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Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study

World Journal of Gastroenterology 2013年第43期19卷 7711-7718页

作者： Hanan Fouad Maissa Saeed El Raziky Rasha ahmed abdel aziz Dina Sabry Ghada Mahmoud abdel aziz Manal Ewais ahmed Reda Sayed Medical Biochemistry Department Faculty of MedicineCairo University11562 CairoEgypt Gastroenterology and Tropical Department Faculty of MedicineCairo University11562 CairoEgypt Medical Biochemistry Department Faculty of MedicineBeni Sueif University19206 Kornish Al NileBani SweifEgypt

AIM:To assess co-stimulatory and co-inhibitory markers of dendritic cells(DCs)in hepatitis C virus(HCV)infected subjects with and without ***:Three subject groups were included in the study:group 1 involved 50 control subjects,group2 involved 50 patients with chronic HCV infection and group 3 involved 50 HCV uremic subjects undergoing ***83,CD86 and CD40 as co-stimulatory markers and PD-L1 as a co-inhibitory marker were assessed in peripheral blood mononuclear cells by realtime polymerase chain ***-10(IL-10)and hyaluronic acid(HA)levels were also *** findings were correlated with disease activity,viral load and ***:There was a significant decrease in costimulatory markers;CD83,CD86 and CD40 in groups2 and 3 vs the control ***-stimulatory markers were significantly higher in group 3 vs group *** was a significant elevation in PD-L1 in both HCV groups vs the control ***-L1 was significantly lower in group 3 vs group *** was a significant elevation in IL-10 and HA levels in groups 2 and 3,where IL-10was higher in group 3 and HA was lower in group 3 vs group *** level was significantly correlated with disease activity and fibrosis grade in group ***-10 was significantly correlated with fibrosis grade in group *** were significant negative correlations between co-stimulatory markers and viral load in groups 2 and3,except CD83 in dialysis *** was a significant positive correlation between PD-L1 and viral load in both HCV ***:A significant decrease in DC co-stimulatory markers and a significant increase in a DC coinhibitory marker were observed in HCV subjects and to a lesser extent in dialysis patients.

关键词： Hepatitis C virus Uremia Hemodialysis Dendritic cells CD83 CD86,CD40 PD-L1 Interleukin-10 Hyaluronic acid

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Relationship between heart girth, serum progesterone and superovulation response ofdonor Holstein cows

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Asian pacific Journal of Reproduction 2019年第3期8卷 118-123页

作者： abdel-Tawab AYKhalil ahmed abdel-Wahab Rabie Labdel aziz Department of Theriogenology Faculty of Veterinary MedicineBeni-Suef UniversityBeni-SuefEgypt Physiology Department Faculty of Veterinary MedicineMinia UniversityEl-MiniaEgypt

Objective: To determine effects of variations of heart girth, volume trait on embryo quality grade, and to explore the relationship between heart girth and circulating progesterone and correlations of circulating progesterone with embryo quality grade in superstimulated donor Holstein cows. Methods: Nineteen cows were subjected to a standard superstimulation protocol using follicle stimulating hormone. Blood samples were collected before superovulation, at insemination and at collection of embryos for progesterone analysis. Embryo quality grades were compared between high and low heart girth donors. Moreover, Pearson's correlations were determined between heart girth, progesterone and embryo quality. Results: Variation of heart girth was not associated with significant differences in embryo quality grade between high and low heart girth donor cows (P>0.05). However, we observed a significantly higher percentage of the third-grade embryo (24.09%) in low heart girth donors compared to 9.64% in high heart girth donors. Moreover, the percentage of the transferable embryo was numerically higher and that of the degenerated embryo was numerically lower in low heart girth cows. Donor cows with low response to superovulation (total structures ≤ 3) expressed numerically higher mean heart girth, compared to donors with high (total structures>15) and medium (total structures = 4-15) superovulation. Heart girth and body weight of donor cows were moderately correlated (r=0.45, P<0.05), but none was correlated with circulating progesterone at different sampling times except for a moderate correlation between body weight and progesterone at embryo collection (r=0.54, P=0.02). Circulating progesterone before superovulation was moderately correlated to the second-grade embryo (r=0.46, P<0.05) and to the third grade (r=0.52, P<0.05) embryo. Conclusions: Volume traits heart girth may influence the response of Holstein cows to superovulation;however, future studies with a higher number

关键词： Heart girth Superovulation Embryo quality Progesterone Holstein cow

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Surgical Management of Mitral Valve Infective Endocarditis with Accidental Finding of Open Pulmonary Tuberculosis

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World Journal of Cardiovascular Surgery 2024年第5期14卷 61-67页

作者： Ahmad Al Khaddour Mohammed Alharthi Alawab M. Mesallam Mohamed Agawi Mahmoud Ghalwash ahmed Gotbi Mohamed abdel Hafez Fouly Marko Samanovic Nelson David Vega Murad El Gharbi Fawaz Altaf King Abdullah Medical Complex Jeddah KSA

Objective: This case report aimed to highlight intersections of TB and Cardiovasular diseases which carry high morbidity and mortality rates. Methods: We are reporting the surgical management of forty seven years female who had back ground history of IDDM (Insulin dependent diabetic Mellitus), ESRD (End stage renal disease) on HD (haemodialysis) also she had left subclavian artery stenosis, and paroxysmal atrial fibrillation. She was diagnosed with mitral valve infective endocarditis and found accidently to have an open pulmonary tuberculosis (TB) on the day before surgery. Results: She was started on first line anti-TB treatment. She was isolated in her private room and airborne precautions measures applied. The patient underwent a tissue Mitral Valve replacement and tricuspid valve repair annuloplasty. Special precautions were applied in Theatre and on cardiopulmonary bypass Machine guided by KAMC-J disinfection protocol. The patient made good recovery postoperatively. She was discharged well on day 7 post operatively. Conclusion: Intersections of TB and cardiovasular diseases carry high morbidity and mortality rates. Early diagnosis and early anti tuberculosis treatment can surely improve the patient prognosis. Our decontamination and disinfective procedures are recommended. Cases like this should be monitored long term for the development of further cardiovascular complication.

关键词： Tuberculosis (TB) Mycobacterium tuberculosis (MTB) Heater-Cooler and Bypass Machine New York Heart Association (NYHA)

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Cartilage tympanoplasty in the treatment of adhesive otitis media with and without Eustachian tube balloon dilatation

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Journal of Otology 2022年第4期17卷 226-231页

作者： ahmed abdel rahman abdel aziz ahmed Mahmoud Youssef Mostafa Mohamed Mostafa Mostafa talaat Khaled Mohamed abdelzaher ahmed Adel Sadeq Department of Otorhinolaryngology Faculty of MedicineEl MiniaEgypt Radiology Department Faculty of MedicineEl MiniaEgypt

Purpose:To compare cartilage tympanoplasty(CT)combined with eustachian tube balloon dilatation(ETBD)and cartilage tympanoplasty alone as a surgical treatment modality for adhesive otitis media(AdOM)in terms of graft healing,audiological outcomes,and impact on life style,using Chronic Otitis Media Outcome Test 15(COMOT-15).Methods:50 patients with AdOM were randomly classified into 2 groups:25 patients for cartilage tympanoplasty only(CT group)and 25 patients for cartilage tympanoplasty combined with eustachian tube balloon dilatation(CT t ETBD group).Clinical outcomes in both groups were compared at 3 and 6 months of follow ***:There was no significant difference in graft healing between the two *** COMOT-15 scores significantly decreased in both groups with a significant difference between the groups with regard to the decrease in COMOT-15 scores at 3 and 6 months of follow-up(P<0.05).Hearing improvement was achieved,as the mean preoperative ABG was 26.5±5.4 and 27.1±4.6 dB,and the mean postoperative ABG at 6 months was 19.4±4.4 and 14.6±3.9 dB in the CT and the CT t ETBD groups,*** difference in the magnitude of ABG reduction in the two groups was significant at 3 and 6 months of postoperative follow-up(P<0.05)in favour of the CT t ETBD ***:ETBD can increase the success rate of cartilage tympanoplasty in patients with AdOM by enhancing the audiological outcome and quality of life.

