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Molecular mechanism of noradrenaline during the stress-induced major depressive disorder

Neural Regeneration Research 2018年第7期13卷 1159-1169页

作者： Kenjiro Seki Satomi yoshida Manoj Kumar Jaiswal Department of Pharmacology School of Pharmaceutical ScienceOhu University Department of Psychiatry Icahn School of Medicine at Mount Sinai

Chronic stress-induced depression is a common hallmark of many psychiatric disorders with high morbidity ***-induced dysregulation of noradrenergic system has been implicated in the pathogenesis of *** of monoamine in the brain has been believed to be the main causative factor behind pathophysiology of major depressive disorder（MDD） and several antidepressants functions by increasing the monoamine level at the synapses in the ***,it is undetermined whether the noradrenergic receptor stimulation is critical for the therapeutic effect of *** to noradrenergic receptor stimulation,it has been suggested that the desensitization of β-adrenoceptor is involved in the therapeutic effect of *** addition,enhanced noradrenaline（NA） release is central response to stress and thought to be a risk factor for the development of ***,fast acting antidepressant suppresses the hyperactivation of noradrenergic neurons in locus coeruleus（LC）.However,it is unclear how they alter the firing activity of LC *** inconsistent reports about antidepressant effect of NA-reuptake inhibitors（NRIs） and enhanced release of NA as a stress response complicate our understanding about the pathophysiology of *** this review,we will discuss the role of NA in pathophysiology of stress and the mechanism of therapeutic effect of NA in *** will also discuss the possible contributions of each subtype of noradrenergic receptors on LC neurons,hypothalamic-pituitary-adrenal axis（HPA-axis） and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress and therapeutic effect of NRIs in MDD.

关键词： major depression stress noradrenaline noradrenaline-reuptake inhibitors serotonin receptors hypothalamic-pituitary-adrenal axis locus coeruleus selective serotonin reuptake inhibitors serotonin noradrenaline-reuptake inhibitors

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Novel environmentally friendly inorganic red pigments based on calcium bismuth oxides

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Journal of Advanced Ceramics 2015年第1期4卷 39-45页

作者： WENDUSU Tetsuro yoshida Toshiyuki MASUI Nobuhito IMANAKA Department of Applied Chemistry Faculty of EngineeringOsaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Novel environmentally friendly inorganic red pigments based on calcium bismuth oxide Ca3(Bi1-xREx)8O15(0≤x≤0.09;RE=Sc^(3+),Er^(3+),Y^(3+),Ho^(3+)and Dy^(3+)),were successfully synthesized and the color properties were *** color of these pigments depended on the composition and the synthesis condition,and the most vivid red color was obtained for the Ca3(Bi0.93Y0.07)8O15 sample calcined thrice at 800℃for 2 *** L*and a*values corresponding to brightness and red chromaticity for this pigment were 45.6 and+30.6,respectively,which were greater than those of a commercially available Fe2O3 pigment(L^(*)=38.4,a^(*)=+29.5).Since the present pigment is composed of nontoxic and safe elements,it should be an attractive alternative to the conventional Fe2O3 pigment.

关键词： calcium bismuth oxide environmentally friendly red pigment solid solution cation complexation method

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Brown slits for colorectal adenoma crypts on conventional magnifying endoscopy with narrow band imaging using the X1 system

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World Journal of Gastroenterology 2022年第24期28卷 2748-2757页

作者： Osamu Toyoshima Toshihiro Nishizawa Shuntaro yoshida Hidenobu Watanabe Nariaki Odawara Kosuke Sakitani Toru Arano Hirotoshi Takiyama Hideyuki Kobayashi Hirofumi Kogure Mitsuhiro Fujishiro Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalChiba 286-8520Japan Department of Pathology Pathology and Cytology Laboratory JapanTokyo 166-0003Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Sakitani Endoscopy ClinicChiba 275-0026Japan Department of Gastroenterology The Fraternity Memorial HospitalTokyo 130-8587Japan Department of Surgical Oncology The University of TokyoTokyo 113-8655Japan Department of Internal Medicine Umegaoka Ekimae ClinicTokyo 154-0022Japan

