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Engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

Acta Pharmaceutica Sinica B 2024年第6期14卷 2475-2504页

作者： ahmed O.Elzoghby Omar samir Hagar E.Emam ahmed Soliman Riham M.Abdelgalil Yomna M.Elmorshedy Kadria A.Elkhodairy Mahmoud L.Nasr Division of Engineering in Medicine and Division of Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(TME)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have been developed to induce immunogenic cell death(ICD)of cancer cells and thereby elicit immunogenicity and boost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for boosting ICD of cancer ***,synergistic approaches used in combination with ICD inducing nanomedicines for remodeling the TME via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell membrane camouflaged nanomedicines,amplified reactive oxygen species(ROS)generation,metallo-immunotherapy,ion modulators and engineered bacteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity T cells Tumor associated antigens Synergistic immune response

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Swift XRT Analysis of Type II-P Supernova SN 2008ij

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International Journal of Astronomy and Astrophysics 2024年第3期14卷 220-229页

作者： SH. M. Shehata ahmed M. Fouad R. M. samir A. A. Shaker National Research Institute of Astronomy and Geophysics (NRIAG) Helwan Egypt

This study investigates the X-ray properties and evolution of Type II supernovae (SNe II) observed by Swift, examining variations among supernovae and exploring their X-ray characteristics over time. We present the first X-ray study of the Type IIp supernova SN 2008ij using data from the Swift X-ray mission. This investigation focuses on its spectral properties, identifying an X-ray flux of 1.20 (+0.11, −0.10) × 10−13 erg/cm2/s and a plasma temperature of 4.76 (+1.22, −0.83) keV. Our study marks an advancement in understanding SN 2008ij, providing crucial results into its X-ray emission characteristics. These results lay the groundwork for future studies of Type IIp supernovae, offering a foundation for exploring their evolutionary and physical processes.

关键词： X-Ray Core Collapse Supernova Swift (XRT) Observations

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Deep Reinforcement Learning Model for Blood Bank Vehicle Routing Multi-Objective Optimization

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Computers, Materials & Continua 2022年第2期70卷 3955-3967页

作者： Meteb M.Altaf ahmed samir.roshdy Hatoon S.AlSagri Director of Advanced Manufacturing and Industry 4.0 Center King Abdul-Aziz City for Science and Technology RiyadhSaudi Arabia Data Science and AI Senior Manager Vodafone CairoEgypt Information System Department Al Imam Mohammad Ibn Saud Islamic UniversityRiyadhSaudi Arabia

The overall healthcare system has been prioritized within development top lists *** many national populations are aging,combined with the availability of sophisticated medical treatments,healthcare expenditures are rapidly *** banks are a major component of any healthcare system,which store and provide the blood products needed for organ transplants,emergency medical treatments,and routine *** delivery of blood products is vital,especially in emergency ***,blood delivery process parameters such as safety and speed have received attention in the literature,as well as other parameters such as delivery *** this paper,delivery time and cost are modeled mathematically and marked as objective functions requiring simultaneous optimization.A solution is proposed based on Deep Reinforcement Learning(DRL)to address the formulated delivery functions as Multi-objective Optimization Problems(MOPs).The basic concept of the solution is to decompose the MOP into a scalar optimization sub-problems set,where each one of these sub-problems is modeled as a separate Neural Network(NN).The overall model parameters for each sub-problem are optimized based on a neighborhood parameter transfer and DRL training *** optimization step for the subproblems is undertaken collaboratively to optimize the overall *** solutions can be directly obtained using the trained ***,the multi-objective blood bank delivery problem is addressed in this *** technical advantage of this approach is that once the trainedmodel is available,it can be scaled without the need formodel *** scoring can be obtained directly using a straightforward computation of the NN layers in a limited *** proposed technique provides a set of technical strength points such as the ability to generalize and solve rapidly compared to othermulti-objective *** model was trained and tested on 5 major hospi

关键词： Optimization blood bank deep neural network reinforcement learning blood centers multi-objective optimization

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Off-Pump Coronary Artery Bypass Grafting in Patients with Left Ventricular Dysfunction: Short-Term Results from a Single Center in Bangladesh

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World Journal of Cardiovascular Surgery 2024年第9期14卷 145-156页

作者： Muhit Abdullah Md. Abir Tazim Chowdhury Satyajit Sharma Rehana Akther Munama Magdum Munjerin Refat Synthee Md. Zafar-Al-Nimari Saikat Das Gupta Saleh ahmed samir Kumar Biswas M. Quamrul Islam Talukder Farooque ahmed Department of Cardiac Surgery National Heart Foundation Hospital and Research Institute (NHFH&RI) Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Dhaka Bangladesh Ispahani Islamia Eye Institute & Hospital Khamarbari Dhaka Bangladesh National Institute of Preventive and Social Medicine Dhaka Bangladesh Square Hospital Dhaka Bangladesh

Background: Off-pump coronary artery bypass grafting (OPCAB) is considered a safer alternative to on-pump surgery, especially in patients with left ventricular dysfunction (LVD). Objectives: This study assessed short-term outcomes and functional improvements in LVD patients post-OPCAB. Methods: The study included 200 coronary artery disease patients who underwent isolated off-pump coronary artery bypass grafting (OPCAB) at the National Heart Foundation Hospital and Research Institute between January 2019 and June 2020. Patients were categorized into Group 1, with a left ventricular ejection fraction (LVEF) of 30% - 39%, and Group 2, with an LVEF of 40% or higher. Echocardiographic assessments of left ventricular dimensions and ejection fraction were performed preoperatively, at discharge, and one month postoperatively. Results: In Group 1, preoperative left ventricular internal dimensions during diastole (LVIDd) and systole (LVIDs) were 53.48 ± 4.40 mm and 44.23 ± 3.93 mm, respectively, with a left ventricular ejection fraction (LVEF) of 35.28% ± 2.26%. At discharge, these values improved to 51.58 ± 4.04 mm (LVIDd), 41.23 ± 5.30 mm (LVIDs), and 39.25% ± 3.75% (LVEF). One month postoperatively, further improvements were observed: 46.29 ± 3.76 mm (LVIDd), 37.45 ± 3.68 mm (LVIDs), and 43.22% ± 4.67% (LVEF). Group 2 showed similar positive outcomes, with preoperative values of 47.09 ± 5.06 mm (LVIDd), 35.11 ± 5.25 mm (LVIDs), and 50.13% ± 7.25% (LVEF), improving to 42.37 ± 4.18 mm (LVIDd), 31.05 ± 4.19 mm (LVIDs), and 55.33% ± 7.05% (LVEF) at one month postoperatively. Both groups demonstrated significant improvements in left ventricular function and NYHA class, with most patients moving from class III/IV to I/II. Complications were minimal, and no mortality was observed. Conclusion: OPCAB is safe and effective for patients with LVEF 30% - 39% and LVEF ≥ 40%, providing significant short-term functional improvements without increased risk.

关键词： Off-Pump Coronary Artery Bypass Grafting Left Ventricular Dysfunction (LVD) Short-Term Outcomes

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Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation:a multi-institutional,retrospective study

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Stroke & Vascular Neurology 2024年第3期9卷 221-229,I0130,I0131页

