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Influence OF anticancer drugs on DNA methylation in liver of female mice

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American Journal of Molecular Biology 2011年第2期1卷 62-69页

作者： Shaden Muawia Hanafy tarek abd El-Raouf Salem Amal ahmed abd El-Aziz Bahgat.abd El-ghafar EL-Fiky Mahmoud abd El-Azeim Shokair 不详

Epigenetic changes such as DNA methylation regulate gene expression in normal development. Methotrexate and Adriamycine are antineoplastic drugs that target DNA and enzymes acting on DNA. We aimed to evaluate their cytotoxic effect on cell lines and on female mice to investigate the in vivo influence of both drugs on the DNA methylation and subsequently the protein expression. the total level of DNA methylation showed a significant reduction from 62.2% to 36.7%, 36.6% as compared to control group, when using different doses of MtX and ADR. Hepatic protein pattern revealed five bands with low MW (16 - 6.1 KDa) in acute and LD50 doses. In conclusion DNA methylation is influenced by anticancer drugs in a dose - dependent manner. Some specific protein fragments may be considered as a potential markers associated with high dose of anticancer drugs.

关键词： Epigenetic DNA Methylation Methotrexate (MtX) and Adriamycine (ADR).

Efficacy of using NRt thresholds in cochlear implants fitting,in prelingual pediatric patients

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Journal of Otology 2019年第4期14卷 128-135页

作者： ahmed Allam ahmed Eldegwi Department of Otolaryngology Mansoura University

Objective:to evaluate the efficacy of using neural response telemetry(NRt)thresholds in predicting behavioural thresholds during programming of cochlear implant in prelingual ***:Prospective study of 28 cochlear implants implanted with Nucleus 24 cochlear *** recorded NRt-thresholds on electrode numbers 1,6,11,16 and 22 of the electrode array in each patient,the neural response thresholds were correlated with the behavioural map after six months of programming the ***:the mean neural response telemetry level was significantly higher than the mean threshold level(t-level)but lower than the comfortable level(C-level)in all the electrodes *** levels could statistically significantly predict t behavioural levels and comfortable behavioural levels,ptrong positive correlation between comfortable thresholds and neural response telemetry level measurements and behavioural threshold level and neural response telemetry threshold ***:there is a useful role for neural response telemetry values in predicting the behavioural threshold and comfortable values in prelingual *** the NRt values with behavioural observations can improve the programming of cochlear implants.

关键词： NRt ECAP Behavioural levels Cochlear implant Programming

Natural radioactivity levels and radiation hazards for gypsum materials used in Egypt

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Natural Science 2014年第1期6卷 5-13页

作者： ahmed Hassan Korna Soad Saad Fares Magda abd El-Rahman Department of Physics Faculty of Science Al Baha University Al Bahah KSA Department of Radiation Physics National Center of Radiation Research and Technology NCRRT Atomic Energy Authority Cairo Egypt

Radionuclides naturally occurring in building materials may significantly contribute to the annual doses to the public. For instance, familiar building materials such as the concrete and gypsum board have been reported to produce a dose of about 0.04 mSv per year for a typical person (NCRP 1987c). External as well as internal exposures are two pathways of radiation dose imparted to human beings from the building materials. As information on the radioactivity of such materials is lacking, the study of gypsum materials used in Egypt was carried out in order to estimate the annual dose to the Egyptian population due to natural radionuclides in building materials. During the study, 18 samples of commonly used gypsum raw materials were collected and measured. the activity concentrations were determined by gamma ray spectrometry. their mean values were in the ranges of 499.29 ± 11.53 Bq·kg-1 for 40K, 91.97 ± 2.61 Bq·kg-1 for 226Ra, 37.62 ± 1.67 Bq·kg-1 for 238U and 42.27 ± 2.22 Bq·kg-1 for 232th. the activity indexed Iγ for 18, different gypsum samples varied from 0.31 ± 0.03 to 2.3 ± 0.19 and the radium equivalent activity (Raeq), from 38.81 ± 1.68 to 324.7 ± 9.42. these values are lower than the limit of 370 Bq·kg-1 adopted by the Organization for Economic Cooperation and Development (OECD). the average indoor annual effective gamma dose rate (DE) in (mSv/y) for the people, caused by the building materials of dwellings, was assessed for most commonly gypsum materials. It was estimated to be in the range from 0.10 ± 0.003 mSv/y to 0.74 ± 0.08 mSv/y. the internal and external hazard indices (Hin, Hex) and the absorbed dose rate in air D in each sample were evaluated to assess the radiation hazard for people living in dwelling made of the studied materials. the absorbed dose rate of indoor air in samples G1, G2, G11, G17 and G18 is less than the international recommended value which is 55 nGyh-1. While the absorbed dose rate for samples G3, G4, G5, G6, G7, G8, G9, G10, G12

关键词： Gypsum Gamma Spectrometer Hazard Indices NORM Building Materials

the Usefulness of Diffusion Weighted and Contrast Enhanced Magnetic Resonance Imaging in Characterization of Inconclusive Ovarian Mass