BACKGROUND Accurate diagnosis of colorectal premalignant polyps,including adenomas,is vital in clinical *** To investigate the diagnostic yields of novel findings of brown slits for *** Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic were *** sized≥5 mm suspected of adenomas or clinically significant serrated polyps were included in the *** defined the surface structures of colorectal polyps,which were brown curves inside and along the tubular glands identified using a combination of a new X1 system(Olympus Corporation)and a conventional magnifying colonoscope with non-staining narrow band imaging(NBI),as brown *** brown slits corresponded to slit-like lumens on endocytoscopy and histological crypt openings of an *** evaluated the diagnostic performance of brown slits for *** A total of 108 Lesions from 62 patients were *** average age was 60.4 years and 41.9%were *** mean polyp size was 7.45±2.83 ***-seven lesions were positive for brown *** diagnosis comprised 59 low-grade tubular adenomas,16 sessile serrated lesions,and 33 hyperplastic *** 59 adenomas,56(94.9%)were positive for brown *** 16 sessile serrated lesions,0(0%)was positive for brown *** 33 hyperplastic polyps,1(3.0%)was positive for brown *** sensitivity,specificity,and accuracy of brown slits for adenoma were 94.9%,98.0%,and 96.3%,*** positive predictive value and negative predictive value of brown slits for adenoma were also excellent for 98.2%,and 94.1%,*** Brown slits on conventional magnifying endoscopy with non-staining NBI using the X1 system were useful for diagnosing colorectal *** new endoscopy system could be examined using new standards.

关键词： Adenoma Colonoscopy Narrow band imaging Magnifying endoscopy X1 Serrated polyp Colorectal neoplasm Endocytoscopy

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Usefulness of intraoperative Indocyanine green video angiography to select the recipient artery for bypass surgery in arteriosclerotic occlusion of the middle cerebral artery: a technical case report

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Chinese Neurosurgical Journal 2018年第3期4卷 173-176页

作者： Hiroaki Matsumoto Yasuhisa yoshida Department of Neurosurgery Cerebrovascular Research InstituteEishokai Yoshida HospitalDaikai-dori9-2-6Hyogo-kuKobe 652-0803Japan

Background: In superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass surgery, indocyanine green video angiography (ICG-VA) is usually used to verify bypass patency. Less-commonly reported is the ability to use this technique to evaluate candidate recipient vessels based on either collateral flow or identification of the distal branch of interest. Case presentation: An 82-year-old man presented with progressive cerebral infarction due to infarction of the M2 inferior trunk of the right middle cerebral artery. He underwent superficial temporal artery-middle cerebral artery bypass to prevent further ischemia 1 week after the initial stroke. In the surgery, M4 cortical arteries fed by the inferior trunk could not be identified as recipient arteries. Intraoperative ICG-VA showed delayed luminescence of some M4 arteries. Because the M4 arteries fed by the inferior trunk showed delayed retrograde flows from the anterior cerebral artery on preoperative digital subtraction angiography, the M4 arteries with delayed luminescence on ICG-VA were considered to be M4 arteries fed by the inferior trunk and selected as the recipient arteries. Conclusions: ICG-VA shows differences in flow speed as delayed luminescence. This finding may be useful for detecting target vessels.

关键词： Indocyanine green video angiography Recipient artery Superficial temporal artery-middle cerebral artery bypass

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Evolutionary Origin of JAZ Proteins and Jasm onate Signaling

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Molecular Plant 2019年第2期12卷 153-155页

作者： Gregg A. Howe Yuki yoshida DOE Plant Research Laboratory Michigan State University East Lansing Ml 48824 USA Department of Biochemistry and Molecular Biology Michigan State University East Lansing Ml 48824 USA Plant Resilience Institute Michigan State University East Lansing Ml 48824 USA Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan

The many roles of jasmonate in plant growth, reproduction, and defense raise interesting questions about how this lipid-derived hormone emerged during evolution. Recent studies indicate that a uhigher plant*5 pathway involving jasmonoyl-L-isoleucine (JA-lle) as the receptor-active ligand is conserved in vascular plants (Bowman et al., 2017;Howe et al., 2018). Within this core sign aling pathway, J AZ protei ns link JA-lle perception to changes in the activity of MYC transcription factors (TFs)(Figure 1) and have emerged as a conserved hub for crosstalk in hormone response pathways.

