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Susceptibility patterns and virulence genotypes of Helicobacter pylori affecting eradication therapy outcomes among Egyptian patients with gastroduodenal diseases

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World Journal of Gastroenterology 2023年第19期29卷 2950-2960页

作者： ahmed Morad Asaad Gasser El-Azab Eman Abdelsameea Osama Elbahr ahmed Kamal Mohamed Abdel-Samiee ahmed Abdelfattah Heba Abdallah Doha Maher ahmed El-Refaie Samar Ebrahim ghanem Shamshul Ansari Samah Mohammed Awad Department of Microbiology College of MedicineZagazig UniversityZagazig 44519Egypt Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Pathology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Clinical Biochemistry and Molecular Diagnostics National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt Department of Health Sciences Higher Colleges of TechnologyAbu Dhabi Women's CollegeAbu Dhabi 25026United Arab Emirates Department of Clinical Microbiology and Immunology National Liver InstituteMenoufia UniversityShebin El-Kom 32511Egypt

BACKGROUND Helicobacter pylori(***)is a significant human pathogen that is responsible for a variety of illnesses,including mucosa-associated lymphoid tissue lymphoma,gastric cancer,peptic ulcers,and *** To investigate the frequency of *** infection and its resistance patterns among Egyptian patients and to determine the influence of *** virulence genetic determinants on the eradication success of 14-d triple therapy *** *** infections were investigated in 72 patients with gastroduodenal complications suggestive of *** *** cagA and vacA genotypes of cultured strains were studied using polymerase chain *** patients underwent 14 d of triple-therapy *** treatment response was examined using histology and a rapid urease test 6 wk after therapy *** The intention-to-treat eradication rate was 59.2%(95%CI:48.2%-70.3%).Rates of *** resistance to clarithromycin,amoxicillin,and metronidazole were 52.8%,81.9%,and 100%,*** eradication of *** was more significantly associated with vacA s1-positive strains[adjusted odds ratio(aOR)=0.507,95%CI:0.175-0.822].A significant association was found between failed eradication rate and *** strains resistant to clarithromycin(aOR=0.204,95%CI:-0.005 to 0.412)and amoxicillin(aOR=0.223,95%CI:0.026-0.537).CONCLUSION This study’s low *** eradication rate following 14-d triple therapy is concerning and *** pan-resistance to metronidazole followed by the high resistance to ciprofloxacin,amoxicillin,and clarithromycin in this research is challenging and of great concern.

关键词： Helicobacter pylori Eradication therapy Virulence Clarithromycin resistance cagA gene vacA gene

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Volumetric Overload Shocks: Why Is Starling’s Law for Capillary Interstitial Fluid Transfer Wrong? The Hydrodynamics of a Porous Orifice Tube as Alternative

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Surgical Science 2016年第6期7卷 245-249页

作者： ahmed N. ghanem Salma A. ghanem Retired Consultant Urologist Mansoura Egypt Guys & St. Thomas NHS Trust London UK

Based on clinical and experimental work two new types of volumetric overload shocks are reported: volumetric overload shock type one and type two depending on the type of fluid causing their induction. Volumetric overload shock type one is induced by sodium-free fluids such as glycine, glucose, mannitol and sorbitol and is characterized with acute dilutional hyponatraemia. Volumetric overload shock type 2 is induced with sodium-based fluids normal saline and plasma substitutes used for resuscitation of the critically ill and has no serological marker. It presents with the multiple vital organs dysfunction or failure syndrome or the adult respiratory distress syndrome. Hypertonic sodium is an effective treatment when given early adequately. The underlying pathophysiology is discussed. An alternative to Starling’s law for the capillary interstitial fluid transfer is given. Hydrodynamic of a porous orifice tube akin to capillary with a surrounding Chamber akin to the interstitial fluid space demonstrated a rapid dynamic magnetic field-like fluid circulation between the surrounding chamber and the lumen of the G tube that represent an adequate replacement for Starling’s law.

