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Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies

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Cellular & Molecular Immunology 2021年第4期18卷 1061-1063页

作者： Jie Hu Pai Peng Kai Wang Liang Fang Fei-yang Luo ai-shun jin Bei-zhong Liu Ni Tang ai-long huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious Diseasesthe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Yong-Chuan Hospital Chongqing Medical UniversityChongqingChina Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqingChina

Coronaviruses are enveloped,positive-stranded RNA viruses that contain the largest known RNA genomes to *** severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to circulate in the human population,mul... 详细信息

关键词： acute monoclonal respiratory

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai huang Yi Hu Xiao-Dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

Revisiting the Evolutionary History of Pigs via De Novo Mutation Rate Estimation in A Three-generation Pedigree

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1040-1052页

作者： Mingpeng Zhang Qiang Yang Huashui ai Lusheng huang State Key Laboratory of Swine Genetic Improvement and Production Technology Jiangxi Agricultural UniversityNanchang 330045China

The mutation rate used in the previous analyses of pig evolution and demographics was cursory and hence invited potential bias in inferring evolutionary ***,we estimated the de novo mutation rate of pigs as 3.6×10-9 per base per generation using high-quality whole-genome sequencing data from nine individuals in a three-generation pedigree through stringent filtering and *** this mutation rate,we re-investigated the evolutionary history of *** estimated divergence time of~10 kiloyears ago(KYA)between European wild and domesticated pigs was consistent with the domestication time of European pigs based on archaeological ***,other divergence events inferred here were not as ancient as previously *** estimates suggest that Sus speciation occurred~1.36 million years ago(MYA);European wild pigs split from Asian wild pigs only~219 KYA;and south and north Chinese wild pigs split~25 ***,our results showed that the most recent divergence event between Chinese wild and domesticated pigs occurred in the Hetao Plain,northern China,approximately 20 KYA,supporting the possibly independent domestication in northern China along the middle Yellow *** also found that the maximum effective population size of pigs was~6 times larger than estimated *** archaic migration from other Sus species originating~2 MYA to European pigs was detected during western colonization of pigs,which may affect the accuracy of previous demographic *** de novo mutation rate estimation and its consequences for demographic history inference reasonably provide a new vision regarding the evolutionary history of pigs.

关键词： Pig De novo mutation rate Three-generation pedigree Evolutionary history Archaic migration

Quantum phase transition of the Jaynes-Cummings model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 1-9页

作者： Cheng Liu jin-Feng huang Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China

Herein,we propose an experimentally feasible scheme to show the quantum phase transition of the Jaynes-Cummings(JC)model by modulating the transition frequency of a two-level system in a quantum Rabi model with strong *** tuning the modulation frequency and amplitude,the ratio of the effective coupling strength of the rotating terms to the effective cavity(atomic transition)frequency can enter the deep-strong coupling regime,while the counter-rotating terms can be ***,a deep-strong JC model is *** ratio of the coupling strength to resonance frequencies in the deep-strong JC model is two orders of magnitude larger than the corresponding ratio in the original quantum Rabi *** scheme can be employed in atom-cavity resonance and off-resonance cases,and it is valid over a broad *** nonzero average cavity photons of the ground state indicate the emergence of a quantum phase ***,we demonstrate the dependence of the phase diagram on the atom-cavity detuning and modulation *** the parameters used in our scheme are within the reach of current experimental *** scheme provides a new mechanism for investigating the critical phenomena of finite-sized systems without requiring classical field limits,thereby opening a door for studying fundamental quantum phenomena occurring in the ultrastrong and even deep-strong coupling regimes.

关键词： Jaynes-Cummings model quantum phase transition frequency modulation

Epitaxial Growth of High-Quality Silicon Films on Double-Layer Porous Silicon

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Chinese Physics Letters 2001年第11期18卷 1507-1509页

作者： huang Yi-Ping ZHU Shi-Yang LI ai-Zhen WANG jin huang jing-Yun YE Zhi-Zhen Department of Microelectronics ASIC&System State Key LaboratoryFudan UniversityShanghai 200433 State Key Laboratory of Silicon Material Science Zhejiang UniversityHangzhou 310027

The epitaxial growth of a high-quality silicon layer on double-layer porous silicon by ultra-high vacuum/chemical vapour deposition has been reported. The two-step anodization process results in a double-layer porous silicon structure with a different porosity. This double-layer porous silicon structure and an extended low-temperature annealing in a vacuum system was found to be helpful in subsequent silicon epitaxial growth. X-ray diffraction,cross-sectional transmission electron microscopy and spreading resistance testing were used in this work to study the properties of epitaxial silicon layers grown on the double-layer porous silicon. The results show that the epitaxial silicon layer is of good crystallinity and the same orientation with the silicon substrate and the porous silicon layer.

