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Prognostic Value of Combined;Cox-2, Cyclin D1 and P21 Expression in Colorectal Cancer (CRC) Patients: An Immunohistochemical Study

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Open Journal of Pathology 2018年第3期8卷 106-121页

作者： Amir M. Salem Mariem A. Elfeky Nashwa Nawar ahmed z. alattar Omar Atef Elekiabi Mostafa M. Elaidy Department of Pathology Faculty of Medicine Zagazig University Zagazig Egypt Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Zagazig University Zagazig Egypt Department of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt

Background: Cyclooxygenase (COX) is a rate limiting enz.me in synthesis of prostanoids pathway and it has 2 isoforms (COX-1 and COX-2). It has many biological roles in inflammation and oncogenesis. Cox-2 was incriminated in performing disturbances in the cell cycle control in CRC, but its role of in CRC needs clarification of the mechanisms by which Cox-2 might affect the process of colorectal carcinogenesis. Cyclin D1 is an oncogene that regulates G1 phase progression to S phase of the cell cycle. Its stimulatory role on cell cycle is antagoniz.d by Cyclin D1-dependent kinase (CDK) inhibitors like p21. P21 plays an essential role in cell cycle regulation;it may have a pro-apoptotic or an antiapoptotic role in cancer. P21 was found to have many roles in cancer;invasion metastases, cellular senescence and stem cells aging. The roles of combined expression of Cox-2, Cyclin D1 and P21 in CRC tissues and their role of prognosis and patients survival are not sufficiently clarified. Aim of the Study: To evaluate tissue expression of Cox-2, Cyclin D1 and P21 in CRC and to correlate such expression with pathological parameters, clinical and prognostic data of the patients. Methods: Cox-2, Cyclin D1 and P21 are evaluated in colon cancer tissues. Correlations between their level of expressions pathological parameters, clinical and prognostic data of patients were analyz.d. Results: Cox-2, Cyclin D1 over-expression was associated with higher grade, higher incidence of occurrence of lymph node & distant metastasis and advanced stage (P = 0.000). Cox-2 was related to higher tumor recurrence rate (P = 0.04) and decreased overall patients survival rate (p = 0.002). (r correlation coefficient = +0.987). Conclusion: Cox-2 and Cyclin D1 are markers of poor prognosis colon cancer patients.

关键词： Cox-2 Cyclin D1 Colon Cancer Immunohistochemistry Prognosis

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The Lambert-G Family:Properties,Inference,and Applications

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 513-536页

作者： Jamal N.Al Abbasi ahmed z.Afify Badr Alnssyan Mustafa S.Shama Accounting Department Ashur UniversityBaghdad10011Iraq Department of Statistics Mathematics and InsuranceBenha UniversityBenha13511Egypt Department of Management Information Systems and Production Management College of Business and EconomicsQassim UniversityBuraydah51452Saudi Arabia Department of Basic Sciences Common First Year(CFY)King Saud UniversityRiyadh11362Saudi Arabia Department of Mathematics and Statistics Osim Higher Institute of Administrative ScienceOsim12961Egypt

This study proposes a new flexible family of distributions called the Lambert-G *** Lambert family is very flexible and exhibits desirable *** three-parameter special sub-models provide all significantmonotonic and non-monotonic failure rates.A special sub-model of the Lambert family called the Lambert-Lomax(LL)distribution is *** expressions for the LL statistical properties are *** of the LL distribution are addressed mathematically based on its haz.rd *** estimation of the LL parameters is discussed using six estimation *** performance of this estimation method is explored through simulation *** usefulness and flexibility of the LL distribution are demonstrated empirically using two real-life data *** LL model better fits the exponentiated Lomax,inverse power Lomax,Lomax-Rayleigh,power Lomax,and Lomax distributions.

关键词： Lambert function Lomax distribution maximum likelihood haz.rd function statistical model simulation

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Pyronaridine combined with diminaz.ne aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed z.Sayed-ahmed Shaimaa ahmed Awad Ali Nourah Alsadaan Nawaz.sh Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Riz. National Research Center for Protoz.an Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminaz.ne aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminaz.ne aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminaz.ne aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminaz.ne aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminaz.ne aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminaz.ne aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normaliz.d the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminaz.ne aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminaz.ne aceturate Babesiosis Theileria

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Experimental Study on Heat Storage Properties Comparison of Paraffin/Metal Foams Phase Change Material Composites

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Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar ahmed Abid HUSSAIN Hanz.a SHAHID Imran ALI Hafiz.Muhammad ALI Department of Mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of Mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of Mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCMs) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCMs can be improved by developing metal foam/PCM *** addition of metal foam in PCMs has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCM composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z. was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

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Boosted photocatalytic removal of NO using direct z.scheme UiO-66-NH_(2)/Bi_(2)MoO_(6) nanoflowers heterojunction:mechanism insight and humidity effect

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Rare Metals 2024年第8期43卷 3758-3770页

