检索结果-南通市图书馆

Differential and Reciprocal Regulation between Hypoxia-inducible Factor-αSubunits and Their Prolyl Hydroxylases in Pulmonary Arteries of Rat with Hypoxia-induced Hypertension

引用

Acta Biochimica et Biophysica Sinica 2006年第6期38卷 423-434页

作者： Yun-Rong CHEN~&,ai-guo Dai~*,Rui-cheng HU,and Yong-Liang JIANGDepartment of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410001,China Department of Respiratory Medicine Hunan Institute of Gerontology Hunan Province Geriatric HospitalChangsha 410001 China

Hypoxia-inducible factor (HIF)-α subunits (HIF-1α,HIF-2α and HIF-3α),which play a pivotalrole during the development of hypoxia-induced pulmonary hypertension (HPH),are regulated through post-U’anslational hydroxylation by their three prolyl hydroxylase domain-containing proteins (PHD 1,PHD2 and PHD3).PHDs could also be regulated by *** differential and reciprocal regulation between HIF-α and PHDs duringthe development of HPH remains *** investigate this problem,a rat HPH model was *** arterial pressure increased significantly after 7 d of *** artery remodeling indexand right ventricular hypertrophy became evident after 14 d of ***-1α and HIF-2α mRNA increasedslightly after 7 d of hypoxia,but HIF-3α increased significantly after 3 d of *** protein expressionlevels of all three HIF-α were markedly upregulated after exposure to ***2 mRNA and proteinexpression levels were upregulated after 3 d of hypoxia;PHD 1 protein declined after 14 d of hypoxia withoutsignificant mRNA ***3 mRNA and protein were markedly upregulated after 3 d of hypoxia,then themRNA remained at a high level,but the protein declined after 14 d of *** hypoxic animals,HIF-lotproteins negatively correlated with PHD2 proteins,whereas HIF-2α and HIF-3α proteins showed negativecorrelations with PHD3 and PHD 1 proteins,*** three HIF-α proteins were positively correlatedwith PHD2 and PHD3 *** the present study,HIF-α subunits and PHDs showed differential andreciprocal regulation,and this might play a key pathogenesis role in hypoxia-induced pulmonary hypertension.

关键词： hypoxia-inducible factor prolyl hydroxylase hypertension pulmonary hydroxylation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High serum lactate dehydrogenase and dyspnea:Positive predictors of adverse outcome in critical COVID-19 patients in Yichang

引用

World Journal of Clinical Cases 2020年第22期8卷 5535-5546页

作者： Xiao-Ting Lv Yong-Ping Zhu ai-guo cheng Yong-Xu Jin Hai-Bo Ding Cai-Yun Wang Shu-Yu Zhang Gong-Ping Chen Qing-Quan Chen Qi-Cai Liu Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Institute of Respiratory Disease Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Cardiovascular Surgery Fujian Medical University Attached Union HospitalFuzhou 350001Fujian ProvinceChina Department of Critical Medicine the Third People's Hospital of YichangYichang 443000Hubei ProvinceChina Department of Laboratory Medicine Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina Department of Reproductive Medicine Centre First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreak in China,constitutes a Public Health Emergency of International *** is well known that COVID-19 patients may have increased serum lactate dehydrogenase(LDH)levels in the early *** clinical changes in LDH may have predictive value in disease evolution and prognosis in critically ill COVID-19 *** To examine serum LDH and clinical characteristics in patients with COVID-19 and their predictive value for *** This retrospective study analyzed the clinical data of forty-seven critical COVID-19 patients in the intensive care unit of the Third People's Hospital of Yichang City from January 27 to March 25,2020 and divided them into survivors and *** patients were diagnosed according to the World Health Organization interim guidance and critical cases met any one of the following criteria:Respiratory failure and required mechanical ventilation,the occurrence of shock,and the combined failure of other organs that required intensive care unit monitoring and treatments,according to the diagnostic criteria of critical *** data including symptoms,detection of SARS-CoV-2,chest computed tomography(CT)images,changes in serum LDH in different clinical phases,and prognosis were *** analysis of the data was *** variables were expressed as median(interquartile range)and compared with the Mann-Whitney U *** variables were compared with the Chi-square *** data were analyzed using Kaplan-Meier survival curves and log-rank *** According to chest CT images,we observed the alveolitis and fibrosis stages in all critical patients in this *** non-survivors died in the fibrosis *** had fewer days of hospitalization,shorter disease duration,shorter duration of alveolitis and fibrosis,and had dyspnea symptoms at disease onset

关键词： COVID-19 SARS-CoV-2 Lactate dehydrogenase Pulmonary fibrosis Dyspnea Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

引用

Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin Bai Xiaodong Li Peng ai Wanrong guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Exendin-4结构的稳定性及其微球制备

