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Values of high-resolution computed tomography and pulmonary function tests in managements of patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2004年第3期10卷 381-384页

作者： Oguzhan Okutan Zafer Kartaloglu ahmet ilvan Ali Kutlu Erkan Bozkanat Emir Silit GATA Haydarpasa Training Hospital Department of Pulmonary DiseasesIstanbulTurkey Gumussuyu Military Hospital Department of Pulmonary DiseasesIstanbulTurkey GATA Haydarpasa Training Hospital Department of RadiologyIstanbulTurkey

AIM:To investigate pulmonary involvement via pulmonary function tests (PFT) and high-resolution computed tomocjraphy (HRCT) in patients with chronic hepatitis C virus (HCV) infection. METHODS:Thirty-four patients with chronic HCV infection without diagnosis of any pulmonary diseases and 10 healthy cases were enrolled in the study,PFT and HRCT were performed in all cases. RESULTS:A decrease lower than 80% of the predicted value was detected in vital capacity in 9/34 patients,in forced expiratory volume in one second in 8/34 patients,and in forced expiratory flow 25-75 in 15/34 patients,*** monoxide diffusing capacity (DLCO) was decreased in 26/34 *** of interstitial pulmonary involvement were detected in the HRCT of 16/34 *** difference was found between controls and patients with HCV infection in findings of HRCT (X^2=4.7,P=0.003).Knodell histological activity index (KHAI) of 28/34 patients in whom liver biopsy was applied was 9.0±*** findings,PFT values and DLCO were not affected by KHAI in patients with HCV *** these patients,all the parameters were related with age. CONCLUSION:We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

关键词： Respiratory Function Tests Tomography, X-Ray Computed Adult Aged Female Hepatitis C, Chronic Humans Lung Diseases Male Middle Aged

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