作者： Jiang-Yu-Shan Liang Hai-Tao Ren Abdelkader Labidi Qiu-Hui z.u Qi-Bing Dong ahmed A.Allam ahmed Rady Chuan-Yi Wang School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China z.ology Department Faculty of ScienceBeni-Suef UniversityBeni-Suef 6251lEgypt Department of z.ology College of ScienceKing Saud University11451 RiyadhSaudi Arabia

In practical applications,relative humidity in the air is a key factor affecting the photocatalytic removal of NO,which is often overlooked in previous ***,we developed a direct z.scheme UiO-66-NH_(2)/Bi_(2)MoO_(6)heterojunction with a nanoflower-like structure to systematically investigate the effect of relative humidity on photocatalytic removal of *** optimiz.d heterojunction for the removal efficiency of NO was 71.6%at1.07 mg·m^(-3)NO concentration(relative humidity=10%),and the generation of NO_(2) was only 1.1%.Interestingly,with the increase in relative humidity,it showed a higher inhibition effect on NO_(2),while the removal of NO decreased slightly(8%),which might be attributed to the affinity effect of NO_(2) with water molecules and the competitive adsorption of H_(2)O and NO on the surface of the heterojunction ***,the reaction pathways of NO removal at the developed heterojunctions were revealed by in situ DRIFTS *** work provides a novel vision for the development of direct z.scheme heterojunction photocatalysts to effectively remove NO and inhibit the formation of toxic intermediate NO_(2) under different humidities.

关键词： NO removal Relative humidity Direct z.scheme Bismuth molybdate Visible-light photocatalysis

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Ibuprofen-Induced Toxic Epidermal Necrolysis:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 108-110页

作者： Nevin Kannappilly Mohamed z.Peediyakkal Mohamad Y.Khatib Dore C.Ananthegowda Moustafa S.Elshafei Hani El z.er Karimulla S.Shaik Moayad M.AlFayoumi Dyaneshwar P.Mutkule ahmed A.Soliman Abdulqadir J.Nashwan Critical Care Department Hamad Medical Corporation(HMC)Doha 3050Qatar

Introduction:Toxic epidermal necrolysis(TEN)is a medical emergency that most commonly occurs as an adverse effect of certain ***,we describe a case of a 41-year-old man with no comorbid illness who developed *** presentation:The patient had been prescribed ibuprofen for myalgia and developed skin lesions after the single *** lesions were erythematous papules and macules distributed all over the body after ibuprofen *** was diagnosed based on the patient’s clinical presentation and laboratory *** was treated with intravenous dexamethasone,intravenous immunoglobulin,and *** dressing changes and skin care was done with saline,chlorhexidine,and liquid *** patient was intubated and tracheostomiz.d,and he gradually improved and ***,he developed septicemia in the intensive care unit and was treated ***:The management of TEN includes cessation of the causative cause,multidisciplinary intensive care unit(ICU)care,prevention and early detection of sepsis,fluid and electrolyte balance,adequate analgesia and temperature control,proper organ support,aggressive nutritional management,and good psychological *** pharmacological therapy for TEN includes corticosteroids,intravenous immunoglobulin,and *** key elements of management are aseptic care and proper dressing of the ***:TEN is associated with high mortality if not managed in a systemic and protocoliz.d way.

关键词： ibuprofen toxic epidermal necrolysis erythema drug-induced erythema

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A journey towards shared governance: status and prospects for collaborative management in the protected areas of Bangladesh

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Journal of Forestry Research 2013年第3期24卷 599-605,602-605页

作者： A. z. M. Manz.or Rashid Donna Craig Sharif ahmed Mukul Niaz.ahmed Khan Environmental Law School of Law University of Western SydneyAustralia Department of Forestry and Environmental Science Shahjalal University of Science and TechnologySylhet Bangladesh School of Agriculture and Food Sciences The University of QueenslandAustralia Department of Development Studies University of DhakaBangladesh

Establishment of Protected Areas （PAs）, in the face of rapid deforestation, forest degradation and climate change has been one of the key efforts in conservation of biodiversity worldwide in recent times. While Bangladesh has gained a degree of prominence in the world for its successful social forestry programs, the concept of collaborative pro- tected area management is rather new in the country, initiated in 2004 by the Bangladesh Forest Department in five PAs with financial assistance from USAID. Based on empirical evidence from three of the pilot PAs, we examined the achievements and associated challenges and prospects for co-management. Our fieldwork revealed a number of challenges faced by co-management institutions：（1） institutions were dominated by the elite group, overshadowing the voice of the community people; （2） mutual trust and collective performance are key to good governance but had not taken root in the PAs; （3） encroachment onto forest land and subsequent conversion to agriculture remained a serious problem that discouraged forest-dependent people from participating actively in co-management initiatives; （4） legal provisions （including acts, rules and policies） were not clearly and adequately disseminated and understood at the community level; （5） there remained a degree of ambiguity regarding the roles and responsibilities of forest department （FD） and co-management committees （CMC） in field operations, and this was not enhancing transparency and accountability of the overall initiative; （6） the long-term sustainability of co-management institutions was another major concern, as the local intuitional structure was still in a nascent stage, and provisioning of resources （either internally or externally） remained somewhat uncertain. We offer recommendations for improve- ment.

关键词： protected area co-management Nishorgo IPAC govern-ance

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青藏高原及其周边寒武纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 968-991页

作者：孙智新孙郎赵方臣潘兵 Malik Muhammad Saud Sajid KHAN Shehryar ahmed 杨传苗兰云殷宗军李国祥朱茂炎中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049

青藏高原及其周边地区具有漫长且复杂的构造演化历史.印度北部、拉萨、羌塘、柴达木、中祁连等大小不同的克拉通和地块,以及位于它们之间的造山带构成了青藏高原的主体.寒武纪时期,这些克拉通和地块大多位于冈瓦纳大陆的西北缘,并以发... 详细信息

青藏高原及其周边地区具有漫长且复杂的构造演化历史.印度北部、拉萨、羌塘、柴达木、中祁连等大小不同的克拉通和地块,以及位于它们之间的造山带构成了青藏高原的主体.寒武纪时期,这些克拉通和地块大多位于冈瓦纳大陆的西北缘,并以发育与原特提斯洋有关的复杂岩浆-构造运动而与周边的阿拉伯、中伊朗、阿富汗、塔里木、阿拉善、华北、华南和滇缅马等构造单元相关联.从地层记录上看,这一时期区域内的大部分稳定陆块上发育了由陆源碎屑岩和碳酸盐岩组成的浅水陆棚沉积,其中包含面貌相近的典型浅水相三叶虫组合.而在原特提斯洋中的祁连构造带,寒武系则是一套在大洋扩张环境下形成的、以中基性火山岩和硅质岩为主的复杂地层序列,其中包含的碳酸盐岩含有斜坡相三叶虫组合.本文在广泛文献调研的基础上,结合第二次青藏高原综合科学考察中的野外观察及新获得的化石证据,对青藏高原及其周边地区不同构造单元上寒武纪地层发育的总体特征进行了概述.在此基础上,利用可获得的生物地层学和同位素年代学等资料,总结了不同构造单元上寒武纪地层的划分和年代地层对比,编制了岩石和生物地层的综合对比表.此外,从生物古地理的角度,简要讨论了寒武纪研究区内主要构造单元的古地理相关性,以及与原特提斯构造带演变有关的问题.

关键词：青藏高原寒武系地层古地理生物群冈瓦纳大陆原特提斯洋

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Peristaltic Flow of Dusty Nanofluids in Curved Channels

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Computers, Materials & Continua 2021年第1期66卷 1011-1026页

作者： z.z.Rashed Sameh E.ahmed mathematics department jouf universityqurayyatsaudi arabia department of mathematics king khalid universityabhasaudi arabia

In this paper,numerical investigations for peristaltic motion of dusty nanofluids in a curved channel are *** systems of partial differential equations are presented for the nanofluid and dusty phases and then the approximations of the long wave length and low Reynolds number are *** physical domain is transformed to a rectangular computational model using suitable grid *** resulting systems are solved numerically using shooting method and mathematical forms for the pressure distributions are *** controlling parameters in this study are the thermal buoyancy parameter G_(r),the concentration buoyancy parameter Gc,the amplitude ratio,the Eckert number Ec,the thermophoresis parameter N_(t) and the Brownian motion parameter Nb and the dusty parameters D_(s);α_(s).The obtained results revealed that an increase in the Eckert number enhances the temperature of the fluid and dusty particles while the nanoparticle volume fraction is ***,both of the temperature and nanoparticles volume fraction are supported by the growing of the Brownian motion parameter.

关键词： Peristaltic motion dusty particles nanofluid curved channels

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A stable flat universe with variable cosmological constant in f(R,T)gravity

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Research in Astronomy and Astrophysics 2018年第10期18卷 65-74页

作者： Nasr ahmed Sultan z.Alamri Astronomy Department National Research Institute of Astronomy and GeophysicsHelwanCairoEgypt Mathematics Department Faculty of ScienceTaibah UniversitySaudi Arabia

In this paper, a general FRW cosmological model has been constructed in f（R, T） gravity reconstruction with variable cosmological constant. A number of solutions to the field equations has been generated by utiliz.ng a form for the Hubble parameter that leads to Berman＇s law of constant deceleration parameter q =m - 1. The possible decelerating and accelerating solutions have been investigated. For （q 〉 0） we get a stable fiat decelerating radiation-dominated universe at q = 1. For （q 〈 0） we get a stable accelerating solution describing a flat universe with positive energy density and negative cosmological constant. Nonconventional mechanisms that are expected to address the late-time acceleration with negative cosmological constant have been discussed.

关键词： modified gravity cosmology deceleration parameter

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