关键词： porous double vacuum

Image processing based three-dimensional model reconstruction for cross-platform numerical simulation

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China Foundry 2023年第2期20卷 139-147页

作者： Yu-cheng Sun Yu-hang huang Na Li Xiao Han ai-long Jiang jin-wu Kang Ji-wu Wang Hai-liang Yu State Key Laboratory of Engine Reliability Weichai Power Co.Ltd.Weifang 261061ShandongChina School of Mechanical Engineering Central South UniversityChangsha 41000China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Key Laboratory for Advanced Materials Processing Technology School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Numerical simulation is the most powerful computational and analysis tool for a large variety of engineering and physical *** a complex problem relating to multi-field,multi-process and multi-scale,different computing tools have to be developed so as to solve particular fields at different scales and for different ***,the integration of different types of software is ***,it is difficult to perform the transfer of the meshes and simulated results among software packages because of the lack of shared data formats or encrypted data *** image processing based method for three-dimensional model reconstruction for numerical simulation was proposed,which presents a solution to the integration problem by a series of slice or projection images obtained by the post-processing modules of the numerical simulation *** means of mapping image pixels to meshes of either finite difference or finite element models,the geometry contour can be extracted to export the stereolithography *** values of results,represented by color,can be deduced and assigned to the *** the models with data can be directly or indirectly integrated into other software as a continued or new numerical *** three-dimensional reconstruction method has been validated in numerical simulation of castings and case studies were provided in this study.

关键词： cross-platform numerical simulation 3D model reconstruction image processing slice

Improvements in properties of NdFeB magnets obtained via magnetron sputtering and thermal diffusion

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Journal of Rare Earths 2024年第9期42卷 1710-1716,I0003页

作者： jin Tang Weichao huang Dan Li School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou545006China China Rare Earth(Guangxi)jinyuan Rare Earth New Materials Co. Ltd.Hezhou542603China China Rare Earth Group Co. Ltd.Ganzhou341000China Center of Experimental Teaching for Common Courses Panzhihua UniversityPanzhihua617000China

The grain boundary diffusion process(GBDP) of Dy and DyAl on sintered NdFeB magnets was conducted via magnetron-sputtering deposition of Dy and DyAl films to enhance coercivity(H_(cj)),The magnetic properties,microstructure and anti-corrosion properties of Dy-surface-alloying NdFeB magnets obtained via magnetron sputtering and thermal diffusion were *** H_(cj) of the Dy_(95)Al_(5)-NdFeB magnet increases by 32.68%,while the remanence declines ***,X-ray diffraction and microstructural analysis confirm the formation of Dy-rich shells,the higher-magnetic-anisotropy field of hard(Nd_(x)Dy_(1-x))2(FeAl)_(14)B magnetic phases and an optimised grain boundary structu re,contributing to the H_(cj)enhancement of the *** elemental distribution and diffusion mechanism of the magnets are also ***,the corrosion resistance of the Dy_(95)Al_(5)-NdFeB magnet is substantially improved by enhancing the electrochemical stability and optimising the distribution and morphology of the intergranular *** findings of this study are of substantial importance in the development of low-heavy rare-earth sintered NdFeB magnets.

关键词： Magnetron sputtering NdFeB Rare earths Microstructure Magnetic property Corrosion resistance

On the Depth Distribution of Constacyclic Codes over Z4 of Length 2e

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Chinese Journal of Electronics 2019年第3期28卷 462-469页

作者： ZHU Shixin huang Shan LI jin School of Mathematics Hefei University of Technology Departmaent of Information Management Anhui Vocational College of Police Officers

In this paper, we consider the depth distribution of constacyclic codes over Z4with length even prime power. The depth distribution of negacyclic codes over Z4of length 2eis completely ***, we determine the depth spectrum of cycilc codes over Z4of length 2e, and the depth distribution of some cyclic codes over Z4of length 2eis also given.

关键词： Depth spectrum Depth distribution Constacyclic codes

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng Su Yanfang huang Bingbing Liu Hu Sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy