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Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus

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World Journal of Gastroenterology 2019年第11期25卷 1366-1377页

作者： Tarek Besheer Hatem elalfy Mohamed abd el-Maksoud ahmed abd el-razek Saher Taman Khaled Zalata Wagdy elkashef Hossam Zaghloul Heba elshahawy Doaa Raafat Wafaa elemshaty Eman elsayed abdel-Hady el-Gilany Mahmoud el-Bendary Department of Tropical Medicine and Hepatology Mansoura Faculty of Medicine-Mansoura University Department of Diagnostic Radiology Mansoura Faculty of Medicine-Mansoura University Department of Pathology Mansoura Faculty of Medicine-Mansoura University Department of Clinical Pathology Mansoura Faculty of Medicine-Mansoura University Department of Public Health and Preventive Medicine Mansoura Faculty of Medicine-Mansoura University

BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic *** To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis *** This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological *** The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.

关键词： Diffusion Magnetic resonance imaging Fibrosis Liver Hepatitis C virus Micro-RNA

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa abd el-Salam el-Sayed Mohamed Z.Sayed-ahmed Shaimaa ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Efficient energy harvesting from PV Panel with reinforced hydrophilic nano-materials for eco-buildings

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Energy and Built Environment 2024年第3期5卷 393-403页

作者： ahmed elnozahy Heba abd-elbary Farag K.Abo-elyousr Department of electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71516Egypt

The main target of this research is to allow solar PV to contribute economically to an on-grid energy-efficient building where the dust accumulation is a significant ***-cleaning coatings such as hydrophobic or hy-drophilic materials have recently been introduced to reduce dust deposition on building-integrated PV(BIPV)*** hydrophilic Nano-coated material is examined as a solution to decrease the impact of the dust on the BIPV panels and harvest more solar *** impartial comparison of the BIPV panels performance under natu-ral dust conditions,manual cleaning,and hydrophilic nanomaterial coating is *** an exhaustive and qualitative experimental analysis,the anti-reflection and anti-static properties of the utilized Nano-coated material are *** experimental results show that the hydrophilic Nano-coated material significantly improves the gathered maximum output power by 18%compared to the manually wiped *** calculated efficiencies of the Nano-coated,manual cleaning,and dusty panels are 11%,9%,and 6%,respectively,which highlights the futureproofing of the Nano-coated solar *** to the dusty panels,the ecological and economical results show that the BIPV carbon emissions are desirably dropped by 11%while using Nano-coated PV panels and the payback period is reduced to 3.9 years,which is approximately 12.8%faster.

关键词： Hydrophilic Self-cleaning BIPV panels Nano-coating Techno-economic

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Assessment of groundwater suitability for different activities in Toshka district,south Egypt

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Journal of Groundwater Science and Engineering 2024年第1期12卷 34-48页

作者： Marwa M Aly Shymaa AK Fayad ahmed MI abd elhamid Faculty of Engineering Mataria Helwan UniversityCairo 11718Egypt Division of Engineering International Academy for Engineering and Media Science(IAEMS)6th of October City 15515Egypt Hydraulics Research Institute National Water Research CenterMWRICairo 13621Egypt

Globally,groundwater has globally emerged as a crucial freshwater source for domestic,irrigation,and industrial *** evaluation of groundwater quality in the Toshka region is imperative to ensure its suitability for the extensive agricultural and industrial activities underway in this promising,groundwater-dependent development *** is particularly significant as Egypt increasingly relies on groundwater reserves to address freshwater deficits and to implement mega-development projects in barren *** this study,fifty-two samples were collected from the recently drilled wells tapping into the Nubian Sandstone Aquifer(NSA)in the Toshka *** quality was assessed through hydrochemical analysis,Piper diagram,and various indicators such as Na%,SAR,RSC,KR,MH and *** hydrochemical analysis revealed improved groundwater quality characteristics,attributed to continuous recharge from Lake *** Piper diagram categorised most of the water samples as"secondary salinity"water *** all wells proved suitable for irrigation with only two wells unsuitable based on MH values and six wells based on KR *** Total Hardness(TH)values,all samples were classified as"Soft",indicating their suitability for domestic and industrial *** Quality Index(WQI)results concluded that all samples met WHO and FAO guidelines for drinking and irrigation,*** distribution maps,constructed using GIS,facilitate the interpretation of the *** monitoring of quality parameters is essential to detect any deviation from permissible limits.

