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Sub-Tenon's urokinase injection-assisted vitrectomy in early treatment of suprachoroidal hemorrhage: Four cases report

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World Journal of Clinical Cases 2018年第15期6卷 1059-1066页

作者： Fang chai hua ai Jin Deng Xi-Quan Zhao Xi'an No.4 Hospital Shaanxi Ophthalmic Medical Center Affiliated Guangren Hospital School of Medicine Xi'an Jiaotong University

BACKGROUND Suprachoroidal hemorrhage(SCH) is a rare but potentially catastrophic ocular event. Surgery for SCH is often challenging because of the difficulty in resolving the retinal and choroidal detachment. Here, we describe a novel surgical technique in which urokinase is administered by sub-Tenon's injection to target an organized clot in SCH prior to *** SUMMARY A consecutive case series of four eyes with serous and hemorrhagic choroidal detachments secondary to cataract surgery or trauma was documented to evaluate the feasibility of using a sub-Tenon's urokinase injection-assisted 23-gauge and 20-gauge incision to drain choroidal detachments. Urokinase(2000 IU) was given by sub-Tenon's injection one day before surgery for clot liquefaction. A 23-gauge infusion line was placed in the anterior chamber. A 20-gauge incision was created in the suprachoroidal space 3.5 mm from the limbus. After drainage, pars plana vitrectomy was performed because of concomitant pathology that demanded this additional procedure. Visual acuity, ocular findings, the timing of surgical interventions, surgical procedures, and outcomes were retrospectively reviewed in four patients. Postoperative follow-up of the patients ranged from 6 to 24 mo(mean, 13 mo). After the treatment, all patients achieved excellent anatomical recovery. CONCLUSION Sub-Tenon's urokinase injection-assisted vitrectomy makes clot liquefaction happen in the early treatment stage, resulting in marked stability during the procedure.

关键词： Urokinase Suprachoroidal hemorrhage Choroidal detachments Vitrectomy Case report

Ultrasensitive assay of ctDNA based on DNA triangular prism and three-way junction nanostructures

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Chinese Chemical Letters 2021年第2期32卷 783-786页

作者： hua chai Peng Miao Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhou 215163China Jinan Guokeyigong Science and Technology Development Co. Ltd.Ji'nan 250103China

Circulating tumor DNA(ctDNA) refers to a class of acellular nucleic acids carrying genetic features of primary tumor,which can be regarded as a promising noninvasive biomarker for cancer *** development of ctDNA assay is an important component of liquid *** this study,we have fabricated a novel electrochemical strategy for ultrasensitive detection of ctDNA combining the merits of strand displacement amplification and DNA *** DNA triangular prism is firstly selfassembled and modified on the electrode *** target initiated strand displacement polymerization reaction,the generated DNA product helps the formation of three-way junction nanostructure on triangular prism,which localizes electrochemical *** carefully investigating the electrochemical responses,the limit of detection(LOD) for ctDNA assay as low as 48 amol/L is *** proposed electrochemical biosensor shows great potential for clinical applications.

关键词： Circulating tumor DNA Biosensor DNA triangular prism DNA three-way junction Strand displacement polymerization

High-fidelity trajectory optimization for aeroassisted vehicles using variable order pseudospectral method

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Chinese Journal of Aeronautics 2021年第1期34卷 237-251页

作者： Runqi chai Antonios TSOURDOS ai SAVVARIS Senchun chai Yuanqing XIA School of Aerospace Transport and ManufacturingCranfield UniversityBedfordshire MK43OALUnited Kingdom School of Automation Beijing Institute of TechnologyBeijing 100081China

In this study,the problem of time-optimal reconnaissance trajectory design for the aeroassisted vehicle is *** from most works reported previously,we explore the feasibility of applying a high-order aeroassisted vehicle dynamic model to plan the optimal flight trajectory such that the gap between the simulated model and the real system can be narrowed.A highly-constrained optimal control model containing six-degree-of-freedom vehicle dynamics is *** solve the formulated high-order trajectory planning model,a pipelined optimization strategy is *** approach is based on the variable order Radau pseudospectral method,indicating that the mesh grid used for discretizing the continuous system experiences several adaption *** of such a strategy can potentially smooth the flight trajectory and improve the algorithm convergence *** simulations are reported to demonstrate some key features of the optimized flight trajectory.A number of comparative studies are also provided to verify the effectiveness of the applied method as well as the high-order trajectory planning model.

关键词： Aeroassisted vehicle High-order Radau pseudospectral method Six-degree-of-freedom Trajectory design Variable order

Impulse-coupling coefficients from a pulsed-laser ablation of semiconductor GaAs

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Nuclear Science and Techniques 2006年第4期17卷 217-221页

作者： LIU ai-hua College of Physics and Electronics Shandong Normal University Jinan 250014 China

Impulse-coupling coefficients from 1.06 - μ m, 10-ns Nd:YAG pulsed-laser radiation to GaAs targets with different areas were measured using the ballistic pendulum method in the laser power density ranging from 4.0 × 108 to 5.0 × 109 W·cm-2. A detonation wave model of the plasma was established theoretically. The expansion process of plasma after the laser pulse ends is described in detail, and the impulse-coupling coefficients from pulsed laser with different energies to GaAs with different areas were calculated using the given model. It is found that the theoretical results agree well with the experimental data.

