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Aryl hydrocarbon receptor dynamics in esophageal squamous cell carcinoma:From immune modulation to therapeutic opportunities

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World Journal of Experimental Medicine 2024年第3期14卷 48-56页

作者： Mina Rahmati Hassan Moghtaderi Saeed Mohammadi ahmed al-harrasi Biotechnology Research Center Pasteur Institute of IranTehran ***TehranIran Natural and Medical Sciences Research Center University of NizwaNizwa 616Ad DakhiliyahOman

Esophageal squamous cell carcinoma(ESCC)is a substantial global health *** escape mechanisms are important in ESCC progression,enabling cancer cells to escape the surveillance of the host immune *** key player in this process is the Aryl Hydrocarbon Receptor(AhR),which influences multiple cellular processes,including proliferation,differentiation,metabolism,and immune *** AhR signaling participates in ESCC development by stimulating carcinogenesis,epithelial-mesenchymal transition,and immune *** AhR signaling is a potential therapeutic approach for ESCC,with AhR ligands showing efficacy in preclinical ***,modification of AhR ligands and combination therapies present new opportunities for therapeutic *** review aims to address the knowledge gap related to the role of AhR signaling in ESCC pathogenesis and immune escape.

关键词： Esophageal squamous cell carcinoma Aryl hydrocarbon receptor Immune escape Tumor microenvironment Immunosuppression Therapeutic targeting

Antituberculosis and cytotoxic activities of triorganotin(Ⅳ) complexes

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Chinese Chemical Letters 2012年第6期23卷 731-735页

作者： Hidayat Hussain NaziaBibi ahmed al-harrasi Salman Siddiqi Shahana U. Kazmi Ying Zhang Amin Badshah Department of Chemisty University of Paderborn 33098 Paderborn Germany Department of Biological Siences and Chemistry College of Arts and Sciences University of Nizwa Oman Immnology and Infectious Disease Research Laboratory Department of Microbiology University of＂ Karachi Pakistan Department of Molecular Muclvbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore MD 21205 USA Becton Dickinson Diagnostic Systems Sparks MD 21152 USA Department of Chemistry Quaid-e-Azam University lslamabad 45320 Pakistan

Five triorganotin（IV）（1-5） complexes of cinnamic acid, （Z）-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by IH-13C-119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin（IV） compounds. Five triorganotin（IV） complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to he 0.08 and 1.25μg/mL.

关键词： Triorganotin(IV) complexes Antituberculosis activity MICs Cytotoxicity

Antimicrobial chemical constituents from endophytic fungus Phoma sp.

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 699-702页

作者： Hidayat Hussain Ines Kock ahmed al-harrasi ahmed al-Rawahi Ghulam Abbas Ivan R.Green Afzal Shah Amin Badshah Muhammad Saleem Siegfried Draeger Barbara Schulz Karsten Krohn Department of Chemistry University of PaderbornWarburger Strasse 10033098 PaderbornGermany UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of NizwaP.O Box 33Postal Code 616Birkat Al MauzNizwaSultanate of Oman Department of Chemistry CUTAbbottabad CampusAbbottabad-22060Pakistan Department of Chemistry and Polymer Science University of StellenboschP/Bag X1 Matieland 7602South Africa Department of Chemistry Quaid-i-Azam University45320 IslamabadPakistan Department of Chemistry The Islamia University of BahawalpurBaghdad Campus-ul-JadidBahawalpurPakistan Institute of Microbiology University of BraunschweigSpielmannstraβe 738106 BraunschweigGermany

Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma *** the tentative identification of their active ***:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion *** compounds were purified using column chromatography and tlieir structures were assigned using～1H and～(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC ***:The ethyl acetate fraction of Phoma *** good antifungal,antibacterial,and algicidal *** new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma *** studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal ***(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal ***:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma *** isolated compounds clearly demonstrate that Phoma *** its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries.

关键词： Natural product Endrophytic fungi Phoma sp

Seimatoric acid and colletonoic acid:Two new compounds from the endophytic fungi,Seimatosporium *** Colletotrichum sp.

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Chinese Chemical Letters 2014年第12期25卷 1577-1579页

作者： Hidayat Hussain Natalia Root Farah Jabeen ahmed al-harrasi ahmed al-Rawahi Manzoor Ahmad Zahid Hassan Ghulam Abbas Fazal Mabood Afzal Shah Amin Badshah Amjad Khan Riaz Ahmad Ivan R.Green Siegfried Draeger Barbara Schulz Karsten Krohn Department of Chemistry University of PaderbornWarburger Strasse 100Paderborn 33098Germany UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of NizwaP.O.Box 33Postal Code 616Birkat Al MauzNizwaOman Department of Chemistry University of MalakandChakdaraDir(L)Pakistan Department of Chemistry CIITAbbottabad CampusAbbottabad 22060Pakistan Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Chemistry and Polymer Science University of StellenboschP/Bag X1Matieland 7602South Africa Institute of Microbiology University of BraunschweigSpielmannstraβe 7Braunschweig 38106Germany