关键词： Nubian Sandstone Aquifer Water Quality Assessment Hydro-chemical Analysis Irrigation Quality Indicators Domestic Use Water Quality Index

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A Comparative Analysis on Surgical Outcomes and Complications of Endoscopic and Open Vein Harvesting Techniques

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Open Journal of Thoracic Surgery 2024年第2期14卷 29-39页

作者： Mohammed Fawzy eltaweel Ismail N. el-Sokkary ahmed Alherazi Mohamed Wael Badawi Mohammed G. abdellatif Bahaa A. elkhonezy Ibrahim K. Gamil Haytham Mohamed abd el Moaty Sarra Sadmi Mahmoud Khalil Department of Cardiothoracic Surgery Faculty of Medicine Menoufia University Shibin El Kom Egypt Department of Cardiovascular & Thoracic Surgery Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiothoracic Surgery Faculty of Medicine Alexandria University Alexandria Egypt Faculty of Medicine University of Algiers Algiers Algeria Department of Cardiac Surgery Sabah Al-Ahmed Cardiac Center Al-Amiri Hospital Kuwait City Kuwait

Objective: The great saphenous vein (GSV) is commonly used as a conduit for grafting during CABG surgery, and open GSV harvesting (OVH), commonly used with long incision to expose the vein. However, endoscopic vein harvesting (EVH) is an alternative approach, utilizing specialized instruments and small incisions to harvest the vein. Methods: A retrospective analysis was conducted on a cohort of patients who underwent Coronary artery bypass graft (CABG) requiring great saphenous vein (GSV) harvesting which was done by EVH or OVH procedures. Demographic variables, including age and gender, were assessed for both groups. Intraoperative variables such as the number of grafts, cardiopulmonary bypass time, X clamp time, and type of procedure were analyzed. Postoperative variables, including infection and bleeding rates, were also evaluated. Results: The study included 30 patients each undergoing Coronary artery bypass graft (CABG) with need of great saphenous vein harvesting which was done by EVH and OVH. Demographic variables were well-matched between the two groups in terms of age, while a significant difference in gender distribution was observed. Obesity and smoking were more prevalent in the OVH group, and EVH was associated with a higher mean number of grafts compared to OVH. Conversion to an open technique occurred in a portion of the EVH cases, and infection rates did not significantly differ between the EVH and OVH groups. However, the incidence of postoperative bleeding was significantly higher in the EVH group. Conclusion: This study provides valuable insights into the demographic, intraoperative, and postoperative variables associated with EVH and OVH techniques. EVH demonstrated advantages in terms of reduced infection rates compared to OVH. However, the higher incidence of postoperative bleeding associated with EVH raises concerns about potential risks.

关键词： Endoscopic Vein Harvesting (EVH) Open Vein Harvesting (OVH) Coronary Artery Bypass Grafting (CABG) Great Saphenous Vein (GSV) Surgical Outcomes

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Dissolved gas analysis and dissipation factor measurement of mineral oil-based nanofluids under thermal and electrical faults

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High Voltage 2023年第3期8卷 455-465页