作者： Chloe Dumot Georgios Mantziaris Sam Dayawansa Zhiyuan Xu Stylianos Pikis Selcuk Peker Yavuz Samanci Gokce D Ardor ahmed M Nabeel Wael A Reda Sameh R Tawadros Khaled Abdelkarim Amr M N El-Shehaby Reem M Emad Eldin ahmed H Elazzazi Nuria Martínez Moreno Roberto MartínezÁlvarez Roman Liscak Jaromir May David Mathieu Jean-Nicolas Tourigny Manjul Tripathi Akshay Rajput Narendra Kumar Rupinder Kaur Piero Picozzi Andrea Franzini Herwin Speckter Wenceslao Hernandez Anderson Brito Ronald E Warnick Juan Alzate Douglas Kondziolka Greg N Bowden samir Patel Jason Sheehan Department of Neurological Surgery Hospices Civils de LyonLyonFrance Department of Neurological Surgery University of VirginiaCharlottesvilleVirginiaUSA Department of Neurosurgery Koc University School of MedicineIstanbulTurkey Gamma-knife Center Nasser institute HospitalCairoEgypt Neurosurgery Department Benha UniversityBenhaEgypt Departments of Neurosurgery Ain Shams UniversityCairoEgypt Department of Clinical Oncology Ain Shams UniversityCairoEgypt Department of Radiation Oncology National Cancer InstituteCairo UniversityGizaEgypt Faculty of Medicine Extended Modular ProgramAin Shams UniversityCairoEgypt Department of Radiosurgery Rúber Internacional HospitalMadridSpain Department of Stereotactic and Radiation Neurosurgery Na Homolce HospitalPragueCzech Republic Neurosurgery Centre de recherche du CHUSUniversitéde SherbrookeSherbrookeQuebecCanada Neurosurgery PGIMERChandigarhChandigarhIndia Radiation Therapy PGIMERChandigarhChandigarhIndia Neurosurgery IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Dominican Gamma Knife Center and Radiology Department CEDIMATSanto DomingoDominican Republic Gamma Knife Center Mayfield ClinicThe Jewish Hospital-Mercy HealthCincinnatiOhioUSA Neurosurgery NYU Langone HealthNew YorkNew YorkUSA Neurosurgery University of AlbertaEdmontonAlbertaCanada Division of Radiation Oncology Department of OncologyUniversity of AlbertaEdmontonAlbertaCanada

Background Cerebral cavernous malformations(CCMs)frequently manifest with *** radiosurgery(SRS)has been employed for CCM not suitable for *** effect on reducing haemorrhage risk is still *** aim of this study was to expand on the safety and efficacy of SRS for haemorrhagic *** This retrospective multicentric study included CCM with at least one haemorrhage treated with single-session *** annual haemorrhagic rate(AHR)was calculated before and after *** event analysis and Cox regression were used to evaluate factors associated with *** radiation effects(AREs)and occurrence of new neurological deficits were *** The study included 381 patients (median age:37.5 years(Q1–Q3:25.8–51.9))with 414 *** AHR from diagnosis to SRS excluding the first haemorrhage was 11.08 per 100 CCM-years and was reduced to 2.7 per 100 CCM-years after *** recurrent event analysis,SRS,HR 0.27(95%CI 0.17 to 0.44),p13 Gy,HR 2.27(95%CI 1.20 to 4.32),p=0.012 and the presence of DVA,HR 2.08(95%CI 1.00 to 4.31),p=0.049 were factors associated with higher probability of post-SRS ***-SRS haemorrhage was symptomatic in 22 out of 381(5.8%)patients,presenting with transient(15/381)or permanent(7/381)neurological *** occurred in 11.1%(46/414)CCM and was responsible for transient neurological deficit in 3.9%(15/381)of the patients and permanent deficit in 1.1%(4/381)of the *** doses>13 Gy and CCM volume>0.7 cc were associated with increased risk of ARE.

关键词： doses haemorrhagic diagnosis

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ON THE SUPERSTABILITY OF THE PEXIDER TYPE GENERALIZED TRIGONOMETRIC FUNCTIONAL EQUATIONS

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Acta Mathematica Scientia 2014年第6期34卷 1749-1760页

作者： Driss ZEGLAMI ahmed CHARIFI samir KABBAJ Department of Mathematics E.N.S.A.M Moulay Ismail University Department of Mathematics Faculty of SciencesIbn Tofail University

The aim of this paper is to investigate the superstability problem for the pexiderized trigonometric functional equation∑ v∈Φ∫Kf（xkv（y）k^-1）dwK（k）= Φ g（x）h（y）, x, y ∈ G,where G is any topological group, K is a compact subgroup of G, ωK is the normalized Haar measure of K, Φ is a finite group of K-invariant morphisms of G and f, g, h are continuous complex-valued ***, we have generalized the results of stability for d＇Alembert＇s and Wilson＇s equations by R. Badora, J. Baker, B. Bouikhalene, P. Gavruta, S. Kabbaj, Pl. Kannappan, G. ***, J.M. Rassias, A. Roukbi, L. Sz′ekelyhidi, D. Zeglami, etc.