关键词：激光-材料相互作用冲击式联接镓砷半导体激光爆破

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD^(+)synthesis by reprogramming H3K79 methylation in uveal melanoma

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Journal of Pharmaceutical Analysis 2023年第1期13卷 24-38页

作者： Xiang Gu Yu hua Jie Yu Ludi Yang Shengfang Ge Renbing Jia Peiwei chai ai Zhuang Xianqun Fan Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

Uveal melanoma(UM)is the most frequent and life-threatening ocular malignancy in *** histone methylation contributes to the abnormal transcriptome during ***,a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains ***,using a systematic epi-drug screening and a high-throughput transcriptome profiling of histone methylation modifiers,we observed that disruptor of telomeric silencing-1-like(DOT1L),a methyltransferase of histone H3 lysine 79(H3K79),was activated in UM,especially in the high-risk ***,a systematic epi-drug library screening revealed that DOT1L inhibitors exhibited salient tumor-selective inhibitory effects on UM cells,both in vitro and in *** Cleavage Under Targets and Tagmentation(CUT&Tag),RNA sequencing(RNA-seq),and bioinformatics analysis,we identified that DOT1L facilitated H3K79 methylation of nicotinate phosphoribosyltransferase(NAPRT)and epigenetically activated its ***,NAPRT served as an oncogenic accelerator by enhancing nicotinamide adenine dinucleotide(NAD^(+))***,DOT1L inhibition epigenetically silenced NAPRT expression through the diminishment of dimethylation of H3K79(H3K79me2)in the NAPRT promoter,thereby inhibiting the malignant behaviors of ***,our findings delineated an integrated picture of the histone methylation landscape in UM and unveiled a novel DOT1L/NAPRT oncogenic mechanism that bridges transcriptional addiction and metabolic reprogramming.

关键词： Histone methylation Metabolic reprogramming Uveal melanoma Transcriptional addiction

Function Projective Lag Synchronization of Chaotic Systems with Certain Parameters via Adaptive-impulsive Control

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International Journal of Automation and computing 2019年第2期16卷 238-247页

作者： Xiu-Li chai Zhi-hua Gan Institute of Image Processing and Pattern Recognition Henan University Institute of Intelligent Network System School of SoftwareHenan University

A new method is presented to study the function projective lag synchronization(FPLS) of chaotic systems via adaptive-impulsive control. To achieve synchronization, suitable nonlinear adaptive-impulsive controllers are designed. Based on the Lyapunov stability theory and the impulsive control technology, some effective sufficient conditions are derived to ensure the drive system and the response system can be rapidly lag synchronized up to the given scaling function matrix. Numerical simulations are presented to verify the effectiveness and the feasibility of the analytical results.

关键词： Function projective lag synchronization (FPLS) adaptive-impulsive chaotic systems numerical simulation Lyapunov stability theory

Reachable set modeling and engagement analysis of exoatmospheric interceptor

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Chinese Journal of Aeronautics 2014年第6期27卷 1513-1526页

作者： chai hua Liang Yangang Chen Lei Tang Guojin College of Aerospace Science and Engineering National University of Defense Technology

A novel reachable set（RS） model is developed within a framework of exoatmospheric interceptor engagement analysis. The boost phase steering scheme and trajectory distortion mechanism of the interceptor are firstly explored. A mathematical model of the distorted RS is then formulated through a dimension–reduction analysis. By treating the outer boundary of the RS on sphere surface as a spherical convex hull, two relevant theorems are proposed and the RS envelope is depicted by the computational geometry theory. Based on RS model, the algorithms of intercept window analysis and launch parameters determination are proposed, and numerical simulations are carried out for interceptors with different energy or launch points. Results show that the proposed method can avoid intensive on-line computation and provide an accurate and effective approach for interceptor engagement analysis. The suggested RS model also serves as a ready reference to other related problems such as interceptor effectiveness evaluation and platform disposition.

关键词： Engagement analysis Flight dynamics Interception Reachable set Spherical convex hull

Online Scheduling on Bounded Batch Machines to Minimize the Maximum Weighted Completion Time

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Journal of the Operations Research Society of China 2018年第3期6卷 455-465页

作者： Wen-hua Li Xing chai School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Financial Engineering Zhengzhou 450001China

We investigate the online scheduling problem on identical parallel-batch machines to minimize the maximum weighted completion *** this problem,jobs arrive over time and the processing times(of the jobs)are identical,and the batch capacity is *** this problem,we provide a best possible online algorithm with a competitive ratio of(√5+1)/***,when restricted to dense-algorithms,we present a best possible dense-algorithm with a competitive ratio of 2.

关键词： Scheduling Online algorithms Maximum weighted completion time Competitive ratio

Bounded Tiles in ■_p are Compact Open Sets

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Acta Mathematica Sinica,English Series 2020年第2期36卷 189-195页

作者： ai hua FAN Shi Lei FAN LA MFA UMR 7352 CNRSUniversity of Picardie33 rue Saint Leu80039 AmiensFrance School of Mathematics and Statistics&Hubei Key Laboratory of Mathematical Sciences Central China Normal UniversityWuhan430079P.R.China

Any bounded tile of the field Qp of p-adic numbers is a compact open set up to a set of zero Haar *** this note,we present two simple and direct proofs of this fact.

关键词： p-adic field tile bounded compact open