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STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats

World Journal of Gastroenterology 2019年第39期25卷 5926-5935页

作者： Mohamed T Khayyal Walaa Wadie Enas A abd el-Haleim Kawkab A ahmed Olaf Kelber Ramy M Ammar Heba abdel-Aziz Department of Pharmacology Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Pathology Faculty of Veterinary MedicineCairo UniversityCairo 12211Egypt Steigerwald Arzneimittelwerk GmbH Bayer Consumer HealthDarmstadt 64295Germany Department of Pharmacology Faculty of PharmacyKafrelsheikh UniversityKafrelsheikh 33511Egypt

BACKGROUND Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory ***,they are not always effective against both gastric and duodenal lesions and their use is not devoid of side *** To explore the mechanisms mediating the clinical efficacy of STW 5 in gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs(NSAIDs),exemplified here by diclofenac,in a comparison to *** Gastro-duodenal lesions were induced in rats by oral administration of diclofenac(5 mg/kg)for 6 successive *** group was given concurrently STW 5(5 mL/kg)while another was given omeprazole(20 mg/kg).A day later,animals were sacrificed,stomach and duodenum excised and divided into 2 segments:One for histological examination and one for measuring inflammatory mediators(tumor necrosis factorα,interleukins-1βand 10),oxidative stress enzyme(heme oxygenase-1)and apoptosis regulator(B-cell lymphoma 2).RESULTS Diclofenac caused overt histological damage in both tissues,associated with parallel changes in all parameters *** 5 and omeprazole effectively prevented these changes,but STW 5 superseded omeprazole in protecting against histological damage,particularly in the *** The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects.

关键词： Diclofenac STW 5 Omeprazole Gastro-intestinal lesions Inflammation

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Cooling and lubrication techniques in grinding:A state-of-the-art review,applications,and sustainability assessment

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Chinese Journal of Aeronautics 2023年第7期36卷 76-113页

作者： ahmed Mohamed Mahmoud IBRAHIM Wei LI abdel-Hamid ISMAIL MOURAD Mohamed A.E.OMER Fadl A.ESSA ahmed Mustafa abd el-NABY Mohammad S.Al SOUFI Muhammad F.EZZAT Ammar elSHEIKH College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Production Engineering and Mechanical Design Department Faculty of EngineeringMinia UniversityEl Minya 61519Egypt Mechanical and Aerospace Engineering Department College of EngineeringUnited Arab Emirates UniversityAl-Ain 15551United Arab Emirates Department of Production Engineering and Mechanical Design Faculty of EngineeringTanta UniversityTanta 31527Egypt Mechanical Engineering Department Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh 33516Egypt Mechanical Engineering Department College of Engineering and Islamic ArchitectureUmm Al-Qura UniversityMakkah 24231Saudi Arabia Mechanical Engineering Department Faculty of EngineeringUniversity of AlbertaEdmonton T6G 2R3Canada Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl Minya 61519Egypt Tokyo Institute of Technology Tokyo 152-8550Japan

Grinding technology is an essential manufacturing operation,in particular,when a component with a superfinishing and an ultra-resolution is *** the required strict quality checklist with maintaining a high level of productivity and sustainability is a substantive *** recent paper outlines the lubrication and cooling technologies and mediums that are used for ***,it provides a basis for a critical assessment of the different lubrication/cooling techniques in terms of machining outputs,environmental impact,hygiene effect,***,the paper put light on the sustainability of different cooling/lubrication *** sustainability of machining aims to get the product with the best accuracy and surface quality,minimum energy consumption,low environmental impact,reasonable economy,and minimum effect on worker’s *** paper revealed that despite some cooling/lubrication mediums like mineral oils and semisynthetic,afford sufficient lubrication or cooling,they have a significant negative impact on the environment and public *** the other hand,emulsions can overcome environmental problems but the economy and the energy consumption during grinding are still a matter of *** and vegetable oils are considered eco-friendly oils,but they suffer from a lack of thermal stability which affects their ability of efficiently *** the cooling medium with the lowest amount can achieve the goal of the economy but it may be reflected negatively on the ***,cryogenic lubrication doesn’t provide sufficient lubrication to reduce friction and hence energy *** research described in the paper is such a comprehensive compilation of knowledge regarding the machinability and machining performance under different cooling and lubrication systems that it will aid the next generation of scientists in identifying current advancements as well as potential future directions of research on ecolo

关键词： Cryogenic cooling Dry lubrication Minimum quantity lubrication Precision grinding Solid lubrication Sustainable machining Vegetable oils

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Binding Media： Methods of Identification： Part 1, Theoretical Work

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Journal of Physical Science and Application 2011年第3期1卷 204-215页

作者： Safaa ahmed abd el Salam Faculty of Fine Arts University of Alexandria 108 Abd El Salam Aref Egypt

The identification of binding media presents a major difficulty in the investigation of painting techniques. The materials used in ancient times as a media for the pigments were varied, such as glues, gums and egg white. These adhesives were mixed with the pigments to adhere to the surface or to prepare the ground. This medium serves to protect the pigments more or less perfectly, from chemical and mechanical injury. Binding media determines the technique of painting. Artists＇ techniques used through the centuries differ more in the binding media than in the pigments used. They are all organic substances containing the same common elements, and in the small samples which can be removed from paintings, occur only in micro quantities, moreover, binding media undergo considerable degradation over long periods of time. In the examination of works of art, only very small specimens can be taken and, the proportion of binding medium to pigment being small, sensitive methods of analysis have to be adopted in an attempt to detect and identify the medium that may have been used. On the other hand, the use of such methods possesses the disadvantage that impurities present in the painting materials may also be detected and may lead to erroneous conclusions. There is no general microanalysis technique existed in the identification of binding media, and the materials commonly used as media are highly complex compared with the simple inorganic compounds employed as pigments. However, several methods can be used in the identification of binding media such as micro-chemical, chemical and physical methods.

关键词： Painting media chemical & physical methods

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Monitoring and Change Detection along the Eastern Side of Qena Bend, Nile Valley, Egypt Using GIS and Remote Sensing

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Advances in Remote Sensing 2013年第3期2卷 276-281页

作者： ahmed Omar abd el-Aziz Senior of Geomatics-Al-Amar Consulting Group Cairo Egyp

This Article is set to track and monitor changes through spatial dependence of remote sensing data and GIS analysis, the suggested working method in this research is by sub pixel classification techniques. Change detection is a central task for land cover monitoring by remote sensing. It uses multi temporal image data sets in order to detect land cover changes from spectral discrepancies [1] (Rafael, et al.). It discusses the study perception of the situation in the past as well as the current and finally the future status of changes that land uses in Eastern Qena meander specifically in places of estuary floods, and the most important estuary leading to Qena, and whether these changes in land are used in direction of the mouth of the stream or not, especially that when it happened before, it caused destruction of both activities, urban & agricultural land. It will rely on Landsat images in years of (1972-2012), conduct analysis, different classifications integration with geographic information systems (GIS), and field as well as samples for the accuracy assessment.

关键词： Sub Pixel-Change Detection

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Heterocyclic Synthesis via Enaminones: Synthesis and Molecular Docking Studies of Some Novel Heterocyclic Compounds Containing Sulfonamide Moiety

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International Journal of Organic Chemistry 2014年第1期4卷 68-81页

作者： ahmed abd el-Hameed Hassan Chemistry Department Faculty of Science Al-Azhar University Nasr City Egypt

4-Acetyl-N, N-diethylbenzenesulfonamide (1) was condensed with dimethylformamide dimethy-lacetal (DMF-DMA) to yield the enaminone, which reacts readily with different reagents to give the corresponding pyrazoles, triazolopyrimidine, imidazopyridine, pyrimidopyrimidine, pyrazolopyrimidine, benzofuran, pyranone, pyridine, pyrimidine and pyrazolopyridazine derivatives. These compounds were designed to comply with the general features of sulfonamide pharmacophore which act as Cyclooxygenase (COX-2) inhibitors. Virtual screening using molecular docking studies of the synthesized compounds was performed by (MOE), the molecular docking results indicate that, some synthesized compounds suitable inhibitor against (COX-2) with further modification.

关键词： DMF-DMA Pyrazoles Benzofuran Pyranone Pyridine Pyrimidine Doking

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Impact of referral pattern and timing of repair on surgical outcome after reconstruction of post-cholecystectomy bile duct injury:A multicenter study

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 53-60页

作者： Ayman el Nakeeb Ahmad Sultan Helmy Ezzat Mohamed Attia Mohamed abd elWahab Taha Kayed Ayman Hassanen Ahmad AlMalki ahmed Alqarni Mohammed M Mohammed Gastrointestinal Surgical Center Mansoura UniversityMansouraEgypt Minia University Hospital MiniaEgypt Aseer Central Hospital Aseer regionSaudi Arabia