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第1期9卷 24-33页

作者： Ghada Mohammed abd El Razeq Mohammad A. M. ahmed Department of Radiodiagnosis Qena Faculty of Medicine South Valley University Qena Egypt Department of Obstetrics & Gynecology Qena Faculty of Medicine South Valley University Qena Egypt

Introduction: Ovarian cancer is the commonest reason for death in females due to gynecologic malignancy around the world. In contrast to other gynecologic tumours, the definitive diagnosis is accomplished days after of the index surgery by the histopathology. Preoperative assessment based on conventional MRI is not accurate. Information is expanding increasing about the ability of new MRI modalities to assess ovarian mass. Aim of the study: to assess the ability of dynamic contrast-enhanced MRI (DCE–MRI), and Diffusion-weighted image (DWI) to describe uncertain ovarian masses. Patients and Methods: this is a retrospective study. Patients were referred from radio-diagnosis department and gynecology department of Qena faculty of medicine hospitals, South Valley University. Patients had uncertain adnexal masses at ultrasound. Magnetic resonance examination was doneutilizing 1.5 tesla machine. the protocol included t1WI, t2WI, t1WI following contrast, and DWI. Results: We included 44 patients with different forms of complex cystic and solid ovarian masses. the final pathology of the ovarian masses was 18 benign, 4 borderline, and 22 malignant. the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DWI were 100%, 94.4%, 96.3%, 100%, and 97.7% respectively. the performance of DWI was higher than the conventional MRI and DCE-MRI. Conclusion: DCE-MRI and DWI have accepted ability to recognize malignant ovarian mass.

关键词： Ovarian Contrast Diffusion MRI

New Derivation of Simple Josephson Effect Relation Using New Quantum Mechanical Equation

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Natural Science 2016年第3期8卷 85-88页

作者： Rashida Ismat.abdalrahman Rasha abd Elhai Mohammad taha Isam ahmed Attia Mubarak Dirar abd Allah Department of Physics College of Science Sudan University of Science and Technology Khartoum Sudan Department of Physics College of Education Majimaah University Zulfi KSA

A relation of the Josephson current density equation is successfully derived;this is done through a new derivation of the equation of quantum by neglecting kinetic Newtonian term in the energy expression.

关键词： Quantum Mechanics Superconductors Josephson Effect tunneling Current

Development of NIS two-temperature Humidity Generator

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Journal of Physical Science and Application 2014年第7期4卷 436-439页

作者： Mohamed Gamal ahmed Said Mazen Doaa abd El-Gelil National Institute for Standard Giza Egypt Physics Department Faculty of Science Zagazig University Sharkia Egypt

Abstract： this paper describes the development and characterization of a two-temperature （2-t）, constant pressure humidity generator It relies on the saturation of a stream of gas flowing over a water surface maintained at constant, well-known, temperature. It was built in order to improve the uncertainties of the dew-point temperature and humidity scales realization at the National Institute for Standard （NIS） in the dew-point range from -50 ℃ to ＋ 10 ℃. Several experiments were carried out in the above mentioned range in order to characterize the generator. Characterization comprised studies of its saturator efficiency, temperature stability and a comparison with a calibrated chilled-mirror hygrometer. the results of the efficiency tests showed good performance of the generator as described below. For uncertainty of measurements, a thorough analysis was also described representing estimations of contributions for all the sources that affecting measurements.

关键词： Dew-point hygrometer two-temperature generator uncertainty.

Electro Analytical Determination of Di Hydroxybenzene Isomers Using Glassy Carbon Electrode

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Journal of Chemistry and Chemical Engineering 2014年第7期8卷 654-661页

作者： Mahmoud Khodari ahmed abd El-Rady Ekram Rabee Nada Nabil Chemistry Department Faculty of Science South Valley University Qena 83523 Egypt

In this study, the electrochemical oxidation of Ct （catechol）, HQ （hydroquinone） and RS （resorcinol） was investigated using cyclic and linear sweep voltammetries at GCE （glassy carbon electrode）. the GCE showed an excellent electro activity and reversibility towards the oxidation of these isomers at different conditions. HQ and Ct showed one defined oxidation peak and one defined reduction peak while RS showed one defined oxidation peak. these isomers were determined also in their binary and tertiary mixtures. the calibration curves for Ct, HQ and RS were obtained in the ranges of 5 × 10-6 to 1 × 10-3 ***-3, 5 × 10-6 to 5 × ***-3 and 1 × 10-5 to 1× 10-3 ***-3, respectively. the detection limits were 9 ×10-7, 3 × 10-7, 6 × 10-6 ***3 for Ct, HQ and RS, respectively. At the optimal experimental conditions, these isomers were determined in different water samples. Also, the removal of catechol from aqueous solution by adsorption on activated charcoal and alumina was studied. After 24 h, 88.7% and 65.9% of catechol was removed using charcoal and alumina, respectively.

