medical University NanningChina Institute of Biomedical Research Yunnan UniversityKunmingChina Department of Otolaryngology-Head and Neck Surgery Affiliated Tumor Hospital and Oncology Medical College of Guangxi Medical UniversityNanningChina Pharmaceutical College Guangxi Medical UniversityNanningChina Life Science Institute Guangxi Medical UniversityNanningChina

Background:Nasopharyngeal carcinoma is a malignant tumor,well known as a cancer type characterized by regional specificity,especially in Southern *** network pharmacology is an emerging discipline developed in recent years,which has been effectively used to predict the potential therapeutic compounds against disease focusing on the possible therapeutic targets and ***,a traditional natural plant-derived phenanthridine alkaloid,has been reported to have a wide variety of pharmacological activities for ***:In the current study,using the comprehensive network pharmacological method,the potential drug targets of sanguinarine against nasopharyngeal carcinoma were successfully predicted,and verified by molecular *** underlying pharmacological mechanism was initially ***:Totally,38 potential common targets were confirmed from these potential nasopharyngeal carcinoma therapeutic targets and pharmacological targets of *** enrichment analyses of GO functions show that protein serine/threonine kinase activity,histone kinase activity,integrin binding,protein tyrosine kinase activity,and cell adhesion molecule binding were top *** functional enrichment analysis indicates that the potential pathways are mainly involved into PI3K-Akt signaling ***"drug-target-disease-pathway"network model diagram points out the key genes containing MAPK10,MAPK14,JAK2,BRAF,GSK3B,MET,HSP90AA1,SRC,et al..According to the results of molecular docking,it was further verified that sanguinarine has strong binding ability with MAPK10 and ***:Taken together,this study would provide a clarified theoretical basis for the subsequent wet laboratory research focusing on sanguinarine against nasopharyngeal carcinoma.

关键词： Nasopharyngeal carcinoma Sanguinarine Network pharmacology Drug target

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min ai Hang-Hang Zhang jun-Bang Feng Chuan-Ming Li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

Almost Sure Convergence and Complete Convergence for the Weighted Sums of Martingale Differences

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Wuhan University Journal of Natural Sciences 1999年第3期4卷 278-284页

作者： Deng ai-jiao Liu Jing-jun Wuhan University College of Mathematical and Computer Sciences Wuhan China (GRID:grid.49470.3e) (ISNI:***)

Let {(D n, FFFn),n/->1} be a sequence of martingale differences and {a ni, 1≤i≤n,n≥1} be an array of real constants. Almost sure convergence for the row sums ?i = 1n ani D1\sum\limits_{i = 1}^n {a_{ni} D_1 } are discussed. We also discuss complete convergence for the moving average processes underB-valued martingale differences assumption.

关键词： complete convergence almost sure convergence weighted sums, martingale differences moving average processes

Performance and mechanism of Cr(Ⅵ)removal by zero-valent iron loaded onto expanded graphite

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Journal of Environmental Sciences 2018年第5期30卷 14-22页

作者： Congbin Xu Wenjie Yang Weijiang Liu Hongliang Sun Chunlei jiao ai-jun Lin College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Chinese Academy for Environmental Planning Beijing 100012China

Zero-valent iron（ZⅥ） was loaded on expanded graphite（EG） to produce a composite material（EG-ZⅥ） for efficient removal of hexavalent chromium（Cr（Ⅵ））. EG and EG-ZⅥ were characterized by X-ray diffraction（XRD）, scanning electron microscopy（SEM）,Fourier-transform infrared（FTIR） spectroscopy and Brunauer–Emmett–Teller（BET） analysis. EG-ZⅥ had a high specific surface area and contained sub-micron sized particles of zero-valent iron. Batch experiments were employed to evaluate the Cr（Ⅵ） removal performance. The results showed that the Cr（Ⅵ） removal rate was 98.80% for EG-ZⅥ,which was higher than that for both EG（10.00%） and ZⅥ（29.80%）. Furthermore, the removal rate of Cr（Ⅵ） by EG-ZⅥ showed little dependence on solution p H within a p H range of 1–*** at pH 11, a Cr（Ⅵ） removal rate of 62.44% was obtained after reaction for 1 hr. EG-ZⅥ could enhance the removal of Cr（Ⅵ） via chemical reduction and physical adsorption,respectively. X-ray photoelectron spectroscopy（XPS） was used to analyze the mechanisms of Cr（Ⅵ） removal, which indicated that the ZⅥ loaded on the surface was oxidized, and the removed Cr（Ⅵ） was immobilized via the formation of Cr（III） hydroxide and Cr（III）–Fe（III）hydroxide/oxyhydroxide on the surface of EG-ZⅥ.

关键词： Zero-valent iron(ZVI) Expanded graphite(EG) Cr(Ⅵ) removalMechanism

Microstructural refinement and performance improvement of Cu-36 wt%Zn alloy by Al_(2)O_(3)nanoparticles coupling electromagnetic stirring

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Rare Metals 2022年第10期41卷 3560-3565页

作者： Ya-Bo Fu Yi-Ping Lu Zhi-jun Wang Zhi-Qiang Cao ai-jiao Xu School of Physics and Electronic Engineering Taizhou UniversityTaizhou318000China School of Materials Science and Engineering Dalian University of TechnologyDalian116024China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an710048China

Cu-36 wt%Zn alloy is widely used in valves of water and heating and auto parts,***,the structure is still coarse,and performances are much *** structure and performances of Cu-36 wt%Zn alloy were investigated by adding Al_(2)O_(3)nanoparticles and *** indicate that by Al_(2)O_(3)nanoparticles coupling electromagnetic stirring,the Cu-36 wt%Zn alloy with refined microstructure was successfully *** average grain size is refined by 99%compared with that without nanoparticles and *** tensile strength(R_m)and percentage elongation after fracture(A11.3)increase by 20.58%and 19.40%,respectively,compared with that without nanoparticles and *** increase heterogeneous nucleation rate by 50%compared with that without *** depth of dezincification layer decreases by 78.71%compared with that without nanoparticles and stirring,as protective layer(Cu-Al_(2)O_(3)-Zn)is completely formed around the grain boundaries.

关键词： Microstructural refinement Rotating electromagnetic field Mechanical performance Al_(2)O_(3)nanoparticles

Automatic software fault localization based on artificial bee colony

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Journal of Systems Engineering and Electronics 2015年第6期26卷 1325-1332页

作者： Linzhi Huang jun ai School of Reliability and Systems Engineering Beihang University

Software debugging accounts for a vast majority of the financial and time costs in software developing and maintenance. Thus, approaches of software fault localization that can help automate the debugging process have become a hot topic in the field of software engineering. Given the great demand for software fault localization, an approach based on the artificial bee colony （ABC） algorithm is proposed to be integrated with other related techniques. In this process, the source program is initially instrumented after analyzing the dependence information. The test case sets are then compiled and run on the instrumented program, and execution results are input to the ABC algorithm. The algorithm can determine the largest fitness value and best food source by calculating the average fitness of the employed bees in the iteralive process. The program unit with the highest suspicion score corresponding to the best test case set is regarded as the final fault localization. Experiments are conducted with the TCAS program in the Siemens suite. Results demonstrate that the proposed fault localization method is effective and efficient. The ABC algorithm can efficiently avoid the local optimum, and ensure the validity of the fault location to a larger extent.

关键词： software debugging software fault localization arti-ficial bee colony (ABC) algorithm program instrumentation.

Statistical analysis on strain-rate effects during serrations in a Zr-based bulk metallic glass

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Journal of Iron and Steel Research International 2017年第4期24卷 455-461页

作者： Bo Yuan jiao-jiao Li jun-wei Qiao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024ShanxiChina

By means of statistical analysis,the deformation mechanisms taking place in elastic loading and plastic shearing stages during serrated flows on the stress-strain curves for bulk metallic glasses were studied *** serration number presented a linear increasing tendency with the decrease of applied strain rates due to the reduction of free *** excellent plastic deformation was illustrated from the influences of structure arrangement with activation *** using mean-field theory（MFT）,maximum elastic-energy density at different strain rates could be predicted by MFT besides maximum stress drops during *** results were helpful for understanding the serrated flow behavior or designing decent schemes to improve the plasticity of bulk metallic glasses at room temperature.

关键词： Bulk metallic glass Shear band Mean-field theory Serration

Bose–Einstein condensates with tunable spin–orbit coupling in the two-dimensional harmonic potential: The ground-state phases, stability phase diagram and collapse dynamics

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Frontiers of physics 2022年第6期17卷 219-233页

作者： Chen jiao jun-Cheng Liang Zi-Fa Yu Yan Chen ai-Xia Zhang Ju-Kui Xue College of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China School of Physics and Electromechanical Engineering Hexi UniversityZhangye 734000China

We study the ground-state phases,the stability phase diagram and collapse dynamics of Bose–Einstein condensates(BECs)with tunable spin–orbit(SO)coupling in the two-dimensional harmonic potential by variational analysis and numerical *** we propose the theory that the collapse stability and collapse dynamics of BECs in the external trapping potential can be manipulated by the periodic driving of Raman coupling(RC),which can be realized *** the high-frequency approximation,an effective time-independent Floquet Hamiltonian with two-body interaction in the harmonic potential is obtained,which results in a tunable SO coupling and a new effective two-body interaction that can be manipulated by the periodic driving *** the variational method,the phase transition boundary and collapse boundary of the system are obtained analytically,where the phase transition between the spin-nonpolarized phase with zero momentum(zero momentum phase)and spin-polarized phase with non-zero momentum(plane wave phase)can be manipulated by the external driving and sensitive to the strong external trapping ***,it is revealed that the collapsed BECs can be stabilized by periodic driving of RC,and the mechanism of collapse stability manipulated by periodic driving of RC is clearly *** addition,we find that the collapse velocity and collapse time of the system can be manipulated by periodic driving strength,which also depends on the RC,SO coupling strength and external trapping ***,the variational approximation is confirmed by numerical simulation of Gross–Pitaevskii *** results show that the periodic driving of RC provides a platform for manipulating the ground-state phases,collapse stability and collapse dynamics of the SO coupled BECs in an external harmonic potential,which can be realized easily in current experiments.

关键词： spin-orbit coupled Bose-Einstein condensates stability collapse dynamics