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Analysis of deformation mechanisms in magnesium single crystals using a dedicated four-point bending tester

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Journal of Magnesium and Alloys 2024年第5期12卷 1911-1917页

作者： Yutaka yoshida Rikuto Izawa Kenji Ohkubo Faculty of Engineering Kitami Institute of TechnologyKoen-choKitamiHokkaido 090-8507Japan Graduate student Department of Mechanical and Electrical EngineeringKitami Institute of TechnologyKoen-choKitamiHokkaido 090-8507Japan Center for Advanced Research of Materials Faculty of EngineeringHokkaido UniversityKita-kuSapproHokkaido 060-8628Japan Kyokuto Kaihatsu Kogyo Co. Ltd.AwajiChuohuOosakaOosaka 541-0047Japan

In this study,we explored the deformation mechanisms of Mg single crystals using a combination of scanning electron microscopy and electron backscattered diffraction in conjunction with a dedicated four-point bending *** prepared two single-crystal samples,oriented along theanddirections,to assess the mechanisms of deformation when the initial basal slip was *** thesample,the primary{1012}twin(T1)was confirmed along thedirection of the sample on the compression side with an increase in bending *** thesample,T1 and the secondary twin(T2)were confirmed to be along thedirection,with an orientation of±60°with respect to the bending stress direction,and their direction matched with(0001)in T1 and *** result implies that crystallographically,the basal slip occurs *** addition,thesample showed the double twin in T1 on the compression side and the tertiary twin along thedirection on the tension *** results demonstrated that the maximum bending stress and displacement changed significantly under the bend loading because the deformation mechanisms were different for these single ***,the correlation between bending behavior and twin orientation was determined,which would be helpful for optimizing the bending properties of Mg-based materials.

关键词： Four-point bending Magnesium single crystal Twinning Basal slip Scanning electron microscopy Electron backscatter diffraction

Deciphering the enigmatic spikelet traits:Resolving trade-offs for enhancing rice yield

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Molecular Plant 2024年第5期17卷 694-695页

作者： Hideki yoshida Makoto Matsuoka Institute of Fermentation Sciences Fukushima UniversityFukushima 960-1248Japan

Increasing the yield is one of the most important goals of crop *** the beginning of rice cultivation thousands of years ago,many efforts have been made to increase rice *** of the successes in this history was the Green *** tremendous improvement in the 1960s was achieved by increasing rice and wheat production through the development and widespread adoption of semi-dwarf varieties with the extensive use of fertilizers(Hedden,2003).Dwarfism in crops lowers the center of gravity of the plant body,reducing the risk of lodging and enabling farmers to use more fertilizer to increase ***-dwarf mutations in both rice and wheat created during the Green Revolution are related to the plant growth hormone gibberellin(GA).Although other mechanisms cause dwarf mutants,only GA-related semi-dwarf mutants were selected during the Green Revolution(Wang et al.,2021).While GA-related abnormalities only make plants shorter,most cases caused by other mechanisms involve not only dwarfism but also other morphological abnormalities.

关键词： dwarf crops traits

Hypercalcemia Due to Parathyroid Hormone-Related Protein Induced by Primary Endometrial Clear Cell Adenocarcinoma: Case Report

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Open Journal of Obstetrics and Gynecology 2016年第9期6卷 521-524页

作者： Kyousuke Takeuchi Akari Shirakuni ai yoshida Akiko Takeda Makoto Sugimoto Department of Obstetrics and Gynecology National Hospital Organization Kobe Medical Center Kobe Japan

Humoral Hypercalcemia of Malignancy (HHM) has been reported in association with a number of malignancies. In gynecologic malignancies, ovarian Clear Cell Carcinoma (CCC) is one of the most commonhistologic subtypes, whereas HHM caused by endometrial CCC is very rare. We report a case of endometrial CCC with HHM, with a low serum intact PTH level, elevated serum PTH-related Peptide (PTH-rP), and immunohistochemically demonstrated PTH-rP in the neoplasm.

关键词： Humoral Hypercalcemia of Malignancy Endometrial Cancer Clear Cell Adenocarcinoma Parathyroid Hormone-Related Protein

Dynamic ultrasonography for optimizing treatment position in superior mesenteric artery syndrome:Two case reports and review of literature

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World Journal of Gastroenterology 2024年第5期30卷 499-508页

作者： Nobuaki Hasegawa Akihiko Oka Muyiwa Awoniyi Yuri yoshida Hiroshi Tobita Norihisa Ishimura Shunji Ishihara Department of Internal Medicine II Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteHepatology SectionCleveland ClinicClevelandOH 44195United States Clinical Laboratory Division Shimane University HospitalIzumo 693-8501ShimaneJapan Division of Hepatology Shimane University HospitalIzumo 693-8501Japan

BACKGROUND Superior mesenteric artery(SMA)syndrome is a rare cause of duodenal obstruction by extrinsic compression between the SMA and the aorta(SMA-Ao).Although the left lateral recumbent position is considered effective in the treatment of SMA syndrome,individual variations in the optimal patient position have been *** this report,we present two elderly cases of SMA syndrome that exhibited rapid recovery due to ultrasonographic dynamic evaluation of the optimal position for each *** SUMMARY Case 1:A 90-year-old man with nausea and *** diagnosis of SMA syndrome by computed tomography(CT),ultrasonography(US)revealed the SMA-Ao distance in the supine position(4 mm),which slightly improved in the lateral position(5.7–7.0 mm)without the passage of duodenal ***,in the sitting position,the SMA-Ao distance was increased to 15 mm accompanied by improved content ***,US indicated enhanced passage upon abdominal massage on the right *** day 2,the patient could eat comfortably with the optimal position and *** 2:An 87-year-old woman with *** the diagnosis of SMA syndrome and aspiration pneumonia by CT,dynamic US confirmed the optimal position(SMA-Ao distance was improved to 7 mm in forward-bent position,whereas it remained at 5 mm in the supine position).By day 7 when her pneumonia recovered,she could eat with the optimal *** The optimal position for SMA syndrome varies among *** US appears to be a valuable tool in improving patient outcomes.

关键词： Superior mesenteric artery syndrome Wilkie’s syndrome Cast syndrome Aorto-mesenteric compass syndrome Ultrasonography Case report

Hyperacute experimental model of rat lung transplantation using a coronary shunt cannula

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World Journal of Transplantation 2024年第2期14卷 155-161页

作者： Munehisa Takata Yusuke Tanaka Daisuke Saito Shuhei yoshida Isao Matsumoto Department of Thoracic Surgery Kanazawa UniversityKanazawa 920-8641IshikawaJapan

BACKGROUND Lung transplantation is a well-established treatment of end-stage lung disease.A rodent model is an inexpensive way to collect biological data from a living model after lung ***,mastering the surgical technique takes time owing to the small organ *** To conduct rat lung transplantation using a shunt cannula(SC)or modified cannula(MC)and assess their *** Rat lung transplantation was performed in 11 animals in the SC group and 12 in the MC *** devised a method of rat lung transplantation using a coronary SC for coronary artery bypass surgery as an anastomosis of pulmonary arteri-ovenous vessels and *** same surgeon performed all surgical proce-dures in the donor and recipient rats without using a magnifying *** success rate of lung transplantation,operating time,and PaO2 values were com-pared after 2-h reperfusion after *** Ten and 12 lungs were successfully transplanted in the SC and MC groups,*** the SC group,one animal had cardiac arrest within 1 h after reperfusion owing to bleeding during pulmonary vein *** opera-ting time for the removal of the heart-lung block from the donor and preparation of the left lung graft was 26.8±2.3 and 25.7±1.3 min in the SC and MC groups,respectively(P=0.21).The time required for left lung transplantation in the recipients was 37.5±2.8 min and 35.9±1.4 min in the SC and MC groups,respectively(P=0.12).PaO2 values at 2 h after reperfusion were 456.2±25.5 and INTRODUCTION Lung transplantation is a well-established treatment of end-stage lung *** immune and non-immune mech-anisms in lung transplantation are highly complex,and post-transplant complications such as infections and primary and chronic lung allograft dysfunction must be reduced to improve ***,there is a need for immunological and pathophysiological analyses using animal lung transplantation *** rat lung transplantation model was f

