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Evaluation of hypolipidemic Marrubium vulgare effect in Triton WR-1339-induced hyperlipidemia in mice

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 439-445页

作者： Abeer Y Ibrahim Saber F Hendawy ahmed A A elsayed elsayed A Omer Medicinal and Aromatic Plants Researches Dept. Pharmaceutical and Drug Industries Division National Research Centre

Objective: To evaluate the hypocholesterolemic and hypotriglyceridemic activities of four Marrbium vulgare(M. vulgare) herb extracts using Triton WR-1339-induced hyperlipidemia in mice. Methods: Hyperlipidemia was developed by intraperitoneal injection of Triton(200 mg/kg body weight). The animals were divided into main four groups of eight mice each: normal control group, hyperlipidemic control group, hyperlipidemic plus tween-40 control and treated group. The fourth one was divided into four subgroups, petroleum ether extract group, chloroform extract group, ethyl acetate extract group and methanol extract treated group each of them contains two sub-sub group for treating animals with two doses at 0.1 and 0.25 LD50. Results: After 7 h and 24 h of treatment, the intragastric administration of all extracts caused a significant decrease of plasma total cholesterol. Triglyceride levels were also significantly lowered by all extracts while petroleum ether produced the lowest decreasing level. Similar results were observed for LDL-cholesterol concentrations. Furthermore, more polar extracts(methanol and ethyl acetate)-soluble fractions showed a significant ameliorative action on elevated atherogenic index(AI) and LDL/HDL-C ratios, while these atherogenic markers were not statistically suppressed by the chloroform and petroleum ether-soluble extract. Conclusion: The findings indicated that Marrubium may contain polar products able to lower plasma lipid concentrations and might be beneficial in treatment of hyperlipidemia and atherosclerosis.

关键词： Anti-hyperlipidemia Marrubium vulgare Triton Antioxidant Atherogenic index

Enhancing the explosive characteristics of a Semtex explosive by involving admixtures of BCHMX and HMX

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Defence Technology（防务技术） 2020年第2期16卷 487-492页

作者： ahmed Elbeih ahmed k.Hussein Tamer Elshenawy Svatopluk Zeman Sara M.Hammad Ahmad Baraka Mohamed A.elsayed Mohamed Gobara Hesham Tantawy Military Technical College Kobry ElkobbahCairoEgypt Technical Research Center CairoEgypt Institute of Energetic Materials Faculty of Chemical TechnologyUniversity of PardubiceCzech Republic Faculty of Pharmacy University of CairoGizaEgypt

A well-known ternary plastic explosive,Czech Semtex 1H,contains a mixture of PETN and RDX softened by *** this work,BCHMX was used to replace PETN in Semtex 1H to form Sem-BC+*** addition,another mixture based on BCHMX and HMX as energetic fillers bonded by the polymeric matrix of Semtex 1H(Sem-BC+HMX)was *** particle size distribution of each individual explosive was determined to obtain the optimum mixing *** and impact sensitivities were *** velocity of detonation was reported practically and the detonation properties were calculated by EXPLO5 *** explosive strength of each sample was measured by the ballistic mortar *** conclusion confirms that the velocity of detonation of Sem-BC+HMX was the highest in comparison with the prepared ***-BC+RDX has the least impact and frictions ***-BC+RDX has higher detonation velocity,detonation properties and explosive strength than Semtex *** of BCHMX in Semtex 1H as a replacement for PETN is the candidate to produce a high performance advanced Czech plastic explosive.

关键词： Semtex Explosives Combustion Sensitivity Detonation Explosive strength

Physical properties of three short period close binaries:kIC 2715417,kIC 6050116 and kIC 6287172

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Research in Astronomy and Astrophysics 2019年第2期19卷 111-124页

作者： Mahmoud AbdelFattah NegmEldin ahmed Essam elsayed Shahinaz Mostafa Yousef Astronomy Space Science and Meteorology Department Faculty of Science Cairo University Department of Astronomy National Research Institute of Astronomy and Geophysics(Egypt)

We present the physical parameters of three short period close binaries using data observed from the kepler Space Telescope. All of these observations were taken in a single bandpass(which approximates the Johnson V-band). Our three systems are kIC 2715417, kIC 6050116 and kIC 6287172. The first system, kIC 2715417, is considered a semi-detached system with the secondary component filling its Roche lobe. The second system, kIC 6050116, is an overcontact system, while the third system, kIC 6287172, belongs to ellipsoidal variables as deduced from the Roche lobe geometry. For photometric analysis, we used the PHOEBE software package, which is based on the Wilson-Devinney code. Due to lack of spectroscopic data, the photometric mass ratios are determined from the analyses of light curves using the q-search method. The absolute parameters are determined using three different methods(Harmanec, Maceroni &Van'tVeer and Gazeas & Niarchos).

关键词： stars:binaries:eclipsing stars:fundamental parameters stars:luminosity function,mass function stars:individual(kIC 2715417,kIC 6050116 and kIC 6287172)

Multi-Task Learning Model with Data Augmentation for Arabic Aspect-Based Sentiment Analysis

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Computers, Materials & Continua 2023年第5期75卷 4419-4444页

作者： Arwa Saif Fadel Osama ahmed Abulnaja Mostafa elsayed Saleh Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Computer Science Faculty of Computer Sciences and EngineeringHodeidah UniversityYemen

Aspect-based sentiment analysis(ABSA)is a fine-grained *** fundamental subtasks are aspect termextraction(ATE)and aspect polarity classification(APC),and these subtasks are dependent and closely ***,most existing works on Arabic ABSA content separately address them,assume that aspect terms are preidentified,or use a pipeline *** solutions design different models for each task,and the output from the ATE model is used as the input to the APC model,which may result in error propagation among different steps because APC is affected by ATE *** methods are impractical for real-world scenarios where the ATE task is the base task for APC,and its result impacts the accuracy of ***,in this study,we focused on a multi-task learning model for Arabic ATE and APC in which the model is jointly trained on two subtasks simultaneously in a *** paper integrates themulti-task model,namely Local Cotext Foucse-Aspect Term Extraction and Polarity classification(LCF-ATEPC)and Arabic Bidirectional Encoder Representation from Transformers(AraBERT)as a shred layer for Arabic contextual text *** LCF-ATEPC model is based on a multi-head selfattention and local context focus mechanism(LCF)to capture the interactive information between an aspect and its ***,data augmentation techniques are proposed based on state-of-the-art augmentation techniques(word embedding substitution with constraints and contextual embedding(AraBERT))to increase the diversity of the training *** paper examined the effect of data augmentation on the multi-task model for Arabic *** experiments were conducted on the original and combined datasets(merging the original and augmented datasets).Experimental results demonstrate that the proposed Multi-task model outperformed existing APC *** results were obtained by AraBERT and LCF-ATEPC with fusion layer(AR-LCF-ATEPC-Fusion)and the proposed data augmentation

关键词： Arabic aspect extraction arabic sentiment classification AraBERT multi-task learning data augmentation

Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： Nora A.elsayed Fatma SM Moawed Esraa SA ahmed ahmed Hammad Omayma AR Abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

Modeling and Experimental Verification of Electric Vehicles Off-Grid Photovoltaic Powered Charging Station

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Computer Systems Science & Engineering 2022年第12期43卷 1009-1025页

作者： Essam Hendawi Sattam Al Otaibi Sherif Zaid Ayman Hoballah Salah k.elsayed Nagy I.Elkalashy Yasser ahmed Department of Electrical Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia Department of Electrical Engineering Faculty of EngineeringUniversity of TabukTabuk47913Saudi Arabia Renewable Energy&Energy Efficiency Center(REEEC) University of TabukTabuk47913Saudi Arabia Department of Electrical Power Faculty of EngineeringCairo UniversityCairo12613Egypt

With the increasing development of EVs, the energy demand from theconventional utility grid increases in proportion. On the other hand, photovoltaic(PV) energy sources can overcome several problems when charging EVs from theutility grid especially in remote areas. This paper presents an effective photovoltaic stand-alone charging station for EV applications. The proposed charging station incorporates PV array, a lithium-ion battery representing the EV battery, and alead-acid battery representing the energy storage system (ESS). A bidirectionalDC-DC converter is employed for charging/discharging the ESS and a unidirectional DC-DC converter is utilized for charging the EV battery. The proposed controllers achieve maximum power extraction from the PV and regulate the DC-linkvoltage. It also controls the voltage and current levels of both the ESS and the EVduring the charging/discharging process. The study has been applied to two caseswith different power levels. Analysis, simulation, and implementation of the proposed system are presented. A 120 W laboratory prototype is carried out to verifythe system performance, experimentally. Design guides for higher power levelsare proposed to help in choosing the proper parameters of the converters. Boththe simulation and experimental results are matched and verify the highperformance of the proposed system.

关键词： Electric vehicle lithium-ion battery lead-acid battery photovoltaic microcontroller charging station

A new technique of monsplasty as an adjunctive procedure in cases of abdominoplasty:A prospective clinical trial

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 124-129页

作者： Laila ahmed Aboul Nasr Sherief Zamer ahmed Fathy elsayed Mohamed Hatem Elsahar Department of Plastic Surgery Faculty of Medicine Kasr Al-AinyCairo UniversityCairo11562Egypt

Background:No standard monsplasty technique has existed until *** various monsplasty methods have been described,they exhibit high complication rates with sparse postoperative *** that used pubic suspension techniques did not describe exact anatomical landmarks for the mons *** study aimed to improve the aesthetic and functional appearance of the pubic region with long-term results for all grades of pubic ptosis or bulging with abdominoplasty and provide exact anatomical points to anchor the mons to the rectus ***:This non-randomized prospective clinical trial included 30 patients with various degrees of abdominal wall laxity between December 2017 and September *** surgical procedure was performed for female patients with pendulous abdomen,pubic ptosis or bulging,body mass index≤35 kg/m^(2),and age 18–60 *** patients were followed for up to one year;patient satisfaction was assessed before and after surgery regarding aesthetic results and impact on outfits,hygiene,and sexual ***:The marginal homogeneity test revealed a statistically significant patient satisfaction rate regarding outfits,sexual function,hygiene,and *** postoperative complications,seroma(one case)was managed by aspiration,and one case of wound dehiscence was managed conservatively with ***:This study recommends a quick and reproducible monsplasty technique with a low complication rate,a technique that helps determine specific anatomical landmarks for anchoring the mons to the rectus *** this technique with abdominal contouring is advisable for optimal aesthetic results and maintained lymphatic drainage in the pubic region.

关键词： Abdominoplasty Mons ptosis Pubic suspension Skin redundancy

Serum vascular endothelial growth factor as a tumor marker for hepatocellular carcinoma in hepatitis C virus-related cirrhotic patients

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 600-611页

作者： ahmed Alzamzamy Huda elsayed Mona Abd Elraouf Hanan Eltoukhy Tarek Megahed Ashraf Aboubakr Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11841Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexCairo 11841Egypt Department of Internal Medicine Faculty of Medicine for GirlsAl-Azhar UniversityCairo 11311Egypt Department of Clinical Pathology Military Medical AcademyCairo 11311Egypt

BACkGROUND Hepatocellular carcinoma(HCC)accounts for 8.2%of all cancer-related deaths *** a vascular tumor,vascular endothelial growth factor(VEGF)plays a vital role in HCC pathogenesis,growth,and *** To determine the accuracy of serum VEGF and VEGF/platelet(PLT)as tumor markers in the early detection of HCC cases in patients with hepatitis C virus(HCV)-related liver *** We conducted a case-control study with HCV patients from the outpatient and inpatient hepatology *** were classified into three groups:(1)HCC group;(2)Cirrhosis group;and(3)HCV without cirrhosis(control group).Patients were clinically evaluated,and blood samples were drawn for the analysis;serum VEGF levels were measured by a specific VEGF human recombinant enzyme-linked immunosorbent assay *** from the three study groups were compared by the one-way analysis of variance or kruskal-Wallis *** operating characteristic curves were constructed to determine the optimal cut-off values of alpha fetoprotein(AFP),VEGF,and VEGF/PLT that provided the best diagnostic *** sensitivity and specificity at the optimal cut-off value of each biomarker were then *** This study included one hundred patients(HCC,cirrhosis,and control groups:n=40,30,30,respectively).HCC patients had significantly higher serum VEGF and VEGF/PLT levels than the non-HCC groups(P=0.001).Serum VEGF and VEGF/PLT showed significant positive correlations with and HCC tumor size,stage,vascular invasion,and Child-Pugh ***,a VEGF cut-off the value of 250 pg/mL provided 80%sensitivity and 81.7%specificity for discriminating HCC patient from non-HCC ***,the ratio of VEGF/PLT provided sensitivity and specificity of 77.5%and 80%,respectively which is higher than the accuracy provided by *** combination of AFP,VEGF,and VEGF/PLT increases the accuracy of diagnosing HCC to>95%.CONCLUSION In HCV patients,serum VEGF and VEGF/PLT separ

关键词： Hepatocellular carcinoma Vascular endothelial growth factor Biomarkers Diagnosis

Numerical Investigations of Flow Pattern and Anti-Vortex Measures of the Pumping Station Forebay

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Numerical Investigations of Flow Pattern and Anti-Vortex Mea...

作者： ahmed Nasr elsayed Ali Nasr Farhan 扬州大学

学位级别：硕士

泵站前池是外河和进水池（进水流道）的连接段,其作用是为了保证水流在从外河流向进水池（进水流道）的过程中能够平顺地扩散,为进水池（进水流道）提供良好的流态。依据水流方向,前池可分为正向进水前池和侧向进水前池两种基本类型,侧... 详细信息

