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Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 341-349页

作者： Nora A.Elsayed Fatma SM Moawed Esraa SA ahmed ahmed Hammad Omayma AR abo-Zaid Biochemistry and Molecular Biology Department Faculty of Vet.Med.Benha UniversityBenha cityEgypt Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt Radiation Biology Department National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairoEgypt

Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver ***:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were ***,a histopathological examination of liver tissues was ***:Nicotine increased liver damage,inflammation,and oxidative ***,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory ***(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed ***:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关键词： Flavone Nicotine Liver Nrf2 HO-1 NF-κB

Efficient energy harvesting from PV Panel with reinforced hydrophilic nano-materials for eco-buildings

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Energy and Built Environment 2024年第3期5卷 393-403页

作者： ahmed Elnozahy Heba Abd-Elbary Farag K.abo-Elyousr Department of Electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71516Egypt

The main target of this research is to allow solar PV to contribute economically to an on-grid energy-efficient building where the dust accumulation is a significant ***-cleaning coatings such as hydrophobic or hy-drophilic materials have recently been introduced to reduce dust deposition on building-integrated PV(BIPV)*** hydrophilic Nano-coated material is examined as a solution to decrease the impact of the dust on the BIPV panels and harvest more solar *** impartial comparison of the BIPV panels performance under natu-ral dust conditions,manual cleaning,and hydrophilic nanomaterial coating is *** an exhaustive and qualitative experimental analysis,the anti-reflection and anti-static properties of the utilized Nano-coated material are *** experimental results show that the hydrophilic Nano-coated material significantly improves the gathered maximum output power by 18%compared to the manually wiped *** calculated efficiencies of the Nano-coated,manual cleaning,and dusty panels are 11%,9%,and 6%,respectively,which highlights the futureproofing of the Nano-coated solar *** to the dusty panels,the ecological and economical results show that the BIPV carbon emissions are desirably dropped by 11%while using Nano-coated PV panels and the payback period is reduced to 3.9 years,which is approximately 12.8%faster.

关键词： Hydrophilic Self-cleaning BIPV panels Nano-coating Techno-economic

Numerical Treatments for Crossover Cancer Model of Hybrid Variable-Order Fractional Derivatives

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1619-1645页

作者： Nasser Sweilam Seham Al-Mekhlafi Aya ahmed Ahoud Alsheri Emad abo-Eldahab Mathematics Department Faculty of ScienceCairo UniversityGiza12613Egypt Mathematics Department Faculty of EducationSana’a UniversitySana’a1247Yemen Mathematics Department Faculty of ScienceHelwan UniversityCairo11795Egypt Department of Mathematics College of ScienceUniversity of BishaAl Namas67398-5644Saudi Arabia

In this paper,two crossover hybrid variable-order derivatives of the cancer model are ***ünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional *** existence,uniqueness,and stability of the proposed model are *** Bashfourth’s fifth-step method with a hybrid variable-order fractional operator is developed to study the proposed *** studies with generalized fifth-order Runge-Kutta method are *** examples and comparative studies to verify the applicability of the used methods and to demonstrate the simplicity of these approximations are *** have showcased the efficiency of the proposed method and garnered robust empirical support for our theoretical findings.

关键词： Cancer diseases hybrid variable-order fractional derivatives adams bashfourth fifth step generalized fifth order Runge-Kutta method

A Hybrid Classification and Identification of Pneumonia Using African Buffalo Optimization and CNN from Chest X-Ray Images

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2497-2517页

作者： Nasser Alalwan ahmed I.Taloba Amr abozeid ahmed Ibrahim Alzahrani Ali H.Al-Bayatti Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Information System Department Faculty of Computers and InformationAssiut UniversityAssiutEgypt Mathematics Department Faculty of ScienceAl-Azhar UniversityCairoEgypt Cyber Technology Institute(CTI) De Montfort UniversityLeicesterUK

