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World Journal of Experimental Medicine 2024年第3期14卷 48-56页

作者： Mina Rahmati Hassan Moghtaderi Saeed Mohammadi ahmed al-Harrasi Biotechnology Research Center Pasteur Institute of IranTehran ***TehranIran Natural and Medical Sciences Research Center University of NizwaNizwa 616Ad DakhiliyahOman

Esophageal squamous cell carcinoma(ESCC)is a substantial global health *** escape mechanisms are important in ESCC progression,enabling cancer cells to escape the surveillance of the host immune *** key player in this process is the Aryl Hydrocarbon Receptor(AhR),which influences multiple cellular processes,including proliferation,differentiation,metabolism,and immune *** AhR signaling participates in ESCC development by stimulating carcinogenesis,epithelial-mesenchymal transition,and immune *** AhR signaling is a potential therapeutic approach for ESCC,with AhR ligands showing efficacy in preclinical ***,modification of AhR ligands and combination therapies present new opportunities for therapeutic *** review aims to address the knowledge gap related to the role of AhR signaling in ESCC pathogenesis and immune escape.

关键词： Esophageal squamous cell carcinoma Aryl hydrocarbon receptor Immune escape Tumor microenvironment Immunosuppression Therapeutic targeting

Higgs inflation model with non-minimal coupling in hybrid Palatini approach

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Chinese Physics C 2024年第4期48卷 193-201页

作者： Brahim Asfour Aatifa Bargach ahmed Errahmani Taoufik Ouali Laboratory of Physics of Matter and Radiation University of Mohammed firstBP 717OujdaMorocco

In this paper,we propose a hybrid metric Palatini approach in which the Palatini scalar curvature is non minimally coupled to the scalar *** derive Einstein’s field equations,i.e.,the equations of motion of the scalar ***,the background and perturbative parameters are obtained by means of Friedmann equations in the slow roll *** analysis of cosmological perturbations allowed us to obtain the main inflationary parameters,e.g.,the scalar spectral index and tensor to scalar ratio *** this perspective,as an application of our analysis,we consider the Higgs field with quartic potential,which plays the inflaton role,and show that predictions of Higgs hybrid inflation are in good agreement with recent observational data[***.641,61(2020)].

关键词： non-minimal coupling hybrid metric Palatini Higgs inflation

Low-Density Microplastics in Recreational Parks of al Ain, United Arab Emirates: Abundance, Composition, and Potential Effects on Soil Health

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Journal of Environmental Protection 2024年第2期15卷 109-123页

作者： Rener De Jesus ahmed Abuibaid Bassam al-Hindawi Ruwaya alKendi Department of Biology College of Science United Arab Emirates University Al Ain UAE Department of Chemistry College of Science United Arab Emirates University Al Ain UAE

Microplastics (MPs) have been an emerging concern due to their harmful effects on the ecosystem and are ubiquitous in various habitats, from marine to terrestrial environments. However, studies on the presence of MPs in recreational areas are limited. One of the previous works has reported that urban recreational parks are considered “sinks” for plastic debris, including MPs. In this study, low-density MPs (LD-MPs) in soil samples collected from recreational parks of al Ain, United Arab Emirates (UAE) were isolated by density flotation method. Results showed that these parks have varying levels of LD-MPs caused by various anthropogenic activities, such as sludge use and application of reclaimed water from wastewater treatment facilities in those areas. These plastic particles were isolated in 87% of the soil samples, with an average concentration of 1550 ± 340 MPs/kg. Predominantly, these comprised large LD-MPs (300 - 5000 μm), with red and blue being the most common colors. Fourier transform infrared (FTIR) spectroscopy identified possible synthetic polymers, including polyethylene and polypropylene. Additionally, a negative correlation was observed between LD-MP concentration and soil pH and moisture content, indicating potential adverse effects on soil health. These findings highlight the need for monitoring and managing microplastic pollution in urban recreational areas to mitigate its ecological impacts.

关键词： Plastic Particles FTIR Analysis Microfibers Soil Pollutants Urban Parks

A Hybrid Model for Improving Software Cost Estimation in Global Software Development

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Computers, Materials & Continua 2024年第1期78卷 1399-1422页

作者： Mehmood ahmed Noraini B.Ibrahim Wasif Nisar Adeel ahmed Muhammad Junaid Emmanuel Soriano Flores Divya Anand Faculty of Computer Science and Information Technology Universiti Tun Hussein Onn Malaysia Parit RajaBatu Pahat86400Malaysia Department of Computer Science COMSATS University Wah Cantt CampusIslamabad47010Pakistan Department of Information Technology The University of HaripurKhyber Pakhtunkhwa22620Pakistan Engineering Research Innovation Group Universidad Europea del AtlanticoSantander39011Spain

