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International Journal of Organic Chemistry 2014年第2期4卷 154-168页

作者： Abeer N. Al-Romaizan Mohammed S. T. Makki Reda M. abdel-rahman Department of Chemistry Faculty of Science King Abdul Aziz University Jeddah KSA

New fluorine substituted 6-(5’-fluoro-2’-triphenylphosphiniminophenyl) 3-thioxo-1,2,4-triazin-5 (2H, 4H) one (2) was obtained via Wittig’s reaction of the corresponding 6-(5’-fluoro-2’-amino-phenyl)-3-thioxo-1,2,4-triazinone (1). Behavior of compound 2 towards alkylating agents and/or oxidizing agents was studied were, N-hydroxyl (3), Mannich base (4,5), S-alkyl (6,7,8) and thiazolo [3,2-b][1,2,4] triazinones (10-14) and or 3-disulfide (18), 3-sulfonic acid 19 and 1,2,4-triazin-3,5-Dionne (20) derivatives obtained. Structures of the new products are established by elemental and spectral data. The new targets obtained screened as Molluscicidalagents against Biomophlaria Alexandrina snails responsible for Bilharziasis diseases, in compare with Baylucide as standard drug.

关键词： Fluorine Phosphorus Sulfur-1 2 4-Triazine Characteristic Properties Molluscicidal Activity

Relationship between peripheral arterial disease, carotid intima-media thickness and C-reactive protein in elderly diabetic patients

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Advances in Aging Research 2013年第4期2卷 115-120页

作者： Moatassem Salah Amer Samia ahmed Abdul-rahman Wafaa Mostafa Abd-El Gawad Ibrahim Ahmad abdel Aal Ahmad abdel Khalek abdel Razek Mohamed Wessam El-Huseiny Moustafa abdel Wahab Clinical Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt Geriatrics and Gerontology Department Faculty of Medicine Ain Shams University Cairo Egypt Geriatrics and Gerontology Department Faculty of Medicine Mansoura University Mansoura Egypt Radiodiagnosis Department Faculty of Medicine Mansoura University Mansoura Egypt

Purpose: To study the association between carotid intima media thickness (CIMT) and high sensitivity CRP (hs-CRP) level as markers for PAD in elderly patients with DM. Subjects: A case-control study on 90 participants aged 60 years and older divided into 60 cases (30 patients with DM alone and 30 patients with DM and comorbidities) and 30 healthy controls. All were assessed by measuring CIMT, ankle brachial index (AB), and markers for cardiovascular disease such as high-sensitivity CRP (hs-CRP), total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL). Results: hs-CRP levels showed statistically significant difference being highest among patients with DM and comorbidities and lowest among controls (P < 0.001). Also, symptoms of PAD were significantly higher among cases than controls. ABI was able to detect PAD in many asymptomatic patients. Color changes were present in only 43.30% (n = 26) of positive PAD cases while delayed wound healing, claudication pain, rest pain, cold extremities, and trophic changes were present in 23.30% (n = 14), 16.71% (n = 10), 16.71% (n = 10), 45.00% (n = 27), and 21.7% (n = 13). Using logistic regression analysis revealed that DM, CIMT, and hs-CRP were independent predictors for PAD (OR = 4.194, 7.236, 1.003;P value = 0.044, 0.25, 0.031) after adjustment of other coronary risk factors such as sex, smoking, hypertension, TC, and TG. Conclusion: Diabetic elderly have higher prevalence of asymptomatic PAD thannon-diabetics using solely ABI. DM, CIMT, and hs-CRP are independent predictors for the occurrence of PAD. Hs-CRP levels are highest among diabetics with comorbidities.

关键词： Peripheral Arterial Disease Carotid Intima-Media Thickness Ankle Brachial Index C-Reactive Protein Elderly

Simple and Efficient Synthesis of Novel Glycosyl Thiourea Derivatives Derived from Thiophene as Potential Antitumor Agents

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Journal of Chemistry and Chemical Engineering 2011年第1期5卷 73-81页

作者： Mohammed Mohsen Babatin Lotfi Khezami abdel-rahman Barakat ahmed EI-Gazzar Department of Mathematics and Chemistry Faculty of Science Al-lmam Muhammad bin Saud Islamic University Riyadh 11623Kingdom of Saudi Arabia

Cytoprotectant and Anti-Oxidant Effects of Olive Oil on Cadmium Induced Nephrotoxicity in Mice

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Open Journal of Pathology 2018年第1期8卷 31-46页

作者： Farooq ahmed Wani Mahrous abdelBasset Ibrahim Medhat M. abdel Moneim Abdul rahman Hamdan A. Almaeen Pathology Department Faculty of Medicine College of Medicine Aljouf University Aljouf KSA Forensic Medicine and Clinical Toxicology Department College of Medicine Aljouf University Aljouf KSA Faculty of Medicine Suez Canal University Ismailia Egypt Department of Medical Biochemistry & Molecular Biology Faculty of Medicine Benha University Benha Egypt Department of Pathology College of Medicine Aljouf University Aljouf KSA