An illness known as pneumonia causes inflammation in the *** there is so much information available fromvarious X-ray images,diagnosing pneumonia has typically proven *** improve image quality and speed up the diagnosis of pneumonia,numerous approaches have been *** date,several methods have been employed to identify *** Convolutional Neural Network(CNN)has achieved outstanding success in identifying and diagnosing diseases in the fields of medicine and ***,these methods are complex,inefficient,and imprecise to analyze a big number of *** this paper,a new hybrid method for the automatic classification and identification of Pneumonia from chest X-ray images is *** proposed method(aboCNN)utilized theAfrican BuffaloOptimization(abo)algorithmto enhanceCNNperformance and *** Weinmed filter is employed for pre-processing to eliminate unwanted noises from chest X-ray images,followed by feature extraction using the Grey Level Co-Occurrence Matrix(GLCM)*** features are then selected from the dataset using the abo algorithm,and ultimately,high-performance deep learning using the CNN approach is introduced for the classification and identification of *** results on various datasets showed that,when contrasted to other approaches,the abo-CNN outperforms them all for the classification *** proposed method exhibits superior values like 96.95%,88%,86%,and 86%for accuracy,precision,recall,and F1-score,respectively.

关键词： African buffalo optimization convolutional neural network pneumonia X-ray

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

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Animal Models and Experimental Medicine 2024年第05期 591-605页

作者： Mohammad Yasin Zamanian Niloofar Taheri Montather F.Ramadan Yasser Fakri Mustafa Safa Alkhayyat Klunko Nataliya Sergeevna hashem O.Alsaab ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar Department of Physiology School of Medicine Hamadan University of Medical Sciences Department of Pharmacology and Toxicology School of Pharmacy Hamadan University of Medical Sciences School of Medicine Shahroud University of Medical Sciences College of Dentistry Al-Ayen University Department of Pharmaceutical Chemistry College of Pharmacy University of Mosul College of Pharmacy The Islamic University Department of Training of Scientific and Scientific-Pedagogical Personnel Russian New University Department of Pharmaceutics and Pharmaceutical Technology Taif University Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Department of Clinical Biochemistry School of Medicine Rafsanjan University of Medical Sciences Department of Surgery School of Medicine Hamadan University of Medical Sciences

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription *** results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase-2 and wingless-related integration site(Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin-dependent kinase 2 and cyclin-dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2(CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y-box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal-regulated kinase 1/2, and disrupting the repair process of DNA double-strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α(PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase(PI3K) expressio

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Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged Mohamed Maher abou-hashem Dina Mohamed abo-elmatty Noha Mostafa Mesbah ahmed Mohamed Abd EL-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HELA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HELA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HELA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HELA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HELA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

ANFIS-based Sensor Fusion System of Sit-to-stand for Elderly People Assistive Device Protocols

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International Journal of Automation and computing 2013年第5期10卷 405-413页

作者： Omar Salah ahmed A.Ramadan Salvatore Sessa ahmed abo Ismail Makasatsu Fujie Atsuo Takanishi Egypt-Japan University of Science and Technology New Borg-El-Arab City Faculty of Engineering Tanta University Faculty of Science and Engineering Waseda University

This paper describes the analysis and design of an assistive device for elderly people under development at the EgyptJapan University of Science and Technology（E-JUST） named E-JUST assistive device（EJAD）.Several experiments were carried out using a motion capture system（VICON） and inertial sensors to identify the human posture during the sit-to-stand *** EJAD uses only two inertial measurement units（IMUs） fused through an adaptive neuro-fuzzy inference systems（ANFIS） algorithm to imitate the real motion of the *** EJAD consists of two main parts,a robot arm and an active *** robot arm is a 2-degree-of-freedom（2-DOF） planar *** addition,a back support with a passive joint is used to support the patient s *** IMUs on the leg and trunk of the patient are used to compensate for and adapt to the EJAD system motion depending on the obtained patient *** ANFIS algorithm is used to train the fuzzy system that converts the IMUs signals to the right posture of the patient.A control scheme is proposed to control the system motion based on practical measurements taken from the experiments.A computer simulation showed a relatively good performance of the EJAD in assisting the patient.

