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A Case of Thomsen Disease in Pregnancy: Case Report

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Open Journal of Obstetrics and Gynecology 2019年第2期9卷 136-141页

作者： Ayesha Anwar Adjoa Kyei-Sarpong John Obodozie S. W. Lindow ahmed el sherif Kashif Ahmad North Cumbria University Hospital NHS Trust Carlisle UK Division Obstetrics Sidra Medical and Research Centre Al Rayyan Qatar

Thomsen disease is a rare genetic disorder which affects the cell membrane of skeletal muscles causing hyper excitability and periods of prolonged muscle contraction. This prolonged muscle contractions can be aggravated during pregnancy and can interfere with normal labour and delivery. In this case report, we describe the case of a gravid patient in her first pregnancy with Thomsen disease and how to minimise the risk. Also, we illustrate the importance of involving multidisciplinary team in the management of such case to achieve the best fetomaternal outcome.

关键词： Thomsen Disease Pregnancy Anaesthesia

Hyperspectral imaging and remote trace detection of cis-1,3,4,6-tetranitrooctahydroimidazo-[4,5 d]imidazole(BCHMX)compared with traditional explosives using laser induced fluorescence

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Defence Technology（防务技术） 2021年第5期17卷 1609-1616页

作者： Hany S.Ayoub Ashraf F.el-sherif ahmed elbeih Department of Physics Faculty of ScienceCairo UniversityEgypt Laser Photonics Research Center Engineering Physics DepartmentMilitary Technical CollegeCairoEgypt Explosives Department Military Technical CollegeKobry ElkobbahCairoEgypt

cis-1,3,4,6-Tetranitrooctahydroimidazo-[4,5 d]imidazole(BCHMX)is an advanced energetic compound that expected to spread worldwide in the near ***,no approved remote detection methods were reported in current literature for this material,we performed hyper-spectral imaging and laser induced fluorescence(LIF)to a BCHMX sample under low laser fluence for determining the optimum laser wavelength used in any future BCHMX-LIF based remote detection *** this purpose,an experimental setup consisted of a sun spectrum lamp and hyper-spectral camera was built to illuminate and image white powder samples of BCHMX in comparison with the traditional explosives,HMX(1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane),RDX(1,3,5-trinitro-1,3,5-triazacyclohexane),PETN(2,2-Bis[(nitroxy)methyl]propane-1,3-diyldinitrate).The imaging reveals strong BCHMX sample absorption contrast among other samples at wavelength ranging from 400 to 410 *** light source was replaced by a 405 nm laser diode illuminator,a strong BCHMX sample LIF at the spectral range from 425 to 700 nm was observed under low laser fluence condition of 0.1 mJ/cm^(2).Finally,we demonstrated successfully the ability of the 405 nm LIF and the hyperspectral imaging technique to detect finger print traces of BCHMX on white cellulose fabric from a distance of 15 m and a detection limit of 1 mg/cm^(2).

关键词： Hyperspectral imaging Remote trace detection BCHMX Laser induced fluorescence

Thermochemical Aspects of Activated Ammonium Perchlorates with Superior Thermal Stability,Decomposition Enthalpy,Propagation Index,and Decomposition Kinetic Parameters

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Journal of Thermal Science 2021年第6期30卷 2196-2201页

作者： sherif elbasuney M.Yehia SHUKRI Ismael sherif Farag ahmed Saleh GHARIEB S.el-Sayyad Head of Nanotechnology Research Center Military Technical College(MTC)Cairo 11646Egypt School of Chemical Engineering Military Technical College(MTC)Cairo 11646Egypt Science and Technology Center of Excellence Cairo 11646Egypt Drug Radiation Research Department National Center for Radiation Research and Technology(NCRRT)Egyptian Atomic Energy Authority(EAEA)Cairo 11646Egypt

Ammonium perchlorate(AP)includes oxidizing and reducing elements on the same *** can act as an efficient oxidizer and mono-propellant as *** this study,AP experienced crystallographic phase change from orthorhombic centrosymmetric to non-centrosymmetric under controlled isothermal heat *** diffractograms confirmed this crystallographic phase *** thermal behaviour of activated AP had been investigated using *** AP demonstrated high chemical stability with an increase in endothermic phase transition enthalpy by 170%.The enthalpy of the subsequent two main exothermic decomposition reactions was increased by 250%.Whereas AP demonstrated total decomposition enthalpy of 733 J/g,activated AP showed 2614 J/*** AP can secure self-sustained response at a high *** index(combustion enthalpy/ignition temperature)was employed to assess self-sustained reaction *** AP demonstrated high propagation index of 8.7 compared with 2.5 for un-activated *** decomposition kinetic parameters had investigated using Kissinger and KAS *** AP showed an increase in activation energy by 89%using the Kissinger method;kinetic parameters using the KAS method were in good agreement with the Kissinger *** can have concluded that AP with novel kinetic decomposition parameters for enhanced safety storage and high combustion characteristics has evolved.