关键词： Shock The Multiple Vital Organs Dysfunction or Failure Syndrome The Adult Respiratory Distress Syndrome The Transurethral Resection of the Prostate Syndrome Hyponatraemia

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The Influence of Welding Parameters on Brittle Fracture of Liquefied Natural Gas Storage Tank Welded Joint

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Materials Sciences and Applications 2013年第3期4卷 198-204页

作者： Abd El Fattah Mustafa Khourshid Mohamed ahmed ghanem Production Engineering and Mechanical Design Department Faculty of Engineering Tanta University Tanta Egypt.

Many applications operate at sufficiently low temperature conditions where most structural steels become very brittle and, therefore, unsuitable for use in safety-critical structures. So the materials used in the vessels or storage tanks which keep the natural gas at liquefaction temperatures need to remain ductile and crack resistant with a high level of safety. The material also needs to have high strength in order to reduce the wall thickness of the container and it must permit welding without any risk of brittle fracture. 9% Ni steel plates are one of most common used materials in the LNG storage tank application. However, the welding procedure for 9% Ni steel plates requires high level of skills of welding that is strictly controlled welding parameter for balancing avoidance of cold and hot cracking and maintenance of high strength. Mechanical properties are important characteristics of the weldment that must confirm to the application feasibility as well as functional requirements of the welded joint. The only way to enhanced the mechanical properties of welded joint by controlling the parameters of using welding process. From the main variables of the arc welding process are the heat input and interpass temperature where the two variables control the thermal cycle of welding process. The experiment show that for thin test specimen with thickness ≤ 14 mm, the heat input range from 1.4 to 2 KJ/mm and controlling interpass temperature within 80°C give high tensile strength with improving the toughness properties of welded joint and reduce the probability of brittle fracture happened by increase the ductility and reduce the yield strength and increased the transition temperature.

关键词： 9% Ni Steel Plate LNG Tank Heat Input Mechanical Properties Welding Process and Brittle Fracture

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First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus

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World Journal of Gastroenterology 2020年第43期26卷 6710-6769页

作者： Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar ahmed M Khassouan Zaher Koutoubi Rahul Nathwani mazen S Taha Jimmy K Limdi Gastroenterology and Endoscopy Department Ibrahim Bin Hamad Obaid Allah HospitalMinistry of Health and PreventionRas Al KhaimanUnited Arab Emirates Department of Gastroenterology Sheikh Shakbout Medical CityAbu DhabiUnited Arab Emirates Department of Gastroenterology Valiant ClinicDubaiUnited Arab Emirates Department of Gastroenterology and Endoscopy American HospitalDubaiUnited Arab Emirates Gastroenterology and Endoscopy Unit Al Zahra HospitalDubaiUnited Arab Emirates Gastroenterology Division Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Digestive Disease Unit Rashid HospitalDubaiUnited Arab Emirates Digestive Disease Institute Cleveland ClinicAbu DhabiUnited Arab Emirates Department of Gastroenterology Mediclinic City HospitalDubaiUnited Arab Emirates Gastroenterology and Hepatology Tawam HospitalAl AinUnited Arab Emirates Department of Gastroenterology The Pennine Acute Hospitals NHS TrustManchester Academic Health SciencesUniversity of ManchesterManchester M85RBUnited Kingdom

Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal *** incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is *** progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with *** guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based *** up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications.

关键词： Ulcerative colitis Crohn’s disease Infliximab Adalimumab Vedolizumab Ustekinumab Tofacitinib

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Development of NIS Two-Temperature Humidity Generator

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Journal of Physical Science and Application 2014年第7期4卷 436-439页

作者： Mohamed Gamal ahmed Said mazen Doaa Abd El-Gelil National Institute for Standard Giza Egypt Physics Department Faculty of Science Zagazig University Sharkia Egypt

Abstract： This paper describes the development and characterization of a two-temperature （2-T）, constant pressure humidity generator It relies on the saturation of a stream of gas flowing over a water surface maintained at constant, well-known, temperature. It was built in order to improve the uncertainties of the dew-point temperature and humidity scales realization at the National Institute for Standard （NIS） in the dew-point range from -50 ℃ to ＋ 10 ℃. Several experiments were carried out in the above mentioned range in order to characterize the generator. Characterization comprised studies of its saturator efficiency, temperature stability and a comparison with a calibrated chilled-mirror hygrometer. The results of the efficiency tests showed good performance of the generator as described below. For uncertainty of measurements, a thorough analysis was also described representing estimations of contributions for all the sources that affecting measurements.

关键词： Dew-point hygrometer two-temperature generator uncertainty.

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Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 411-416页

作者： Saad Bin Dajem Sara Bayoumi Ali Omar ghanem Abdelrady Nouraldin Mahmoud Salahaldin ahmed Muhammed Soliman Yasmin Mohamed Kamal Ammar Yasser Abdelazim Aya Fadi Mohamed Kareem Morsy Ayman Saber Mohamed Sohair Ramadan Fahmy Department of Biology College of ScienceKing Khalid UniversityAbhaSaudi Arabia Department of Zoology Faculty of ScienceCairo UniversityCairoEgypt

Objective:To explore the efficacy of earthworm’s coelomic fluid against gentamicin-induced hepatic and renal toxicity in ***:The animals were divided randomly into three groups(n=6 per group):control,gentamicin,and Allolobophora caliginosa coelomic fluid-treated *** was established after injection of gentamicin daily for 8 days at a dose of 100 mg/*** aminotransferase,alanine aminotransferase,alkaline phosphatase,total proteins,albumin,creatinine,urea,uric acid,malondialdehyde,glutathione,catalase and histopathology of tissues were investigated in the ***:Allolobophora caliginosa coelomic fluid significantly decreased urea,creatinine,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and malondialdehyde levels while significantly increasing levels of total proteins,albumin,glutathione and *** histopathological investigation showed partial restoration of renal and hepatic ***:This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.

关键词： Allolobophora caliginosa Coelomic fluid Gentamicin Hepatorenal toxicity Earthworm

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Realization of Relative Humidity Scale Using NIS Two-Temperature Humidity Generator

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Journal of Physical Science and Application 2014年第8期4卷 484-487页

作者： Mohamed Gamal ahmed Said mazen Doaa Abd El-Gelil Nabila Ismail El Sayed National Institute for Standard Giza Egypt Physics Department Faculty of Science Zagazig University Sharkia Egypt

A new humidity calibration facility using a 2-T （two-temperature）, constant pressure principle for generating gas of known humidity has been developed at NIS for primary realization of relative humidity scale in the range from 13% to 98% for calibrating and testing hygrometers to improve the uncertainty. This paper reports the construction of the 2-T humidity generator describing its saturator and the test chamber system. Results of the efficiency tests of its saturator showed satisfactory generation performance for a primary realization of relative humidity scale. The expanded uncertainty of the relative humidity with a coverage factor k = 2 was found to be from ± 0.25 % to ± 0.67%.

关键词： Calibration relative humidity generator saturator uncertainty.

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The effect of treatment package time in head and neck cancer patients treated with adjuvant radiotherapy and concurrent systemic therapy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第3期5卷 160-167页

作者： ahmed I.ghanem Matthew Schymick Souheyla Bachiri Aniruddh Mannari Jawad Sheqwara Charlotte Burmeister Steven Chang Tamer ghanem Farzan Siddiqui Department of Radiation Oncology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Medical Oncology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Public Health Science Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Department of Otolaryngology Henry Ford Hospital2799 W.Grand BlvdDetroitMI 48202USA Alexandria Clinical Oncology Department Alexandria UniversityQasm Bab SharqiAlexandria Governate00302Egypt

Objectives:In patients with head and neck carcinoma,“treatment package time”(TPT)was proven to impact outcomes in cases receiving adjuvant radiotherapy *** impact in patients receiving radiotherapy with concurrent systemic therapy has not been studied *** TPT influence on survival endpoints for patients treated with surgery followed by radiation and concurrent systemic therapy was ***:Institutional database to identify head and neck carcinoma cases treated with definitive surgery followed by concomitant chemo(bio)radiotherapy(CRT)was *** was the number of days elapsed between surgery and the last day of radiation.%FINDCUT SAS macro tool was used to search for the cutoff TPT that was associated with significant survival ***-Meier curves,log-rank tests as well as univariate and multivariate analyses were used to assess overall survival(OS)and recurrence free survival(RFS).Results:One hundred and three cases with a median follow up of 37 months were included in the *** tumors were 43%,oral cavity 40%and laryngeal 17%of *** systemic therapy included platinum and cetuximab in 72%and 28%,*** TPT was found to be<100 days with significantly better OS(P=0.002)and RFS(P=0.043)compared to TPT≥100 *** multivariate analysis;TPT<100 days,extracapsular nodal extension,high-risk score,iymphovascular space and perineural invasion were independent predictors for worse OS(P<0.05).T4,extracapsular nodal extension and high-risk score were all significantly detrimental to RFS(P<0.05).Conclusions:Addition of concomitant systemic therapy to adjuvant radiotherapy did not compensate for longer TPT in head and neck squamous cell *** coordinated care must be provided to ensure the early start of CRT with minimal treatment breaks.

关键词： Head and neck cancer Treatment package time Adjuvant radiation therapy Concomitant systemic therapy Survival

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NIS One-Temperature Dew-Point Generator Operating in the Ranae -50℃ to 0 ℃

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Journal of Physical Science and Application 2012年第9期2卷 335-339页

作者： Mohamed Gamal ahmed Doaa Abd El-Gelil Essam El-Din Mahmoud Said mazen National Institute for Standard Giza Egypt Physics Department Faculty of Science Zagazig University Sharkia Egypt

This paper describes construction and characterization of a dew/frost -point generator developed at national institute for standards. It is intended to operate in the range from -50 ℃to 0 ℃. The air flows through a saturator controlled by a regulated flow meter. The reference dew/frost -point temperature was measured by standard platinum resistance thermometer （SPRT） connected to a resistance bridge. A comparative study between the saturator temperature of the new generator measured by SPRT and the dew/frost-point temperature of a calibrated chilled-mirror hygrometer was conducted. It helped to determine the uncertainty of saturator; this uncertainty was found to be between ±0.06℃ to -4- 0.15℃ at confidence limit of 95%.Several experiments were carried out in the mentioned range. Obtained results gave the confidence that NIS generator could be used as a primary humid air generator.

关键词： Characterization standard dew/frost point generator measurement uncertainty.

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Dietary Magnesium Intake Related to C-Reactive Protein in Newly Diagnosed Coronary Heart Disease Patients at Middle Zone, Gaza Strip. A Hospital Based Study

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Pharmacology & Pharmacy 2014年第7期5卷 601-611页

作者： Jehad H. El-Hissi Adham I. ahmed Ihab M. Al-Masri mazen A. El-Sakka Atef A. Masad ahmed A. Najem Al-Aqsa Martyr’s Hospital Ministry of Health Dier El-Balah Palestine Faculty of Intermediate Studies University of Palestine Gaza Palestine Faculty of Medicine Al-Azhar University Gaza Palestine Faculty of Pharmacy Al-Azhar University Gaza Palestine Faculty of Science The Islamic University Gaza Palestine

Coronary Heart Disease (CHD) is a highly prevalent disease all over the world. Magnesium (Mg) plays a role in CHD but it is still unclear. C-Reactive Protein (CRP) is an inflammatory marker which may rise in CHD. Aim of study: To assess the impact of dietary Mg intake and its level in relation to CRP among newly diagnosed CHD at middle zone of Gaza Strip. Methodology: Patients (n = 140) with confirmed CHD, 50 ± 10 years, presented in the cardiac care unit at Aqsa Martyr’s Hospital between 1 April 2012 and 30 December 2012, were enrolled in this cross-sectional study after taking consent. ECG, clinical status, and cardiac markers were used to confirm diagnosis by cardiologist. Food frequency questionnaire was used to assess Mg intake and calcium intake in addition to measurement of its level in serum. CRP latex slide was used for measurement of CRP. Results: Mg intake and serum Mg were?inversely associated with risk?of CHD. Mean of serum Mg among cases (1.80) was lower than controls (2.41) (P = 0.001). Percent of positive CRP was higher in cases (32.9%) than controls (12.9%) (P = 0.005). Mean of serum Mg was (1.96 ± 0.47) for positive CRP which was lower than the mean of serum Mg (2.15 ± 0.44) for negative CRP. Conclusion: Newly diagnosed patients with CHD have a positive CRP, low serum and low?Mg intake, and low serum Mg was associated with elevated CRP.

关键词： Coronary Heart Disease C-Reactive Protein Magnesium Dietary Behavior Life Style

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