检索结果-南通市图书馆

Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum

引用

World Journal of Gastrointestinal Surgery 2022年第11期14卷 1219-1229页

作者： Kohei Nishio Kenjiro Kimura Akihiro Murata Go Ohira Hiroji Shinkawa Shintaro Kodai Ryosuke Amano Shogo Tanaka Sadatoshi shimizu Shigekazu Takemura Akishige Kanazawa Shoji Kubo Takeaki Ishizawa Department of Hepato-Biliary-Pancreatic Surgery Osaka Metropolitan UniversityOsaka 5458585Japan Department of HepatoBiliary-Pancreatic Surgery Osaka City General HospitalOsaka 5340021Japan

BACKGROUND Few studies compared the oncological and biological characteristics between ampullary carcinoma(AC) and cancer of the second portion of the duodenum(DC-Ⅱ), although both tumors arise from anatomically close *** To elucidate differences in clinicopathological characteristics, especially the patterns of lymph node metastasis(LNM), between AC and DC-Ⅱ.METHODS This was a retrospective cohort study of 80 patients with AC and 27 patients with DC-Ⅱ who underwent pancreaticoduodenectomy between January 1998 and December 2018 in two institutions. Clinicopathological factors, LNM patterns, and prognosis were compared between the two *** The patients with AC and DC-Ⅱ did not exhibit significant differences in 5-year overall survival(66.0% and 67.1%, respectively) and 5-year relapse-free survival(63.5% and 62.2%, respectively). Compared to the patients with DC-Ⅱ, the rate of preoperative biliary drainage was higher(P = 0.042) and the rates of digestive symptoms(P = 0.0158), ulcerative-type cancer(P < 0.0001), large tumor diameter(P < 0.0001), and advanced tumor stage(P = 0.0019) were lower in the patients with AC. The LNM rates were 27.5% and 40.7% in patients with AC and DC-Ⅱ,respectively, without significant difference(P = 0.23). The rates of LNM to hepatic nodes(N-He)and pyloric nodes(N-Py) were significantly higher in patients with DC-Ⅱ than in those with AC(metastasis to N-HE: 18.5% and 5% in patients with DC-Ⅱ and AC, respectively;P = 0.0432;metastasis to N-Py: 11.1% and 0% in patients with DC-Ⅱ and AC, respectively;P = 0.0186)CONCLUSION Although there were no significant differences in the prognosis and recurrence rates between the two groups, metastases to N-He and N-Py were more frequent in patients with DC-Ⅱ than in those with AC.

关键词： Ampulla of Vater Duodenum Lymphatic metastasis pattern Lymphatic metastasis station Lymph node excision Neoplasm Pancreaticoduodenectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

White-opaque Switching in Different Mating Type-like Locus Gene Types of Clinical Candida albicans Isolates

引用

Chinese Medical Journal 2016年第22期129卷 2725-2732页

作者： Hou-Min Li Yumi shimizu-Imanishi Reiko Tanaka Ruo-Yu Li Takashi Yaguchi Department of Dermatology Peking University People's Hospital Beijing 100044 China Medical Mycology Research Center Chiba University Chiba 260-8673 Japan Department of Dermatology Peking University First Hospital Beijing 100034 China

Background：Candida albicans （***） can become a pathogen causing superficial as well as life-threatening systemic infections,especially in immunocompromised *** phenotypic attributes contribute to its capacity to colonize human *** our study,93 *** isolates from patients of various candidiasis in a hospital of China were *** aimed to investigate the white-opaque （WO） switching competence,drug sensitivity,and virulence of mating type-like （MTL） a/α ***：Internal transcribed spacer （ITS） gene and the MTL configuration were detected in all the isolates by reverse transcription-polymerase chain ***/opaque phenotype and doubling time of cell growth were *** minimum inhibitory concentrations of antifungal agent were measured using broth microdilution ***：Sixty-four isolates （69.6%） were classified to serotype A,19 （20.6%） to serotype B,and 9 （9.8%） to serotype ***,phylogenetic analysis showed that these isolates were divided into four different subgroups of ITS *** of our clinical isolates were MTLa/α type,while 6.8% remained MTLa or MTLα *** frequency of opaque phenotype was 71.0% （66 isolates）.Following the guidelines of Clinical and Laboratory Standards Institute M27-A3,all isolates were susceptible to caspofungin and a few （0.6-3.2%） of them showed resistance against amphotericin B,flucytosine,fluconazole,itraconazole,and ***：From these analyses,there were comparatively more *** strains classified into serotype B,and the frequency of opaque phase strains was significant in the clinical isolates from ***,phenotypic,or drug susceptibility patterns were not significantly different from previous ***/α isolates could also undergo WO switching which facilitates their survival.