关键词： Evolutionary Origin JAZ Proteins Jasm onate Signaling

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Transileocolic endovascular treatment by a hybrid approach for severe acute portal vein thrombosis with bowel necrosis:Two case reports

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World Journal of Clinical Cases 2022年第6期10卷 1876-1882页

作者： Sayaka Shirai Tatsuo Ueda Fumie Sugihara Daisuke Yasui Hidemasa Saito Hiroyasu Furuki Shiei Kim Hiroshi yoshida Shoji Yokobori Hiromitsu Hayashi Shin-ichiro Kumita Department of Radiology Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Radiology Nippon Medical School Musashi Kosugi HospitalKawasaki-shi 211-8533KanagawaJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School Tamanagayama HospitalTama-shi 206-8512TokyoJapan Department of Emergency and Critical Care Medicine Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School HospitalBunkyo-ku 113-8603TokyoJapan

BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality *** report describes the successful endovascular treatment(EVT)of two patients with severe *** SUMMARY The first patient was a 22-year-old man who presented with abdominal pain lasting 3 *** second patient was a 48-year-old man who presented with acute abdominal *** contrast-enhanced computed tomography,both patients were diagnosed with massive PVT extending to the splenic and superior mesenteric *** treatment(simultaneous necrotic bowel resection and EVT)was performed in a hybrid operating room(OR).EVTs,including aspiration thrombectomy,catheter-directed thrombolysis(CDT),and continuous CDT,were performed via the ileocolic vein under *** portal veins were patent 4 and 6 mo posttreatment in the 22-year-old and 48-year-old patients,*** Hybrid necrotic bowel resection and transileocolic EVT performed in a hybrid OR is effective and safe.

关键词： Bowel necrosis Endovascular treatment Hybrid operating room Hybrid treatment Portal vein thrombosis Transileocolic approach Case report

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In Vivo Observation of Allergic Dermatitis of the Genuine Pig by Optical Coherence Tomography

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Modern Research in Inflammation 2022年第1期11卷 1-8页

作者： Masato Ohmi Yuki yoshida Yoken Son Kohji Abe Course of Allied Health Science Graduate School of Medicine Osaka University Suita Japan Shionogi & Co. Ltd. Toyonaka Japan

In order to understand pathogenic mechanism of allergic dermatitis, it is important to find morphological changes of the internal structure of the skin by non-invasive imaging. Optical coherence tomography (OCT) is powerful tool for in vivo tomographic imaging of the internal microstructure in biological tissue. In this study, we prepared the animal model of genuine pig with allergic dermatitis developed by chemical administration to examining their skin inflammation by microscopic observations with OCT images captured continuously, aiming at tracking the morphological changes in the skin structure induced by the chronological inflammation. As a result, epidermis thickening became evident as the days passed since Day 7, and the capillary vessel expansion was confirmed since Day 14;the process of inflammation development was successfully observed.

关键词： OCT Allergic Dermatitis In Vivo Observation Thickening of Epidermis

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Evaluating the Effects of Crystallinity on Drug Release Behaviour in Itraconazole- or Miconazole-Loaded PLGA Microparticles Prepared Using a Co-Grinding Method

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Pharmacology & Pharmacy 2023年第9期14卷 348-362页

作者： Kazuhiro Matsuura Honami Kojima Miyako yoshida Takahiro Uchida Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd. Hiratsuka Japan Faculty of Pharmaceutical Science Mukogawa Women’s University Nishinomiya Japan

This study aimed to prepare and characterize itraconazole (ITCZ)- or miconazole (MCZ)-loaded poly (lactide-co-glycolide) (PLGA) microparticles (MP) using a co-grinding method with ball milling, which is a solvent-free and convenient procedure. PLGA MP was prepared by grinding for 60 min, and the fixed theoretical drug loading was set at 9.1% and 16.7% for both drugs. The obtained loading efficiency for both drugs was estimated to be approximately 100%. The average diameters of the drug-loaded PLGA MP were approximately 20 - 35 μm. Powder X-ray diffraction (PXRD) or differential scanning calorimetry (DSC) confirmed amorphization of ITCZ and MCZ in ITCZ- or MCZ-loaded PLGA MP in all formulations. The drug release percentage from 9.1%-loaded ITCZ-PLGA7505 MP at 24 h was almost 50%, which was higher than that of ITCZ powder. The drug release percentage from MCZ-loaded PLGA7505 MP at 4 h was over 80%, which was higher than that of MCZ powder. This enhancement of release rate is caused by the amorphization of ITCZ or MCZ in the PLGA matrix. MCZ-loaded PLGA7510 MP showed a sustained release profile up to 24 h, suggesting that MCZ exists in an amorphous form in the PLGA matrix;however, the release rate declined owing to the large molecular weight of PLGA. Therefore, the release enhancement of antifungal drugs loaded on PLGA MP could be achieved by their amorphization using a co-grinding method with ball milling.

