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Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study

World Journal of Gastroenterology 2013年第43期19卷 7711-7718页

作者： Hanan Fouad Maissa Saeed El Raziky Rasha ahmed Abdel Aziz Dina Sabry Ghada Mahmoud Abdel Aziz Manal Ewais ahmed reda sayed Medical Biochemistry Department Faculty of MedicineCairo University11562 CairoEgypt Gastroenterology and Tropical Department Faculty of MedicineCairo University11562 CairoEgypt Medical Biochemistry Department Faculty of MedicineBeni Sueif University19206 Kornish Al NileBani SweifEgypt

AIM:To assess co-stimulatory and co-inhibitory markers of dendritic cells(DCs)in hepatitis C virus(HCV)infected subjects with and without ***:Three subject groups were included in the study:group 1 involved 50 control subjects,group2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing ***83,CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by realtime polymerase chain ***-10(IL-10)and hyaluronic acid(HA)levels were also *** findings were correlated with disease activity,viral load and ***:There was a significant decrease in costimulatory markers;CD83,CD86 and CD40 in groups2 and 3 vs the control ***-stimulatory markers were significantly higher in group 3 vs group *** was a significant elevation in PD-L1 in both HCV groups vs the control ***-L1 was significantly lower in group 3 vs group *** was a significant elevation in IL-10 and HA levels in groups 2 and 3,where IL-10was higher in group 3 and HA was lower in group 3 vs group *** level was significantly correlated with disease activity and fibrosis grade in group ***-10 was significantly correlated with fibrosis grade in group *** were significant negative correlations between co-stimulatory markers and viral load in groups 2 and3,except CD83 in dialysis *** was a significant positive correlation between PD-L1 and viral load in both HCV ***:A significant decrease in DC co-stimulatory markers and a significant increase in a DC coinhibitory marker were observed in HCV subjects and to a lesser extent in dialysis patients.

关键词： Hepatitis C virus Uremia Hemodialysis Dendritic cells CD83 CD86,CD40 PD-L1 Interleukin-10 Hyaluronic acid

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Regulatory and activated effector T cells in chronic hepatitis C virus: Relation to autoimmunity

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World Journal of Hepatology 2016年第30期8卷 1287-1294页

作者： Hanan Fouad Maissa El Raziky Eman Medhat Hassan Ghada Mahmoud Abdel Aziz Samar K Darweesh ahmed reda sayed Department of Medical Biochemistry Faculty of Medicine Cairo University Department of Pharmacology and Toxicology Faculty of Pharmacy Hail University Department of Hepato-gastroenterology and Tropical Medicine Faculty of Medicine Cairo University Department of Medical Biochemistry Faculty of Medicine Beni Suef University

AIMTo investigate how Tregs are regulated in chronic hepatitis C virus (HCV) patients via assessment of Tregs markers (granzyme 2, CD69 and FoxP3), Teffs markers [TNFRSF4 (OX40), INFG] and CD4, CD25 genes. METHODSA prospective study was conducted on 120 subjects divided into 4 groups: Group I (n = 30) treatment naïve chronic HCV patients; Group II (n = 30) chronic HCV treated with Peg/Riba; Group III (n = 30) chronic HCV associated with non-organ specific autoantibody and Group IV (n = 30) healthy persons as a control group. Tregs and Teffs markers were assessed in peripheral blood mononuclear cells by quantitative real time reverse transcriptase-polymerase chain reaction. RESULTSChronic HCV patients exhibited significant higher levels of both Teffs and Tregs in comparison to healthy control group. Tregs markers were significantly decreased in Peg/Riba treated HCV patients in comparison to treatment naïve HCV group. In HCV patients with antinuclear antibody (ANA) +ve, Tregs markers were significantly decreased in comparison to all other studied groups. Teffs markers were significantly elevated in all HCV groups in comparison to control and in HCV group with ANA +ve in comparison to treatment naïve HCV group. CONCLUSIONElevated Tregs cells in chronic HCV patients dampen both CD4+ and CD8+ autologous T cell immune response. Interferon-α and ribavirin therapy suppress proliferation of Tregs. More significant suppression of Tregs was observed in HCV patients with autoantibodies favoring pathological autoimmune response.

关键词： Autoimmunity T regulatory cells Hepatitis C virus T activator cells Interferon

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Experimental and parametrical investigation of pre-stressed ultrahigh-performance fiberreinforced concrete railway sleepers

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Frontiers of Structural and Civil Engineering 2023年第3期17卷 411-428页

作者： sayed ahmed Hossam ATEF Mohamed HUSAIN Department of Structural Engineering Faculty of EngineeringZagazig UniversityZagazig 44519Egypt Track Work Department National Authority for TunnelsCairo 11522Egypt

In this study,ultrahigh-performance fiber-reinforced concrete(UHPFRC)used in a type B70 concrete sleeper is investigated experimentally and *** main parameters investigated are the steel fiber volume fractions(0%,0.5%,1%,and 1.5%).Under European standards,35 UHPFRC sleepers are subjected to static bending tests at the center and rail seat sections,and the screw on the fastening system is pulled *** first cracking load,failure load,failure mode,crack propagation,load–deflection curve,load–crack width,and failure load from these tests are measured and compared with those of a control sleeper manufactured using normal concrete *** accuracy of the parametric study is verified ***,the results of the study are applied to UHPFRC sleepers with different concrete volumes to investigate the effects of the properties of UHPFRC on their *** and parametric study results show that the behavior of UHPFRC sleepers improves significantly when the amount of steel fiber in the mix is *** manufactured using UHPFRC with a steel fiber volume fraction of 1%and a concrete volume less than 25%that of standard sleeper B70 can be used under the same loads and requirements,which contributes positively to the cost and surrounding environment.

关键词： pre-stressed concrete sleeper ultrahigh performance fiber-reinforced concrete pull-out test static bending test steel fiber aspect ratio volume fraction

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Assessment of clay stiffness and strength parameters using index properties

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第3期10卷 579-593页

作者： sayed M.ahmed Structural Engineering Department Ain Shams University

A new approach is developed to determine the shear wave velocity in saturated soft to firm clays using measurements of the liquid limit, plastic limit, and natural water content with depth. The shear wave velocity is assessed using the site-specific variation of the natural water content with the effective mean stress. Subsequently, an iterative process is envisaged to obtain the clay stiffness and strength *** at-rest earth pressure coefficient, as well as bearing capacity factor and rigidity index related to the cone penetration test, is also acquired from the analyses. Comparisons are presented between the measured clay parameters and the results of corresponding analyses in five different case studies. It is demonstrated that the presented approach can provide acceptable estimates of saturated clay stiffness and strength parameters. One of the main privileges of the presented methodology is the site-specific procedure developed based on the relationships between clay strength and stiffness parameters, rather than adopting direct correlations. Despite of the utilized iterative processes, the presented approach can be easily implemented using a simple spreadsheet, benefiting both geotechnical researchers and practitioners.

关键词： Soft to firm clays Atterberg limits Shear wave velocity Small-strain shear modulus Constrained modulus Undrained shear strength Effective friction angle Cone penetration test

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A Transfer Learning-Enabled Optimized Extreme Deep Learning Paradigm for Diagnosis of COVID-19

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Computers, Materials & Continua 2022年第1期70卷 1381-1399页

作者： ahmed reda Sherif Barakat Amira Rezk Department of Information System Faculty of Computer and Information ScienceMansoura UniversityMansouraEgypt

Many respiratory infections around the world have been caused by ***-19 is one of the most serious coronaviruses due to its rapid spread between people and the lowest survival *** is a high need for computer-assisted diagnostics(CAD)in the area of artificial intelligence to help doctors and radiologists identify COVID-19 patients in cloud *** learning(ML)has been used to examine chest X-ray *** this paper,a new transfer learning-based optimized extreme deep learning paradigm is proposed to identify the chest X-ray picture into three classes,a pneumonia patient,a COVID-19 patient,or a normal ***,three different pre-trainedConvolutionalNeuralNetwork(CNN)models(resnet18,resnet25,densenet201)are employed for deep feature ***,each feature vector is passed through the binary Butterfly optimization algorithm(bBOA)to reduce the redundant features and extract the most representative ones,and enhance the performance of the CNN *** selective features are then passed to an improved Extreme learning machine(ELM)using a BOA to classify the chest X-ray *** proposed paradigm achieves a 99.48%accuracy in detecting covid-19 cases.

关键词： Butterfly optimization algorithm(BOA) covid-19 chest X-ray images convolutional neural network(CNN) extreme learning machine(ELM) feature selection

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Standard precaution measurements during ophthalmology practice in the pandemic stage of COVID-19

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1017-1022页

作者： ahmed Mohamed reda Wael M.ahmed Department of ophthalmology Faculty of MedicineAin Sham UniversityCairo 11566Egypt Dar Eloyoun Eye Laser Centers Muscat 118Oman

AIM:To take specific precautions and keep a safe practice during providing ophthalmology health services without compromising the patient’s safety as well as the team workers and the community in the pandemic stage of corona virus disease 2019(COVID-19).METHODS:Applying patient circulation scheme implemented in our ophthalmology centers with the guidance of ministry of health infection control guidelines star ted from the moment that we receive a call or Whats App message or Facebook inquiry from patients until 21 d after patients first visit if *** directions were ***,community awareness of the disease and the ophthalmology related advices in how eye can transfers the infection and how to protect our eyes not to be infected through videos interviews of our consultants and distribution in social media like Instagram,Facebook,Whats App pages radio and TV interviews as well as leaflet health awareness for distribution for ***,scheduling of patients’appointments to prevent overcrowdings and cross ***,protective measurements tools in the center to detect and prevent any exposure of the patients to patients and to protect medical staff,COVID-19 scoring system was set up to identify patients with fever,respiratory symptoms,acute conjunctivitis or recent travel to outbreak areas and to encourage these individuals to postpone their appointments for at least 21 *** use of personal protective equipment was *** all the elective surgeries keeping only the emergency types advised by fourth:how to deal with our patients if they need an urgent ophthalmological intervention and how to deal with suspected cases of corona if any cases ***:Our measures helped our colleagues to try to keep providing ophthalmology health services without increasing the incidence of infection for COVID-19 until this pandemic is ***:In our practice,ophthalmologists should work with new aura of social media to facilitate the

关键词： corona virus COVID-19 Instagram Facebook WhatsApp personal protective equipment

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Position Control of Synchronous Motor Drive by Modified Adaptive Two-phase Sliding Mode Controller

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International Journal of Automation and computing 2008年第4期5卷 406-412页

作者： Mohamed Said sayed ahmed Automation Science and Electrical Engineering School Beijing University of Aeronautics and Astronautics

A modified adaptive two-phase sliding mode controller for the synchronous motor drive that is highly robust to uncertain- ties and external disturbances is proposed in this *** proposed controller uses two-phase sliding mode control (SMC) where the 1st phase mainly controls the system in steady states and disturbed states-it is a smoothing *** 2nd phase is used mainly in the case of disturbed ***,it is an autotuning phase and uses a simple adaptive algorithm to tune the gain of conventional variable structure control (VSC).The modified controller is useful in position control of a permanent magnet synchronous drive.

关键词： Reaching law adaptive control sliding mode control (SMC) chattering.