关键词： balloon healing otitis

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Types of trematodes infecting freshwater snails found in irrigation canals in the East Nile locality,Khartoum,Sudan

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Infectious Diseases of Poverty 2016年第1期5卷 139-148页

作者： Nidal A.I.Mohammed Henry Madsen abdel aziz A.R.M.ahmed Department of Zoology Khartoum College of Medical SciencesKhartoumSudan Parasitology and Aquatic Diseases Department of Veterinary Disease BiologyFaculty of Health and Medical SciencesUniversity of CopenhagenFrederiksbergDenmark Education Expert Company RiyadhKingdom of Saudi Arabia

Background:The planorbid freshwater snails of the two genera,Biomphalaria and Bulinus-have been vigorously studied due to the role they play as intermediate hosts of *** Sudan specifically,most studies have focused on the chemical and ecological control of the two genera,but few studies have looked at their biological *** study explored the coexistence of other species of freshwater snails and the two genera along with their trematode infections in relation to a number of environmental factors in the East Nile locality,Khartoum state,***:Freshwater snails from irrigation canals(abueshreens)were sampled monthly from January 2004 to December *** snails were examined for trematode infections by cercarial emergence immediately after collection and then weekly for an additional four weeks to allow for the maturation of prepatent *** cover in the study sites as well as the physicochemical characteristics of the water,including temperature,were also ***:A total of 10,493 snails,representing seven species,were *** most abundant species was Biomphalaria pfeifferi,representing 48.6%of the ***,14.1%of the snails were found to be shedding some type of *** species were found to have infections;among these the Bulinus truncatus species was found to be the most heavily infected,with an overall prevalence of 46.2%.Double infections were recorded in only two *** snails and one Cleopatra bulimoides *** different morphotypes of cercariae were recorded,seven of which appeared not to conform to previously described cercariae from *** type 1 was the most common type of cercariae recovered,accounting for 44.3% of all *** density of snails tended to be lower during the summer months than the winter months,except for *** snails,which were not affected by seasonal ***:The findings of this study indicate that besides sc

关键词： Freshwater snails Trematode cercariae Biomphalaria Bulinus East Nile locality Khartoum Sudan

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Familial Forms of Spondyloarthritis Study of 100 Senegalese Multiplex Families

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第3期14卷 132-143页

作者： Adama Bah Chiekh Ahamadou Bamba Diaw Dieynaba Sala Tamara Kane Adama Doucouré Siddiki Charifah Ramadhane Bouchrane Harine abdel aziz Garba Aissatou N’diaye Mondukpe Joane Immanuelle Houansou Laurine Marlyse Adogle Yaye Aminata Gueye Moustapha Niasse Saidou Diallo Service de Rhumatologie CHU Aristide Le Dantec Dakar Sngal Service de Rhumatologie Hpital National Ignace Deen Conakry Conakry Guine Service de Mdecine Interne Hpital Dalal Jamm de Dakar Dakar Sngal

Introduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel diseases (IBD), SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis), juvenile spondyloarthritis (JSPA), and undifferentiated SpA. Their exact cause is unknown but is believed to stem from a combination of factors. The first familial forms were described by de Blécourt et al. in 1961. The objective was to evaluate the epidemiological, clinical, therapeutic and evolutionary aspects of familial forms of SpA and in particular, to prove the severity of the disease in family members compared to index cases in the rheumatology department of the Aristide Le Dantec University Hospital in Dakar. Methodology: This was a prospective, cross-sectional and descriptive study with an analytical aim on patients with the familial form of spondyloarthritis defined by the existence of at least one other family member with SpA outside the propositus, collected within the Aristide Le Dantec rheumatology department in Dakar over a period of 10 years between January 2012 and December 2021. There were two phases of study, the first of which consisted of collecting index cases with miserly SpA and the second of which consisted of family screening after consent. The data analysed were epidemiological, clinical, paraclinical, therapeutic and evolving. Results: Out of 100 families of 1905 members, 667 SpA patients included, i.e. a prevalence of 35%, including 225 (33.73%) men and 412 women (61.17%), i.e. a ratio of 1.8. The mean age at diagnosis among relatives was 26.3 years (range 13 and 80 years), 47.14 years among the propositus, in whom the mean age at onset was 36.26 years and that of relatives 49.9 years in the first degree, 15 years in the second degree and 1 year in the third degree.

关键词： Familial Forms of Spondyloarthritis Propositus Senegal

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Finite element modeling assumptions impact on seismic response demands of MRF-buildings

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 821-834页

作者： Shehata E abdel Raheem ahmed K abdel Zaher ahmed MA Taha Civil Engineering Department Engineering College Taibah University Civil Engineering Department Faculty of Engineering Assiut University

Recent seismic events have raised concerns over the safety and vulnerability of reinforced concrete moment resisting frame ＂RC-MRF＂ buildings. The seismic response of such buildings is greatly dependent on the computational tools used and the inherent assumptions in the modelling process. Thus, it is essential to investigate the sensitivity of the response demands to the corresponding modelling assumption. Many parameters and assumptions are justified to generate effective structural finite element（FE） models of buildings to simulate lateral behaviour and evaluate seismic design demands. As such, the present study focuses on the development of reliable FE models with various levels of refinement. The effects of the FE modelling assumptions on the seismic response demands on the design of buildings are investigated. the predictive ability of a FE model is tied to the accuracy of numerical analysis; a numerical analysis is performed for a series of symmetric buildings in active seismic zones. The results of the seismic response demands are presented in a comparative format to confirm drift and strength limits requirements. A proposed model is formulated based on a simplified modeling approach, where the most refined model is used to calibrate the simplified model.

关键词： RC-MRF buildings design codes provisions seismic design finite element modeling modeling assumptions response demands

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Seismic response of skewed RC box-girder bridges

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Earthquake Engineering and Engineering Vibration 2008年第4期7卷 415-426页

作者： ahmed abdel-Mohti Gokhan Pekcan Civil and Environmental Engineering Department University of Nevada Reno

It is critical to ensure the functionality of highway bridges after earthquakes to provide access to important facilities. Since the 1971 San Fernando earthquake, there has been a better understanding of the seismic performance of bridges. Nonetheless, there are no detailed guidelines addressing the performance of skewed highway bridges. Several parameters affect the response of skewed highway bridges under both service and seismic loads which makes their behavior complex. Therefore, there is a need for more research to study the effect of skew angle and other related factors on the performance of highway bridges. This paper examines the seismic performance of a three-span continuous concrete box girder bridge with skew angles from 0 to 60 degrees, analytically. Finite element （FE） and simplified beam-stick （BS） models of the bridge were developed using SAP2000. Different types of analysis were considered on both models such as： nonlinear static pushover, and linear and nonlinear time history analyses. A comparison was conducted between FE and BS, different skew angles, abutment support conditions, and time history and pushover analysis. It is shown that the BS model has the capability to capture the coupling due to skew and the significant modes for moderate skew angles. Boundary conditions and pushover load profile are determined to have a major effect on pushover analysis. Pushover analysis may be used to predict the maximum deformation and hinge formation adequately.

关键词： skew bridge seismic response pushover analysis time history analysis modeling

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Geometric Phase of a Coupled System

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Communications in Theoretical Physics 2004年第5X期42卷 672-674页

作者： H.S.abdel-aziz MathematicsDepartment FacultyofScienceSouthValleyUniversitySohagEgypt

In this contribution, my main attention is paid to the study of the geometric phase ora two-level *** expansion of the eigenvalue and analytic information are obtained. The results are illustrated with an application ... 详细信息

关键词：几何相位二平面偏微分方程量子论

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Attitude dynamics and control of spacecraft using geomagnetic Lorentz force

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Research in Astronomy and Astrophysics 2015年第1期15卷 127-144页

作者： Yehia A.abdel-aziz Muhammad Shoaib National Research Institute of Astronomy and Geophysics (NRIAG) Helwan Cairo 11721Egypt University of Hail Department of Mathematics PO BOX 2440 Kingdom of Saudi Arabia

Attitude stabilization of a charged rigid spacecraft in Low Earth Orbit using torques due to Lorentz force in pitch and roll directions is considered. A spacecraft that generates an electrostatic charge on its surface in the Earth’s magnetic field will be subject to perturbations from the Lorentz force. The Lorentz force acting on an electrostatically charged spacecraft may provide a useful thrust for controlling a spacecraft’s orientation. We assume that the spacecraft is moving in the Earth’s magnetic field in an elliptical orbit under the effects of gravitational, geomagnetic and Lorentz torques. The magnetic field of the Earth is modeled as a non-tilted dipole.A model incorporating all Lorentz torques as a function of orbital elements has been developed on the basis of electric and magnetic fields. The stability of the spacecraft orientation is investigated both analytically and numerically. The existence and stability of equilibrium positions is investigated for different values of the charge to mass ratio（α＊）. Stable orbits are identified for various values of α＊. The main parameters for stabilization of the spacecraft are α＊and the difference between the components of the moment of inertia for the spacecraft.

关键词： space vehicles atmospheric effects celestial mechanics kinematics and dynamics

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