Background: Cadmium is a heavy metal having toxic effects on most organ systems of the body. Objectives: We aim to investigate the postulated protective properties of olive oil in Cadmium-induced renal toxicity in mice by utilizing standard biomarkers of renal toxicity, oxidative stress and histopathological characterization. Materials and Methods: Forty mice were randomly divided into four groups of 10 mice each. Group 1 served as control group, group 2 was given Extra-virgin olive oil orally, group 3 was given Cadmium chloride and group 4 was given Cadmium chloride with Extra-virgin olive oil. At the end of the experimental period, biochemical analysis histopathology of kidney was done. Results: The present study depicted that blood urea, serum creatinine and the antioxidant markers (Superoxide dismutase, Glutathione peroxidase and Catalase) levels were significantly increased in group 3 compared to group 1 and 2. After administration of Extra-virgin olive oil with Cadmium in group 4, the levels of those markers significantly improved. Histopathology of the renal tissue showed severe damage of glomeruli, severely congested blood vessels and marked dilatation of Bowman’s capsule in group 3 with improvements of these changes in group 4. Conclusion: This study suggests that Extra-virgin olive oil can be used as a cost effective safe anti-oxidative agent in the prevention of Cadmium toxicity.

关键词： Reactive Oxygen Species Cadmium EVOO Nephrotoxicity Oxidative Stress

Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression

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World Journal of Gastroenterology 2005年第42期11卷 6624-6630页

作者： abdel-rahman N Zekri Mohammed S El-Din Ashour ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby Maha A Abu-Shady Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Microbiology Department Faculty of Pharmacy Azhar University Egypt Microbiology and Immunology Department Sohag Faculty of Medicine South Valley University Egypt Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Biochemistry Department El-Kaser El-Aini School of Medicine Cairo University Egypt

AIM: To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression.METHODS: We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RⅠ and Ⅱ)by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus(HCV) markers served as controls.RESULTS: Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases.On the other hand, HCV viremia was detected using RTPCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases.Also bilharzial-Ab was positive in 55% of HCC cases,65% of CLD cases and in 70% of asymptomatic carriers (ASC). HCC patients had significantly higher values of IL-2R, TNF-RⅡ (P＜0.001), and TNF-RⅠ (P＞0.05), but lower TNFα (P＜0.001) and IL-6 (P = 0.032) in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P＜0.001). CLD patients had higher IL-2R, TNF-RⅠ, and TNF-RⅡ (P＜0.001) than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P＜0.001). IL-10 was higher (though not significantly) in HCC and CLD patients than in symptomatic carriers and non-cancer controls.CONCLUSION: Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R,TNF-RⅠ, and TNF-RⅡ could be used as potential markers.

关键词：细胞因子埃及丙型肝炎病毒肝疾病

Mental Health and Quality of Life of Disable Palestinian Children in the Gaza Strip

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Health 2015年第8期7卷 994-1006页

作者： abdel aziz Thabet ahmed Abu Tawahina David Henley Henrick Pelling Panos Vostanis Kamal Abu Qamar School of Public Health Al Quds University Gaza Palestine Gaza Community Mental Health Programme Gaza Palestine University Children’s Hospital Uppsala University Uppsala Sweden Department of Child Psychiatry University Hospital Uppsala Sweden University of Leicester Greenwood Institute of Child Health Leicester UK National Society for Rehabilitation Gaza Palestine

The aim of the study was to investigate the prevalence of mental health problems and quality of life among Palestinian disable children. The sample consisted of 391 disable Palestinian children in the Gaza Strip which was selected randomly from the data base of two NGOs working with such group of children. The age of children ranged from 6 - 18 years with mean age (11.73). Instruments: The children and adolescents demographic data were collected by questionnaire include sex, age, class, and place of residence, Gaza Child Health Study Scales (parents and children forms), and The Pediatric Quality of Life Inventory generic core (version 4.0) scale. The results showed that children reported mean conduct disorder was 1.33;oppositional disorder was 5;mean overanxious was 6.75;separation anxiety mean was 6.36;and depression was 7.57. There were statistically significant differences toward boys in depression. According to parents, mean conduct disorder mean was 1.94;mean oppositional disorder was 6.09;mean overanxious was 7.47;separation anxiety mean was 6.48;and mean depression was 9.6. The study showed that mean depression in boys was 10.4 compared to 8.9 in girls. There were statistically significant differences toward boys in depression. Parents of children with physical disabilities reported more overanxious problems in their children compared to other parents with other types of disabilities (vision, mental, and multiple). Also, parents of children with physical disability had more separation anxiety than other groups (mental and multiple disabilities). Quality of life of children was scored by children themselves;mean emotional functioning was 8.24;mean social functioning was 6.65;school functioning mean was 9.17;and cognitive functioning was 8.57. The study showed that mental health problems rated by children such as conduct disorder was positively correlated with emotional and cognitive functioning;oppositional disorder was correlated with emotional, social, and cognitive function;overanxious disorder was corre

关键词： Disabled Children Mental Health Problems Quality of Life Gaza Strip

Liver Segmentation Technique for CT Images Based on Statistical Analysis

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通讯和计算机（中英文版） 2014年第3期11卷 274-277页

作者： Khaled El-Sayed Ali abdel rahman Elsayed Sherif A. Sami Abdallah S. ahmed Department of Biomedical Engineering and Systems Faculty of Engineering Cairo University Cairo 12111 Egypt

Green Synthesis of Silver Nanoparticles Using <i>Nigella sativa</i>Seeds and Evaluation of Their Antibacterial Activity

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Advances in Nanoparticles 2020年第2期9卷 41-48页

作者： Marvit Osman Widdatallah Alaa Abdulmoneim Mohamed Ayat ahmed Alrasheid Hiba Abbas Widatallah Layla Fathi Yassin Sahar Hussein Eltilib Shimaa abdel rahman ahmed

Synthesis of silver nanoparticles using seeds of Nigella sativa as a capping agent was evaluated in this study. Different concentrations of the aqueous extract of N. sativa with silver nitrate solution were exposed to sunlight;as a force for acceleration of the formulation. Then the silver nanoparticles were characterized by UV-Vis, scanning electron microscope (SEM) and X-ray diffraction (XRD) techniques. Antibacterial activity of the nanoparticles was investigated against Staphylococcus aureus and Escherichia coli by the disc diffusion method. The characterization of nanoparticles was detected by the change in color to yellow-brown which indicated the formulation of silver nanoparticles. Irregular shapes within range of nanoscale were detected using SEM and XRD techniques. The finding suggests that silver nanoparticles may be effectively used as antibacterial agent.

关键词： Silver Nanoparticles Nigella sativa UV-Vis SEM XRD Antibacterial Activity

患上消化道疾病的埃及患者中分离幽门螺杆菌的基因型表征(英文)

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The Chinese-German Journal of Clinical Oncology 2012年第1期11卷 15-23页

作者： abdel Hamid Hussein Ezzat Mona Hamza Ali Eman ahmed El-Seidi Iman Ezzat Wali Nagwa Abd El rahman Sedky Sherif Medhat Mahmoud Naguib Department of Surgical Oncology National Cancer Institute Cairo University Laboratory Forensic Medicine Egyptian Ministry of Justice Medical Microbiology and Immunology Faculty of Medicine Cairo University Internal Medicine Faculty of Medicine Cairo University

Objective:Over 50% of the world populations are infected with Helicobacter pylori (H. pylori). Most subjects are asymptomatic;however, in 1994, H. pylori has been categorized as group I carcinogen. The aim of the study was to investigate the relationship between H. pylori infection and gastric cancer. Methods:Thirty gastric cancer patients (GCs) and 30 gastritis patients were enrolled in the study. H. pylori was cultured on non-selective and selective medias, infection density was assessed by quantitative culture. Antibiotic sensitivity testing was performed. PCR was done for the H. pylori 16S rRNA gene in addition to cagA, vacA and iceA genes. Results:H. pylori could be cultured from 100% of specimens obtained from all patients. The density of H. pylori was higher in cancer cases than in gastritis patients. The 16S rRNA was detected in all GC patients (100%) while it was only detected in 70% of gastritis patients. The cagA gene was found in 53.3% vs 13.3% of GC and gastritis patients, respectively. The vacA gene was present in all GC patients (by at least one of its alleles) while it was only found in 33.3% of gastritis patients. The vacA s1m1 combination was the most predominant genotype in GC patients, while m2 was the commonest allele in gastritis patients (10%). The iceA gene was found in 86.7% vs 40% of GC and gastritis patients, respectively. Simultaneous presence of multiple H. pylori strains was proved, both phenotypically and genotypically. Conclusion:The development of GC is linked to infection with H. pylori harboring certain virulence genes. Higher infection density of H. pylori was found in GC patients. Co-existence of more than one strain of H. pylori in the same patient occurs in both malignant and benign lesions.

关键词：基因型鉴定幽门螺杆菌消化道疾病患者幽门螺旋杆菌 rRNA基因埃及抗生素敏感性

Synthesis of Some More New Fluorinated 1,2,4-triazino[3,4-b][1,3,4]Thiadiazolonesand Their Molluscicidal Against Selective Snails - Part I

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Journal of Chemistry and Chemical Engineering 2015年第3期9卷 162-175页

作者： Mohammed Saleh TawfekMakki RedaMohammady abdel rahman Ola Ahmad AbuAli Chemistry Department Faculty of Science King Abdul Aziz University Jeddah 80203 Kingdom of Saudi Arabia