Accurate software cost estimation in Global Software Development(GSD)remains challenging due to reliance on historical data and expert *** models,such as the Constructive Cost Model(COCOMO II),rely heavily on historical and accurate *** addition,expert judgment is required to set many input parameters,which can introduce subjectivity and variability in the estimation ***,there is a need to improve the current GSD models to mitigate reliance on historical data,subjectivity in expert judgment,inadequate consideration of GSD-based cost drivers and limited integration of modern technologies with cost *** study introduces a novel hybrid model that synergizes the COCOMO II with Artificial Neural Networks(ANN)to address these *** proposed hybrid model integrates additional GSD-based cost drivers identified through a systematic literature review and further vetted by industry *** article compares the effectiveness of the proposedmodelwith state-of-the-artmachine learning-basedmodels for software cost *** the NASA 93 dataset by adopting twenty-six GSD-based cost drivers reveals that our hybrid model achieves superior accuracy,outperforming existing *** findings indicate the potential of combining COCOMO II,ANN,and additional GSD-based cost drivers to transform cost estimation in GSD.

关键词： Artificial neural networks COCOMO II cost drivers global software development linear regression software cost estimation

Improved Manta Ray Foraging Optimizer-based SVM for Feature Selection Problems:A Medical Case Study

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Journal of Bionic Engineering 2024年第1期21卷 409-425页

作者： Adel Got Djaafar Zouache Abdelouahab Moussaoui Laith Abualigah ahmed alsayat Faculty of informatics University of Science and Technology Houari BoumedieneAlgiersAlgeria LRIA Laboratory University of Science and Technology Houari BoumedieneAlgiersAlgeria Computer Science Department University of Mohamed El Bachir El IbrahimiBordj Bou ArreridjAlgeria Computer Science Department University of Ferhat AbbasSetifAlgeria Computer Science Department Prince Hussein Bin Abdullah Faculty for Information TechnologyAl al-Bayt UniversityMafraq 25113Jordan Department of Computer Science College of Computer and Information SciencesJouf UniversityJoufSaudi Arabia Department of Electrical and Computer Engineering Lebanese American University13-5053ByblosLebanon Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman 19328Jordan MEU Research Unit Middle East UniversityAmman 11831Jordan Applied science research center Applied science private universityAmman 11931Jordan School of Computer Sciences Universiti Sains Malaysia11800 PenangMalaysia School of Engineering and Technology Sunway University Malaysia27500 Petaling JayaMalaysia

Support Vector Machine(SVM)has become one of the traditional machine learning algorithms the most used in prediction and classification ***,its behavior strongly depends on some parameters,making tuning these parameters a sensitive step to maintain a good *** the other hand,and as any other classifier,the performance of SVM is also affected by the input set of features used to build the learning model,which makes the selection of relevant features an important task not only to preserve a good classification accuracy but also to reduce the dimensionality of *** this paper,the MRFO+SVM algorithm is introduced by investigating the recent manta ray foraging optimizer to fine-tune the SVM parameters and identify the optimal feature subset *** proposed approach is validated and compared with four SVM-based algorithms over eight benchmarking ***,it is applied to a disease Covid-19 *** experimental results show the high ability of the proposed algorithm to find the appropriate SVM’s parameters,and its acceptable performance to deal with feature selection problem.

关键词： Support vector machine Parameters tuning Feature selection Bioinspired algorithms Manta ray foraging optimizer

Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： Nora A.Elsayed Fatma SM Moawed Esraa SA ahmed ahmed Hammad Omayma AR Abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

Analysis of Progressively Type-Ⅱ Inverted Generalized Gamma Censored Data and Its Engineering Application

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 459-489页

作者： Refah alotaibi Sanku Dey ahmed Elshahhat Department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Statistics St.Anthony’s CollegeShillong793001India Faculty of Technology and Development Zagazig UniversityZagazig44519Egypt

A novel inverted generalized gamma(IGG)distribution,proposed for data modelling with an upside-down bathtub hazard rate,is *** many real-world practical situations,when a researcher wants to conduct a comparative study of the life testing of items based on cost and duration of testing,censoring strategies are frequently *** this point of view,in the presence of censored data compiled from the most well-known progressively Type-Ⅱ censoring technique,this study examines different parameters of the IGG *** a classical point of view,the likelihood and product of spacing estimation methods are *** Fisher information and the deltamethod are used to obtain the approximate confidence intervals for any unknown parametric function of the *** the Bayesian paradigm,the same traditional inferential approaches are used to estimate all unknown ***-Chain with Monte-Carlo steps are considered to approximate all Bayes’*** numerical comparisons are presented to examine the performance of the proposed methodologies using various criteria of ***,using several optimality criteria,the optimumprogressive censoring design is *** highlight how the proposed estimators can be used in practice and to verify the flexibility of the proposed model,we analyze the failure times of twenty mechanical components of a diesel engine.