引用

中国生物制品学杂志 2009年第10期22卷 993-997页

作者：艾国单成启程远国军事医学科学院微生物流行病研究所药物代谢动力学实验室北京100071

目的分析影响Exendin-4二级结构稳定性的各种因素,并制备Exendin-4微球。方法利用远紫外圆二色光谱(Circular dichroism,CD)技术,分析pH值、温度、高速搅拌、油水界面对Exendin-4二级结构的影响及冰浴和蛋白质保护剂对其二级结构的保护... 详细信息

目的分析影响Exendin-4二级结构稳定性的各种因素,并制备Exendin-4微球。方法利用远紫外圆二色光谱(Circular dichroism,CD)技术,分析pH值、温度、高速搅拌、油水界面对Exendin-4二级结构的影响及冰浴和蛋白质保护剂对其二级结构的保护作用。在此基础上,选用乳酸-羟基乙酸共聚物(PLGA)为成球材料,采用复乳法(W/O/W)制备Exendin-4微球,并对其理化性质进行评价。结果优化了实现Exendin-4二级结构稳定性的药剂学方法。制备的Exendin-4微球流动性良好,球形圆整,平均粒径为(25.3±3.2)μm,结构保持完好,微球的载药量约为1.0%,包封率为72.3%±2.4%,微球的释药曲线符合Higuchi释放模型,未发生明显的突释,具有良好的缓释效果。结论采取适当的药剂学方法,可以保证Exendin-4结构的稳定性并制备出理化性质合格的微球。

关键词： Exendin-4 二级结构稳定性圆二色光谱乳酸-羟基乙酸共聚物微球

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

谷氨酰胺对饥饿大鼠内毒素移位和肠黏膜免疫功能的影响

引用

世界华人消化杂志 2006年第20期14卷 1982-1986页

作者：张小平程爱国陈玉红华北煤炭医学院附属医院麻醉科河北省唐山市063000 华北煤炭医学院附属医院骨外科河北省唐山市063000 华北煤炭医学院附属医院骨外科研究生河北省唐山市063000

目的：探讨饥饿后大鼠肠黏膜形态学结构的变化规律,并动态观察GLN肠内补充对饥饿大鼠内毒素移位和肠黏膜免疫功能的影响.方法：采用饥饿大鼠模型,将90只3月龄♂SD大鼠随机分为正常对照组N：(给予正常饮食n =10)、饥饿组A(n=40)、谷氨酰... 详细信息

目的：探讨饥饿后大鼠肠黏膜形态学结构的变化规律,并动态观察GLN肠内补充对饥饿大鼠内毒素移位和肠黏膜免疫功能的影响.方法：采用饥饿大鼠模型,将90只3月龄♂SD大鼠随机分为正常对照组N：(给予正常饮食n =10)、饥饿组A(n=40)、谷氨酰胺组B(n= 40)3个大组,分别于饥饿后3,5,7,9d,取门静脉血测血浆内毒素的变化,在光镜下观察肠组织的组织形态学改变,利用免疫组化技术检测肠黏膜组织中SIgA的表达和CD4^+、CD8^+T细胞的数量.结果：A组大鼠饥饿后,3d可见小肠黏膜明显萎缩,绒毛变短、变稀.部分黏膜上皮细胞变性、坏死、脱落,绒毛横径增宽,高度缩短；至饥饿后9d上述变化更加明显.B组在饥饿后3d较同时间点A组肠黏膜损伤有明显的改善,小肠的黏膜厚度、绒毛数量、高度增加,至饥饿后5d基本恢复至N组水平.随着饥饿时间的延长小肠黏膜再次出现黏膜萎缩、绒毛变短、变稀,黏膜上皮细胞变性、坏死、脱落.但明显轻于同时间点的A组.饥饿后各时间点血浆内毒素与N组相比明显升高,A,B组均在饥饿后7d达到高峰,B组在饥饿后3,5,7,9d较A组降低且有非常显著性差异(322.4±65.1,389.4±32.6,464.4±76.6,413.7±67.2EU/L vs 527.1±74.9,546.3±65.7,623.9±85.9,587.5±140.8EU/L,均P＜0.01).与N组比较,A组大鼠肠黏膜SIgA及CD4^+,CD8^+T细胞数量明显减少,差异有显著性性(P＜0.05,P＜0.01).补充GLN后,SIgA及CD4^+,CD8^+T细胞数量明显升高,B组与A组比较差异非常显著(P＜0.01).结论：大鼠饥饿后早期确有肠黏膜组织结构受损,发生内毒素移位,同时伴有肠黏膜免疫学屏障受损.早期给予GLN可减轻肠黏膜的受损,明显降低内毒素移位,增强肠黏膜的免疫功能发挥肠黏膜的保护作用.

关键词：饥饿谷氨酰胺内毒素移位肠黏膜屏障

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

氨基胍对饥饿大鼠肠道胆碱能神经元及肠动力功能的保护

引用

世界华人消化杂志 2010年第8期18卷 825-829页

作者：陆之辉张小平程爱国唐山工人医院麻醉科河北省唐山市063000 华北煤炭医学院附属医院麻醉科河北省唐山市063000 华北煤炭医学院附属医院骨外科河北省唐山市063000

目的:观察饥饿大鼠肠道胆碱能神经元和肠传输功能的变化,探讨氨基胍对肠动力功能保护的神经机制.方法:90只♂SD大鼠随机分为正常对照组(C组,n=10)、全饥饿组(S组,n=40)和氨基胍(aminoguanidine AG)组(A组,n=40),S、A组随机分为饥饿3、5... 详细信息

目的:观察饥饿大鼠肠道胆碱能神经元和肠传输功能的变化,探讨氨基胍对肠动力功能保护的神经机制.方法:90只♂SD大鼠随机分为正常对照组(C组,n=10)、全饥饿组(S组,n=40)和氨基胍(aminoguanidine AG)组(A组,n=40),S、A组随机分为饥饿3、5、7、9d亚组(n=10).A组给予AG150mg/(kg·d)腹腔注射.采用葡聚糖蓝染色法测定各组肠道色素推进比率,AchE组织化学染色法测定各组回肠肌间神经丛胆碱能神经元分布密度.结果:S、A组各时间点肠道色素推进率较对照组明显降低(P<0.05或0.01),并随饥饿时间延长呈进行性下降,均于9d达最低点,A组在饥饿后3、5、7d较S组高且有显著性差异(52.2%±4.7%,49.8%±5.6%,43.3%±6.4%vs47.5%±4.2%,42.3%±5.4%,36.6%±5.2%,均P<0.05),饥饿后9dA组较S组无显著差异.S、A组各时间点胆碱能神经元分布密度较对照组明显降低(P<0.01),并随饥饿时间延长呈进行性下降,均于9d达最低点,A组在饥饿后5、7d较S组高且有显著性差异(均P<0.05),饥饿后3、9dA组较S组无显著差异.结论:饥饿后早期给予氨基胍能够一定程度减轻肠胆碱能神经元损伤,改善肠传输功能,发挥肠神经保护作用.

关键词：饥饿氨基胍肠神经系统胆碱能神经元胃肠动力

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of SUMOylation of hypoxia-inducible factor-1 alpha by SUMO-1 in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension

The role of SUMOylation of hypoxia-inducible factor-1 alpha ...

引用

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Hua TIAN,ai-guo Dai,Rui-cheng HU,Li-Ming ZHU Department of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410016,China

＜正＞Hypoxia-inducible factor-1 alpha（HIF-1α） plays a pivotal role in the development of hypoxia-induced pulmonary hypertension（HPH） through transactiviating its target *** small ubiquitin-related modifier-1 （SUMO-1） is an 11.5 kDa ubiquitin-related protein that is 18%identical to ***-1 protein is up-regulated in response to *** increased levels of SUMO-1 participate in the modulation of HIF-1αfunction through *** the role of the SUMOylation of HIF-1αby SUMO-1 during the development of HPH remains *** investigate this,a HPH rat model was *** pulmonary arterial pressure increased significantly after 7 d of *** artery remodeling index became evident after 7 d of hypoxia,while the right ventricular hypertrophy index became significant after 14 d of *** messenger RNA（mRNA） and protein expression of HIF-1αand VEGF,a well-characterized target gene of HIF-1α,were markedly up-regulated after exposure to hypoxia in tunica intima and tunica media of pulmonary *** messenger RNA（mRNA） and protein expression of SUMO-1 increased after exposure to hypoxia in lung tissues especially in pulmonary arterial *** also detected the specific interaction between SUMO-1 and HIF-1αwas increased significantly after 3 d of hypoxia and increased further as the duration of hypoxia prolonged with *** hypoxic rats,the expression levels of interacted complexes of SUMO-1/HIF-1αshowed significant positive correlation with the mRNA and protein expression of HIF-1αand *** they were positively correlated with Mean pulmonary arterial pressure,pulmonary artery remodeling index and right ventricular hypertrophy index *** together,our results suggest that,in lung tissues especially in pulmonary arteries of rat exposed to moderate hypoxia,SUMOylation of HIF-1αby SUMO-1 may contribute to the development of rat HPH by increases HIF-1αstability and enhancing the transactivation of HIF-1αta

关键词： hypoxia-inducible factor-1 αsubunit small ubiquitin-related modifier-1(SUMO-1) hypertension pulmonary

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Recent progress on photoactive nonprecious transition-metal complexes

引用

Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang Yan cheng Jianxun Liu Yuhan ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Positive correlation between PPARγ,PGC-1αandγ-GCS in lungs of rats and patients with chronic obstructive pulmonary disease

Positive correlation between PPARγ,PGC-1αandγ-GCS in lung...