关键词： Adaptive neuro-fuzzy inference systems(ANFIS) sensor fusion assistive technologies sit-to-stand motion analysis inertial measurement units

Development of Non-abo Red Blood Cell Alloantibodies in Patient Undergoing Allogeneic Haematopoietic Stem Cell Transplant

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Case Reports in Clinical Medicine 2024年第5期13卷 162-170页

作者： ahmed Alsuhaibani Khalid Batarfi ahmed Alharbi Haya Alwasel Abdullah Alenazi Abdulmohsen Alotaibi Jalal Hassan Rayyan Alotaibi Hajer Aziz Nourah Alharethi Sara Alobaidi Maram Alonayzan Sanad Alharthi Majd Alanazi Sarah Alotaibi ahmed Shareefi Bandar Alqahtani Department of Laboratory and Pathology King Abdulaziz Medical City of National Guard Riyadh Saudi Arabia

Alloantibodies that are non abo Alloimmunization to protein antigens happens only after exposure, in contrast to abo isohaemagglutinins, which are present naturally, even in the absence of prior exposure. It is recognized that while non-abo RBC antibodies are less common than abo antibodies, they generate essentially the same issues that lead to unfavorable clinical results. If non-abo alloantibodies are identified early on, these issues related complications may be avoided This call for an in-depth understanding of the recipient and donor’s abo-Rh grouping, antibody screening, and the phenotype of certain antigens. Equally important, the temporal association time between transplantation and hemolysis can help identify the underlying mechanism of hemolysis and direct appropriate management. Therefore, for that, it is crucial to identify the etiology of post-HSCT anemia for prevention and therapy, in addition to a thorough grasp of the mechanism of anemia in non-abo-incompatible HSCT and the temporal link between HSCT and anemia. Finding the cause of post-HSCT anemia is essential for prevention and therapy, in addition to a thorough grasp of the mechanism of anemia in non-abo-incompatible HSCT and the temporal link between HSCT and anemia. Therefore, for that, it is crucial to identify the etiology of post-HSCT anemia. In this case report review, we would like to highlight the vital role of transfusion medicine services and stem cell clinical teams in paying particular attention to the clinical significance of non-abo alloantibodies involved to avoid causing overt hemolysis of incompatible donor RBCs or delayed erythropoiesis. Considering the fact that some of the Haematopoietic stem cell transplant centers do not give an attention to the other non-abo RBC antigens.

关键词： Haematopoietic Stem Cell Transplant (HSCT) Non-abo Red Blood Cell Antibodies Alloantibodies

4-Port Octagonal Shaped MIMO Antenna with Low Mutual Coupling for UWB Applications

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1999-2015页

作者： Mahmoud A.Abdelghany Mohamed Fathy abo Sree Arpan Desai ahmed A.Ibrahim Electrical Engineering Department College of EngineeringPrince Sattam bin Abdulaziz UniversityWadi Addwasir11991Saudi Arabia Electronic and Communication Department Arab Academy for ScienceTechnology and Maritime TransportCairo11865Egypt Department of Electronics and Communication Engineering CSPITCharotar University of Science and Technology(CHARUSAT)Changa388421India Electronics and Communications Engineering Department Minia UniversityEl-Minia61519Egypt

A4-port multiple-input multiple-output(MIMO)antenna exhibiting lowmutual coupling andUWBperformance is *** octagonal-shaped four-antenna elements are connected with a 50microstrip feed line that is arranged rotationally to achieve the orthogonal polarization for improving the MIMO system *** antenna has a wideband impedance bandwidth of 7.5GHz with S11<−10 dB from(103.44%)3.5–11GHz and inter-element isolation higher than 20 *** validation is carried out by verifying the simulated and measured results after fabricating the *** results in the form of omnidirectional radiation patterns,peak gain(≥4 dBi),and Envelope Correlation Coefficient(ECC)(≤0.01)are extracted to validate the suggested antenna ***,time-domain analysis was investigated to demonstrate the operation of the suggested antenna in wideband ***,the simulated and experimental outcomes have almost similar tendenciesmaking the antenna suitable for its use in UWBMIMOapplications.

关键词： MIMO antenna low mutual coupling time domain analysis UWB antenna