关键词： Inverted generalized gamma censoring spacing function likelihood Bayesian optimal plan

Evaluating mechanism of banana pseudo-stem retting using seawater:A cost-effective surface pre-treatment approach

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Journal of Bioresources and Bioproducts 2024年第3期9卷 322-335页

作者： Prince Hotor ahmed H.Hassanin Osbert Akatwijuka Mohamed A.H.Gepreel Mitsuo Yamamoto Yukie Saito ahmed Abdel-Mawgood Egypt-Japan University of Science and Technology Biotechnology ProgramAlexandria GovernorateNew Borg Al Arab 21934Egypt alexandria University Department of Textile EngineeringAlexandria GovernorateBab Sharqi 5424041Egypt Egypt-Japan University of Science and Technology Material Science and EngineeringAlexandria GovernorateNew Borg Al Arab 21934Egypt Graduate School of Agricultural and Life Sciences The University of TokyoBunkyo-KuTokyo 113-8657Japan

Retting has been employed to extract natural fibers from agricultural wastes as a biological and cost-effective approach for *** its global abundance,banana pseudo-stem is a promising agro-waste for lignocellulosic fiber *** this study,fibers were extracted from the pseudo-stems after being pre-treated under four conditions using seawater at room temperature for up to 35 d Bacterial isolation from the fresh seawater sample and screening for ligninolytic ability were *** load as well as laccase and manganese peroxidase enzyme activity profile assay during the retting duration were *** transform infrared(FT-IR)and X-day diffraction(XRD)analyses were also examined for both pre-treated and untreated extracted *** results shows that six out of the eight bacterial isolates had the ability to degrade *** treatments(Raw stem+Raw seawater)and(Autoclaved stem+Raw seawater)recorded the highest viable bacterial load of 9.24×102 and 4.46×102 CFU,respectively,on the 14th day of the retting ***,the highest laccase and manganese peroxidase enzymes activity was recorded for(Raw stem+Raw seawater)and(Autoclaved stem+Raw seawater)treatments in the second to the third *** FT-IR spectra of the pre-treated fibers revealed relative reductions in peaks attributed to polysaccharides and other amorphous substances for all retting *** XRD diffractogram revealed that the crystallinity index(CI)of pre-treated fibers increased in all seawater retting treatment ***,the CI for fibers pre-treated under enzymatic conditions were enhanced even after five *** analysis for selected bacterial isolates showed homology to sequences of Bacillus velezensis,Shewanella sp.L8–5,and Citrobacter amalonaticus and Bacillus subtilis j8 *** these findings,it was suggested that physical,biological,and chemical actions were collectively involved in the seawater retting process of banana ps

关键词： Seawater retting Banana pseudo-stem Natural fiber Enzyme activity Colony forming unit

Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice:One-year observational study

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World Journal of Diabetes 2024年第3期15卷 455-462页

作者： ahmed Eldib Shilton Dhaver Karim Kibaa Astrid Atakov-Castillo Tareq Salah Marwa al-Badri Abdelrahman Khater Ryan McCarragher Omnia Elenani Elena Toschi Osama Hamdy Department of Clinical Behavioral&Outcomes ResearchJoslin Diabetes CenterBostonMA 02215United States Department of Medicine Harvard Medical SchoolBostonMA 02115United States

BACKGROUND In 2016,the Food and Drug Administration approved the first hybrid closed-loop(HCL)insulin delivery system for adults with type 1 diabetes(T1D).There is limited information on the impact of using HCL systems on patient-reported outcomes(PROs)in patients with T1D in real-world clinical *** this independent study,we evaluated glycemic parameters and PROs over one year of continuous use of Medtronic’s 670G HCL in real-world clinical *** To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with *** We evaluated 71 patients with T1D(mean age:45.5±12.1 years;59%females;body weight:83.8±18.7 kg,body mass index:28.7±5.6 kg/m2,A1C:7.6%±0.8%)who were treated with HCL at Joslin Clinic from 2017 to *** measured A1C and percent of glucose time-in-range(%TIR)at baseline and 12 *** measured percent time in auto mode(%TiAM)for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes *** At 12 mo,A1C decreased by 0.3%±0.1%(P=0.001)and%TIR increased by 8.1%±2.5%(P=0.002).The average%TiAM was only 64.3%±32.8%and was not associated with A1C,%TIR or ***,provided at baseline and at the end of the study,showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9%(Pale decreased significantly by 24.9%(Pal burden submodules of dietary diversity score reduced significantly by-44.7%(P=0.001).Furthermore,analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic ***-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL ***,analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality,sleep latency,or duration o

关键词： Artificial pancreas Continuous blood glucose monitor Type 1 diabetes Hybrid closed-loop insulin delivery Quality of life

The impact of chemotherapy-naïve open radical cystectomy delay and perioperative transfusion on the recurrence-free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： ahmed M.Harraz ahmed Elkarta Mohamed H.Zahran ahmed Mosbah Atallah A.Shaaban Hassan Abol-Enein Urology and Nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confidence interval [CI] 1.05-1.08, pal hydronephrosis (HR 1.54, 95% CI 1.21-1.97, palidation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram