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Clinical implication of hematological indices in the essential hypertension

World Journal of Hypertension 2015年第2期5卷 93-97页

作者： ahmet karabulut Aytac Karadag Department of Cardiology Acibadem University School of MedicineAcibadem Atakent Hospital Department of Internal Medicine Acibadem Atakent Hospital

Prognostic value of haematological indices,especially red cell distribution width,neutrophil lymphocyte ratio and mean platelet volume,was reported with numerous investigations in miscellaneous cardiovascular *** major prognostic value was linked to oxidative stress and inflammation since their level was correlated with major inflammatory markers such as high sensitive C-reactive protein and *** stress and chronic inflammation are also postulated as the main pathophysiologic mechanism of essential hypertension(HT) and its vascular ***,correlation between HT and haematological parameters was searched in numerous studies,which has made the topic more ***,we reveal the correlation between haematological indices and HT and we also demonstrate the clinical implication of this *** haematological parameters may strongly indicate hypertensive end-organ damage.

关键词： Hypertension Inflammation End-organ damage Haematological indice Platelet activation

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An investigation of 10 Y-STR loci and the detection of specific haplotype frequencies in Turkish population

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American Journal of Molecular Biology 2011年第2期1卷 114-121页

作者： Aydin Rüstemoglu Güvem Gümüs Akay Halil Gürhan karabulut ahmet Kadikiran Isik Bokesoy Gaziosmanpasa University Faculty of MedicineDepartment of Medical BiologyTokatTurkey Ankara University Brain Studies Application and Research CenterAnkaraTurkey Ankara University Faculty of MedicineDepartment of Medical GeneticsAnkaraTurkey Ankara University Faculty of ScienceDepartment of Molecular BiologyAnkaraTurkey

This study is to survey 10 Y-STR loci in 241 males from Turkey. In this study, the 241 healthy and unrelated males living in different parts of Turkey for at least three generations were included. Genomic DNAs were isolated from peripheral blood samples by standard phenol-chloroform extraction method. 10 Y-STR loci including DYS19, DYS385a/b, DYS388, DYS389I/II, DYS390, DYS391, DYS392, DYS393, and YCAIIa/b were analyzed by using PCR and denaturing PAGE. Allele frequencies, gene diversities and haplotype frequencies were analyzed. Gene diversity per locus varied from 0.5788 (DYS388) to 0.8903 (DYS385a/b). The numbers of haplotypes in minHt recommended by YCC and Ht10 have been 208 and 186, respectively. When our minHt haplotypes frequencies compared with the other seven populations, we have found statistically significant differences between our results and other populations (P 0.05). We suggest that an alternative haplotype designated as aHt maybe alternative to minHt in respect of its Y-STR content with the highest gene diversity value. The aHt haplotype has found a higher discriminatory potential than minHt haplotype with a better Pd combined value (0.9999936 vs 0.9999836) and has higher average gene diversity per locus (0.7834 vs 0.7518) in Turkish population. aHt haplotype can be proposed as an alternative to minHt in paternity testing and forensic medicine applications involving Turkish male population. This study has also provided additional information to the framework of variation involving 10 Y-STR loci as well as a further contribution to the Y-STR database for Turkish male population.

关键词： Y Chromosome Y-STR Polymorphism Ha- plotype Turkey

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