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Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： Wei Luo Yue Zhou Li-Ying wang Lei ai Department of Sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of Sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal ***,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to *** exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is *** To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal *** We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical ***,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG *** effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent *** mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG *** The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube n

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation Insulin sensitivity

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Micro-sized nanoaggregates:Spray-drying-assisted fabrication and applications

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Particuology 2024年第2期85卷 22-48页

作者： Dan-Lei Yang Rong-Kun Liu Yan Wei Qian Sun jie-Xin wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning530004China

The applications of nanoparticles suffer from their extremely small size and intrinsic trend of *** nanoparticles to form micro-sized nanoaggregates(MNAs)with increased size,ordered structure,as well as controllable size,shape,and morphology is a crucial step in various fields of science and technology to maintain the unique characteristics of nanoparticles while obtaining greatly enhanced or new performance at the *** structure of MNAs prominently affects their functionality,which is determined by the arrangement of nanoparticles and the interaction between primary *** methods have been proposed to prepare the MNAs,in which spray-drying technology stands out considering the feasibility,scalability for industry,cost,and *** assembly of nanoparticles through spray-drying under tunable process parameters yields diverse physical properties and structural arrangements of nanoparticles of the MNAs,they therefore exhibit enormous potential in a wide range of application *** review presents the construction and applications of spray-dried *** factors that influence the size,morphology,and structure of the MNAs are discussed in *** addition,the outstanding application performance resulting from the tightly packed nanoparticles in regular-shaped MNAs obtained by the spray-drying process is illustrated.

关键词： Spray-drying Micro-sized nanoaggregates Applications

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WRKY11 up-regulated dirigent expression to enhance lignin/lignans accumulation in Lilium regale Wilson during response to Fusarium wilt

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Journal of Integrative Agriculture 2024年第8期23卷 2703-2722页

作者： jie Deng Zi’e wang Wenyun Li Xiaohua Chen Diqiu Liu Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650500China

Lilium are highly economically valuable ornamental plants that are susceptible to Fusarium wilt caused by Fusarium *** regale Wilson,a wild lily native to China,is highly resistant to *** this study,a WRKY transcription factor,WRKY11,was isolated from ***,and its function during the interaction between *** and *** was *** ectopic expression of LrWRKY11 in tobacco increased the resistance to F oxysporum,moreover,the transcriptome sequencing and UHPLC-MS/MS analysis indicated that the methyl salicylate and methyl jasmonate levels rose in LrWRKY11 transgenic tobacco,meanwhile,the expression of lignin/lignans biosynthesis-related genes including a dirigent(DiR)was *** lignin/lignans contents in LrWRKY11-transgenic tobacco also significantly increased compared with the wild-type *** addition,the resistance of *** scales in which LrWRKY11 expression was silenced by RNai evidently decreased,and additionally,the expression of lignin/lignans biosynthesis-related genes including LrDIR1 was significantly ***,LrDIR1 and its promoter(PLrDIR1)sequence containing the W-box element were isolated from *** interaction assay indicated that LrWRKY11 specifically bound to the W-box element in PLrDIR1 and activated LrDIR1 ***,β-glucuronidase activity in the transgenic tobacco co-expressing LrWRKY11/PLrDIR1-β-glucuronidase was higher than that in transgenic tobacco expressing PLrDIR1-β-glucuronidase ***,the ectopic expression of LrDIR1 in tobacco enhanced the resistance to *** and increased the lignin/lignans *** brief,this study revealed that LrWRKY11 positively regulated *** resistance to *** through interaction with salicylic acid/jasmonic acid signaling pathways and modulating LrDIR1 expression to accumulate lignin/lignans.

关键词： Lilium regale Fusarium oxysporum WRKY transcription factor dirigent

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Synthesis of porous flower-like SnO_(2)/CdSnO_(3) microstructures with excellent sensing performances for volatile organic compounds

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Frontiers of Materials Science 2024年第1期18卷 45-57页

作者： jie Wan Gang wang Haibo Ren Jiarui Huang Sang Woo Joo School of Materials Science and Engineering Anhui Polytechnic UniversityWuhu 241000China Key Laboratory of Functional Molecular Solids of the Ministry of Education College of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China School of Mechanical Engineering Yeungnam UniversityGyeongsanGyeoungbuk 712749Republic of Korea

Porous flower-like SnO_(2)/CdSnO_(3) microstructures self-assembled by uniform nanosheets were synthesized using a hydrothermal process followed by calcination,and the sensing performance was measured when a gas sensor,based on such microstructures,was exposed to various volatile organic compound(VOC)*** response value was found to reach as high as 100.1 when the SnO_(2)/CdSnO_(3) sensor was used to detect 100 ppm formaldehyde gas,much larger than those of other tested VOC gases,indicating the high gas sensitivity possessed by this sensor especially in the detection of formaldehyde ***,the response/recovery process was fast with the response time and recovery time of only 13 and 21 s,*** excellent gas sensing performance derive from the advantages of SnO_(2)/CdSnO_(3),such as abundant n-n heterojunctions built at the interface,high available specific surface area,abundant porosity,large pore size,and rich reactive oxygen species,as well as joint effects arising from SnO_(2) and CdSnO_(3),suggesting that such porous flower-like SnO_(2)/CdSnO_(3) microstructures composed of nanosheets have a high potential for developing gas sensors.

关键词： SnO_(2)/CdSnO_(3) porous flower-like microstructure volatile organic gas sensingproperty gas sensor

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Effects of Diamond on the Mechanical Properties and Thermal Conductivity of Si_(3)N_(4)Composites Fabricated Using Spark Plasma Sintering

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1319-1324页

作者： GAO Ying LIU Di wang aiyang ZHANG Song HE Qianglong REN Shifeng FANG jie wang Zihan wang Weimin State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Jingdezhen Huaxun Special Ceramics Co.ltd. Jingdezhen 333000China Aerospace Science&Industry Defense Technology Research and Test Center Beijing 100854China

Micrometer-sized diamonds were incorporated into silicon nitride(Si_(3)N_(4))matrix to manufacture high-performance Si_(3)N_(4)-based composites using spark plasma sintering at 1500℃under 50 *** effects of the diamond content on the phase composition,microstructure,mechanical properties and thermal conductivity of the composites were *** results showed that the addition of diamond could effectively improve the hardness of the *** thermal conductivity of Si_(3)N_(4)increased to 52.97 W/m·k at the maximum with the addition of 15 wt%diamond,which was 27.5%higher than that of the monolithic Si_(3)N_(4).At this point,the fracture toughness was 7.54 MPa·m^(1/2).Due to the addition of diamond,the composite material generated a new substance,MgSiN2,which effectively combined Si_(3)N_(4)with ***2 might improve the hardness and thermal conductivity of the materials.

关键词： spark plasma sintering Si_(3)N_(4) diamond thermal conductivity mechanical properties

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Monitoring seismicity in the southern Sichuan Basin using a machine learning workflow

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Earthquake Research Advances 2024年第1期4卷 59-66页

作者： Kang wang jie Zhang Ji Zhang Zhangyu wang Huiyu Zhu School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China

Monitoring seismicity in real time provides significant benefits for timely earthquake warning and *** this study,we propose an automatic workflow based on machine learning(ML)to monitor seismicity in the southern Sichuan Basin of *** workflow includes coherent event detection,phase picking,and earthquake location using three-component data from a seismic *** combining Phase Net,we develop an ML-based earthquake location model called Phase Loc,to conduct real-time monitoring of the local *** approach allows us to use synthetic samples covering the entire study area to train Phase Loc,addressing the problems of insufficient data samples,imbalanced data distribution,and unreliable labels when training with observed *** apply the trained model to observed data recorded in the southern Sichuan Basin,China,between September 2018 and March *** results show that the average differences in latitude,longitude,and depth are 5.7 km,6.1 km,and 2 km,respectively,compared to the reference *** Loc combines all available phase information to make fast and reliable predictions,even if only a few phases are detected and *** proposed workflow may help real-time seismic monitoring in other regions as well.

关键词： Earthquake monitoring Machine learning Local seismicity Gaussian waveform Sparse stations

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Electrochemistry-stimulated environmental bioremediation:Development of applicable modular electrode and system scale-up

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Environmental Science and Ecotechnology 2020年第3期3卷 32-40页

作者： ai-jie wang Hong-Cheng wang Hao-Yi Cheng Bin Liang Wen-Zong Liu Jing-Long Han Bo Zhang Shu-Sen wang School of Civil&Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen518055PR China Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085PR China

Bioelectrochemical systems(BESs)have been studied extensively during the past decades owing primarily to their versatility and potential in addressing the water-energy-resource *** stark contrast to the significant advancements that have been made in developing innovative processes for pollution control and bioresource/bioenergy recovery,minimal progress has been achieved in demonstrating the feasibility of BESs in scaled-up *** lack of scaled-up demonstration could be ascribed to the absence of suitable electrode modules(EMs)engineered for large-scale *** this study,we report a scalable composite-engineered EM(total volume of 1 m^(3)),fabricated using graphite-coated stainless steel and carbon felt,that allows integrating BESs into mainstream wastewater treatment *** cost-effectiveness and easy scalability of this EM provides a viable and clear path to facilitate the transition between the success of the lab studies and applications of BESs to solve multiple pressing environmental issues at full-scale.