关键词： Candida albicans Drug Susceptibility Genotype Mating Type-like White-opaque

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics of Non-Small Cell Lung Cancer Located in the Right Middle Lobe According to a Retrospective Study of Recurrence and Prognosis

引用

Open Journal of Thoracic Surgery 2012年第3期2卷 52-57页

作者： Katsuhiko shimizu Yuji Hirami Riki Okita Shinsuke Saisho Takuro Yukawa ai Maeda Koichiro Yasuda Masao Nakata Department of General Thoracic Surgery Kawasaki Medical School Kurashiki Japan

Background: Some studies have suggested that among all cases of lung cancer, the outcome of lung cancer located in the right middle lobe (RML) is the worst. However, with the advances in the diagnosis and treatment methods of lung cancer over the last couple of decades, we investigated whether the prognosis of primary lung cancer located in the RML still remains inferior to that of lung cancer arising from other lobes. Methods: Between July 2003 and December 2011, 505 consecutive patients with non-small cell lung cancer (NSCLC) underwent surgical resection at our institution. Of these, 32 patients (6.3%) had tumors arising from the RML. Results: The rate of incomplete resection was higher for cancer located in the RML than that for cancer arising from other lobes. Significant associations were noted between cancer located in the RML and the rate of lymph node metastasis and initial locoregional recurrence. Multivariate analysis identified lymph node metastasis and location in the RML as independent risk factors influencing the recurrence-free survival (p = 0.006), although location in the RML was not extracted as an independent risk factor influenceing the overall survival (p = 0.060). Conclusion: Despite the recent advances in the treatment of lung cancer, evaluation of complete resection revealed that the outcome of cancer located in the RML is still the worst among cancer of all the lobes. Further early diagnosis and adjuvant therapy are needed for improving the prognosis of cancer located in the RML.

关键词： Right Middle Lobe Non-Small Cell Lung Cancer Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intragingival injection of Porphyromonas gingivalis-derived lipopolysaccharide induces a transient increase in gingival tumour necrosis factor-a, but not interleukin-6,in anaesthetised rats

引用

International Journal of Oral Science 2015年第3期7卷 155-160页

作者： Hiroko Taguchi Yuri Aono Takayuki Kawato Masatake Asano Noriyoshi shimizu Tadashi Saigusa Department of Orthodontics Nihon University School of Dentistry Department of Pharmacology Nihon University School of Dentistry at Matsudo Department of Pharmacology Nihon University School of Dentistry Department of Oral Health Sciences Nihon University School of Dentistry Department of Pathology Nihon University School of Dentistry

This study used in vivo microdialysis to examine the effects of intragingival application of lipopolysaccharide（LPS） derived from Porphyromonas gingivalis（Pg-LPS） on gingival tumour necrosis factor（TNF）-a and interleukin（IL）-6 levels in rats. A microdialysis probe with an injection needle attached to the surface of the dialysis membrane was implanted into the gingiva of the upper incisor. For comparison, the effects of LPS derived from Escherichia coli（Ec-LPS） on IL-6 and TNF-a levels were also analysed. Pg-LPS（1 mg/1 m L） or Ec-LPS（1 or 6 mg/1 m L） was applied by microsyringe, with gingival dialysates collected every hour. Enzyme-linked immunosorbent assay（ELISA） revealed that gingival dialysates contained approximately 389 pg？m L21 of IL-6 basally; basal TNF-a levels were lower than the detection limit of the ELISA. Pg-LPS failed to alter IL-6 levels but markedly increased TNF-a levels, which remained elevated for 2 h after treatment. Neither IL-6 nor TNF-a were affected by Ec-LPS. Reverse transcriptase-polymerase chain reaction（RT-PCR） analysis revealed that the gingiva expresses Toll-like receptor（TLR） 2 and TLR4 m RNA. Immunohistochemical examination showed that TLR2 and TLR4 are expressed by gingival epithelial cells. The present study provides in vivo evidence that locally applied Pg-LPS, but not Ec-LPS, into the gingiva transiently increases gingival TNF-a without affecting IL-6. The present results suggest that TLR2 but not TLR4 expressed on gingival epithelial cells may mediate the Pg-LPS-induced increase in gingival TNF-a in rats.

关键词： Porphyromonas gingivalis lipopolysaccharide gingiva tumour necrosis factor-a microdialysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phenomenological aspects of possible vacua of a neutrino flavor model

引用

Chinese Physics C 2018年第2期42卷 27-37页

作者： Takuya Morozumi Hideaki Okane Hiroki Sakamoto Yusuke shimizu Kenta Takagi Hiroyuki Umeeda Graduate School of Science Hiroshima University Core of Research for the Energetic Universe Hiroshima University Graduate School of Science and Engineering Shimane University

We discuss a supersymmetric model with discrete flavor symmetry A4×Z3. The additional scalar fields which contribute masses of leptons in the Yukawa terms are introduced in this model. We analyze their scalar potential and find that they have various vacuum structures. We show the relations among 24 different vacua and classify them into two types. We derive expressions of the lepton mixing angles, Dirac CP violating phase and Majorana phases for the two types. The model parameters which are allowed by the experimental data of the lepton mixing angles are different for each type. We also study the constraints on the model parameters which are related to Majorana phases. The different allowed regions of the model parameters for the two types are shown numerically for a given region of two combinations of the CP violating phases.

关键词： flavor symmetry non-Abelian discrete group neutrino flavor model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gallbladder Burkitt's lymphoma mimicking gallbladder cancer:A case report

引用

World Journal of Gastroenterology 2022年第6期28卷 675-682页

作者： Kiyotaka Hosoda Akira shimizu Koji Kubota Tsuyoshi Notake Hikaru Hayashi Koya Yasukawa Kentaro Umemura Atsushi Kamachi Takamune Goto Hidenori Tomida Shiori Yamazaki Yuri Narusawa Naoko Asano Takeshi Uehara Yuji Soejima Division of Gastroenterological Hepato-Biliary-PancreaticTransplantation and Pediatric SurgeryDepartment of SurgeryShinshu University School of MedicineMatsumoto 390-8621Japan Department of Laboratory Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

BACKGROUND Malignant lymphoma is a rare form of gallbladder *** of these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas;however,Burkitt’s lymphoma of the gallbladder is extremely rare,and only two previous reports are available in the ***,we report a rare case of Burkitt’s lymphoma of the gallbladder mimicking gallbladder *** SUMMARY An 83-year-old man with no abdominal complaints was found to have a gallbladder tumor and periportal lymph node enlargement on computed tomography(CT)performed for hypertension *** laboratory data revealed slightly elevated serum levels of carcinoembryonic antigen and soluble interleukin 2 *** examinations revealed two irregular and contrastenhanced masses extending into the gallbladder lumen,but these did not infiltrate the ***,a periportal lymph node had enlarged to 30 *** on these findings,we diagnosed the patient as having gallbladder adenocarcinoma with lymph node metastasis,which was treated using bile duct resection with gallbladder bed resection and periportal lymph node ***,the patient was finally diagnosed as having Burkitt’s *** the surgical margin was pathologically negative,recurrence was noted at the hepatic radical margin and superior pancreaticoduodenal lymph nodes on positron emission tomography/CT soon after ***,he was referred to a hematologist and started receiving treatment with reduced-dose cyclophosphamide,doxorubicin,vincristine,and *** Burkitt’s lymphoma can occur in the *** can be useful in cases with findings suggestive of gallbladder malignant lymphoma.