A new metabolite,named seimatoric acid（1）,representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-enone（2）,（-）-phyllostine（3）,（＋）-epiepoxydon（4） and（＋）-epoxydon monoacetate（5）.Similarly one new benzoic acid derivative,named colletonoic acid（6） was isolated from the ethyl acetate fraction of Colletotrichum *** structures of the new compounds were elucidated by detailed ^1 H NMR,^13C NMR,COSY,*** spectroscopic analysis,and *** acid（1）was also isolated from another taxonomical unidentified fungal strain 4295 in *** structures of the known compounds were elucidated by their spectral data comparison to literature *** studies showed that colletonoic acid（6） showed good antibacterial,antifungal,and antialgal activities.

关键词： Seimatosporium sp. Colletotrichum sp. Activity Natural product

A novel variant of GalC in a familial case of Krabbe disease:Insights from structural bioinformatics and molecular dynamics simulation

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Genes & Diseases 2023年第6期10卷 2263-2266页

作者： Ikram Ullah Muhammad Waqas Muhammad Ilyas Sobia Ahsan Halim Akmal Ahmad Natalia Dominik Wahid Ullah Muhammad Abbas Muhammad Aamir Henry Houlden Stephanie Efthymiou Ajmal Khan ahmed al-harrasi Centre for Omic Sciences Islamia College University PeshawarPeshawarKhyber Pakhtunkhwa 25120Pakistan Department of Biotechnology and Genetic Engineering Hazara UniversityMansehraDhodial 21120Pakistan Natural and Medical Sciences Research Center University of NizwaNizwa 616Sultanate of Oman Department of Bioengineering University of Engineering and Applied SciencesSwatKhyber Pakhtunkhwa 19060Pakistan Department of Neuromuscular Disorders UCL Queen Square Institute of NeurologyLondon WC1N 3BGUnited Kingdom

Krabbe disease or globoid cell leukodystrophy(GLD;MIM#245200)is a rare and fatal lysosomal storage disease with an autosomal recessive mode of inheritance that results from the deficiency of galactocerebrosidase(GalC;E.C.3.***.1.46),a lysosomal enzyme encoded by the GalC gene.1 GalC breaks down galactosylceramide,a cerebroside located mainly in the myelin *** in GalC cause the accumulation of a cytotoxic metabolite,galactosylsphingosine or psychosine,which can be toxic to oligodendrocytes and Schwann cells.2 The failure to digest galactosylceramide triggers the formation of multi-nucleated globoid cells,causing severe demyelination,axonopathy,and neuronal death.3 The reported frequency of Krabbe disease is 1 in 100,000 live births with symptoms including irritability,loss of motor ability,spasticity,ataxia,visual dysfunction,seizures,andcognitive impairment.

关键词： dynamics birth Gal

Dimethylformamide Dimethyl Acetal (DMFDMA) in Heterocyclic Synthesis: Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and Their Fused Derivatives

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International Journal of Organic Chemistry 2011年第4期1卷 207-214页

作者： Fathi A. Abu-Shanab Sayed A. S. Mousa E. A. Eshak ahmed Z. Sayed ahmed al-harrasi 不详

Reaction of N,N’-dimethylformamide dimethyl acetal (DMFDMA) with malononitrile dimer 8 (1:1) mole afforded 9 while, this reaction when carried out in (2:1) mole to give amidine 11 which can be used for the preparation of pyrimidine 13, amidine 14 and pyridine 19 when reacted with 4-nitroaniline, 4-methylaniline and alkoxide respectively. Malononitrile dimer reacted with diazonium chloride to give pyridazine 21, which can be reacted with DMFDMA, AcOH/HCl and cyanoacetamide to give pyridazine 22, 23 and pyrido[4,3-c] pyridazine 24 respectively. The latter reacted with DMFDMA to afford tricyclic compound 25.

关键词： DMFDMA Malononitrile Dimer Pyridazine-3 5-carbonitrile Pyridine-4-alkoxide

Endophytes from medicinal plants and their potential for producing indole acetic acid, improving seed germination and mitigating oxidative stress

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第2期18卷 125-137页

作者： Abdul Latif KHAN Syed Abdullah GILANI Muhammad WAQAS Khadija al-HOSNI Salima al-KHIZIRI Yoon-Ha KIM Liaqat alI Sang-Mo KANG Sajjad ASAF Raheem SHAHZAD Javid HUSSAIN In-Jung LEE ahmed al-harrasi UoN Chair of Oman's Medicinal Plants & Marine Natural Products University of Nizwa Nizwa 616 Oman Department of Biological Sciences & Chemistry University of Nizwa Nizwa 616 Oman School of Applied Biosciences Kyungpook National University Daegu 702-701 Korea Department of Agriculture Abdul Wali Khan University Mardan Mardan 23200 Pakistan Division of Plant Sciences University of Missouri Columbia MO 65211 USA