作者： ahmed Maher Diaa-eldin A.Mansour Khaled Helal Ramadan A.A.abd el Aal Department of electrical Engineering Faculty of EngineeringPort-Said UniversityPort-SaidEgypt Department of electrical Power Engineering Faculty of EngineeringEgypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityAlexandriaEgypt Department of electrical Power and Machines Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Mineral oil is the most frequent insulating liquid used in oil-immersed transformers for electrical insulation and heat ***,oil-based nanofluids are becoming more popular in scientific research as they have proved to have better dielectric and thermal *** applying these nanofluids into actual transformers,they would be exposed to thermal and electrical ***,The aim of the authors is to investigate the generation pattern of dissolved gases in nanofluids under thermal and electrical faults and to assess the applicability of traditional Dissolved Gas Analysis(DGA)techniques if oil-based nanofluids are used in ***-based nanofluid samples were prepared using a magnetic stirrer and an ultrasonic homogeniser and then subjected to simulated thermal and electrical faults in the laboratory using properly sealed test *** types of metal oxides,Silicon dioxide,Titanium dioxide,and Aluminium oxide nanoparticles,have been used to prepare nanofluids with 0.02 g/L and 0.04 g/L *** gases released and dissolved into oil due to the simulated faults were analysed and compared to traditional mineral oil as a *** dielectric dissipation factor was obtained and analysed for all *** to the findings,the presence and concentration of nanoparticles were shown to influence the amount of gases *** a result,this research is crucial in guaranteeing that traditional DGA techniques can be employed in transformers that use oil-based nanofluids.

关键词： electrical thermal dioxide

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Analysis of BrainMRI: AI-Assisted Healthcare Framework for the Smart Cities

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Intelligent Automation & Soft Computing 2023年第2期35卷 1843-1856页

作者： Walid el-Shafai Randa Ali ahmed Sedik Taha el-Sayed Taha Mohammed abd-elnaby Fathi E.abd el-Samie Department electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenoufia32952Egypt Department of ROBOTICS and Intelligent Machines Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

The use of intelligent machines to work and react like humans is vital in emerging smart ***-aided analysis of complex and huge MRI(Mag-netic Resonance Imaging)scans is very important in healthcare *** AI(Artiﬁcial Intelligence)driven healthcare applications,tumor detection is one of the contemporary researchﬁelds that have become attractive to *** are several modalities of imaging performed on the brain for the pur-pose of tumor *** paper offers a deep learning approach for detecting brain tumors from MR(Magnetic Resonance)images based on changes in the division of the training and testing data and the structure of the CNN(Convolu-tional Neural Network)*** proposed approach is carried out on a brain tumor dataset from the National Centre of Image-Guided Therapy,including about 4700 MRI images of ten brain tumor cases with both normal and abnormal *** dataset is divided into test,and train subsets with a ratio of the training set to the validation set of 70:*** main contribution of this paper is introdu-cing an optimum deep learning structure of CNN *** simulation results are obtained for 50 epochs in the training *** simulation results reveal that the optimum CNN architecture consists of four layers.

关键词： Healthcare smart cities clinical automation CNN machine learning brain tumor medical diagnosis

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Micropunch grafting for healing of refractory chronic venous leg ulcers

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Chinese Journal Of Plastic and Reconstructive Surgery 2022年第4期4卷 166-170页

作者： Aya Mohamed Samy Mostafa abd el-Halim ahmed Hassan el-Sabbagh Department of Plastic and Reconstructive Surgery Mansoura University HospitalMansoura 35516Egypt Plastic Surgery Center Faculty of MedicineMansoura UniversityMansoura 35516Egypt

Background: Chronic venous ulcers are a serious problem for both patients and physicians. The CEAP classification(clinical manifestations(C), etiologic factors(E), anatomic distribution of disease(A), and underlying pathophysiologic findings(P)) for chronic venous disorders(CVD) was developed in 1994. Published papers on CVD use all or part of the CEAP. Micropunch grafts, which are a variation of skin grafts, have been used with great success in plastic surgery for both esthetic and reconstructive purposes. This study aimed to assess the outcomes of micropunch grafting in the treatment of chronic refractory venous ***: Patients with chronic venous ulcers who did not respond to conservative treatment for more than 6months were included in the study. All patients underwent ulcer coverage by micropunch skin grafts using a micrometer. The patients were discharged on the same day as the surgery. Micropunch skin grafts were manually counted per square centimeter intraoperatively and during follow-up using Dermlite DermatoschopeTM II Pro *** satisfaction was assessed by using a ***: Twenty patients underwent the surgery. Most of the patients were middle-aged males. The ulcers were predominantly small-and medium-sized. The mean operation time was 167.00 ± 86.01 min. After 6 months, the survival rate of the planted micrografts was 84%. Three ulcers had graft loss and two patients had an infection at the ulcer site, which was managed conservatively. The patients were followed-up for 14 ***: Micropunch grafting is a useful and convenient method for the treatment of difficult venous ulcers and can be performed on an outpatient basis.

关键词： Venous ulcer Micropunch grafting

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Magnetic Field Effect and Heat Transfer of Nanofluids within Waveform Microchannel

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1957-1973页

作者： Mehdi Moslemi Motahare Mahmoodnezhad S.A.Edalatpanah Sulima ahmed Mohammed Zubair Hamiden abd el-Wahed Khalifa Ayandegan Institute of Higher Education TonekabonIran Department of Mathematics College of Science and ArtsQassim UniversityAr RassSaudi Arabia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGizaEgypt

In this research,a numerical study of mixed convection of non-Newtonian fluid and magnetic field effect along a vertical wavy surface was investigated.A simple coordinate transformation to transform wavy surface to a flat surface is employed.A cubic spline collocation numerical method is employed to analyze transformed *** effect of various parameters such as Reynolds number,volume fraction 0-,Hartmann number,and amplitude of wave length was evaluated in improving the performance of a wavy *** to the presented results,the sinusoidal shape of the microchannel has a direct impact on heat *** increasing the microchannel wave amplitude,the Nusselt number has *** the other hand,increasing the heat transfer in the higher wavelength ratio corrugated channel is seen as an effective method of increasing the heat transfer,especially at higher Reynolds *** results showed that with increasing Hartmann numbers,the flow line near thewall becomesmore regular and,according to the temperature gradient created,theNusselt number growth.

关键词： Heat transfer magnetic field nano fluid vorticity wavy micro channel

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An Efficient Indoor Localization Based on Deep Attention Learning Model

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Computer Systems Science & Engineering 2023年第8期46卷 2637-2650页

作者： Amr Abozeid ahmed I.Taloba Rasha M.abd el-Aziz Alhanoof Faiz Alwaghid Mostafa Salem ahmed elhadad Department of Computer Science College of Science and ArtsJouf UniversityQurayyatSaudi Arabia Information System Department Faculty of Computers and InformationAssiut UniversityEgypt Computer Science Department Faculty of Computers and InformationAssiut UniversityAssiutEgypt Department of Computer Science Faculty of Computers and InformationSouth Valley UniversityQenaEgypt

Indoor localization methods can help many sectors,such as healthcare centers,smart homes,museums,warehouses,and retail malls,improve their service *** a result,it is crucial to look for low-cost methods that can provide exact localization in indoor *** this context,imagebased localization methods can play an important role in estimating both the position and the orientation of cameras regarding an ***-based localization faces many issues,such as image scale and rotation ***,image-based localization’s accuracy and speed(latency)are two critical *** paper proposes an efficient 6-DoF deep-learning model for image-based *** model incorporates the channel attention module and the Scale PyramidModule(SPM).It not only enhances accuracy but also ensures the model’s real-time *** complex scenes,a channel attention module is employed to distinguish between the textures of the foregrounds and *** model adapted an SPM,a feature pyramid module for dealing with image scale and rotation variance ***,the proposed model employs two regressions(two fully connected layers),one for position and the other for orientation,which increases outcome *** on standard indoor and outdoor datasets show that the proposed model has a significantly lower Mean Squared Error(MSE)for both position and *** the indoor 7-Scenes dataset,the MSE for the position is reduced to 0.19 m and 6.25°for the ***,on the outdoor Cambridge landmarks dataset,the MSE for the position is reduced to 0.63 m and 2.03°for the *** to the findings,the proposed approach is superior and more successful than the baseline methods.

关键词： Image-based localization computer vision deep learning attention module VGG-16

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