关键词： superstability generalized Pexider d'Alembert equation Wilson's functional equation group of morphisms

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Prognostic Role of Preoperative Tricuspid Annular Plane Systolic Excursion (TAPSE) in Mitral Valve Replacement (MVR) for Rheumatic Mitral Stenosis Patients

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World Journal of Cardiovascular Surgery 2024年第8期14卷 115-130页

作者： Satyajit Sharma Muhit Abdullah Md. Noor-E-Elahi Mozumder Munjerin Refat Synthee Md. Zafar-Al-Nimari Anowarul Azim Saikat Das Gupta Dewan Iftakher Raza Chowdhury Siddhartha Shankar Howlader Noel Crypian Gomes Saleh ahmed samir Kumar Biswas Department of Cardiac Surgery National Heart Foundation Hospital & Research Institute (NHFH & RI) Dhaka Bangladesh Department of Cardiac Surgery National Institute of Cardiovascular Diseases & Hospital Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Square Hospital Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Chattogram Bangladesh

Tricuspid annular plane systolic excursion has been proposed as a simple and reproducible parameter for quantitative assessment of the right ventricular ejection fraction. The prognostic importance of preoperative TAPSE in patients with mitral valve replacement for rheumatic mitral stenosis patients is still under focused. Therefore, the objective of the study was to predict the outcome after MVR in rheumatic mitral stenosis patients in relation to preoperative TAPSE. This comparative cross-sectional study was conducted at the Department of Cardiac Surgery, National Heart Foundation Hospital and Research Institute. A total of 72 patients of rheumatic mitral stenosis patients who underwent mitral valve replacement were included in the study. They were divided into two groups: Group A and B. Group A included 36 patients with TAPSE 0.05) except for the preoperative TAPSE. Mean TAPSE of Group A was 13.17 (±1.40) and Group B was 18.61 (±1.57), the difference was statistically significant (p 0.05). Among the postoperative complications, including postoperative atrial fibrillation was higher in Group A (30.56%) than Group B (11.11%), mean ventilation time was higher in Group A (27.78%) than Group B (5.56%), length of intensive care was higher in Group A (33.33%) than Group B (11.12%), and hospital stay was higher in Group A (25.0%) than Group B (5.56%), (p < 0.05). Higher preoperative TASPE could be used as a prognostic tool for MVR in rheumatic mitral stenosis patients in our settings.

关键词： Tricuspid Annular Plane Systolic Excursion Mitral Valve Replacement Rheumatic Heart Disease Mitral Stenosis Right Ventricular Ejection Fraction Postoperative Complications

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Improving of photocatalytic activity of barium ferrate via bismuth and copper co-doping for degradation of paracetamol under visible light irradiation

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Journal of Environmental Sciences 2022年第2期34卷 331-342页

作者： Hussien ahmed Abbas Rabab ahmed Nasr Rose-Noelle Vannier Tarek samir Jamil Inorganic Chemistry Department National Research CentreCairo 12622Egypt Water Pollution Control Department National Research CenterCairo 12622Egypt Univ.Lille CNRSCentrale LilleENSCLUniv.ArtoisUMR 8181Unite de Catalyse et Chimie du Solide(UCCS)Lille 59000France