关键词： Di hydroxybenzene isomers glassy carbon electrode electroanalytical chemistry removal ofcatechol adsorption.

Improving Adherence to Prescribed Antidiabetics and Cardiovascular Medications in Primary Health Care Centers in Nyala City, South Darfur State-Sudan

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Pharmacology & Pharmacy 2013年第9期4卷 701-709页

作者： ahmed Dahab ahmed Asim ahmed Elnour Mirghani abd Elrahman Yousif Farah Hamad Farah Hasab Alrasoul Akasha ahmed Osman Abobakr Abasaeed College of Pharmacy and Health Sciences Ajman University of Sciences and Technology Ajman UAE College of Pharmacy Clinical Pharmacy Taif University Taif KSA Consultant Clinical Pharmacist Al Ain Hospital Abu Dhabi Health Services Company (SEHA) Al Ain UAE Department of Pharmacology College of Medicine and Health Sciences UAE University Al Ain UAE Revolving Drug Fund (RDF) Ministry of Health (MOH) Nyala Sudan Department of Pharmaceutics Faculty of Pharmacy Gezira University Medani Sudan Social and Clinical Pharmacy Department Faculty of Pharmacy Charles University Hradec Kralove Czech Republic Registration and Drug Control Department Ministry of Health Abu Dhabi UAE. the Epidemiological Laboratory (Epi-Lab) Khartoum Sudan

Aims: Prospective pharmacist’s interventions aimed to improve patient’s knowledge and behaviors to adhere to medications in patients with type 2 diabetes with or without cardiovascular medical conditions in primary health care (PHCs) centers in Nyala city, South Darfur State, Sudan. Methodology and Materials: 300 patients were enrolled for assessing adherence with the Brief Medication Questionnaire (BMQ) in ten PHCs in Nyala city. We assessed patients’ responses to BMQ pre-and post-interventions plan by: complex interventions, humanitarianism and disease outcomes determined by health-related outcomes (SF-36), glycosylated hemoglobin (HbA1c) and blood pressure. Results: BMQ scores have improved significantly in four screens (pre-and post-interventions): regimen [4.6 ± 0.2 to 1.8 ± 0.1;P = 0.001], belief [1.6 ± 0.3 to 0.3 ± 0.3;P = 0.007], recall [1.7 ± 0.2 to 0.6 ± 0.2;P = 0.043] and access screens [1.8 ± 0.1 to 0.4 ± 0.1;P = 0.005];which have indicated an improved patients’ adherence to medications. Percentage of subjects reaching target of post prandial blood glucose (PPBG) have increased from 28.0% to 49.3%;[P = 0.02] post interventions. PPBG mean values have decreased significantly from [11.1 ± 0.6 mmol/L to 8.1 ± 0.8 mmol/L;

关键词： Adherence Darfur Medications Nyala PHCs Sudan

Effect of Egyptian propolis on cryptosporidiosis in immunosuppressed rats with special emphasis on oocysts shedding,leukogram,protein profile and ileum histopathology

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Asian Pacific Journal of tropical Medicine 2017年第3期10卷 240-248页

作者： Hamdy Soufy Nadia M.El-Beih Soad M.Nasr tamer H.abd El-Aziz Fathia A.M.Khalil Youssef F.ahmed Hala A.A.Abou Zeina Department of Parasitology and Animal Diseases National Research Centre Department of Zoology Faculty of ScienceAin Shams University Department of Reproduction and Artificial Insemination National Research Centre

Objective:to investigate the activity of Egyptian propolis extracts(ethanol and water)on cryptosporidiosis in experimentally infected dexamethasone-immunosuppressed ***:A total of 180 male rats(190-220)g BWt were randomly divided into 9 equal groups(G1-G9).Groups of rats were kept as(G1):normal control,(G2-G9):immunosuppressed with dexamethasone and(G3-G9):infected with Cryptosporidium *** from(G4to G9)were given orally ethanol and water extract of propolis(at a dose of 50 mg/kg BWt)and nitazoxanide(standard anti-cryptosporidial drug at a dose of 100 mg/kg BWt)to infected rats with different *** pellets were collected from all groups to monitor oocysts shedding from the 2nd to the 15th day post *** the end of the experiment,blood was collected from all groups for determination of leukogram and serum *** specimens were also examined ***:the highest reduction of oocysts shedding in faecal samples was 88%in rats prophylactically treated with propolis ethanol extract at the 4th dpi,and in rats prophylactically treated with water extract of propolis,was91%at the 6th *** was a marked increase in neutrophils count and α_2-andβ-globulins levels in infected rats treated with both extracts,while a significant decrease was detected in lymphocytes compared to the infected non treated group.β-globulin level markedly increased in the rats administered *** changes were observed in the ileum of rats infected with ***:Egyptian propolis extracts have an activity on cryptosporidiosis in ***,propolis modulated the immunity in dexamethasone-immunosuppressed rats.

关键词： Cryptosporidiosis Propolis Rat model Leukogram Serum proteins Histopathology