关键词： solid propellants oxidizers thermal behavior Kinetic parameters activation energy

The role of polymorphic cytochrome P450 gene(CYP2B6)in B-chronic lymphocytic leukemia(B-CLL)incidence and outcome among Egyptian patients

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Oncology Research 2024年第4期32卷 785-797页

作者： MENNA AL-ADL MAGDY MYOUSSEF ahmed el-SEBAIE sherif REFAAT AFAF el-SAID Division of Biochemistry Department of ChemistryFaculty of ScienceMansoura UniversityMansoura35511Egypt Hematology Unit Department of Clinical PathologyFaculty of MedicineMansoura UniversityMansoura35511Egypt Medical Oncology Unit Oncology Center Mansoura UniversityMansoura35511Egypt Department of Genetics Mansoura University Children’s HospitalMansoura35511Egypt

Cytochromes P450(CYPs)play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75%of the total metabolism of commercially available drugs,including *** gene expression and enzyme activity of CYPs are variable between individuals,which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics,as well as differences in the efficacy and toxicity of clinically used *** research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients,as well as the clinical outcome after receiving cyclophosphamide *** was isolated from whole blood samples of 100 de novo B-CLL cases and also from 100 sex-and age-matched healthy *** presence of the CYP2B6*9(G516T)polymorphism was examined by PCR-based allele specific amplification(ASA).Patients were further indicated for receiving chemotherapy,and then they were followed *** CYP2B6*9 variant indicated a statistically significant higher risk of B-CLL under different genetic models,comprising allelic(T-allele vs.G-allele,OR=4.8,pely to achieve remission compared to those with the wild-type genotype(GG),with a response percentage of(37.5%vs.83%,respectively).In conclusion,our findings showed that the CYP2B6*9(G516T)polymorphism is associated with B-CLL susceptibility among Egyptian *** variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.

关键词： B-CLL Xenobiotics Cytochromes P450 CYP2B6

A Transfer Learning-Enabled Optimized Extreme Deep Learning Paradigm for Diagnosis of COVID-19

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Computers, Materials & Continua 2022年第1期70卷 1381-1399页

作者： ahmed Reda sherif Barakat Amira Rezk Department of Information System Faculty of Computer and Information ScienceMansoura UniversityMansouraEgypt

Many respiratory infections around the world have been caused by ***-19 is one of the most serious coronaviruses due to its rapid spread between people and the lowest survival *** is a high need for computer-assisted diagnostics(CAD)in the area of artificial intelligence to help doctors and radiologists identify COVID-19 patients in cloud *** learning(ML)has been used to examine chest X-ray *** this paper,a new transfer learning-based optimized extreme deep learning paradigm is proposed to identify the chest X-ray picture into three classes,a pneumonia patient,a COVID-19 patient,or a normal ***,three different pre-trainedConvolutionalNeuralNetwork(CNN)models(resnet18,resnet25,densenet201)are employed for deep feature ***,each feature vector is passed through the binary Butterfly optimization algorithm(bBOA)to reduce the redundant features and extract the most representative ones,and enhance the performance of the CNN *** selective features are then passed to an improved Extreme learning machine(elM)using a BOA to classify the chest X-ray *** proposed paradigm achieves a 99.48%accuracy in detecting covid-19 cases.

关键词： Butterfly optimization algorithm(BOA) covid-19 chest X-ray images convolutional neural network(CNN) extreme learning machine(elM) feature selection

Chemical stability, thermal behavior, and shelf life assessment of extruded modified double-base propellants

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Defence Technology（防务技术） 2018年第1期14卷 70-76页

作者： sherif elbasuney ahmed Fahd Hosam E.Mostafa sherif F.Mostafa Ramy Sadek School of Chemical Engineering Military Technical College

Double base propellant suffers from lack of chemical stability; this could result in self ignition during storing. Modified double base(MDB) propellant based on stoichiometric binary mixture of oxidizermetal fuel(Ammonium perchlorate/Aluminum), and energetic nitramines(HMX) offered enhanced thrust as well as combustion characteristics. This study is devoted to evaluate the impact of such energetic additives on thermal behavior, chemical stability, and shelf life. Extruded MDB formulations were manufactured by extrusion process. Artificial aging at 80℃ for 28 days was conducted. Shelf life assessment was performed using Van't Hoff's equation. Quantification of evolved NOxgases with aging time was performed using quantitative stability tests. MDB formulation based on HMX demonstrated extended service life of 16 years compared with(AP/Al)-MDB which demonstrated 9 years. This finding was ascribed to the reactivity of AP with nitroglycerin with the formation of perchloric acid. Thermal behavior of aged MDB, exhibited an increase in heat released with time; this was ascribed to the autocatalytic thermal degradation during artificial aging. The increase in released heat by 31% was found to be equivalent to evolved NOx gases of 6.2 cm^3/5 g and 2.5 cm^3/1 g for Bergmann-Junk test, and Vacuum stability test respectively. This manuscript shaded the light on a novel approach to quantify evolved NOx gases to heat released with aging time. MDB based on HMX offered balanced ballistic performance,chemical stability, and service life.

关键词： Double-base Chemical stability Thermal behavior Artificial aging Shelf life assessment

Chandelier-assisted scleral buckling using wide angle viewing contact lens for pseudophakic retinal detachment repair

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 627-633页

作者： Ashraf ahmed Nossair Wael ahmed Ewais sherif ahmed Eissa Department of Ophthalmology Faculty of Medicine Cairo University Dar el Oyoun Hospital

AIM: To evaluate a modified technique for scleral buckling(SB) in pseudophakic retinal detachment(RD).METHODS: A retrospective non-comparative study included 21 consecutive eyes with uncomplicated pseudophakic RD that was repaired by chandelier assisted SB using wide angle viewing(WAV) contact lens. Segmental tire alone was used in 5 eyes(23.81%), and combined with encircling band in 7 eyes(33.33%). Radial sponge alone was used in 3 eyes(14.29%) and combined with encircling band in 6 eyes(28.57%).RESULTS: Primary success rate was(90.48%). External drainage of subretinal fluid was performed in 8 eyes(38.1%). Intraoperative complications included vitreous prolapse at chandelier sclerotomy site in 4 eyes(19.05%) and localized subretinal hemorrhage at drainage site in one eye(4.76%). No case of intraocular lens(IOL) displacement, retinal incarceration or iatrogenic retinal tear was detected. Postoperative complications included choroidal detachment in one eye(4.76%), elevated intraocular pressure in 2 eyes(9.52%), epiretinal membrane formation in one eye(4.76%) and proliferative vitreoretinopathy in 3 eyes(14.29%). Mean postoperative corrected distance visual acuity was 0.7±0.3 logMAR units. CONCLUSION: Chandelier-assisted SB using WAV contact lens is a reliable technique for repairing selected cases of simple pseudophakic RD.

关键词： buckling pseudophakia rhegmatogenous detachment

Three-dimensional printing of biomaterials for bonetissue engineering: a review

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Frontiers of Materials Science 2023年第2期17卷 1-43页

作者： ahmed el-Fiqi Glass Research Department Advanced Materials Technology and Mineral Resources Research InstituteNational Research CentreCairo 12622Egypt

Processing biomaterials into porous scaffolds for bone tissueengineering is a critical and a key step in defining and controlling their physicochemical,mechanical,and biological *** such as polymers are commonlyprocessed into porous scaffolds using conventional processing techniques,e.g.,***,these traditional techniques have shown unavoidable limitations andseveral *** instance,tissue-engineered porous scaffolds with a complexthree-dimensional(3D)geometric architecture mimicking the complexity of theextracellular matrix of native tissues and with the ability to fit into irregular tissue defectscannot be produced using the conventional processing techniques.3D printing hasrecently emerged as an advanced processing technology that enables the processing ofbiomaterials into 3D porous scaffolds with highly complex architectures and tunableshapes to precisely fit into irregular and complex tissue defects.3D printing providescomputer-based layer-by-layer additive manufacturing processes of highly precise andcomplex 3D structures with well-defined porosity and controlled mechanical propertiesin a highly reproducible ***,3D printing technology provides anaccurate patient-specific tissue defect model and enables the fabrication of a patientspecifictissue-engineered porous scaffold with pre-customized properties.

关键词： 3D printing biomaterial ink printability 3D printing technique 3D printed scaffold bone tissue engineering

Sol-gel synthesis,properties and protein loading/delivery capacity of hollow bioactive glass nanospheres with large hollow cavity and mesoporous shell

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Frontiers of Materials Science 2022年第3期16卷 145-157页

作者： ahmed el-FIQI Glass Research Department National Research CentreCairo 12622Egypt

Hollow nanospheres exhibit unique properties and find a wide interest in several potential applications such as drug ***,novel hollow bioactive glass nanospheres(HBGn)with large hollow cavity and large mesopores in their outer shells were synthesized by a simple and facile one-pot ultrasound assisted sol-gel method using PEG as the core ***,the produced HBGn exhibited large hollow cavity with ~43 nm in diameter and mesoporous shell of ~37 nm in thickness and 7 nm pore size along with nanosphere size around 117 *** confirmed the presence of Si and Ca elements at the surface of the HBGn outer ***,HBGn showed high protein loading capacity(~570 mg of Cyto c per 1 g of HBGn)in addition to controlled protein release over 5 *** also demonstrated a good in vitro capability of releasing calcium(Ca^(2+):170 ppm)and silicate(SiO_(4)^(4-):78 ppm)ions in an aqueous medium over 2 weeks under physiological-like *** in vitro growth of bone-like hydroxyapatite nanocrystals was exhibited by HBGn during the soaking in SBF.A possible underlying mechanism involving the formation of spherical aggregates(coils)of PEG was proposed for the formation process of HBGn.

关键词： bioactive glass hollow nanosphere hollow cavity mesoporous shell soft-template ultrasound assisted sol-gel synthesis therapeutic protein delivery