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Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： ahmed Ali Jerah Manal Mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam Mohamed Ali Sidahmed Siddig Ibrahim abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(P<0.05)with CEWE *** antagonizes 5-HT receptors in isolated rat fundus *** findings indicated that the khat ligands bound to 5-HT2C *** and cathinone levels in rat plasma were ***:Khat extract may suppress appetite by antagonizing the 5-HT *** research is required to understand its mechanism and potential applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

Intoxication Induced by Urea Containing Diets in Broiler Chickens: Effect on Weight Gain, Feed Conversion Ratio, Hematological and Biochemical Profiles

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Advances in Bioscience and Biotechnology 2023年第3期14卷 106-119页

作者： Mohammed Al-Zharani Mohammed Mubarak Hassan ahmed Rudayni Mahmoud M. abdelwahab Mohammed Al-Eissa Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia Department of Mathematics and Statistics College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia

Urea as a source of cheap non-protein nitrogen is used to adulterate fish and meat meals which are basic components of broiler diets. The present study was carried out to elucidate the effects of urea on weight gain, and hematological and biochemical profiles. A total of 48 broiler chicks were randomly allotted into 4 groups, designated Groups 1, 2, 3 and 4 of 12 birds each. Birds in Groups 2, 3 and 4 were fed on diets containing urea at the levels of 1%, 2.5% and 4%, respectively. Birds in Group 1 served as control and were not exposed to urea. Experimentation period was for 3 weeks and experiment was terminated when birds were 42 days of age. Body weight of all intoxicated birds at the various intervals was significantly decreased in comparison with that of the untreated control. Compared with control, all intoxicated broilers manifested significant (P ≤ 0.05) decrease in all hematological parameters involving erythrocytic and total leucocytic counts, Hemoglobin (Hb) and Packed Cell Volume (PCV) on a dose- and time-pattern. In comparison with the control levels, biochemical profile of the intoxicated birds disclosed significant decrease in blood glucose level and significant increase in serum uric acid, urea, Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH) levels. Based upon the present data, it was concluded that the addition of urea to broiler diets bears serious sequences concerning the general health condition, performance, weight gain, and hematological and biochemical profiles.

关键词： Urea Intoxication Broiler Chickens Weight Gain Feed Conversion Ratio

Status of hepatitis C virus vaccination:Recent update

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World Journal of Gastroenterology 2016年第2期22卷 862-873页

作者： kouka saadeldin abdelwahab zeinab nabil ahmed said Department of Microbiology and Immunology Faculty of Medicine(for girls)Al-Azhar UniversityCairo 11435Egypt

Hepatitis C virus(HCV) infection is still a major public health problem worldwide since its first identification in 1989. At the start, HCV infection was post-transfusion viral infection, particularly in developing countries. Recently, due to iv drug abuse, HCV infection became number one health problem in well-developed countries as well. Following acute HCV infection, the innateimmune response is triggered in the form of activated coordinated interaction of NK cells, dendritic cells and interferon α. The acquired immune response is then developed in the form of the antibody-mediated immune response(ABIR) and the cell-mediated immune response(CMIR). Both are responsible for clearance of HCV infection in about 15% of infected patients. However, HCV has several mechanisms to evade these antivirus immune reactions. The current review gives an overview of HCV structure, immune response and viral evasion mechanisms. It also evaluates the available preventive and therapeutic vaccines that induce innate, ABIR, CMIR. Moreover, this review highlights the progress in recent HCV vaccination studies either in preclinical or clinical phases. The unsatisfactory identification of HCV infection by the current screening system and the limitations of currently available treatments, including the ineligibility of some chronic HCV patients to such antiviral agents, mandate the development of an effective HCV vaccine.

关键词： Hepatitis C Viral envelope glycoproteins Immune response Hepatitis C virus vaccine Clinicaltrials

Excision and Partial Primary Closure of Wound for Pilonidal Disease

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Surgical Science 2012年第7期3卷 366-370页

作者： ahmed Lasheen Khalid Safwat Mansour Morsy Alaa Fiad abdelwahab Elmoregy General Surgery Department Faculty of Medicine Zagazig University Zagazig Egypt

Background: Pilonidal disease is a common chronic disorder of the sacrococcygeal region;and its surgical management is still a matter of discussion. The ideal therapy would be a quick cure that allowed patients to return rapidly to normal activity, that is minimally invasive with no morbidity, a low risk of complication and easy to learn. Methods: Sixty seven patients with pilonidal disease were subjected to excision and partial closure procedure, from November 2006 to March 2010 at General Surgery Department, Zagazig University Hospital, Zagazig University, Egypt. The mean age was 27.5 years. Complete but close excision of all diseased tissues was achieved. Then, the wound partially was closed from the deepest parts only by multiples buried vertical mattress sutures by using Lasheen’s needle, and left the superficial wound parts to heal by second intention. The follow up period was ranged from 14 - 39 months (mean 27 months). Results: The mean hospital stay was 12 hours, mean operation time was 30 minutes and mean time to return to normal activity was 8 days (range 7 - 12 days). Nine cases show superficial wound infection and one case of recurrence. Conclusion: Excision and partially closure technique by using Lasheen’s needle for pilonidal diseases is minimal invasive and less morbidity, easy to learn and has favorable results regarding to return to normal activity, rate of recurrence and cosmetically acceptable.