关键词： Gallbladder Malignant lymphoma Burkitt’s lymphoma Gallbladder cancer Lymphadenopathy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus

引用

World Journal of Hepatology 2022年第6期14卷 1226-1234页

作者： Ryosuke Yamane Kentaro Yoshioka Kazuhiko Hayashi Yuko shimizu Yuki Ito Komei Matsushita Michiyo Yoshizaki Go Kajikawa Taro Mizutani Atsuko Watarai Kosuke Tachi Hidemi Goto Department of Gastroenterology and Hepatology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Center for Liver Diseases Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan Department of Diabetes and Endocrinology Federation of National Public Service Personnel Mutual Aid Associations Meijo HospitalNagoya 460-0001AichiJapan

BACKGROUND Type 2 diabetes mellitus(T2DM)is a risk factor for nonalcoholic fatty liver disease(NAFLD).aiM To determine the prevalence and clinical correlates of NAFLD in a large cohort of patients with *** Four hundred thirty-seven participants with T2DM who consulted at Meijo Hospital from April 2019 to September 2020 and underwent computed tomography(CT)were *** mean age was 74±13 years,and 269 were *** attenuation minus splenic attenuation(CTL−S)less than 1 Hounsfield unit was considered fatty *** was defined as fatty liver in the absence of significant alcohol consumption and hepatitis virus infection.A multiple logistic regression was used to assess the independent factors associated with *** NAFLD was identified in 25.2%of the *** age(odds ratio[OR]=−0.945;95%confidence interval[CI]:0.922–0.969),higher hemoglobin levels(OR=1.501,95%CI:1.278–1.764),lower high-density lipoprotein(HDL)cholesterol levels(OR=0.971,95%CI:0.953–0.989),and the absence of dialysis(OR=0.109,95%CI:0.014–0.856)were independent predictors of *** NAFLD was detected with CT in 25.2%of the *** was associated with younger age,higher hemoglobin levels,lower HDL cholesterol levels,and an absence of dialysis.

关键词： Age Computed tomography Dialysis Hemoglobin Nonalcoholic fatty liver disease Type 2 diabetes mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unsteady Flow Condition of Contra-Rotating Small-Sized Axial Fan

引用

Journal of Thermal Science 2011年第6期20卷 495-502页

作者： T.Shigemitsu J.Fukutomi Y.Okabe K.Iuchi H.shimizu Institute of Technology and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN Associate ProfessorDr.Eng. Institute of Technology and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN Graduate School of Advanced Technology and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN

Small-sized axial fans are used as air cooler for electric *** there is a strong demand for higher power of fans according to the increase of quantity of heat from electric ***,higher rotational speed design is conducted,although,it causes the deterioration of efficiency and the increase of ***,the adoption of contra-rotating rotors for the small-sized axial fan is proposed for the improvement of *** the case of contra-rotating rotors,it is necessary to design the rotor considering the unsteady flow condition of each front and rear *** the present paper,the fan performance of the contra-rotating small-sized axial fan with 100mm diameter at a designed and a partial flow rates is shown,and the unsteady flow conditions at the inlet and the outlet of each front and rear rotor are clarified with unsteady numerical ***,the relation between the performance and the unsteady flow condition of the contra-rotating small-sized axial fan is discussed and the methods to improve the performance are considered.