关键词： Co-Grinding Method Ball Milling Poly (Lactide-co-Glycolide) Itraconazole Miconazole Amorphization

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DCWord: A Novel Deep Learning Approach to Deceptive Review Identification by Word Vectors

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Journal of Systems Science and Systems Engineering 2019年第6期28卷 731-746页

作者： Wen Zhang Qiang Wang Xiangjun Li Taketoshi yoshida Jian Li Research Base of Beijing Modem Manufacturing Development College of Economics and ManagementBeijing University of TechnologyBeijing 100124China School of Information Engineering Xi'an UniversityXi'an 710065China School of Knowledge Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1292Japan

Due to the anonymous and free-for-all characteristics of online forums,it is very hard for human beings to differentiate deceptive reviews from truthful *** paper proposes a deep learning approach for text representation called DCWord (Deep Context representation by Word vectors) to deceptive review *** basic idea is that since deceptive reviews and truthful reviews are composed by writers without and with real experience on using the online purchased goods or services,there should be different contextual information of words between *** state-of-the-art techniques in seeking best linguistic features for representation,we use word vectors to characterize contextual information of words in deceptive and truthful reviews *** average-pooling strategy (called DCWord-A) and maxpooling strategy (called DCWord-M) are used to produce review vectors from word *** results on the Spam dataset and the Deception dataset demonstrate that the DCWord-M representation with LR (Logistic Regression) produces the best performances and outperforms state-of-the-art techniques on deceptive review ***,the DCWord-M strategy outperforms the DCWord-A strategy in review representation for deceptive review *** outcome of this study provides potential implications for online review management and business intelligence of deceptive review identification.

关键词： Online business intelligence skip-gram model DCWord representation deceptive review identification deep learning

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Clinical Trial Protocol: Randomized Controlled Trial of Cancer Pain Monitoring System (CAPAMOS) in Patients with Advanced Cancer

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Open Journal of Nursing 2022年第2期12卷 113-124页

作者： Shiori yoshida Fumiko Sato Keita Tagami Shin Takahashi Department of Oncology Nursing Tohoku University Graduate School of Medicine Sendai Japan Department of Palliative Medicine Tohoku University Graduate School of Medicine Sendai Japan Department of Medical Oncology Tohoku University Hospital Sendai Japan

Purpose: This randomized controlled trial (RCT) protocol was designed to evaluate the effectiveness of the Cancer Pain Monitoring System (CAPAMOS), a telenursing system designed to alleviate pain in ambulatory patients with advanced cancer. Methods: The study design involved a randomized controlled trial consisting of an intervention group using CAPAMOS and a control group that received usual care. At the time of enrollment, both groups will be given a questionnaire regarding issues, such as concerns related to cancer pain and self-management of opioid medication. Patients will then receive pain relief education based on the results of the questionnaire. Subjects in the control group will receive a pain diary and pain-relief pamphlet that acts as an educational tool. They could also call the outpatient clinic if they wanted to ask for a nursing consultation. The intervention group will be able to use CAPAMOS to manage their pain and receive video consultation with a telenurse, who is an oncology nursing specialist. Educational tools will be built into CAPAMOS. The study will be conducted for one month. The primary endpoint of this study was to calculate the Japanese Brief Pain Inventory score. The secondary endpoints were to assess the opioid medication self-management, Barriers Questionnaire, Japanese EuroQol 5-dimensions 5-level, and economic evaluation. Assessment items will be evaluated at registration and 2 and 4 weeks after registration. Conclusions: A RCT based on this protocol is expected to validate the efficacy of telenursing using CAPAMOS in patients with advanced cancer and pain.

关键词： Telenursing Cancer Pain Advanced Cancer Patients Symptom Management Patient Care Randomized Controlled Trial

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