Medicinal plants have been used by marginal communities to treat various ailments. However, the potential of endophytes within these bio-prospective medicinal plants remains unknown. The present study elucidates the endophytic diversity of medicinal plants（Caralluma acutangula, Rhazya stricta, and Moringa peregrina） and the endophyte role in seed growth and oxidative stress. Various organs of medicinal plants yielded ten endophytes, which were identified as Phoma sp.（6 isolates）, alternaria sp.（2）, Bipolaris sp.（1）, and Cladosporium sp.（1） based on 18 S rD NA sequencing and phylogenetic analysis. The culture filtrates（CFs; 25%, 50%, and 100% concentrations） from these endophytes were tested against the growth of normal and dwarf mutant rice lines. Endophytic CF exhibited dose-dependent growth stimulation and suppression effects. CF（100%） of Phoma sp. significantly increased rice seed germination and growth compared to controls and other endophytes. This growth-promoting effect was due to the presence of indole acetic acid in endophytic CF. The gas chromatography/mass spectrometry（GC/MS） analysis showed the highest indole acetic acid content（（54.31±0.21） μmol/L） in Bipolaris sp. In addition, the isolate of Bipolaris sp. exhibited significantly higher radical scavenging and anti-lipid peroxidation activity than the other isolates. Bipolaris sp. and Phoma sp. also exhibited significantly higher flavonoid and phenolic contents. The medicinal plants exhibited the presence of bio-prospective endophytic strains, which could be used for the improvement of crop growth and the mitigation of oxidative stresses.

关键词： Fungal endophytes Diversity Medicinal plants Antioxidants Indole acetic acid

Generation of Electricity by Electrogenic Bacteria in a Microbial Fuel Cell Powered by Waste Water

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Advances in Bioscience and Biotechnology 2016年第7期7卷 329-335页

作者： Zakira Naureen Zainab ali Rashid al Matani Miyassa Nasser al Jabri Saif Khalfan al Housni Syed Abdullah Gilani Fazal Mabood Saima Farooq Javid Hussain ahmed al harrasi Department of Biological Science and Chemistry University of Nizwa Nizwa Oman

The present study aimed at isolation characterization and evaluation of electrogenic bacteria for electricity generation using waste water. In this context, waste water samples were collected from University of Nizwa waste water treatment plant. A total of eight distinct bacterial isolates were isolated from these samples by serial dilution and plating on LB Agar medium. The bacterial isolates were than grown at different temperatures and pH. DNA from bacterial samples was isolated and 16S rRNA gene amplification was carried out. The 16S rRNA gene PCR products were directly sequenced and the resulting sequence was blasted using BLASTn. Based on BLAST results, the bacterial strains were identified. The bacteria were used in different combinations to generate electricity from waste water in microbial fuel cells constructed using plastic bottles. The microbial isolates were found to produce varying levels of currents and their electrogenic potential in waste water was observed to increase with the passage of time.

关键词： Electricity Production Electrogenic Bacteria Waste Water Microbial Fuel Cell

Appropriate Combination of Crossover Operator and Mutation Operator in Genetic algorithms for the Travelling Salesman Problem

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Computers, Materials & Continua 2024年第5期79卷 2399-2425页

作者： Zakir Hussain ahmed Habibollah Haron Abdullah al-Tameem Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia Faculty of Computing Universiti Teknologi MalaysiaJohor Bahru81310Malaysia College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Kingdom of Saudi Arabia

Genetic algorithms(GAs)are very good metaheuristic algorithms that are suitable for solving NP-hard combinatorial optimization *** a set of solutions represented by a population of chromosomes and then uses the idea of survival of the fittest in the selection process to select some fitter *** uses a crossover operator to create better offspring chromosomes and thus,converges the ***,it uses a mutation operator to explore the unexplored areas by the crossover operator,and thus,diversifies the GA search space.A combination of crossover and mutation operators makes the GA search strong enough to reach the optimal ***,appropriate selection and combination of crossover operator and mutation operator can lead to a very good GA for solving an optimization *** this present paper,we aim to study the benchmark traveling salesman problem(TSP).We developed several genetic algorithms using seven crossover operators and six mutation operators for the TSP and then compared them to some benchmark TSPLIB *** experimental studies show the effectiveness of the combination of a comprehensive sequential constructive crossover operator and insertion mutation operator for the *** GA using the comprehensive sequential constructive crossover with insertion mutation could find average solutions whose average percentage of excesses from the best-known solutions are between 0.22 and 14.94 for our experimented problem instances.

关键词： Travelling salesman problem genetic algorithms crossover operator mutation operator comprehensive sequential constructive crossover insertion mutation