Background:Bile duct injury(BDI)after cholecystectomy remains a significant surgical *** guideline exists to guide the timing of repair,while few studies compare early versus late repair *** study aimed to analyze the outcomes in patients undergoing immediate,intermediate,and delayed repair of ***:We retrospectively analyzed 412 patients with BDI from March 2015 to January *** patients were divided into three groups based on the time of BDI *** 1 underwent an immediate reconstruction(within the first 72 hours post-cholecystectomy,n=156);group 2 underwent an intermediate reconstruction(from 4 days to 6 weeks post-cholecystectomy,n=75),and group 3 underwent delayed reconstruction(after 6 weeks post-cholecystectomy,n=181).Results:Patients in group 2 had significantly more early complications including anastomotic leakage and intra-abdominal collection and late complications including anastomotic stricture and secondary liver cirrhosis compared with groups 1 and *** outcome was observed in 111(71.2%)patients in group 1,31(41.3%)patients in group 2,and 157(86.7%)patients in group 3(P=0.0001).Multivariate analysis identified that complete ligation of the bile duct,level E1 BDI and the use of external stent were independent factors of favorable outcome in group 1,the use of external stent was an independent factor of favorable outcome in group 2,and level E4 BDI was an independent factor of unfavorable outcome in group *** BDI and level E4 BDI were independent factors of unfavorable ***:Favorable outcomes were more frequently observed in the immediate and delayed reconstruction of post-cholecystectomy *** ligation of the bile duct,level E1 BDI and the use of external stent were independent factors of a favorable outcome.

关键词： Bile duct injury Hepaticojejunostomy Anastomotic stricture Biloma Biliary peritonitis

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New Polymer Syntheses Part 60: A Facile Synthetic Route to Polyamides Based on Thieno[2,3-b]thiophene and Their Corrosion Inhibition Behavior

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Chinese Journal of Polymer Science 2018年第7期36卷 835-847页

作者： Kamal I.Aly Amr H.Moustafa Essam K.ahmed Hany M.abd el-lateef Mohamed Gamal Mohamed Sahar M.Mohamed Polymer Research Lab Chemistry Department Faculty of Science Assiut University Chemistry Department Faculty of Science Sohag University Chemistry Department Faculty of Science Minia University Chemistry Department College of Science King Faisal university

Polyamides containing thieno[2,3-b]thiophene moiety were prepared via a simple polycondensation reaction of the diaminothieno[2,3-b]thiophene monomer la with different kinds of diacid chlorides （including oxalyl, adipoyl, sebacoyl, isophthaloyl, terephthaloyl, 4,4＇-azodibenzoyl, 3,3＇-azodibenzoyl, p-phenylene diacryloyl） in the presence of LiC1 and NMP as a solvent through lowtemperature solution polycondensation. The chemical structures of model compound and synthesized polyamides were confirmed by FTIR, nuclear magnetic resonance spectroscopy （including 1 H-NMR and 13 C-NMR） and elemental analysis. In addition, the thermal stability, crystallinity structure and surface morphology of synthesized polyamides were characterized via thermogravametric analysis （TGA）, wide-angle X-ray diffraction analysis （WAXD） and scanning electron microscopy （SEM）. Also, the corrosion inhibition behavior of selected examples ofpolyamides was investigated; the inhibitive effect of the investigated polymers for carbon steel in 1.0 mol＇L-1 HCI was studied using potentiodynamic polarization （PDP） and electrochemical impedance spectroscopy （EIS） methods. PDP results displayed that the polyamides containing thieno[2,3-b]thiophene moiety can be as mixed-type inhibitors. The inhibition efficiency （P, %） was found to be in the range from 67.13% to 96.01%. There is an increase in P by the synthesized polymers in comparison to the starting monomer. The adsorption of these polymers was found to obey Langmuir adsorption isotherm.

关键词： Thieno[2 3-b]thiophene Polymer synthesis Thermal properties Industrial applications Corrosion inhibition

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Enhancing the explosive characteristics of a Semtex explosive by involving admixtures of BCHMX and HMX

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Defence Technology（防务技术） 2020年第2期16卷 487-492页

作者： ahmed elbeih ahmed K.Hussein Tamer elshenawy Svatopluk Zeman Sara M.Hammad Ahmad Baraka Mohamed A.elsayed Mohamed Gobara hesham Tantawy Military Technical College Kobry ElkobbahCairoEgypt Technical Research Center CairoEgypt Institute of Energetic Materials Faculty of Chemical TechnologyUniversity of PardubiceCzech Republic Faculty of Pharmacy University of CairoGizaEgypt

A well-known ternary plastic explosive,Czech Semtex 1H,contains a mixture of PETN and RDX softened by *** this work,BCHMX was used to replace PETN in Semtex 1H to form Sem-BC+*** addition,another mixture based on BCHMX and HMX as energetic fillers bonded by the polymeric matrix of Semtex 1H(Sem-BC+HMX)was *** particle size distribution of each individual explosive was determined to obtain the optimum mixing *** and impact sensitivities were *** velocity of detonation was reported practically and the detonation properties were calculated by EXPLO5 *** explosive strength of each sample was measured by the ballistic mortar *** conclusion confirms that the velocity of detonation of Sem-BC+HMX was the highest in comparison with the prepared ***-BC+RDX has the least impact and frictions ***-BC+RDX has higher detonation velocity,detonation properties and explosive strength than Semtex *** of BCHMX in Semtex 1H as a replacement for PETN is the candidate to produce a high performance advanced Czech plastic explosive.

关键词： Semtex Explosives Combustion Sensitivity Detonation Explosive strength

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Spatial distribution of air temperature and relative humidity in the greenhouse as affected by external shading in arid climates

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Journal of Integrative Agriculture 2019年第12期18卷 2869-2882页

作者： hesham Aahmed TONG Yu-xin YANG Qi-chang abdulellah AAl-Faraj ahmed Mabdel-Ghany Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Key Laboratory of Energy Conservation and Waste Management of Agricultural Structures Beijing 100081P.R.China Department of Agricultural Engineering College of Food and Agriculture SciencesKing Saud UniversityRiyadh 11451Saudi Arabia Department of Agricultural Engineering Faculty of AgricultureSana'a UniversitySana'a 2124Yemen

The effect of external roof shading on the spatial distribution of air temperature and relative humidity in a greenhouse(Tin and RHin) was evaluated under the arid climatic conditions of Riyadh City, Saudi Arabia. Two identical, evaporatively-cooled, single-span greenhouses were used in the experiment. One greenhouse was externally shaded(Gs) using a movable black plastic net(30% transmissivity), and the other greenhouse was kept without shading(Gc). Strawberry plants were cultivated in both greenhouses. The results showed that the spatial distribution of the Tin and RHin was significantly affected by the outside solar radiation and evaporative cooling operation. The regression analysis showed that when the outside solar radiation intensity increased from 200 to 800 W m–2, the Tin increased by 4.5℃ in the Gc and 2℃in the Gs, while the RHin decreased by 15% in the Gc and 5% in the Gs, respectively. Compared with those in the Gc, more uniformity in the spatial distribution of the Tin and RHin was observed in the Gs. The difference between the maximum and minimum Tin of 6.4℃ and the RHin of 10% was lower in the Gs than those in the Gc during the early morning. Around 2℃ difference in the Tin was shown between the area closed to the exhausted fans and the area closed to the cooling pad with the external shading. In an evaporatively-cooled greenhouse in arid regions, the variation of the Tin and RHin in the vertical direction and along the sidewalls was much higher than that in the horizontal direction. The average variation of the Tin and RHin in the vertical direction was 5.2℃ and 10% in the Gc and 5.5℃ and 13% in the Gs, respectively. The external shading improved the spatial distribution of the Tin and RHin and improved the cooling efficiency of the evaporative cooling system by 12%, since the transmitted solar radiation and accumulated thermal energy in the greenhouse were significantly reduced.

关键词： greenhouse temperature humidity distribution uniformity evaporative cooling shading arid climate

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Correlation between Mode of Delivery and Newborn’s Cord Blood Composition

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Open Journal of Obstetrics and Gynecology 2019年第3期9卷 395-403页

作者： abd el-Naser abd el-Gaber Ali ahmed Mustafa Mahmoud Obstetrics & Gynecology Department Qena Faculty of Medicine South Valley University Qena Egypt Medical Physiology Department Faculty of Medicine Sohag University Sohag Egypt

OBJECTIVE: The aim of this study is to find out the effect of delivery mode on newborn’s cord blood parameters particularly hemoglobin and hematocrite values. SETTING: Obstetrics and Gynecology Department, Qena Faculty of Medicine, South Valley University, Egypt. DURATION: From April 2015 to December 2017. STUDY DESIGN: A cross sectional study. METHODS: 900 live born neonates for healthy mothers were included in this study;all cases were delivered at full-term, with birth weight ranged from 2.5 to 3.5 Kg and had APGAR scores above 7 at 1 and 5 minutes. Newborns were divided into three groups (Group I included 300 newborns delivered by vaginal delivery without augmentation of labor, Group II included 300 newborns delivered vaginally with augmentation of labor and Group III included 300 newborns delivered by elective cesarean section). Blood sample was collected from the umbilical vein of each neonate for estimation of hemoglobin, hematocrit, RBCs count, platelets, WBCs count and reticulocytes. RESULTS: Cesarean section delivery had a statistically significant decrease in the level of iron-related hematologic indices including hemoglobin, hematocrit and RBCs count (p value elation among newborns cord blood hemoglobin as regard to head circumference, length and gestational age and negative correlations as regard to maternal age, parity and birth weight with no statistically significance (P value > 0.05). CONCLUSIONS: Cesarean section delivery had a significant decrease in the level of iron-related hematologic indices including hemoglobin, hematocrit and RBCs count and has a non-significant decrease in WBCs and platelets counts in neonatal cord blood, which suggest high prevalence of newborn iron-deficiency anemia among cesarean births particularly in developing communities.

关键词： Correlation Mode of Delivery Newborn Cord Blood Composition

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