关键词：旋转设计轴流风机非定常流流动条件非定常数值模拟性能改进电气设备空气冷却器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Long-term prognosis of focal segmental glomerulosclerosis treated with therapeutic low-density lipoprotein-apheresis in patients with severe kidney dysfunction and proteinuria

引用

Rheumatology & Autoimmunity 2023年第1期3卷 35-42页

作者： Shinji Kitajima Megumi Osima Hisayuki Ogura Shiori Nakagawa Yuta Yamamura Taito Miyake Taro Miyagawa Tadashi Toyama Akinori Hara Norihiko Sakai Miho shimizu Takashi Wada Yasunori Iwata Department of Nephrology and Laboratory Medicine Faculty of MedicineInstitute of MedicalPharmaceutical and Health SciencesGraduate School of Medical SciencesKanazawa UniversityKanazawaJapan Division of Blood Purification Kanazawa University HospitalKanazawaJapan

Background:The prognosis of focal segmental glomerulosclerosis patients with nephrotic syndrome is estimated to be 10%-20%in 5 years and 30%-50%in 10 years,leading to end-stage kidney *** response rate with steroid therapy is 40%-60%.Therapeutic low-density lipoprotein-apheresis(LDL-A)may be effective in patients with steroid *** regarding the long-term prognosis of patients with focal segmental glomerulosclerosis receiving this therapy is ***:We investigated the effectiveness of treatment in 50 patients with primary focal segmental glomerulosclerosis diagnosed between 1961 and 2017 at Kanazawa University Hospital and related *** patients were observed at least 12 months after biopsy or until end-stage kidney disease occurrence or ***:LDL-A was performed in four patients who presented with steroidresistant nephrotic syndrome(two patients had concurrent acute renal failure for which hemodialysis was performed).In comparison with 17 patients who did not receive LDL-A after 1989,the LDL-A group had higher urinary protein excretion(13.7 vs.5.2 g/day,P=0.053)and serum creatinine(4.11 vs.1.65 mg/dL)levels at onset,and a numerically higher remission rate(75.0%vs.58.7%)compared with the nonlipoprotein-apheresis ***:Therapeutic LDL-A can be performed for critical cases and may improve the remission rate.

关键词： apheresis end-stage kidney disease focal segmental glomerulosclerosis LDL prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effectiveness of early colonoscopy in patients with colonic diverticular hemorrhage:A single-center retrospective cohort study

引用

World Journal of Gastrointestinal Endoscopy 2022年第12期14卷 759-768页

作者： Chikamasa Ichita Sayuri shimizu Akiko Sasaki Chihiro Sumida Takashi Nishino Karen Kimura Department of Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan

BACKGROUND Current guidelines recommend colonoscopy within 24 h for acute lower gastrointestinal bleeding;however,the evidence in support for colonic diverticular hemorrhage(CDH)indications remains *** To investigate the effectiveness of early colonoscopy on the length of hospital stay for CDH *** We conducted a single-center retrospective cohort *** who underwent colonoscopy within 24 h of presentation(early group)were compared with those who underwent colonoscopy beyond 24 h of presentation(elective group).The primary outcome was the length of hospital stay,and secondary outcomes were the identification of stigmata of recent hemorrhage(SRH),rebleeding,red blood cell transfusion more than 4 units,and interventional radiology and abdominal surgery after *** We identified 574 CDH *** were divided into the early(n=328)and elective(n=226)*** propensity score matching,191 pairs were *** length of hospital stay did not significantly differ between the two groups(early group vs elective group;median,7 vs 8 d;P=0.10).The early group had a significantly high identification of SRH(risk difference,11.6%;95%CI:2.7 to 20.3;P=0.02).No significant differences were found in the rebleeding(risk difference,4.7%;95%CI:-4.1 to 13.5;P=0.35),red blood cell transfusion more than 4 units(risk difference,1.6%;95%CI:-7.5 to 10.6;P=0.82),and interventional radiology and abdominal surgery rate after colonoscopy(risk difference,0.5%;95%CI:-2.2 to 3.2;P=1.00).CONCLUSION Early colonoscopy within 24 h,on arrival for CDH,could not improve the length of hospital stay.

关键词： Colonic diverticular hemorrhage Colonic diverticular bleeding Diverticular hemorrhage Diverticular bleeding Early colonoscopy Colonoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：