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Three New Cycloartane Triterpene Glycosides from Actaea asiatica

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Chinese Chemical Letters 2006年第11期17卷 1477-1480页

作者： Yun Shuang FAN Wei JIA ai hua zhao Jie TENG Hong Quan DUAN The College of Pharmaceuticals and Biotechnology Tianjin University Tianjin 300072 The School of Pharmacy Shanghai Jiao Tong University Shanghai 200030 The School of Pharmacy Tianjin Medical University Tianjin 300070

Three new cycloartane triterpene glycosides were isolated from the rhizomes of Actaea asiatica. Their structures were elucidated as 25-ethoxyl-cimigenol-3-O-β-D-xylopyranoside 1, 2＇-O-acetyl soulieoside C 2, 2＇-O-a... 详细信息

关键词： Ranunculaceae Actaea asiatica cycloartane triterpene glycosides.

Two New Abietane Quinones from Isodon lophanthoides var. Micranthus

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Chinese Chemical Letters 2003年第6期14卷 591-593页

作者： ai hua zhao Sheng Hong LI Yong Wei LI Quan Bin huaN Qin Shi zhao Zhong Wen LIN Han Dong SUN State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which we... 详细信息

关键词： Isodon lophanthoides var. micranthus Labiatae abietane quinones micranthin A miranthin B.

Use of the Metabolomics Approach to Characterize Chinese Medicinal Material huangqi

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Molecular Plant 2012年第2期5卷 376-386页

作者： Li-Xin Duan Tian-Lu Chen Ming Li Min Chen Ye-Qing Zhou Guang-Hong Cui ai-hua zhao Wei Jia Lu-Qi huang Xiaoquan Qi The Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences20 Nanxincun Xiangshan RoadBeijing 100093China Shanghai Center for Systems Biomedicine(Ministry of Education Key Laboratory of Systems Biomedicine) Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Institute of Chinese Materia Medica Chinese Academy of Chinese Medical Sciences16 Nanxiao RoadBeijing 100700China School of Pharmacy Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

Integration of the genetic and metabolic fingerprinting can provide a new approach to differentiate similar Traditional Chinese Medical （TCM） materials. Two leguminous plants, Mojia huangqi and Menggu huangqi, are important medical herbs and share great similarities in morphology, chemical constituent, and genomic DNA sequence. The taxonomy of Mojia huangqi and Menggu huangqi has been debated for more than 50 years and discrimination of TCM materials directly affects the pharmacological and clinical effects. AFLP based genetic fingerprinting and GC-TOF/MS-based meta- bolic fingerprinting were used to successfully discriminate the two species. The results of AFLP supported the opinion that Menggu huangqi was a variant of Mojia huangqi. The metabolic fingerprinting showed growth locations have greater impacts on the metabolite composition and quantity than the genotypes （cultivated versus wild） in Menggu huangqi. The difference of some soluble sugars, fatty acids, proline, and polyamine reflected plant adaptation to different growth environments. Using multivariate and univariate statistical analysis, three AFLP markers and eight metabolites were identified as candidate DNA and metabolic markers to distinguish the two herb materials. The correlation network between AFLP markers and metabolites revealed a complex correlation network, which indicated the special metabolic pathways and the regulation networks of huangqi.

关键词： Astragalus membranaceus metabolic fingerprinting amplified fragment length polymorphisms gas chromatography time-of-flight mass spectrometry.

基于偏离份额分析的中国区域间产业转移与污染转移的定量测度

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中国人口·资源与环境 2018年第5期28卷 49-57页

作者：成艾华赵凡中南民族大学经济学院湖北武汉430074

当前,在转变经济发展方式的大背景下,跨区域产业转移已成为中国区域政策中促进区域协调发展的重要手段。如何根据中国各区域间产业转移和污染转移的趋势与规律,促进区域产业有序转移与协调发展,是当前需要考虑的一个重要战略问题。本文... 详细信息

当前,在转变经济发展方式的大背景下,跨区域产业转移已成为中国区域政策中促进区域协调发展的重要手段。如何根据中国各区域间产业转移和污染转移的趋势与规律,促进区域产业有序转移与协调发展,是当前需要考虑的一个重要战略问题。本文基于偏离—份额分析法的基本思想,构建改进的区域产业转移与污染转移模型,利用30省市1998—2014年的工业增加值、工业碳排放量、工业COD排放量、工业固体废弃物产生量以及工业SO2排放量等数据,对中国区域间的工业产业转移和污染转移情况进行定量测度。研究结果表明:从时间维度看,1998—2005年,中国的产业主要向东部地区集聚,自2005年开始东部地区向外转移的产业规模不断扩大,而2012年以后东部地区向外转移产业速度趋缓;从转移方向看,中国产业转移没有完全遵循梯度规律逐级转移,出现梯度背离现象,部分产业偏向西部地区;从省级尺度,根据1998—2014年间各省产业转移总量的变化情况来看,中国工业产业转移可以明显分为产业净转出区、产业强转入区、产业弱转入区三类区域。同时在产业转移的进程中,东、中和东北地区除了少数几个省外均为污染净转出区,而西部地区除了四川和重庆外均为污染转入区,已经成为承接污染转移的主要区域,其中,新疆、云南、内蒙古以及青海为高污染转入区。根据以上分析,针对西部地区成为中国的污染避难所这一现象,建议中央政府进一步发挥宏观调控能力,制定科学的产业政策,发挥各地自身优势,合理规划各地重点承接的产业,引导产业有序转移。同时,建立跨区域环境协同治理机制,提升西部地区环境治理能力。

关键词：偏离一份额分析产业转移污染转移定量测度

Differentially Expression of Tual,a Tubulin-encoding Gene,during Flowering of Tea Plant Camellia sinensis (L.) *** Using cDNA Amplified Fragment Length Polymorphism Technique

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Acta Biochimica et Biophysica Sinica 2006年第9期38卷 653-662页

作者： Wan-Ping FANG~(1,2) Chang-Jun JIANG~1* Mei YU~1 ai-hua YE~1 zhao-Xia WANG~(1,3) 1 Key Laboratory of Tea Biochemistry and Biotechnology,Ministry of Agriculture,Anhui Agricultural University,Hefei 230036,China 2 College Of Horticulture,Nanjing Agriculture University,Nanjing 210095,China 3 Auhui Institute of Education,Hefei 230036,China Key Laboratory of Tea Biochemistry and Biotechnology Ministry of Agriculture Anhui Agricultural UniversityHefei 230036 China College Of Horticulture Nanjing Agriculture UniversityNanjing 210095 China Auhui Institute of EducationHefei 230036 China

The complementary DNA （cDNA） amplified fragment length polymorphism technique wasused to isolate transcript-derived fragments corresponding to genes involved in the flowering of tea *** sequence analysis of an approximately 300 bp differential fragment amplified by primer combi-nation E11M11revealed 80%-84% similarity to the corresponding part of an α-tubulin gene of other *** complete cDNA sequence of this α-tubulin was cloned by the rapid amplification of cDNA ends technique;its full length is 1537 bp and contains an open reading frame of 450 amino acid residues with two N-glycosylation sites and four protein kinase C phosphorylation *** deduced amino acid sequences didshow significant homology to the α-tubulin from other plants that has been reported to be a pollen-specificprotein and could be correlated with plant cytoplasm-nucleus-interacted male *** named this completecDNA *** nucleotide and amino acid sequence data of Tual have been recorded in the GenBanksequence database with the accession *** Tual gene was cloned into the pET-32aexpression system and expressed in Escherichia coli BL21trxB（DE3）.The molecular weight of expressedprotein was deduced to be approximately 49 *** blot analysis was used to identify the temporalexpression of Tual in tea *** studies of the effect of Tual protein on pollen tube growth indicatedthe Tual solution obviously promoted the growth of tea pollen tube.

关键词： cDNA-AFLP Camellia sinensis flower bud α-tubulin Western blot pollen

巴西生物遗传资源获取与惠益分享管理制度研究

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植物遗传资源学报 2017年第5期18卷 920-924页

作者：武建勇王爱华孟蕊赵富伟戴蓉环境保护部南京环境科学研究所南京210042 环境保护部环境保护对外合作中心北京100035 华南理工大学广州510641

巴西是世界上生物多样性最丰富的国家之一,同时也曾一度是世界遗传资源的主要提供者。巴西很早就意识到保护本国生物遗传资源的重要性,巴西政府于2001年发布了《巴西保护生物多样性和遗传资源暂行条例》。随后又对《暂行条例》进行了数... 详细信息

巴西是世界上生物多样性最丰富的国家之一,同时也曾一度是世界遗传资源的主要提供者。巴西很早就意识到保护本国生物遗传资源的重要性,巴西政府于2001年发布了《巴西保护生物多样性和遗传资源暂行条例》。随后又对《暂行条例》进行了数十次修订,直到2015年由总统签署以宪法修正案的形式通过了《生物多样性保护法》(第13.123号法律)。巴西立法对有关概念和术语做了比《名古屋议定书》更为详细的区分和解释,并分别对生物遗传资源与传统知识的获取、审批、转让、惠益分享、行政处罚等内容做出了规定。为了更好地管理生物遗传资源,巴西还成立了"遗传资源委员会(CGEN)",并建立了"国家惠益分享基金(FNRB)"。中国与巴西同属生物多样性大国,且国情相似,本文对巴西遗传资源立法过程及其在遗传资源获取程序、管理机构、惠益分享等方面的相关规定进行了系统整理分析,为国内立法提供参考依据。

关键词：巴西生物遗传资源名古屋议定书获取与惠益分享

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Painstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

二乙基亚硝胺诱导大鼠肝纤维化模型血清N-糖组表达分析

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现代免疫学 2011年第1期31卷 38-43页

作者：房萌赵云鹏王爱华季君赵金艳高春芳第二军医大学东方肝胆外科医院实验诊断科上海200438

糖蛋白糖链具有广泛的生物学意义,异常糖基化状态与疾病的发生发展密切相关。肝纤维化易向肝硬化和肝癌发展,早期肝纤维化具有可逆转性,所以早期诊断尤为重要。本研究通过二乙基亚硝胺(DENA)诱导的大鼠肝纤维化模型,验证N-糖标志物在肝... 详细信息

糖蛋白糖链具有广泛的生物学意义,异常糖基化状态与疾病的发生发展密切相关。肝纤维化易向肝硬化和肝癌发展,早期肝纤维化具有可逆转性,所以早期诊断尤为重要。本研究通过二乙基亚硝胺(DENA)诱导的大鼠肝纤维化模型,验证N-糖标志物在肝纤维化发生发展中的变化过程。用DENA腹腔注射的方法诱导大鼠肝脏纤维化,用DSA-FACE的方法检测血清及血清中纯化的免疫球蛋白的N-糖组图谱。研究发现,peak1,peak2,peakR5a和peakR5b随着肝纤维化程度的加深而升高,而peak5和peak8则降低。Peak2主要来源于免疫球蛋白,可能与肝纤维化过程中的炎症状态密切相关,而大鼠特异性的N-糖peakR5a和peakR5b则主要来源于肝脏,可以评估和检测大鼠肝脏的纤维化状态,从而验证了N-糖标志物作为肝病诊断标志物的可靠性和潜在价值,为进一步筛选肝病的早期诊断指标打下了基础。

关键词：二乙基亚硝胺动物模型肝纤维化 N-糖组血清标志物

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萹蓄的化学成分研究

天然产物研究与开发 2002年第5期14卷 29-32页

作者：赵爱华赵勤实林中文孙汉董中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室昆明650204

从药用植物蓄 (Polygonumaviculare)全草的丙酮提取物中分离鉴定了 10个化合物 ,经波谱学鉴定为 :山奈酚 (kaempferol) (1) ,槲皮素 (quercetin) (2 ) ,胡桃宁 (juglanin) (3) ,黄芪甙 (astragalin) (4) ,蓄甙 (avicularin) (5 ) ,... 详细信息

从药用植物蓄 (Polygonumaviculare)全草的丙酮提取物中分离鉴定了 10个化合物 ,经波谱学鉴定为 :山奈酚 (kaempferol) (1) ,槲皮素 (quercetin) (2 ) ,胡桃宁 (juglanin) (3) ,黄芪甙 (astragalin) (4) ,蓄甙 (avicularin) (5 ) ,槲皮甙 (quercetrin) (6 ) ,杨梅树皮甙 (myricitrin) (7) ,desmanthin 1(8) ,loliolide(9)和丁香脂素 (syringaresinol) (10 )。其中 ,化合物 (8) ,(9) ,(10 )为首次从该植物中分离得到。

关键词：萹蓄蓼科化学成分黄酮类化合物