Nanosized Ba_(1-x)Bi_(x)Fe_(1-x)Cu_(x)O_(3)(12–50 nm)with x values of 0,0.01,0.05,and 0.1 system was prepared using the Pechini ***,morphological,surface and optical characterizations were performed for the prepared *** phase was the predominant phase for the undoped BaFeO_(3)and Bi and Cu co-doped BaFeO_(3)*** phases of monoclinic Ba_(2)Fe_(2)O_(5),orthorhombic BaFe_(2)O_(4)and orthorhombic BaCO_(3)were identified for all the prepared ***_(0.95)Bi_(0.05)Fe_(0.95)Cu_(0.05)O_(3)sample has the lowest band gap(2.43 e V).98.1%paracetamol removal was achieved with 0.75 g/L of Ba_(0.95)Bi_(0.05)Fe_(0.95)Cu_(0.05)O_(3)at pH9 after 120 *** paracetamol degradation follows the pseudo first-order ***·is the main oxidative species responsible for the paracetamol *** chromatography–mass spectrometry(GC–MS)analysis was performed at the end of the photocatalytic degradation experiment under optimum operating condition using Ba_(0.95)Bi_(0.05)Fe_(0.95)Cu_(0.05)O_(3)to explain the reaction mechanism and identify the intermediate by-products which is confirmed by ultraviolet/visible(UV/Vis)spectroscopy study at different reaction times.

关键词： Ba_(1-x)Bi_(x)Fe_(1-x)Cu_(x)O_(3) Photocatalytic degradation Nanomaterials Paracetamol

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Shear reinforcement effect of reinforced concrete tie-columns on the lateral resistance of confined masonry walls

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Earthquake Engineering and Engineering Vibration 2016年第2期15卷 313-324页

作者： samir Bouhedja Abdelkrim Bourzam ahmed Boukhaled Ammar Nechnech University of Sciences and Technology Houari Boumediene(USTHB)Faculty of Civil EngineeringLaboratory of EnvironmentWaterGeomechanics and Structures(LEEGO)BP 32 El AliaBab EzzouarAlgiers16111Algeria University of Sciences and Technology Houari Boumediene(USTHB)Faculty of Civil EngineeringLaboratory of Built Environment Research(LBE)BP 32 El AliaBab EzzouarAlgiers16111Algeria

Tie-columns improve significantly the lateral resistance of masonry bearing walls against persistent, transient and accidental loads. The research work described herein has been carried out to assess the lateral resistance of confined masonry walls, where contribution of the masonry panel is evaluated according to material mechanics and tie-columns effect is estimated by a proposed analytical formulation based on a model reported on previously. This approach takes into account the effect of dowel support on the reaction of its adjacent shear reinforcement： the conditions for the various contributions of transverse reinforcements are better defined following a clear evaluation of the participation ratio of these reinforcements. Lateral resistances of confined masonry walls measured in full-scale tests and gleaned from the literature are compared and checked with resistances calculated using the present approach.

关键词： reinforcement columns confined reinforced walls Shear formulation panel participation herein

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A Novel Design of Octal-Valued Logic Full Adder Using Light Color State Model

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Computers, Materials & Continua 2021年第6期67卷 3487-3503页

作者： ahmed Talal Osama Abu-Elnasr samir Elmougy Department of Computer Science Faculty of Computes and InformationMansoura UniversityMansoura35516Egypt

Due to the demand of high computational speed for processing big data that requires complex data manipulations in a timely manner,the need for extending classical logic to construct new multi-valued optical models becomes a challenging and promising research *** paper establishes a novel octal-valued logic design model with new optical gates construction based on the hypothesis of Light Color State Model to provide an efficient solution to the limitations of computational processing inherent in the electronics *** provide new mathematical definitions for both of the binary OR function and the PLUS operation in multi valued logic that is used as the basis of novel construction for the optical full adder *** case studies were used to assure the validity of the proposed *** cases proved that the proposed optical 8-valued logic models provide significantly more information to be packed within a single bit and therefore the abilities of data representation and processing is increased.

关键词： Mathematical modeling numerical simulations optical logic optics in computing multi-valued logic full adder

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