关键词： Environmental bioremediation Bio-electrochemical systems(BESs) Electrode modular Scaling-up Intergradation system

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Experimental studies on the energy dissipation of bolted structures with frictional interfaces:A review

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Friction 2024年第8期12卷 1623-1654页

作者： Yongfeng wang Yanhong MA jie HONG Giuseppe B.ATTIATO Christian M.FIRRONE School of Energy and Power Engineering Beihang UniversityBeijing 102206China Research Institute of Aero-Engine Beihang UniversityBeijing 102206China Politecnico di Torino Department of Mechanical and Aerospace EngineeringTorino 10139Italy

Bolted joints play a more and more important role in the structure with lighter weight and heavier *** paper aims to provide an overview of different experimental approaches for the dynamic behavior of structures in the presence of bolted joints,especially the energy dissipation or damping at frictional *** comprehension of energy dissipation mechanisms due to friction is provided first,while the key parameters and the measurement techniques,such as the excitation force,the preload of the bolt,or the pressure at the interfaces,are briefly ***,the round-robin systems aim to measure the hysteresis parameters of the frictional joints under tangential loads are reviewed,summarizing the basic theory and the strategies to apply the excitation force or acquire the response in different testing *** by parameter identification strategies for bolted structures,the test rigs with one or more simplified bolted joints are summarized to give an insight into the understanding of typical characteristics of bolted structures,which are affected by the presence of *** complex test rigs hosting real-like or actual engineering structures with bolted lap or flange joints are also introduced to show the identification process of the dynamic characteristics of bolted connections employed in specific *** on the review paper,researchers can get the basic knowledge about the experimental systems of the bolted structures,especially several classical round robin systems,such as the Gaul resonator and widely used Brake-Reußbeam *** can take advantage of this background for more creative and effective future studies,make more progress on the study of assembled structures and understand the influence of bolting frictional connections on the dynamic response better.

关键词： review study bolted joints frictional damping experimental rigs measurements

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An envelope-based machine learning workflow for locating earthquakes in the southern Sichuan Basin

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Earthquake Research Advances 2024年第2期4卷 45-54页

作者： Kang wang jie Zhang Ji Zhang Zhangyu wang Ziyu Li School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China

The development of machine learning technology enables more robust real-time earthquake monitoring through automated implementations. However, the application of machine learning to earthquake location problems faces challenges in regions with limited available training data. To address the issues of sparse event distribution and inaccurate ground truth in historical seismic datasets, we expand the training dataset by using a large number of synthetic envelopes that closely resemble real data and build an earthquake location model named ENVloc. We propose an envelope-based machine learning workflow for simultaneously determining earthquake location and origin time. The method eliminates the need for phase picking and avoids the accumulation of location errors resulting from inaccurate picking results. In practical application, ENVloc is applied to several data intercepted at different starting points. We take the starting point of the time window corresponding to the highest prediction probability value as the origin time and save the predicted result as the earthquake location. We apply ENVloc to observed data acquired in the southern Sichuan Basin, China, between September 2018 and March 2019. The results show that the average difference with the catalog in latitude, longitude, depth, and origin time is 0.02°,0.02°, 2 km, and 1.25 s, respectively. These suggest that our envelope-based method provides an efficient and robust way to locate earthquakes without phase picking, and can be used in earthquake monitoring in near-real time.

关键词： Waveform envelope Earthquake location Local seismicity Synthetic data Sparse stations

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Migration and transformation of Pb,Cu,and Zn during co-combustion of high-chlorine-alkaline coal and Si/Al dominated coal

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Journal of Environmental Sciences 2024年第7期141卷 26-39页

作者： Jiangze Luo Qiwei Yang Jianqiao wang Boxiong Shen Zhuozhi wang Qiqi Shi Zhong Zhao Chao Huang jie Xu Tianjin Key Laboratory of Clean Energy and Pollution Control School of Energy and Environmental EngineeringHebei University of TechnologyTianjin 300103China School of Chemical Engineering Hebei University of TechnologyTianjin 300103China

Shaerhu(SEH)coal is abundant in Xinjiang,*** utilization of SEH suffers from severe ash deposition,slagging,and fouling problems due to its high-chlorine-alkaline *** co-combustion of high-alkaline coal and other type coals containing high Si/Al oxides has been proven to be a simple and effective method that will alleviate ash-related problems,but the risk of heavy metals(HMs)contamination in this process is ***,the volatilization rates and chemical speciation of Pb,Cu,and Zn in co-combusting SEH and a high Si/Al oxides coal,i.e.,Yuanbaoshan(YBS)coal were investigated in this *** results showed that the addition of SEH increased the volatilization rates of Pb,Cu,and Zn during the co-combustion at 800℃from 23.70%,23.97%,and 34.98%to 82.31%,30.01%,and 44.03%,respectively,and promoted the extractable state of Cu and *** addition,the interaction between SEH and YBS inhibited the formation of the Pb residue ***-EDS mapping results showed that compared to Zn and Cu,the signal intensity of Pb was extremely weak in regions where some of the Si and Al signal distributions *** DFT results indicated that the O atoms of the metakaolin(Al_(2)O_(3)·2SiO_(2))(001)surface were better bound to the Zn and Cu than Pb atoms after adsorption of the chlorinated *** results contribute to a better understanding of the effects of high-alkaline coal blending combustion on Pb,Cu,and Zn migration and transformation.

关键词： Heavy metals High-chlorine-alkaline coal Coal blending combustion Density functional theory

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