引用

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Jie LI,ai-guo Dai,Rui-cheng HU,Li-Ming ZHU,Shuang-Xiang TAN Department of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410016,China

＜正＞Oxidative stress is one of the major pathogenesis of chronic obstructive pulmonary disease（COPD）.γ-Glutamylcysteine synthetase（γ-GCS） is one of the paramount antioxidant enzymes in *** proliferatoractivated receptor gamma（PPARγ） is a ligand-activated transcription factor,which is activated by specific ligands such as rosiglitazone（RGZ）,exerting multiple biological ***γcoactivator-1α（PGC-1α） is a PPARγcoactivator, which binds to PPARγby induction of PPARγligands,co-activating PPARγtarget *** evidence has suggested that PPARγ/PGC-1αcan regulate multiple antioxidant ***,the effect of PPARγ/ PGC-1αonγ-GCS during the development of COPD remains unclear *** measured the expression levels of PPARγ,PGC-1αandγ-GCS,γ-GCS activity and reactive oxygen species（ROS） contents in lungs of rats treated by cigarette smoke（CS）+lipopolysaccharide（LPS） and CS+LPS+RGZ,as well as lungs of patients suffering from *** with lungs from CS+LPS-treated rats,lungs of RGZ-treated rats demonstrated markedly lower ROS contents,and remarkable increase ofγ-GCS activity and increase of the expression levels of PPARγ,PGC-1αandγ-***,compared with controls,expression levels of PPARγ,PGC-1αandγ-GCS significantly increased in lungs of mild COPD patients,and progressively decreased in lungs of patients with moderate and severe COPD.γ-GCS protein was positively correlated with FEV1%.PPARγand PGC-1αproteins were positively correlated withγ-GCS activity and mRNA *** conclusion,γ-GCS showed compensatory up-regulation in the early stage of COPD,which progressively decompensate with increasing COPD *** activation of the PPARγ/PGC-1αpathway may protect against COPD progression by up-regulatingγ-GCS and relieving oxidative stress.

关键词： peroxisome proliferator-activated receptor gamma peroxisome proliferator-activated receptorγcoactivator-1 γ-glutamylcysteine synthetase chronic obstructive pulmonary disease

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Expression and role of factor inhibiting hypoxia-inducible factor-1 in pulmonary arteries of rat with hypoxia-induced hypertension

Expression and role of factor inhibiting hypoxia-inducible f...

引用

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Dai-Yan FU,ai-guo Dai,Rui-cheng HU,Yun-Chong CHEN,Li-Ming ZHU Department of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410016,China

＜正＞Hypoxia-inducible factor-1（HIF-1） plays a pivotal role during the development of hypoxia-induced pulmonary hypertension（HPH） through transactiviating target *** inhibiting HIF-1（FIH）,as an oxygen-sensitive attenuator,hydroxylates a conserved asparagines residue within the C-terminal transactivation domain（CTAD） of HIF-1αunder normoxia and moderate *** protein is down-regulated in response to *** dynamic expression and role of FIH during the development of HPH remain *** investigate this,a HPH rat model was *** pulmonary arterial pressure（mPAP） increased significantly after 7d of hypoxia. Pulmonary artery remodeling index became evident after 7 d of hypoxia,while right ventricular hypertrophy became significant after 14 d of *** mRNA and protein expression of HIF-1 and VEGF,a well-characterized target gene of HIF-1αwere markedly up-regulated after exposure to hypoxia in tunica intima and tunica media of pulmonary *** protein,in pulmonary arterial walls,declined after 7 d of hypoxia and lessened further as the duration of hypoxia *** mRNA had little changes after exposure to hypoxia compared with normoxia. In hypoxic rats,HIF-1αmRNA,HIF-1αprotein,VEGF mRNA and VEGF protein were positively correlated with mPAP,pulmonary artery remodeling index and *** protein showed significant negative correlations with VEGF mRNA and VEGF *** protein was negatively correlated with mPAP,pulmonary artery remodeling index and *** together,our results suggest that in the pulmonary arteries of rat exposed to moderate hypoxia,a time-dependent decrease in FIH protein may contribute to development of rat HPH through enhancing the transactivation of HIF-1αtarget genes such as VEGF.

关键词： hypoxia-inducible factor-1 factor inhibiting hypoxia-inducible factor-1 asparaginl hydroxylase hypertension pulmonary

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：