泵站前池是外河和进水池（进水流道）的连接段,其作用是为了保证水流在从外河流向进水池（进水流道）的过程中能够平顺地扩散,为进水池（进水流道）提供良好的流态。依据水流方向,前池可分为正向进水前池和侧向进水前池两种基本类型,侧向进水前池拥有占的地方少、投资省等各种特点,在中国的农业灌溉、火电厂循环供水及城战给水排水泵站中较为常见,若泵站兴建所处地形条件狭窄、正向进水不容易布置的情况下常采用侧向进水前池,此时侧向进水前池的水流与进水池（进水流道）水流方向正交或斜交,因流向的改变,前池内易形成回流或旋涡,流速分布变得不均匀,流态紊乱,造成进水池（进水流道）入口处流速分布不均匀,将会导致泵装置水力效率从而降低,影响泵装置中安全稳定的运行,并缩短水泵的使用寿命。本论文以江苏省徐州市翟山大沟泵站为本次的研究对象,该泵站的前池为典型的侧向进水结构且前池具有较大纵向底坡,为明确该泵站侧向进水前池的流场分布特征并且能够确保机组安全稳定的运行,本文将使用数值模拟技术的方法对该泵站的侧向进水前池内流场进行数值模拟,通过定性和定量相结合的分析方法揭示前池的流场特征并对前池流态调控措施的流场调控效果进行对比和分析,优选整流措施,为实际工程提供技术支撑,也为同类型泵站的前池流态调控提供参考。目前,国内外一些学者针对泵站前池的流场及流态调控措施的研究展开了不少的研究工作,研究方法主要集中于数值模拟和物理模型试验。随着实际泵站工程规模越来越大且复杂,物理模型试验的研究方式越来越不经济,且具有耗时长、人力受限和所需场地大等诸多困难而在前池流场及流态调控研究中应用的较少,随着CFD（Computational Fluid Dynamic）技术的不断发展和成熟。通过中国知网以及其他等数据库的文献查询,采用数值模拟技术研究前池流场的论文占比89.33%,CFD数值模拟技术具有省时、省工及研究成本低的优点在前池流场及流态调控中的应用也变得越来越多,很多学者采用CFD数值模拟技术模拟实际泵站工程的运行以得出问题并分析解决,通过数值模拟结果提出了流态调控措施解决实际泵站前池中的流态问题,对实际工程的前池流场做出改善,同时和物理模型试验相比,CFD数值模拟技术可模拟更大范围的泵站建筑物并更快捷、更经济地获得结论,本文对泵站前池流场及流态调控措施的研究采用数值模拟技术。翟山大沟泵站主要承担暴雨季排除多余的降水,在旱季为了能够保证农作物的正常需水,属于农业灌排泵站。泵站有四个进水池,每个进水池都装有潜水轴流泵装置单机设计流量为4.25 m3/s,泵站总设计流量为17 m3/s,每台泵之间的间距为4.4 m,进水池的长度为9.8m。引河的研究尺寸为:长83.3m,宽11.2m。该泵站受限于实际地形条件布置,前池通过两个斜坡与进水池相连接,第一级斜坡高差为1.1 m,第二级斜坡高差为4.9 m。（一）研究内容及技术路线（1）采用数值模拟技术分析翟山大沟泵站的侧向进水前池的流场分布特征;（2）针对该侧向进水前池的流态特征,提出不同的整流措施并开展数值计算;（3）采用定量和定性相结合的方法对比分析各整流措施方案与初设方案的前池流场的差异性,选优合适的整流方案。本文采用Solidworks三维建模软件对翟山大沟泵站引河、前池、进水池和潜水泵进行流体域的整体三维建模,通过网格数量无关性和网格收敛性确定数值计算网格数量从而确保数值计算的有效性,在分析初设方案前池流场特征的基础上提出若干侧向进水前池的整流措施,并通过定量和定性相结合的方法对比分析各整流措施方案,最终优选合适的整流措施,本文所研究的技术路线如图1所示:图1技术路线图（二）数值计算方法基于对三维不可压缩流体的雷诺时均N-S方程和RNG k-ε湍流模型,RNG k-ε湍流模型计算式如式（1）所示,壁面函数采用可伸缩壁面函数处理近壁区流动,采用ANSYSCFX软件对翟山大沟泵站的引河、前池、进水池和潜水泵的流场进行整体数值求解。非结构化网格拥有着很强的自适应几何形体的优点,则引河、前池、进水池和潜水泵均使用非结构化网格剖分,针对流场分析的重点关注区域进行了局部网格加密处理。计算模型的进口边界条件设置为流量,出口边界条件设置为压力,固体壁面采用无滑移壁面处理,引河的平均粗糙度设置为2.5 mm,前池和进水池的壁面粗糙度设置为2 mm。引河、前池和进水池的表面为自由液面,忽略空气对水面产生的切应力和热交换采用对称平面条件,各相连过流建筑物的交界面均采用静静交界面。泵站前池数值计算各物理量的残差收敛精度设置为1×10-6。RANS可以如下进行:（1）k方程可以表示为:（2）ε方程可以定义为:（3）ε方程可以从RANS方程得到。涡流粘度为:μt=ρCμk2/ε（4）常数σκ,σε,C1,C2,＆Cμ是根据软件ANSYS-CFX中基于实验数据在5%

关键词：泵站前池流态数值模拟整流侧向进水