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Effectiveness of external prestressing in enhancing the non-ductile hanger failure mechanism in reinforced concrete inverted T-beams

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1050-1065页

作者： ahmed M.ATTA reda N.BEHIRY Mohammed I.HARAZ Structural Engineering Department Faculty of EngineeringTanta UniversityTanta 33511Egypt Nile Higher Institute for Engineering and Technology Mansoura 11001Egypt

Recently,inverted T-beams have been used in reinforced concrete(RC)bridges to support transverse precast *** T-beams,contrary to practice with conventional beams,are loaded on the flanges upper *** loading configuration causes hanger failure due to the generation of vertical tensile stresses near the bottom of the *** key purpose of this study is to investigate the efficiency of vertical external prestressing stainless-steel bars in mitigating non-ductile hanger failure in reinforced concrete inverted *** experimental study on six inverted-T beams,including two un-strengthened specimens,was carried *** study showed that the value of the prestressing level had a considerable impact on the performance of hanger mechanism in relation to crack pattern,ultimate loads,cracking behavior,load-deflection,strains,and *** experimental results indicated that the suggested method for strengthening inverted T-beams had efficacy in reducing the seriousness of the non-ductile hanger failure and resulted in a strength increase of up to 53% when compared to that of the un-strengthened ***,two analytical models for estimating the hanger capacity and the average crack width of the strengthened RC inverted T-beams were *** models that were proposed exhibited a high degree of agreement with the experimental results.

关键词： RC bridges inverted T-beams strengthening hanger failure external prestressing

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VeriFace:Defending against Adversarial Attacks in Face Verification Systems

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Computers, Materials & Continua 2023年第9期76卷 3151-3166页

作者： Awny sayed Sohair Kinlany Alaa Zaki ahmed Mahfouz Information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddahSaudi Arabia Computer Science Department Faculty of ScienceMinia UniversityAl MinyaEgypt Faculty of Computer Studies Arab Open UniversityMuscatOman

Face verification systems are critical in a wide range of applications,such as security systems and biometric ***,these systems are vulnerable to adversarial attacks,which can significantly compromise their accuracy and *** attacks are designed to deceive the face verification system by adding subtle perturbations to the input *** perturbations can be imperceptible to the human eye but can cause the systemtomisclassifyor fail torecognize thepersoninthe *** this issue,weproposeanovel system called VeriFace that comprises two defense mechanisms,adversarial detection,and adversarial *** first mechanism,adversarial detection,is designed to identify whether an input image has been subjected to adversarial *** second mechanism,adversarial removal,is designed to remove these perturbations from the input image to ensure the face verification system can accurately recognize the person in the *** evaluate the effectiveness of the VeriFace system,we conducted experiments on different types of adversarial attacks using the Labelled Faces in the Wild(LFW)*** results show that the VeriFace adversarial detector can accurately identify adversarial imageswith a high detection accuracy of 100%.Additionally,our proposedVeriFace adversarial removalmethod has a significantly lower attack success rate of 6.5%compared to state-of-the-art removalmethods.

关键词： Adversarial attacks face aerification adversarial detection perturbation removal

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Optical and near-infrared photometric study of NGC 6724

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Research in Astronomy and Astrophysics 2018年第2期18卷 37-42页

作者： reda Bendary Ashraf Tadross Priya Hasan Anas Osman ahmed Essam National Research Institute of Astronomy & Geophysics 11421-Helwan Cairo Egypt Maulana Azad National Urdu University Gachibowli Hyderabad - 500 032 India

BVRI CCD photometry of the poorly studied open cluster NGC 6724 has been carried out down to a limiting magnitude of V-20 mag. The stars of the cluster have been observed using the Newtonian focus （f/4.84） of the 74-inch telescope at Kottamia Astronomical Observatory in Egypt. Also, the 2MASS - JHK system is used to confirm the results we obtained. The main photometric parameters have been estimated for the present object; the diameter is found to be 6 arcmin, the distance is 15304-60pc from the Sun and the age is 900＋50Myr. The optical reddening E（B - V） = 0.65 mag, while the infrared reddening is E（J - H） = 0.20 mag. The slope of the mass function distribution and the relaxation time estimations indicate that cluster NGC 6724 is dynamically relaxed.

关键词： Milky Way -- open clusters and associations: individual (NGC 6724) - optical photom-etry - IR photometry - color-magnitude diagrams

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