关键词： Partially Closure Lasheen’s Needle Pilonidal Disease

Utilization of Cement Kiln Dust (CKD) with Silica Fume (SF) as a Partial Replacement of Cement in Concrete Production

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Journal of Minerals and Materials Characterization and Engineering 2019年第4期7卷 137-149页

作者： Arafa Elsayed Elhelloty Mohammed Taha Nooman Rafik Khairy abdelwahab ahmed Islam Abdullah Civil Engineering Department Faculty of Engineering Al-Azhar University Cairo Egypt

This research aimed to clarify the role of by-product materials, such as CKD with SF as partial replacement by weight of cement in concrete manufacturing and inclusion on different characteristics of concrete. Concrete test specimens were mixed with 0%, 5%, 10%, 15%, 20% and 25% (CKD) with 15% (SF) as partial replacement by weight of Cement (CEM I-52.5N). Fresh concrete properties have been evaluated by workability measurement slump test. While hardened concrete properties have been evaluated by compressive, split tensile and flexural strengths tests at ages 7, 28 and 56 days, but evaluated for bond strength, modulus of elasticity and chemical composition measurement with X-Ray Fluorescence at age of 28 days. The test results have revealed that the increase of CKD amount with fixed amount of SF in concrete mixtures as partial replacement by weight of cement leads to gradual decrease of fresh concrete workability. In concrete mixtures, 20% CKD in the presence of 15% SF as partial replacement by the weight of cement are the optimum ratios which can be used without any negative effect on mechanical properties compressive, indirect tensile, flexural and bond strength at all the ages of concrete. Also modulus of elasticity and bond strength increased by 8.81% and 0.69% respectively at the age 28 days compared with control mixture.

关键词： Partial Replacement of Cement Cement Kiln Dust (CKD) Silica Fume (SF) Properties of Fresh and Hardened Concrete Modulus of Elasticity Bond Strength XRF

The Impact of Obesity on Performing Lymphadenectomy and Its Outcome in Ovarian Cancer Patients

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Journal of Cancer Therapy 2018年第7期9卷 568-575页

作者： Basel Refky Mosab Shetiwy ahmed Zaki Mohamed Elmetwally Hanan Nabil Islam Abdou ahmed Abdallah Amr Soliman Khaled abdelwahab Anas Gamal Essam Elshiekh Khaled Gaballa Oncology Center Mansoura University Mansoura Egypt Mansoura University Hospitals Mansoura Egypt Oldenburg University Oldenburg Germany Tanta Cancer Center Tanta Egypt

Background: This study discusses the effect of obesity on the number of lymph nodes harvested during systematic LND and the LND-related complications in ovarian cancer patients. Methods: This retrospective study enrolled women with ovarian cancer who were consecutively subjected to open surgical resection that included systematic LND (pelvic and para-aortic) in the Oncology Center in Mansoura University (OCMU) during the period between January 2012 and June 2017. Patients were categorized according to the recommendations of World Health Organization by their BMI as non-obese (BMI 30.0 kg/m2) and obese (BMI ≥ 30.0 kg/m2). Results: Seventy-seven women with ovarian cancer were enrolled in the study according to our inclusion and exclusion criteria. 43 females (55.8%) were grouped as obese and 34 (44.2%) as non-obese. Lymph nodes retrieved in total and in different stations separately (pelvic and para-aortic) were all similar among patients in both groups. LND-related intraoperative complications were observed in 8 patients (18.6%) in the obese group and 3 patients in the non-obese group (8.8%) (P = 0.347). Hospital stay was the same in the two groups with a median of 4 days (IQR 3 - 5). Postoperative complications occurred in 13 patients (30.2%) in the obese group and only in one patient (3%) in the non-obese group (P = 0.004). Conclusion: Obese ovarian cancer patients may safely undergo comprehensive staging involving extensive lymph node dissection in open surgeries without significant increase in the rates of intraoperative complications. Whereas, postoperative complications (wound infection and thromboembolic events) tend to occur at higher rates with obese patients. Trial registration: This study was retrospectively registered and approved at faculty of Medicine Mansoura University, Egypt with IRB approval number R.18.02.46.

关键词： Lymphadenectomy Obesity Ovarian Cancer

Molecular docking of amphetamine,cathine and cathinone with dihydrofolate reductase:a computational analysis of inhibition of dihydrofolate reductase by khat alkaloids

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Toxicology Communications 2022年第2期4卷 23-28页

作者： Siddig Ibrahim abdelwahab Abdullah Farasani ahmed Jerah Manal Mohamed Elhassan Taha Anil Bidwai Medical Research Centre Jazan UniversityJazan 45142Saudi Arabia College of Applied Medical Sciences Jazan UniversityJazan 45142Kingdom of Saudi Arabia Substance Abuse Research Center Jazan UniversityJazan 45142Saudi Arabia

Interaction of amphetamine,cathine and cathinone with the enzyme dihydrofolate reductase was studied by molecular docking using AutoDock 4.2 as the docking software *** 4.2 software serves as a valid and acceptable docking application to study the interactions of small compounds with *** of amphetamine,cathine and cathinone with dihydrofolate reductase were compared to those of methotrexate,a known inhibitor of the *** calculated free energy of binding(ΔG binding)shows that the three ligands(ΔG=-6.87 to-7.21 kcal/mol;Ki=9.15 to 5.18μM)bind with affinity slightly lower than methotrexate(ΔG=-8.78 kcal/mol;Ki=363 nM).Binding interactions of the three ligands with active site residues of the enzyme are also *** the ligands appear to bind in a similar conformation making extensive VDW contacts in the active site of the *** bonding and pi-pi interaction with key active site residues is also ***,a probable inhibition of dihydrofolate reductase by khat alkaloids can be explained on the basis of this in silico binding and khat alkaloids can be considered as potential lead compounds in the development of new inhibitors of dihydrofolate reductase which is a potential target of anti-cancer *** results of these studies can serve as a starting point for further computational and experimental studies.

关键词： amphetamine cathine cathinone methotrexate docking AutoDock DHFR khat alkaloids

Fifty-year of Global Research in Calendula Officinalis L.(1971−2021):A Bibliometric Study

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Clinical Complementary Medicine and Pharmacology 2022年第4期2卷 73-82页

作者： Siddig Ibrahim abdelwahab Manal Mohamed Elhassan Taha Sarah Mohamed Elhassan Taha Abdulrahman ahmed Alsayegh Medical Research Centre Jazan UniversityJazan 46852Saudi Arabia Clinical Nutrition Department College of Applied Medical SciencesJazan UniversityJazan 46852Saudi Arabia

Background:Calendula officinalis L.(Compositae)is a Mediterranean annual plant widely used for its versatile biological ***:A bibliometric study of research data conducted from 1971 to 2021 was ***:Bibliographic data was retrieved from the Scopus database and analyzed using VOSviewer and MS *** regression was used to assess the annual production of research documents related to ***:A total of 1,252 journal articles and conference papers were published by 4,452 authors,originated from 98 countries and disseminated in 706 ***(n=131),Brazil(n=119),India(n=113),Poland(n=112),and Italy(n=72)are the top-publishing *** of Ethnopharmacology is the top-cited journal,while Italy is the top-cited *** growth was observed in the last fifty years,from 1971 to *** anti-inflammatory,wound-healing,and anti-microbial properties are among the most prolific studies that have been conducted on this *** research has been carried out on antioxidant compounds,terpenes,and volatile *** care and wound healing are the most common clinical ***-citation analysis,keywords co-occurrence,and bibliographic coupling revealed diverse knowledge structures and intellectual ***:This comprehensive bibliometric study indicates that Calendula officinalis received significant *** structured information may help understand research trends and locate this plant’s research hot spots and gaps.

关键词： Calendula officinalis L. Bibliometric study VOSviewer Scopus

COVID-19 and Chronic Viral Liver Diseases

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Journal of Biosciences and Medicines 2021年第9期9卷 138-146页

作者： Maged Tharwat Elghannam Motaz Hasan Hassanien Yosry Abdelrahman Gamalaldin Mohammed ALattar Emad abdelwahab Turky ahmed Aly EL Ray Mohammed Darwish EL Talkawy Hepatogastroenterology Department Theodor Bilharz Research Institute EL Warak Giza Egypt

Coronavirus causes an outbreak of viral pneumonia that spread throughout the world. Liver injury is becoming more widely recognized as a component of the clinical picture of COVID-19 infection. We aimed to review this relation in a concise way. This review article includes a large number of patients from both western and eastern countries with no clear difference of liver affection. The more severe and frequent liver injury, the more severe COVID-19 infection. Up to half of patients developed hepatitis with serum ALT elevation. Both hepatocellular and/or ductular injury were observed as evidenced by alkaline phosphatase elevation. Increase incidence of morbidity and mortality had been recorded in patients with CLD. Cirrhosis mortality extended in line with the Child-Turcotte-Pugh class. The incidence of ACLF in CLD patients with COVID 19 is not clear. There are no significant associations with the etiology of liver disease and death in cirrhosis. COVID-19 hinders HCV elimination by 2030. Patients should continue their medications if already receiving treatment. Patients with occult or resolved HBV and COVID-19 who are receiving immunosuppressive agents should use antiviral therapy to prevent viral flare-ups.

关键词： COVID-19 Chronic Liver Disease Cell Entry Pathology Pathogenesis and Pathophysiology Impact on CLD