关键词： Lung transplantation Rat Shunt cannula Modified cannula Reperfusion

The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

Spontaneous Uterine Perforation Secondary to Leiomyosarcoma Arising in a Uterine Leiomyoma

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Open Journal of Obstetrics and Gynecology 2014年第4期4卷 186-189页

作者： Kyousuke Takeuchi Makoto Sugimoto ai yoshida Shino Yamashita Taro Tsujino Riichiro Nishino Department of Obstetrics and Gynecology Kobe Medical Center Kobe Japan

Histogenesis of uterine leiomyosarcoma has been controversial. It is generally believed that uterine leiomyosarcomas arise de novo, rather than from any precursor lesions. We report an unusual case of spontaneous rupture of leiomyosarcoma arising in pre-existing calcified uterine leiomyoma, which has been monitored over the years after menopause. This case also suggests that spontaneous intraperitoneal hemorrhage associated with malignant transformation of uterine leiomyoma, although rare, should be considered in postmenopausal women presenting with rapid growing uterine mass.

关键词： Uterine Leiomyosarcoma Leiomyoma Malignant Transformation Spontaneous Rupture

Evaluation of temperature dependent vortex pinning properties in strongly pinned YBa_(2)Cu_(3)O_(7-δ)thin films with Y_(2)BaCuO_(5)nanoinclusions

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Superconductivity 2024年第1期9卷 95-105页

作者： Alok K.Jha Kaname Matsumoto Tomoya Horide Shrikant Saini Ataru Ichinose Paolo Mele Yutaka yoshida Satoshi Awaji Department of Materials Science and Engineering Kyushu Institute of TechnologyTobata-kuKitakyushu 804-8550Japan Department of Mechanical and Control Engineering Kyushu Institute of TechnologyTobata-kuKitakyushu 804-8550Japan Central Research Institute of Electrical Power Industry YokosukaKanagawa 240-0196Japan College of Engineering-Innovative Global Program Shibaura Institute of TechnologyMinuma-kuSaitama 337-8570Japan Department of Energy Engineering and Science Nagoya UniversityChikusa-kuNagoya 464-8603Japan Institute for Materials Research Tohoku UniversityAoba-kuSendai 980-8577Japan

The pinning of quantized magnetic vortices in superconducting YBa_(2)Cu_(3)O_(7-δ)(YBCO or Y123)thin films with Y_(2)BaCuO_(5)(Y211)nanoinclusions have been investigated over wide temperature range(4.2-77 K).The concentration of Y211 nanoinclusions has been systematically varied inside YBCO thin films prepared by laser ablation technique using surface modified target *** pinning force density values(Fp∼0.5 TNm^(−3)at 4.2 K,9 T)have been observed for the YBCO film with moderate concentration of Y211 nanoinclusions(3.6 area%on ablation target).In addition,uniform enhancement in critical current density(J_(c))was observed in the angular dependent J_(c)measurement of YBCO+Y211 nanocomposite films.Y211 nanoinclusions have been found to be very efficient in pinning the quantized vortices thereby enhancing the in‐field J_(c)values over a wide range of *** the concentration of Y211 secondary phase into Y123 film matrix results into agglomeration of Y211 phase and observed as increased Y211 nanoparticle *** larger secondary phase nanoparticles are not as efficient pinning centers at lower temperatures as they are at higher temperatures due to substantial reduction of the coherence length at lower *** of the temperature dependence of J_(c)for YBCO+Y211 nanocomposite films has been conducted and possible vortex pinning mechanism in these nanocomposite films has been discussed.

关键词： YBCO thin film Critical current Vortex pinning Nanoscale APCs

Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

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World Journal of Clinical Cases 2024年第15期12卷 2499-2505页

作者： Kenji Matsuda Kazuhiro Shimazu Hanae Shinozaki Koji Fukuda Taichi yoshida Daiki Taguchi Kyoko Nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensive Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasis has various negative *** of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may *** is estimated that at least 5%cancer patients might be suffering from bone *** 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone *** then,the therapeutic outcomes for patients have gradually *** life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be *** To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone *** For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was *** association with survival was determined for each *** Data from 136 patients were *** 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was *** factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(Paintain ADL and improve *** Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly *** and scoring system for p

关键词： Bone metastasis New Katagiri scoring system Prognosis Immune check point inhibitors Survival